Amino acid dipepetide frequency for Polaromonas naphthalenivorans (strain CJ2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.351AlaAla: 16.351 ± 0.17	1.434AlaCys: 1.434 ± 0.032	5.991AlaAsp: 5.991 ± 0.066	6.288AlaGlu: 6.288 ± 0.086	4.033AlaPhe: 4.033 ± 0.056	10.433AlaGly: 10.433 ± 0.106	2.623AlaHis: 2.623 ± 0.047	5.307AlaIle: 5.307 ± 0.062	4.335AlaLys: 4.335 ± 0.075	14.502AlaLeu: 14.502 ± 0.129	3.555AlaMet: 3.555 ± 0.052	2.967AlaAsn: 2.967 ± 0.047	5.743AlaPro: 5.743 ± 0.076	5.957AlaGln: 5.957 ± 0.067	8.163AlaArg: 8.163 ± 0.084	7.573AlaSer: 7.573 ± 0.089	5.959AlaThr: 5.959 ± 0.08	8.503AlaVal: 8.503 ± 0.085	1.834AlaTrp: 1.834 ± 0.04	2.497AlaTyr: 2.497 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.236CysAla: 1.236 ± 0.032	0.14CysCys: 0.14 ± 0.009	0.552CysAsp: 0.552 ± 0.019	0.596CysGlu: 0.596 ± 0.018	0.363CysPhe: 0.363 ± 0.017	1.016CysGly: 1.016 ± 0.029	0.302CysHis: 0.302 ± 0.014	0.502CysIle: 0.502 ± 0.016	0.294CysLys: 0.294 ± 0.014	0.93CysLeu: 0.93 ± 0.024	0.244CysMet: 0.244 ± 0.012	0.287CysAsn: 0.287 ± 0.017	0.532CysPro: 0.532 ± 0.021	0.326CysGln: 0.326 ± 0.014	0.633CysArg: 0.633 ± 0.019	0.638CysSer: 0.638 ± 0.022	0.517CysThr: 0.517 ± 0.019	0.715CysVal: 0.715 ± 0.021	0.146CysTrp: 0.146 ± 0.01	0.198CysTyr: 0.198 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.793AspAla: 6.793 ± 0.084	0.494AspCys: 0.494 ± 0.018	2.558AspAsp: 2.558 ± 0.04	3.093AspGlu: 3.093 ± 0.047	2.101AspPhe: 2.101 ± 0.032	4.178AspGly: 4.178 ± 0.053	1.027AspHis: 1.027 ± 0.03	2.57AspIle: 2.57 ± 0.041	2.045AspLys: 2.045 ± 0.04	5.114AspLeu: 5.114 ± 0.06	1.294AspMet: 1.294 ± 0.027	1.258AspAsn: 1.258 ± 0.027	2.552AspPro: 2.552 ± 0.041	1.624AspGln: 1.624 ± 0.037	2.88AspArg: 2.88 ± 0.044	2.568AspSer: 2.568 ± 0.042	2.394AspThr: 2.394 ± 0.037	3.681AspVal: 3.681 ± 0.051	0.942AspTrp: 0.942 ± 0.024	1.342AspTyr: 1.342 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.521GluAla: 6.521 ± 0.072	0.422GluCys: 0.422 ± 0.017	2.198GluAsp: 2.198 ± 0.046	2.509GluGlu: 2.509 ± 0.048	2.035GluPhe: 2.035 ± 0.037	3.501GluGly: 3.501 ± 0.054	1.305GluHis: 1.305 ± 0.03	2.797GluIle: 2.797 ± 0.044	2.476GluLys: 2.476 ± 0.054	6.05GluLeu: 6.05 ± 0.065	1.35GluMet: 1.35 ± 0.031	1.518GluAsn: 1.518 ± 0.034	2.39GluPro: 2.39 ± 0.04	2.602GluGln: 2.602 ± 0.051	4.229GluArg: 4.229 ± 0.059	2.784GluSer: 2.784 ± 0.052	2.614GluThr: 2.614 ± 0.037	3.949GluVal: 3.949 ± 0.057	0.688GluTrp: 0.688 ± 