Amino acid dipepetide frequency for Marinobacter daqiaonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.917AlaAla: 9.917 ± 0.121
0.948AlaCys: 0.948 ± 0.033
5.688AlaAsp: 5.688 ± 0.078
6.675AlaGlu: 6.675 ± 0.085
3.631AlaPhe: 3.631 ± 0.06
9.035AlaGly: 9.035 ± 0.108
1.821AlaHis: 1.821 ± 0.039
5.469AlaIle: 5.469 ± 0.085
2.507AlaLys: 2.507 ± 0.045
11.272AlaLeu: 11.272 ± 0.124
3.145AlaMet: 3.145 ± 0.06
2.664AlaAsn: 2.664 ± 0.047
3.957AlaPro: 3.957 ± 0.065
3.055AlaGln: 3.055 ± 0.05
7.42AlaArg: 7.42 ± 0.098
5.779AlaSer: 5.779 ± 0.077
4.821AlaThr: 4.821 ± 0.067
7.2AlaVal: 7.2 ± 0.09
1.369AlaTrp: 1.369 ± 0.04
2.144AlaTyr: 2.144 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.748CysAla: 0.748 ± 0.029
0.114CysCys: 0.114 ± 0.01
0.525CysAsp: 0.525 ± 0.02
0.561CysGlu: 0.561 ± 0.022
0.34CysPhe: 0.34 ± 0.018
0.881CysGly: 0.881 ± 0.03
0.303CysHis: 0.303 ± 0.016
0.417CysIle: 0.417 ± 0.018
0.228CysLys: 0.228 ± 0.013
0.938CysLeu: 0.938 ± 0.026
0.187CysMet: 0.187 ± 0.014
0.24CysAsn: 0.24 ± 0.015
0.478CysPro: 0.478 ± 0.021
0.369CysGln: 0.369 ± 0.02
0.709CysArg: 0.709 ± 0.025
0.52CysSer: 0.52 ± 0.02
0.407CysThr: 0.407 ± 0.02
0.58CysVal: 0.58 ± 0.023
0.122CysTrp: 0.122 ± 0.012
0.241CysTyr: 0.241 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.988AspAla: 4.988 ± 0.065
0.49AspCys: 0.49 ± 0.02
3.509AspAsp: 3.509 ± 0.068
4.271AspGlu: 4.271 ± 0.067
2.148AspPhe: 2.148 ± 0.049
4.39AspGly: 4.39 ± 0.07
1.467AspHis: 1.467 ± 0.036
3.252AspIle: 3.252 ± 0.064
1.668AspLys: 1.668 ± 0.041
6.042AspLeu: 6.042 ± 0.095
1.498AspMet: 1.498 ± 0.036
1.763AspAsn: 1.763 ± 0.052
3.036AspPro: 3.036 ± 0.063
2.6AspGln: 2.6 ± 0.051
4.45AspArg: 4.45 ± 0.071
3.035AspSer: 3.035 ± 0.06
2.958AspThr: 2.958 ± 0.054
3.961AspVal: 3.961 ± 0.065
0.981AspTrp: 0.981 ± 0.032
1.898AspTyr: 1.898 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
7.088GluAla: 7.088 ± 0.076
0.428GluCys: 0.428 ± 0.02
3.65GluAsp: 3.65 ± 0.056
4.803GluGlu: 4.803 ± 0.082
2.162GluPhe: 2.162 ± 0.048
5.003GluGly: 5.003 ± 0.069
1.56GluHis: 1.56 ± 0.039
3.387GluIle: 3.387 ± 0.059
2.885GluLys: 2.885 ± 0.062
7.184GluLeu: 7.184 ± 0.084
1.633GluMet: 1.633 ± 0.039
2.231GluAsn: 2.231 ± 0.049
3.086GluPro: 3.086 ± 0.069
3.48GluGln: 3.48 ± 0.054
5.054GluArg: 5.054 ± 0.075
3.561GluSer: 3.561 ± 0.058
3.652GluThr: 3.652 ± 0.057
4.715GluVal: 4.715 ± 0.069
0.818GluTrp: 0.818 ± 0.026
1.458GluTyr: 1.458 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.361PheAla: 3.361 ± 0.058
0.432PheCys: 0.432 ± 0.017
2.333PheAsp: 2.333 ± 0.044
2.283PheGlu: 2.283 ± 0.047
1.463PhePhe: 1.463 ± 0.047
3.25PheGly: 3.25 ± 0.065
0.857PheHis: 0.857 ± 0.03
1.874PheIle: 1.874 ± 0.041
0.844PheLys: 0.844 ± 0.032
3.69PheLeu: 3.69 ± 0.07
0.923PheMet: 0.923 ± 0.031
1.234PheAsn: 1.234 ± 0.034
1.559PhePro: 1.559 ± 0.036
1.198PheGln: 1.198 ± 0.035
2.699PheArg: 2.699 ± 0.045
2.513PheSer: 2.513 ± 0.052
1.96PheThr: 1.96 ± 0.042
2.56PheVal: 2.56 ± 0.052
0.528PheTrp: 0.528 ± 0.027
1.072PheTyr: 1.072 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
7.061GlyAla: 7.061 ± 0.094
0.847GlyCys: 0.847 ± 0.032
4.646GlyAsp: 4.646 ± 0.072
5.452GlyGlu: 5.452 ± 0.074
3.456GlyPhe: 3.456 ± 0.06
6.302GlyGly: 6.302 ± 0.105
1.999GlyHis: 1.999 ± 0.049
4.685GlyIle: 4.685 ± 0.065
3.077GlyLys: 3.077 ± 0.059
8.729GlyLeu: 8.729 ± 0.103
2.463GlyMet: 2.463 ± 0.051
2.407GlyAsn: 2.407 ± 0.05
2.984GlyPro: 2.984 ± 0.059
3.223GlyGln: 3.223 ± 0.058
5.408GlyArg: 5.408 ± 0.085
4.626GlySer: 4.626 ± 0.069
4.102GlyThr: 4.102 ± 0.053
5.921GlyVal: 5.921 ± 0.083
1.286GlyTrp: 1.286 ± 0.04
2.526GlyTyr: 2.526 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.814HisAla: 1.814 ± 0.041
0.313HisCys: 0.313 ± 0.018
1.195HisAsp: 1.195 ± 0.035
1.318HisGlu: 1.318 ± 0.035
0.923HisPhe: 0.923 ± 0.028
1.907HisGly: 1.907 ± 0.042
0.746HisHis: 0.746 ± 0.03
1.034HisIle: 1.034 ± 0.031
0.653HisLys: 0.653 ± 0.024
2.366HisLeu: 2.366 ± 0.049
0.517HisMet: 0.517 ± 0.021
0.63HisAsn: 0.63 ± 0.021
1.417HisPro: 1.417 ± 0.04
1.045HisGln: 1.045 ± 0.028
1.747HisArg: 1.747 ± 0.042
1.17HisSer: 1.17 ± 0.03
1.018HisThr: 1.018 ± 0.034
1.347HisVal: 1.347 ± 0.035
0.43HisTrp: 0.43 ± 0.016
0.792HisTyr: 0.792 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.494IleAla: 5.494 ± 0.076
0.507IleCys: 0.507 ± 0.024
3.13IleAsp: 3.13 ± 0.061
3.405IleGlu: 3.405 ± 0.059
1.652IlePhe: 1.652 ± 0.042
4.271IleGly: 4.271 ± 0.059
1.163IleHis: 1.163 ± 0.033
2.439IleIle: 2.439 ± 0.053
1.481IleLys: 1.481 ± 0.039
4.902IleLeu: 4.902 ± 0.075
1.09IleMet: 1.09 ± 0.037
1.836IleAsn: 1.836 ± 0.033
2.507IlePro: 2.507 ± 0.046
1.734IleGln: 1.734 ± 0.04
4.028IleArg: 4.028 ± 0.06
3.183IleSer: 3.183 ± 0.056
2.851IleThr: 2.851 ± 0.054
3.422IleVal: 3.422 ± 0.056
0.543IleTrp: 0.543 ± 0.025
1.191IleTyr: 1.191 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.517LysAla: 3.517 ± 0.057
0.195LysCys: 0.195 ± 0.014
1.789LysAsp: 1.789 ± 0.043
2.05LysGlu: 2.05 ± 0.055
0.809LysPhe: 0.809 ± 0.031
2.482LysGly: 2.482 ± 0.05
0.705LysHis: 0.705 ± 0.023
1.403LysIle: 1.403 ± 0.039
1.431LysLys: 1.431 ± 0.043
3.179LysLeu: 3.179 ± 0.051
0.756LysMet: 0.756 ± 0.029
0.927LysAsn: 0.927 ± 0.032
1.747LysPro: 1.747 ± 0.04
1.332LysGln: 1.332 ± 0.039
2.191LysArg: 2.191 ± 0.041
1.749LysSer: 1.749 ± 0.041
1.83LysThr: 1.83 ± 0.04
2.514LysVal: 2.514 ± 0.054
0.33LysTrp: 0.33 ± 0.017
0.701LysTyr: 0.701 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
12.327LeuAla: 12.327 ± 0.135
0.969LeuCys: 0.969 ± 0.03
6.427LeuAsp: 6.427 ± 0.083
7.416LeuGlu: 7.416 ± 0.098
3.888LeuPhe: 3.888 ± 0.068
8.348LeuGly: 8.348 ± 0.094
2.057LeuHis: 2.057 ± 0.042
5.291LeuIle: 5.291 ± 0.068
3.771LeuLys: 3.771 ± 0.051
11.032LeuLeu: 11.032 ± 0.155
2.836LeuMet: 2.836 ± 0.05
3.207LeuAsn: 3.207 ± 0.055
5.494LeuPro: 5.494 ± 0.074
3.604LeuGln: 3.604 ± 0.057
6.926LeuArg: 6.926 ± 0.095
6.678LeuSer: 6.678 ± 0.09
5.866LeuThr: 5.866 ± 0.069
8.025LeuVal: 8.025 ± 0.101
1.308LeuTrp: 1.308 ± 0.038
2.272LeuTyr: 2.272 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
3.13MetAla: 3.13 ± 0.055
0.181MetCys: 0.181 ± 0.012
1.445MetAsp: 1.445 ± 0.033
1.604MetGlu: 1.604 ± 0.043
0.775MetPhe: 0.775 ± 0.028
2.023MetGly: 2.023 ± 0.039
0.453MetHis: 0.453 ± 0.021
1.36MetIle: 1.36 ± 0.033
1.13MetLys: 1.13 ± 0.028
2.637MetLeu: 2.637 ± 0.043
0.712MetMet: 0.712 ± 0.029
0.94MetAsn: 0.94 ± 0.028
1.447MetPro: 1.447 ± 0.033
0.845MetGln: 0.845 ± 0.025
1.433MetArg: 1.433 ± 0.034
1.725MetSer: 1.725 ± 0.04
1.788MetThr: 1.788 ± 0.038
1.949MetVal: 1.949 ± 0.049
0.189MetTrp: 0.189 ± 0.013
0.468MetTyr: 0.468 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.778AsnAla: 2.778 ± 0.049
0.283AsnCys: 0.283 ± 0.016
1.587AsnAsp: 1.587 ± 0.038
1.762AsnGlu: 1.762 ± 0.044
0.985AsnPhe: 0.985 ± 0.026
2.392AsnGly: 2.392 ± 0.049
0.711AsnHis: 0.711 ± 0.022
1.574AsnIle: 1.574 ± 0.04
0.802AsnLys: 0.802 ± 0.027
3.324AsnLeu: 3.324 ± 0.053
0.738AsnMet: 0.738 ± 0.025
0.976AsnAsn: 0.976 ± 0.039
1.996AsnPro: 1.996 ± 0.049
1.227AsnGln: 1.227 ± 0.03
2.436AsnArg: 2.436 ± 0.045
1.522AsnSer: 1.522 ± 0.052
1.574AsnThr: 1.574 ± 0.04
1.928AsnVal: 1.928 ± 0.037
0.448AsnTrp: 0.448 ± 0.02
0.828AsnTyr: 0.828 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
4.902ProAla: 4.902 ± 0.074
0.306ProCys: 0.306 ± 0.017
3.832ProAsp: 3.832 ± 0.055
4.776ProGlu: 4.776 ± 0.07
1.718ProPhe: 1.718 ± 0.037
4.55ProGly: 4.55 ± 0.063
0.97ProHis: 0.97 ± 0.031
1.866ProIle: 1.866 ± 0.039
1.287ProLys: 1.287 ± 0.034
4.753ProLeu: 4.753 ± 0.073
1.271ProMet: 1.271 ± 0.031
1.125ProAsn: 1.125 ± 0.033
2.053ProPro: 2.053 ± 0.049
1.515ProGln: 1.515 ± 0.038
2.66ProArg: 2.66 ± 0.049
2.5ProSer: 2.5 ± 0.051
2.004ProThr: 2.004 ± 0.043
4.492ProVal: 4.492 ± 0.064
0.775ProTrp: 0.775 ± 0.029
1.111ProTyr: 1.111 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.359GlnAla: 4.359 ± 0.063
0.3GlnCys: 0.3 ± 0.017
1.882GlnAsp: 1.882 ± 0.044
2.417GlnGlu: 2.417 ± 0.049
1.263GlnPhe: 1.263 ± 0.035
2.973GlnGly: 2.973 ± 0.057
0.792GlnHis: 0.792 ± 0.03
1.672GlnIle: 1.672 ± 0.041
1.374GlnLys: 1.374 ± 0.039
4.196GlnLeu: 4.196 ± 0.068
1.022GlnMet: 1.022 ± 0.03
1.042GlnAsn: 1.042 ± 0.031
1.93GlnPro: 1.93 ± 0.045
2.012GlnGln: 2.012 ± 0.059
2.949GlnArg: 2.949 ± 0.059
2.041GlnSer: 2.041 ± 0.045
1.808GlnThr: 1.808 ± 0.04
3.011GlnVal: 3.011 ± 0.051
0.675GlnTrp: 0.675 ± 0.022
0.872GlnTyr: 0.872 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
5.876ArgAla: 5.876 ± 0.076
0.602ArgCys: 0.602 ± 0.026
4.036ArgAsp: 4.036 ± 0.058
5.408ArgGlu: 5.408 ± 0.078
2.979ArgPhe: 2.979 ± 0.052
4.371ArgGly: 4.371 ± 0.059
1.869ArgHis: 1.869 ± 0.04
3.903ArgIle: 3.903 ± 0.063
2.725ArgLys: 2.725 ± 0.06
8.142ArgLeu: 8.142 ± 0.107
1.834ArgMet: 1.834 ± 0.039
2.296ArgAsn: 2.296 ± 0.04
3.277ArgPro: 3.277 ± 0.057
3.614ArgGln: 3.614 ± 0.064
5.138ArgArg: 5.138 ± 0.081
3.747ArgSer: 3.747 ± 0.069
3.106ArgThr: 3.106 ± 0.052
5.029ArgVal: 5.029 ± 0.071
1.15ArgTrp: 1.15 ± 0.035
2.144ArgTyr: 2.144 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
5.521SerAla: 5.521 ± 0.068
0.443SerCys: 0.443 ± 0.021
3.422SerAsp: 3.422 ± 0.059
3.664SerGlu: 3.664 ± 0.057
2.108SerPhe: 2.108 ± 0.053
5.639SerGly: 5.639 ± 0.08
1.337SerHis: 1.337 ± 0.04
2.63SerIle: 2.63 ± 0.053
1.559SerLys: 1.559 ± 0.035
6.378SerLeu: 6.378 ± 0.088
1.471SerMet: 1.471 ± 0.033
1.514SerAsn: 1.514 ± 0.041
2.915SerPro: 2.915 ± 0.054
2.183SerGln: 2.183 ± 0.044
4.335SerArg: 4.335 ± 0.069
3.384SerSer: 3.384 ± 0.065
2.678SerThr: 2.678 ± 0.053
4.165SerVal: 4.165 ± 0.059
0.81SerTrp: 0.81 ± 0.029
1.386SerTyr: 1.386 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
4.931ThrAla: 4.931 ± 0.068
0.441ThrCys: 0.441 ± 0.023
3.048ThrAsp: 3.048 ± 0.047
3.067ThrGlu: 3.067 ± 0.057
1.848ThrPhe: 1.848 ± 0.042
5.159ThrGly: 5.159 ± 0.076
1.07ThrHis: 1.07 ± 0.031
2.507ThrIle: 2.507 ± 0.045
0.989ThrLys: 0.989 ± 0.035
6.343ThrLeu: 6.343 ± 0.076
1.166ThrMet: 1.166 ± 0.035
1.334ThrAsn: 1.334 ± 0.035
2.998ThrPro: 2.998 ± 0.045
1.411ThrGln: 1.411 ± 0.035
3.563ThrArg: 3.563 ± 0.055
2.874ThrSer: 2.874 ± 0.049
2.72ThrThr: 2.72 ± 0.048
4.124ThrVal: 4.124 ± 0.062
0.721ThrTrp: 0.721 ± 0.026
1.142ThrTyr: 1.142 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
7.674ValAla: 7.674 ± 0.086
0.672ValCys: 0.672 ± 0.025
4.22ValAsp: 4.22 ± 0.07
4.734ValGlu: 4.734 ± 0.068
2.863ValPhe: 2.863 ± 0.063
5.152ValGly: 5.152 ± 0.072
1.507ValHis: 1.507 ± 0.035
4.327ValIle: 4.327 ± 0.07
2.195ValLys: 2.195 ± 0.055
7.546ValLeu: 7.546 ± 0.107
2.101ValMet: 2.101 ± 0.046
2.289ValAsn: 2.289 ± 0.049
3.54ValPro: 3.54 ± 0.052
2.144ValGln: 2.144 ± 0.045
4.78ValArg: 4.78 ± 0.065
4.664ValSer: 4.664 ± 0.065
4.457ValThr: 4.457 ± 0.065
6.107ValVal: 6.107 ± 0.088
0.87ValTrp: 0.87 ± 0.031
1.666ValTyr: 1.666 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.004TrpAla: 1.004 ± 0.029
0.156TrpCys: 0.156 ± 0.012
0.616TrpAsp: 0.616 ± 0.023
0.714TrpGlu: 0.714 ± 0.026
0.617TrpPhe: 0.617 ± 0.026
0.932TrpGly: 0.932 ± 0.03
0.361TrpHis: 0.361 ± 0.018
0.67TrpIle: 0.67 ± 0.024
0.398TrpLys: 0.398 ± 0.02
2.114TrpLeu: 2.114 ± 0.053
0.372TrpMet: 0.372 ± 0.021
0.442TrpAsn: 0.442 ± 0.021
0.668TrpPro: 0.668 ± 0.027
0.847TrpGln: 0.847 ± 0.028
1.067TrpArg: 1.067 ± 0.03
0.834TrpSer: 0.834 ± 0.026
0.62TrpThr: 0.62 ± 0.023
0.947TrpVal: 0.947 ± 0.035
0.229TrpTrp: 0.229 ± 0.017
0.381TrpTyr: 0.381 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.029TyrAla: 2.029 ± 0.048
0.282TyrCys: 0.282 ± 0.016
1.425TyrAsp: 1.425 ± 0.042
1.458TyrGlu: 1.458 ± 0.037
1.009TyrPhe: 1.009 ± 0.033
2.139TyrGly: 2.139 ± 0.044
0.633TyrHis: 0.633 ± 0.022
1.07TyrIle: 1.07 ± 0.032
0.634TyrLys: 0.634 ± 0.024
2.976TyrLeu: 2.976 ± 0.05
0.498TyrMet: 0.498 ± 0.023
0.773TyrAsn: 0.773 ± 0.028
1.377TyrPro: 1.377 ± 0.035
1.153TyrGln: 1.153 ± 0.029
2.252TyrArg: 2.252 ± 0.051
1.436TyrSer: 1.436 ± 0.038
1.236TyrThr: 1.236 ± 0.035
1.507TyrVal: 1.507 ± 0.035
0.406TyrTrp: 0.406 ± 0.02
0.715TyrTyr: 0.715 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3504 proteins (1168533 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski