Amino acid dipepetide frequency for bacterium F11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.622AlaAla: 4.622 ± 0.145
0.478AlaCys: 0.478 ± 0.031
3.188AlaAsp: 3.188 ± 0.099
3.741AlaGlu: 3.741 ± 0.112
3.207AlaPhe: 3.207 ± 0.087
4.775AlaGly: 4.775 ± 0.137
1.468AlaHis: 1.468 ± 0.051
4.467AlaIle: 4.467 ± 0.103
3.846AlaLys: 3.846 ± 0.098
7.145AlaLeu: 7.145 ± 0.135
1.436AlaMet: 1.436 ± 0.062
2.465AlaAsn: 2.465 ± 0.082
2.445AlaPro: 2.445 ± 0.068
2.465AlaGln: 2.465 ± 0.076
3.371AlaArg: 3.371 ± 0.1
4.039AlaSer: 4.039 ± 0.108
3.555AlaThr: 3.555 ± 0.111
4.224AlaVal: 4.224 ± 0.129
0.89AlaTrp: 0.89 ± 0.039
2.123AlaTyr: 2.123 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.385CysAla: 0.385 ± 0.032
0.071CysCys: 0.071 ± 0.011
0.333CysAsp: 0.333 ± 0.025
0.373CysGlu: 0.373 ± 0.023
0.345CysPhe: 0.345 ± 0.026
0.576CysGly: 0.576 ± 0.038
0.195CysHis: 0.195 ± 0.019
0.345CysIle: 0.345 ± 0.026
0.277CysLys: 0.277 ± 0.023
0.773CysLeu: 0.773 ± 0.044
0.1CysMet: 0.1 ± 0.011
0.171CysAsn: 0.171 ± 0.018
0.345CysPro: 0.345 ± 0.028
0.298CysGln: 0.298 ± 0.023
0.401CysArg: 0.401 ± 0.029
0.412CysSer: 0.412 ± 0.03
0.28CysThr: 0.28 ± 0.023
0.496CysVal: 0.496 ± 0.033
0.09CysTrp: 0.09 ± 0.013
0.2CysTyr: 0.2 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.155AspAla: 3.155 ± 0.091
0.304AspCys: 0.304 ± 0.026
2.856AspAsp: 2.856 ± 0.105
3.588AspGlu: 3.588 ± 0.115
2.777AspPhe: 2.777 ± 0.08
4.337AspGly: 4.337 ± 0.23
1.302AspHis: 1.302 ± 0.054
3.634AspIle: 3.634 ± 0.089
2.814AspLys: 2.814 ± 0.074
5.802AspLeu: 5.802 ± 0.135
0.992AspMet: 0.992 ± 0.042
2.149AspAsn: 2.149 ± 0.106
3.524AspPro: 3.524 ± 0.089
2.317AspGln: 2.317 ± 0.072
2.962AspArg: 2.962 ± 0.078
3.308AspSer: 3.308 ± 0.092
2.651AspThr: 2.651 ± 0.101
3.711AspVal: 3.711 ± 0.093
0.881AspTrp: 0.881 ± 0.039
1.822AspTyr: 1.822 ± 0.078
0.0AspXaa: 0.0 ± 0.0
Glu
4.67GluAla: 4.67 ± 0.13
0.283GluCys: 0.283 ± 0.025
3.534GluAsp: 3.534 ± 0.117
5.045GluGlu: 5.045 ± 0.161
2.479GluPhe: 2.479 ± 0.085
4.427GluGly: 4.427 ± 0.116
0.998GluHis: 0.998 ± 0.04
4.582GluIle: 4.582 ± 0.121
5.623GluLys: 5.623 ± 0.13
5.356GluLeu: 5.356 ± 0.117
1.605GluMet: 1.605 ± 0.057
3.088GluAsn: 3.088 ± 0.087
2.094GluPro: 2.094 ± 0.063
1.922GluGln: 1.922 ± 0.084
3.403GluArg: 3.403 ± 0.115
3.74GluSer: 3.74 ± 0.077
3.53GluThr: 3.53 ± 0.111
3.856GluVal: 3.856 ± 0.082
0.976GluTrp: 0.976 ± 0.046