0.018	1.002GluTyr: 1.002 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.957PheAla: 3.957 ± 0.053	0.458PheCys: 0.458 ± 0.016	2.382PheAsp: 2.382 ± 0.036	2.25PheGlu: 2.25 ± 0.04	1.469PhePhe: 1.469 ± 0.035	3.3PheGly: 3.3 ± 0.05	0.688PheHis: 0.688 ± 0.021	1.615PheIle: 1.615 ± 0.037	1.492PheLys: 1.492 ± 0.036	3.084PheLeu: 3.084 ± 0.046	0.958PheMet: 0.958 ± 0.024	1.245PheAsn: 1.245 ± 0.031	1.511PhePro: 1.511 ± 0.028	1.124PheGln: 1.124 ± 0.025	1.872PheArg: 1.872 ± 0.036	2.549PheSer: 2.549 ± 0.039	1.941PheThr: 1.941 ± 0.039	2.671PheVal: 2.671 ± 0.041	0.51PheTrp: 0.51 ± 0.02	0.909PheTyr: 0.909 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.521GlyAla: 8.521 ± 0.106	0.954GlyCys: 0.954 ± 0.028	3.746GlyAsp: 3.746 ± 0.056	4.098GlyGlu: 4.098 ± 0.057	3.256GlyPhe: 3.256 ± 0.05	6.377GlyGly: 6.377 ± 0.096	1.863GlyHis: 1.863 ± 0.036	4.081GlyIle: 4.081 ± 0.057	3.792GlyLys: 3.792 ± 0.065	8.861GlyLeu: 8.861 ± 0.089	2.338GlyMet: 2.338 ± 0.042	2.372GlyAsn: 2.372 ± 0.043	2.835GlyPro: 2.835 ± 0.051	3.608GlyGln: 3.608 ± 0.05	4.965GlyArg: 4.965 ± 0.059	4.673GlySer: 4.673 ± 0.068	4.116GlyThr: 4.116 ± 0.06	6.056GlyVal: 6.056 ± 0.079	1.416GlyTrp: 1.416 ± 0.032	2.241GlyTyr: 2.241 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.791HisAla: 2.791 ± 0.044	0.303HisCys: 0.303 ± 0.014	1.178HisAsp: 1.178 ± 0.028	1.249HisGlu: 1.249 ± 0.028	0.876HisPhe: 0.876 ± 0.027	2.053HisGly: 2.053 ± 0.039	0.67HisHis: 0.67 ± 0.022	1.044HisIle: 1.044 ± 0.028	0.679HisLys: 0.679 ± 0.019	2.212HisLeu: 2.212 ± 0.032	0.47HisMet: 0.47 ± 0.017	0.547HisAsn: 0.547 ± 0.019	1.429HisPro: 1.429 ± 0.03	0.854HisGln: 0.854 ± 0.025	1.399HisArg: 1.399 ± 0.034	1.116HisSer: 1.116 ± 0.029	1.001HisThr: 1.001 ± 0.026	1.511HisVal: 1.511 ± 0.032	0.421HisTrp: 0.421 ± 0.017	0.613HisTyr: 0.613 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.145IleAla: 6.145 ± 0.064	0.49IleCys: 0.49 ± 0.018	3.115IleAsp: 3.115 ± 0.046	3.298IleGlu: 3.298 ± 0.05	1.493IlePhe: 1.493 ± 0.036	3.967IleGly: 3.967 ± 0.061	0.979IleHis: 0.979 ± 0.025	1.791IleIle: 1.791 ± 0.039	1.977IleLys: 1.977 ± 0.045	3.498IleLeu: 3.498 ± 0.048	0.829IleMet: 0.829 ± 0.024	1.656IleAsn: 1.656 ± 0.039	2.209IlePro: 2.209 ± 0.039	1.473IleGln: 1.473 ± 0.033	2.709IleArg: 2.709 ± 0.038	2.755IleSer: 2.755 ± 0.047	2.576IleThr: 2.576 ± 0.043	3.216IleVal: 3.216 ± 0.05	0.463IleTrp: 0.463 ± 0.017	1.051IleTyr: 1.051 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.832LysAla: 4.832 ± 0.068	0.226LysCys: 0.226 ± 0.013	1.959LysAsp: 1.959 ± 0.044	1.863LysGlu: 1.863 ± 0.039	1.215LysPhe: 1.215 ± 0.029	2.761LysGly: 2.761 ± 0.046	0.793LysHis: 0.793 ± 0.024	1.894LysIle: 1.894 ± 0.035	1.931LysLys: 1.931 ± 0.049	4.094LysLeu: 4.094 ± 0.057	1.009LysMet: 1.009 ± 0.025	1.45LysAsn: 1.45 ± 0.038	2.427LysPro: 2.427 ± 0.041	1.408LysGln: 1.408 ± 0.03	2.446LysArg: 2.446 ± 0.049	2.349LysSer: 2.349 ± 0.048	2.54LysThr: 2.54 ± 0.042	2.782LysVal: 2.782 ± 0.049	0.41LysTrp: 0.41 ± 0.018	0.82LysTyr: 0.82 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.343LeuAla: 14.343 ± 0.133	1.086LeuCys: 1.086 ± 0.027	5.829LeuAsp: 5.829 ± 0.072	5.34LeuGlu: 5.34 ± 0.066	3.394LeuPhe: 3.394 ± 0.053	8.376LeuGly: 8.376 ± 0.099	2.348LeuHis: 2.348 ± 0.043	4.622LeuIle: 4.622 ± 0.052	4.537LeuLys: 4.537 ± 0.062	11.447LeuLeu: 11.447 ± 0.13	2.662LeuMet: 2.662 ± 0.041	3.123LeuAsn: 3.123 ± 0.046	6.027LeuPro: 6.027 ± 0.073	4.715LeuGln: 4.715 ± 0.071	7.109LeuArg: 7.109 ± 0.077	6.52LeuSer: 6.52 ± 0.064	5.458LeuThr: 5.458 ± 0.074	7.557LeuVal: 7.557 ± 0.069	1.3LeuTrp: 1.3 ± 0.033	2.103LeuTyr: 2.103 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	3.299MetAla: 3.299 ± 0.041	0.194MetCys: 0.194 ± 0.011	1.186MetAsp: 1.186 ± 0.028	1.124MetGlu: 1.124 ± 0.026	0.718MetPhe: 0.718 ± 0.022	1.929MetGly: 1.929 ± 0.036	0.587MetHis: 0.587 ± 0.02	1.002MetIle: 1.002 ± 0.029	1.212MetLys: 1.212 ± 0.032	2.761MetLeu: 2.761 ± 0.048	0.627MetMet: 0.627 ± 0.022	1.001MetAsn: 1.001 ± 0.028	1.595MetPro: 1.595 ± 0.031	1.18MetGln: 1.18 ± 0.026	1.538MetArg: 1.538 ± 0.032	1.604MetSer: 1.604 ± 0.034	1.655MetThr: 1.655 ± 0.037	1.719MetVal: 1.719 ± 0.035	0.216MetTrp: 0.216 ± 0.012	0.374MetTyr: 0.374 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.599AsnAla: 3.599 ± 0.055	0.319AsnCys: 0.319 ± 0.015	1.372AsnAsp: 1.372 ± 0.029	1.386AsnGlu: 1.386 ± 0.033	1.091AsnPhe: 1.091 ± 0.029	2.334AsnGly: 2.334 ± 0.049	0.585AsnHis: 0.585 ± 0.02	1.361AsnIle: 1.361 ± 0.032	1.042AsnLys: 1.042 ± 0.028	2.859AsnLeu: 2.859 ± 0.048	0.662AsnMet: 0.662 ± 0.028	0.856AsnAsn: 0.856 ± 0.027	2.073AsnPro: 2.073 ± 0.035	1.08AsnGln: 1.08 ± 0.024	1.76AsnArg: 1.76 ± 0.041	1.561AsnSer: 1.561 ± 0.039	1.576AsnThr: 1.576 ± 0.036	1.925AsnVal: 1.925 ± 0.036	0.472AsnTrp: 0.472 ± 0.019	0.734AsnTyr: 0.734 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.214ProAla: 7.214 ± 0.089	0.448ProCys: 0.448 ± 0.017	3.006ProAsp: 3.006 ± 0.051	3.405ProGlu: 3.405 ± 0.053	1.774ProPhe: 1.774 ± 0.034	4.674ProGly: 4.674 ± 0.063	1.025ProHis: 1.025 ± 0.026	1.858ProIle: 1.858 ± 0.036	1.705ProLys: 1.705 ± 0.036	5.152ProLeu: 5.152 ± 0.061	1.318ProMet: 1.318 ± 0.027	1.278ProAsn: 1.278 ± 0.027	2.543ProPro: 2.543 ± 0.052	2.102ProGln: 2.102 ± 0.04	2.655ProArg: 2.655 ± 0.043	2.848ProSer: 2.848 ± 0.047	2.35ProThr: 2.35 ± 0.04	4.233ProVal: 4.233 ± 0.048	0.724ProTrp: 0.724 ± 0.022	1.125ProTyr: 1.125 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	6.276GlnAla: 6.276 ± 0.082	0.342GlnCys: 0.342 ± 0.017	1.707GlnAsp: 1.707 ± 0.035	1.809GlnGlu: 1.809 ± 0.038	1.307GlnPhe: 1.307 ± 0.026	3.174GlnGly: 3.174 ± 0.05	0.988GlnHis: 0.988 ± 0.024	1.932GlnIle: 1.932 ± 0.032	1.482GlnLys: 1.482 ± 0.034	4.533GlnLeu: 4.533 ± 0.071	0.966GlnMet: 0.966 ± 0.026	1.057GlnAsn: 1.057 ± 0.024	2.405GlnPro: 2.405 ± 0.04	1.986GlnGln: 1.986 ± 0.044	3.241GlnArg: 3.241 ± 0.059	2.289GlnSer: 2.289 ± 0.041	2.161GlnThr: 2.161 ± 0.037	3.034GlnVal: 3.034 ± 0.041	0.671GlnTrp: 0.671 ± 0.022	0.795GlnTyr: 0.795 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.87ArgAla: 6.87 ± 0.071	0.599ArgCys: 0.599 ± 0.021	3.185ArgAsp: 3.185 ± 0.047	3.771ArgGlu: 3.771 ± 0.063	2.621ArgPhe: 2.621 ± 0.042	4.094ArgGly: 4.094 ± 0.054	1.823ArgHis: 1.823 ± 0.038	3.521ArgIle: 3.521 ± 0.051	2.453ArgLys: 2.453 ± 0.047	7.675ArgLeu: 7.675 ± 0.085	1.781ArgMet: 1.781 ± 0.035	1.813ArgAsn: 1.813 ± 0.037	2.966ArgPro: 2.966 ± 0.041	3.182ArgGln: 3.182 ± 0.047	4.366ArgArg: 4.366 ± 0.064	3.454ArgSer: 3.454 ± 0.05	2.918ArgThr: 2.918 ± 0.046	4.447ArgVal: 4.447 ± 0.064	1.08ArgTrp: 1.08 ± 0.028	1.689ArgTyr: 1.689 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.868SerAla: 6.868 ± 0.08	0.552SerCys: 0.552 ± 0.017	2.743SerAsp: 2.743 ± 0.043	2.775SerGlu: 2.775 ± 0.047	2.248SerPhe: 2.248 ± 0.036	5.421SerGly: 5.421 ± 0.069	1.288SerHis: 1.288 ± 0.032	2.709SerIle: 2.709 ± 0.04	2.013SerLys: 2.013 ± 0.045	6.301SerLeu: 6.301 ± 0.065	1.501SerMet: 1.501 ± 0.032	1.593SerAsn: 1.593 ± 0.035	3.178SerPro: 3.178 ± 0.055	2.226SerGln: 2.226 ± 0.04	3.849SerArg: 3.849 ± 0.05	3.667SerSer: 3.667 ± 0.059	3.037SerThr: 3.037 ± 0.049	4.222SerVal: 4.222 ± 0.059	0.811SerTrp: 0.811 ± 0.024	1.342SerTyr: 1.342 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.939ThrAla: 5.939 ± 0.073	0.477ThrCys: 0.477 ± 0.02	2.454ThrAsp: 2.454 ± 0.04	2.449ThrGlu: 2.449 ± 0.039	1.747ThrPhe: 1.747 ± 0.039	4.774ThrGly: 4.774 ± 0.087	1.216ThrHis: 1.216 ± 0.028	2.102ThrIle: 2.102 ± 0.039	1.479ThrLys: 1.479 ± 0.033	6.303ThrLeu: 6.303 ± 0.066	1.068ThrMet: 1.068 ± 0.026	1.261ThrAsn: 1.261 ± 0.033	3.571ThrPro: 3.571 ± 0.051	2.064ThrGln: 2.064 ± 0.039	3.092ThrArg: 3.092 ± 0.042	2.918ThrSer: 2.918 ± 0.049	2.757ThrThr: 2.757 ± 0.051	4.055ThrVal: 4.055 ± 0.051	0.599ThrTrp: 0.599 ± 0.021	1.091ThrTyr: 1.091 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	8.642ValAla: 8.642 ± 0.069	0.774ValCys: 0.774 ± 0.022	3.571ValAsp: 3.571 ± 0.05	3.881ValGlu: 3.881 ± 0.054	2.743ValPhe: 2.743 ± 0.04	5.026ValGly: 5.026 ± 0.052	1.531ValHis: 1.531 ± 0.034	3.499ValIle: 3.499 ± 0.054	2.901ValLys: 2.901 ± 0.043	7.894ValLeu: 7.894 ± 0.088	2.034ValMet: 2.034 ± 0.039	2.305ValAsn: 2.305 ± 0.042	3.658ValPro: 3.658 ± 0.05	2.981ValGln: 2.981 ± 0.053	4.636ValArg: 4.636 ± 0.057	4.287ValSer: 4.287 ± 0.062	3.93ValThr: 3.93 ± 0.048	5.817ValVal: 5.817 ± 0.073	0.957ValTrp: 0.957 ± 0.024	1.548ValTyr: 1.548 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.35TrpAla: 1.35 ± 0.031	0.179TrpCys: 0.179 ± 0.012	0.609TrpAsp: 0.609 ± 0.022	0.535TrpGlu: 0.535 ± 0.019	0.555TrpPhe: 0.555 ± 0.02	0.885TrpGly: 0.885 ± 0.025	0.355TrpHis: 0.355 ± 0.013	0.61TrpIle: 0.61 ± 0.02	0.553TrpLys: 0.553 ± 0.019	2.13TrpLeu: 2.13 ± 0.04	0.422TrpMet: 0.422 ± 0.016	0.437TrpAsn: 0.437 ± 0.019	0.661TrpPro: 0.661 ± 0.021	0.754TrpGln: 0.754 ± 0.025	1.115TrpArg: 1.115 ± 0.028	0.861TrpSer: 0.861 ± 0.024	0.758TrpThr: 0.758 ± 0.025	0.959TrpVal: 0.959 ± 0.027	0.24TrpTrp: 0.24 ± 0.014	0.275TrpTyr: 0.275 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.501TyrAla: 2.501 ± 0.041	0.277TyrCys: 0.277 ± 0.013	1.165TyrAsp: 1.165 ± 0.029	1.222TyrGlu: 1.222 ± 0.026	0.946TyrPhe: 0.946 ± 0.023	1.899TyrGly: 1.899 ± 0.034	0.421TyrHis: 0.421 ± 0.018	0.871TyrIle: 0.871 ± 0.025	0.811TyrLys: 0.811 ± 0.027	2.494TyrLeu: 2.494 ± 0.039	0.431TyrMet: 0.431 ± 0.017	0.62TyrAsn: 0.62 ± 0.019	1.133TyrPro: 1.133 ± 0.029	0.91TyrGln: 0.91 ± 0.026	1.652TyrArg: 1.652 ± 0.033	1.332TyrSer: 1.332 ± 0.032	1.158TyrThr: 1.158 ± 0.03	1.566TyrVal: 1.566 ± 0.03	0.342TyrTrp: 0.342 ± 0.015	0.545TyrTyr: 0.545 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4879 proteins (1560234 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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