1.581GluTyr: 1.581 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
2.494PheAla: 2.494 ± 0.066
0.423PheCys: 0.423 ± 0.029
3.043PheAsp: 3.043 ± 0.094
2.79PheGlu: 2.79 ± 0.072
2.545PhePhe: 2.545 ± 0.113
3.854PheGly: 3.854 ± 0.101
1.235PheHis: 1.235 ± 0.053
2.755PheIle: 2.755 ± 0.096
2.27PheLys: 2.27 ± 0.059
5.664PheLeu: 5.664 ± 0.16
0.882PheMet: 0.882 ± 0.039
1.974PheAsn: 1.974 ± 0.076
2.156PhePro: 2.156 ± 0.07
1.925PheGln: 1.925 ± 0.062
2.497PheArg: 2.497 ± 0.067
3.772PheSer: 3.772 ± 0.095
2.265PheThr: 2.265 ± 0.096
3.424PheVal: 3.424 ± 0.08
0.739PheTrp: 0.739 ± 0.041
1.681PheTyr: 1.681 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.332GlyAla: 4.332 ± 0.115
0.547GlyCys: 0.547 ± 0.035
3.889GlyAsp: 3.889 ± 0.135
4.377GlyGlu: 4.377 ± 0.104
3.828GlyPhe: 3.828 ± 0.09
4.941GlyGly: 4.941 ± 0.122
1.618GlyHis: 1.618 ± 0.05
5.366GlyIle: 5.366 ± 0.112
4.501GlyLys: 4.501 ± 0.115
7.291GlyLeu: 7.291 ± 0.132
1.678GlyMet: 1.678 ± 0.049
3.009GlyAsn: 3.009 ± 0.118
2.668GlyPro: 2.668 ± 0.058
2.653GlyGln: 2.653 ± 0.072
3.606GlyArg: 3.606 ± 0.094
5.021GlySer: 5.021 ± 0.132
4.372GlyThr: 4.372 ± 0.147
4.883GlyVal: 4.883 ± 0.107
1.186GlyTrp: 1.186 ± 0.05
2.323GlyTyr: 2.323 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.272HisAla: 1.272 ± 0.049
0.164HisCys: 0.164 ± 0.018
0.906HisAsp: 0.906 ± 0.037
1.129HisGlu: 1.129 ± 0.044
1.225HisPhe: 1.225 ± 0.045
1.372HisGly: 1.372 ± 0.051
0.744HisHis: 0.744 ± 0.036
1.323HisIle: 1.323 ± 0.048
1.056HisLys: 1.056 ± 0.045
2.666HisLeu: 2.666 ± 0.07
0.42HisMet: 0.42 ± 0.027
0.721HisAsn: 0.721 ± 0.031
1.491HisPro: 1.491 ± 0.059
1.17HisGln: 1.17 ± 0.046
1.293HisArg: 1.293 ± 0.058
1.286HisSer: 1.286 ± 0.049
1.125HisThr: 1.125 ± 0.052
1.381HisVal: 1.381 ± 0.058
0.369HisTrp: 0.369 ± 0.025
0.776HisTyr: 0.776 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
3.671IleAla: 3.671 ± 0.097
0.454IleCys: 0.454 ± 0.034
3.764IleAsp: 3.764 ± 0.106
4.231IleGlu: 4.231 ± 0.092
3.036IlePhe: 3.036 ± 0.096
4.796IleGly: 4.796 ± 0.105
1.586IleHis: 1.586 ± 0.055
3.724IleIle: 3.724 ± 0.098
4.038IleLys: 4.038 ± 0.116
7.236IleLeu: 7.236 ± 0.183
1.238IleMet: 1.238 ± 0.048
2.878IleAsn: 2.878 ± 0.074
3.807IlePro: 3.807 ± 0.098
2.944IleGln: 2.944 ± 0.081
4.083IleArg: 4.083 ± 0.085
4.786IleSer: 4.786 ± 0.118
3.482IleThr: 3.482 ± 0.098
4.01IleVal: 4.01 ± 0.083
0.861IleTrp: 0.861 ± 0.057
1.983IleTyr: 1.983 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
4.086LysAla: 4.086 ± 0.114
0.33LysCys: 0.33 ± 0.026
3.524LysAsp: 3.524 ± 0.091
5.351LysGlu: 5.351 ± 0.133
2.043LysPhe: 2.043 ± 0.059
4.786LysGly: 4.786 ± 0.125
0.953LysHis: 0.953 ± 0.044
4.625LysIle: 4.625 ± 0.103
6.779LysLys: 6.779 ± 0.196
5.012LysLeu: 5.012 ± 0.117
1.665LysMet: 1.665 ± 0.055
3.249LysAsn: 3.249 ± 0.088
2.631LysPro: 2.631 ± 0.071
1.768LysGln: 1.768 ± 0.063
3.656LysArg: 3.656 ± 0.109
3.93LysSer: 3.93 ± 0.097
3.611LysThr: 3.611 ± 0.092
3.894LysVal: 3.894 ± 0.091
0.874LysTrp: 0.874 ± 0.04
1.468LysTyr: 1.468 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
7.285LeuAla: 7.285 ± 0.137
0.668LeuCys: 0.668 ± 0.034
5.211LeuAsp: 5.211 ± 0.103
5.886LeuGlu: 5.886 ± 0.121
5.124LeuPhe: 5.124 ± 0.14
7.339LeuGly: 7.339 ± 0.161
1.919LeuHis: 1.919 ± 0.06
6.831LeuIle: 6.831 ± 0.163
6.94LeuLys: 6.94 ± 0.146
10.01LeuLeu: 10.01 ± 0.243
2.312LeuMet: 2.312 ± 0.074
4.355LeuAsn: 4.355 ± 0.09
4.733LeuPro: 4.733 ± 0.114
3.234LeuGln: 3.234 ± 0.089
5.266LeuArg: 5.266 ± 0.119
8.033LeuSer: 8.033 ± 0.133
5.825LeuThr: 5.825 ± 0.12
6.758LeuVal: 6.758 ± 0.13
1.323LeuTrp: 1.323 ± 0.069
2.698LeuTyr: 2.698 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.127MetAla: 2.127 ± 0.066
0.08MetCys: 0.08 ± 0.01
1.267MetAsp: 1.267 ± 0.05
1.494MetGlu: 1.494 ± 0.06
0.658MetPhe: 0.658 ± 0.039
2.078MetGly: 2.078 ± 0.071
0.27MetHis: 0.27 ± 0.022
1.373MetIle: 1.373 ± 0.052
1.66MetLys: 1.66 ± 0.066
1.512MetLeu: 1.512 ± 0.058
0.578MetMet: 0.578 ± 0.03
0.956MetAsn: 0.956 ± 0.038
0.821MetPro: 0.821 ± 0.032
0.449MetGln: 0.449 ± 0.031
1.135MetArg: 1.135 ± 0.046
1.322MetSer: 1.322 ± 0.046
1.236MetThr: 1.236 ± 0.043
1.607MetVal: 1.607 ± 0.063
0.213MetTrp: 0.213 ± 0.017
0.369MetTyr: 0.369 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
2.484AsnAla: 2.484 ± 0.072
0.254AsnCys: 0.254 ± 0.024
2.138AsnAsp: 2.138 ± 0.083
2.433AsnGlu: 2.433 ± 0.077
1.801AsnPhe: 1.801 ± 0.07
3.065AsnGly: 3.065 ± 0.102
1.008AsnHis: 1.008 ± 0.049
2.804AsnIle: 2.804 ± 0.075
2.682AsnLys: 2.682 ± 0.072
4.501AsnLeu: 4.501 ± 0.092
0.855AsnMet: 0.855 ± 0.041
1.898AsnAsn: 1.898 ± 0.115
2.898AsnPro: 2.898 ± 0.072
2.114AsnGln: 2.114 ± 0.069
2.682AsnArg: 2.682 ± 0.074
2.487AsnSer: 2.487 ± 0.088
2.146AsnThr: 2.146 ± 0.092
2.574AsnVal: 2.574 ± 0.071
0.784AsnTrp: 0.784 ± 0.043
1.224AsnTyr: 1.224 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
2.664ProAla: 2.664 ± 0.083
0.241ProCys: 0.241 ± 0.021
2.925ProAsp: 2.925 ± 0.077
2.94ProGlu: 2.94 ± 0.085
2.611ProPhe: 2.611 ± 0.077
3.057ProGly: 3.057 ± 0.1
1.228ProHis: 1.228 ± 0.051
3.192ProIle: 3.192 ± 0.075
2.724ProLys: 2.724 ± 0.081
4.759ProLeu: 4.759 ± 0.098
0.839ProMet: 0.839 ± 0.04
2.217ProAsn: 2.217 ± 0.068
2.532ProPro: 2.532 ± 0.105
1.697ProGln: 1.697 ± 0.064
2.033ProArg: 2.033 ± 0.075
3.434ProSer: 3.434 ± 0.079
2.643ProThr: 2.643 ± 0.083
3.117ProVal: 3.117 ± 0.084
0.662ProTrp: 0.662 ± 0.04
1.465ProTyr: 1.465 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
2.845GlnAla: 2.845 ± 0.077
0.182GlnCys: 0.182 ± 0.019
1.909GlnAsp: 1.909 ± 0.067
2.367GlnGlu: 2.367 ± 0.084
1.65GlnPhe: 1.65 ± 0.048
2.304GlnGly: 2.304 ± 0.07
0.713GlnHis: 0.713 ± 0.035
2.726GlnIle: 2.726 ± 0.076
2.824GlnLys: 2.824 ± 0.083
3.334GlnLeu: 3.334 ± 0.076
0.866GlnMet: 0.866 ± 0.04
1.666GlnAsn: 1.666 ± 0.05
1.426GlnPro: 1.426 ± 0.052
1.298GlnGln: 1.298 ± 0.063
1.84GlnArg: 1.84 ± 0.06
2.592GlnSer: 2.592 ± 0.065
2.249GlnThr: 2.249 ± 0.06
2.391GlnVal: 2.391 ± 0.08
0.546GlnTrp: 0.546 ± 0.035
1.154GlnTyr: 1.154 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
3.26ArgAla: 3.26 ± 0.086
0.37ArgCys: 0.37 ± 0.027
2.916ArgAsp: 2.916 ± 0.088
3.555ArgGlu: 3.555 ± 0.116
2.887ArgPhe: 2.887 ± 0.08
3.154ArgGly: 3.154 ± 0.093
1.182ArgHis: 1.182 ± 0.048
3.927ArgIle: 3.927 ± 0.091
3.743ArgLys: 3.743 ± 0.102
5.606ArgLeu: 5.606 ± 0.125
1.277ArgMet: 1.277 ± 0.055
2.349ArgAsn: 2.349 ± 0.081
1.927ArgPro: 1.927 ± 0.063
1.937ArgGln: 1.937 ± 0.076
3.2ArgArg: 3.2 ± 0.102
3.624ArgSer: 3.624 ± 0.119
2.814ArgThr: 2.814 ± 0.095
3.431ArgVal: 3.431 ± 0.087
0.863ArgTrp: 0.863 ± 0.042
1.89ArgTyr: 1.89 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.01SerAla: 4.01 ± 0.105
0.475SerCys: 0.475 ± 0.032
3.667SerAsp: 3.667 ± 0.106
3.766SerGlu: 3.766 ± 0.1
4.017SerPhe: 4.017 ± 0.118
4.905SerGly: 4.905 ± 0.138
1.708SerHis: 1.708 ± 0.06
4.226SerIle: 4.226 ± 0.083
3.683SerLys: 3.683 ± 0.087
7.974SerLeu: 7.974 ± 0.141
1.317SerMet: 1.317 ± 0.047
2.603SerAsn: 2.603 ± 0.086
3.518SerPro: 3.518 ± 0.082
2.816SerGln: 2.816 ± 0.063
3.561SerArg: 3.561 ± 0.103
5.182SerSer: 5.182 ± 0.144
3.637SerThr: 3.637 ± 0.169
4.319SerVal: 4.319 ± 0.088
1.029SerTrp: 1.029 ± 0.084
2.239SerTyr: 2.239 ± 0.137
0.0SerXaa: 0.0 ± 0.0
Thr
3.497ThrAla: 3.497 ± 0.118
0.295ThrCys: 0.295 ± 0.027
2.946ThrAsp: 2.946 ± 0.103
3.035ThrGlu: 3.035 ± 0.1
2.726ThrPhe: 2.726 ± 0.094
4.213ThrGly: 4.213 ± 0.102
1.336ThrHis: 1.336 ± 0.054
3.688ThrIle: 3.688 ± 0.092
3.002ThrLys: 3.002 ± 0.081
5.878ThrLeu: 5.878 ± 0.127
0.99ThrMet: 0.99 ± 0.043
2.482ThrAsn: 2.482 ± 0.091
2.901ThrPro: 2.901 ± 0.093
1.916ThrGln: 1.916 ± 0.067
2.558ThrArg: 2.558 ± 0.087
3.704ThrSer: 3.704 ± 0.145
3.661ThrThr: 3.661 ± 0.179
3.729ThrVal: 3.729 ± 0.129
0.85ThrTrp: 0.85 ± 0.065
1.94ThrTyr: 1.94 ± 0.091
0.0ThrXaa: 0.0 ± 0.0
Val
4.427ValAla: 4.427 ± 0.101
0.506ValCys: 0.506 ± 0.036
3.988ValAsp: 3.988 ± 0.105
3.909ValGlu: 3.909 ± 0.093
3.146ValPhe: 3.146 ± 0.091
4.843ValGly: 4.843 ± 0.099
1.433ValHis: 1.433 ± 0.051
4.228ValIle: 4.228 ± 0.086
3.432ValLys: 3.432 ± 0.093
6.599ValLeu: 6.599 ± 0.148
1.267ValMet: 1.267 ± 0.052
2.553ValAsn: 2.553 ± 0.068
3.031ValPro: 3.031 ± 0.086
2.148ValGln: 2.148 ± 0.066
3.648ValArg: 3.648 ± 0.08
4.807ValSer: 4.807 ± 0.095
3.93ValThr: 3.93 ± 0.124
5.129ValVal: 5.129 ± 0.113
0.893ValTrp: 0.893 ± 0.039
1.966ValTyr: 1.966 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.94TrpAla: 0.94 ± 0.044
0.124TrpCys: 0.124 ± 0.017
1.014TrpAsp: 1.014 ± 0.054
1.006TrpGlu: 1.006 ± 0.056
0.66TrpPhe: 0.66 ± 0.033
1.156TrpGly: 1.156 ± 0.049
0.245TrpHis: 0.245 ± 0.019
1.129TrpIle: 1.129 ± 0.051
0.865TrpLys: 0.865 ± 0.039
1.224TrpLeu: 1.224 ± 0.065
0.38TrpMet: 0.38 ± 0.03
0.802TrpAsn: 0.802 ± 0.045
0.48TrpPro: 0.48 ± 0.029
0.399TrpGln: 0.399 ± 0.025
0.8TrpArg: 0.8 ± 0.032
1.063TrpSer: 1.063 ± 0.084
0.905TrpThr: 0.905 ± 0.052
1.075TrpVal: 1.075 ± 0.039
0.246TrpTrp: 0.246 ± 0.026
0.341TrpTyr: 0.341 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.726TyrAla: 1.726 ± 0.056
0.214TyrCys: 0.214 ± 0.021
1.869TyrAsp: 1.869 ± 0.099
1.779TyrGlu: 1.779 ± 0.071
1.621TyrPhe: 1.621 ± 0.068
2.112TyrGly: 2.112 ± 0.073
0.749TyrHis: 0.749 ± 0.039
1.666TyrIle: 1.666 ± 0.06
1.475TyrLys: 1.475 ± 0.053
3.41TyrLeu: 3.41 ± 0.087
0.51TyrMet: 0.51 ± 0.027
1.248TyrAsn: 1.248 ± 0.059
1.554TyrPro: 1.554 ± 0.05
1.412TyrGln: 1.412 ± 0.049
1.913TyrArg: 1.913 ± 0.067
2.109TyrSer: 2.109 ± 0.089
1.428TyrThr: 1.428 ± 0.078
1.872TyrVal: 1.872 ± 0.056
0.578TyrTrp: 0.578 ± 0.042
1.156TyrTyr: 1.156 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1550 proteins (621162 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski