Amino acid dipepetide frequency for Fimbriiglobus ruber

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.305AlaAla: 17.305 ± 0.129
1.152AlaCys: 1.152 ± 0.019
7.814AlaAsp: 7.814 ± 0.062
6.557AlaGlu: 6.557 ± 0.059
3.859AlaPhe: 3.859 ± 0.042
11.064AlaGly: 11.064 ± 0.103
2.008AlaHis: 2.008 ± 0.026
4.615AlaIle: 4.615 ± 0.039
4.561AlaLys: 4.561 ± 0.063
10.031AlaLeu: 10.031 ± 0.077
1.899AlaMet: 1.899 ± 0.028
3.123AlaAsn: 3.123 ± 0.048
5.804AlaPro: 5.804 ± 0.061
2.911AlaGln: 2.911 ± 0.037
7.912AlaArg: 7.912 ± 0.071
5.232AlaSer: 5.232 ± 0.057
7.298AlaThr: 7.298 ± 0.093
10.029AlaVal: 10.029 ± 0.07
1.596AlaTrp: 1.596 ± 0.029
2.433AlaTyr: 2.433 ± 0.031
0.0AlaXaa: 0.0 ± 0.0
Cys
0.86CysAla: 0.86 ± 0.018
0.157CysCys: 0.157 ± 0.008
0.591CysAsp: 0.591 ± 0.015
0.512CysGlu: 0.512 ± 0.014
0.327CysPhe: 0.327 ± 0.009
1.021CysGly: 1.021 ± 0.022
0.353CysHis: 0.353 ± 0.011
0.277CysIle: 0.277 ± 0.009
0.296CysLys: 0.296 ± 0.009
0.94CysLeu: 0.94 ± 0.02
0.151CysMet: 0.151 ± 0.006
0.205CysAsn: 0.205 ± 0.008
0.682CysPro: 0.682 ± 0.016
0.364CysGln: 0.364 ± 0.011
0.869CysArg: 0.869 ± 0.02
0.478CysSer: 0.478 ± 0.013
0.478CysThr: 0.478 ± 0.014
0.773CysVal: 0.773 ± 0.017
0.194CysTrp: 0.194 ± 0.007
0.284CysTyr: 0.284 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
6.914AspAla: 6.914 ± 0.062
0.462AspCys: 0.462 ± 0.013
3.411AspAsp: 3.411 ± 0.036
3.445AspGlu: 3.445 ± 0.037
2.025AspPhe: 2.025 ± 0.028
6.112AspGly: 6.112 ± 0.068
1.364AspHis: 1.364 ± 0.023
1.939AspIle: 1.939 ± 0.027
2.151AspLys: 2.151 ± 0.04
6.035AspLeu: 6.035 ± 0.052
0.816AspMet: 0.816 ± 0.015
1.301AspAsn: 1.301 ± 0.021
4.488AspPro: 4.488 ± 0.046
1.861AspGln: 1.861 ± 0.026
4.8AspArg: 4.8 ± 0.048
2.296AspSer: 2.296 ± 0.036
2.961AspThr: 2.961 ± 0.036
4.449AspVal: 4.449 ± 0.045
0.963AspTrp: 0.963 ± 0.019
1.458AspTyr: 1.458 ± 0.021
0.0AspXaa: 0.0 ± 0.0
Glu
5.835GluAla: 5.835 ± 0.061
0.449GluCys: 0.449 ± 0.011
2.23GluAsp: 2.23 ± 0.029
2.648GluGlu: 2.648 ± 0.041
2.043GluPhe: 2.043 ± 0.025
3.188GluGly: 3.188 ± 0.039
1.028GluHis: 1.028 ± 0.02
2.427GluIle: 2.427 ± 0.033
2.626GluLys: 2.626 ± 0.039
5.542GluLeu: 5.542 ± 0.052
1.196GluMet: 1.196 ± 0.02
1.333GluAsn: 1.333 ± 0.026
2.947GluPro: 2.947 ± 0.037
2.109GluGln: 2.109 ± 0.032
4.049GluArg: 4.049 ± 0.046
2.649GluSer: 2.649 ± 0.031
3.065GluThr: 3.065 ± 0.035
4.003GluVal: 4.003 ± 0.044
0.924GluTrp: 0.924 ± 0.016
1.425GluTyr: 1.425 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.202PheAla: 4.202 ± 0.042
0.406PheCys: 0.406 ± 0.013
2.609PheAsp: 2.609 ± 0.034
1.878PheGlu: 1.878 ± 0.024
1.303PhePhe: 1.303 ± 0.022
3.442PheGly: 3.442 ± 0.038
0.785PheHis: 0.785 ± 0.016
1.017PheIle: 1.017 ± 0.019
1.055PheLys: 1.055 ± 0.019
3.315PheLeu: 3.315 ± 0.036
0.445PheMet: 0.445 ± 0.012
0.98PheAsn: 0.98 ± 0.02
1.85PhePro: 1.85 ± 0.025
1.113PheGln: 1.113 ± 0.018
2.696PheArg: 2.696 ± 0.037
1.876PheSer: 1.876 ± 0.028
2.288PheThr: 2.288 ± 0.044
2.955PheVal: 2.955 ± 0.03
0.535PheTrp: 0.535 ± 0.013
0.825PheTyr: 0.825 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
7.912GlyAla: 7.912 ± 0.087
1.025GlyCys: 1.025 ± 0.021
4.753GlyAsp: 4.753 ± 0.052
4.097GlyGlu: 4.097 ± 0.037
3.098GlyPhe: 3.098 ± 0.035
8.719GlyGly: 8.719 ± 0.155
1.791GlyHis: 1.791 ± 0.027
3.45GlyIle: 3.45 ± 0.04
4.079GlyLys: 4.079 ± 0.052
7.752GlyLeu: 7.752 ± 0.064
1.803GlyMet: 1.803 ± 0.026
2.689GlyAsn: 2.689 ± 0.056
4.656GlyPro: 4.656 ± 0.057
2.955GlyGln: 2.955 ± 0.038
6.445GlyArg: 6.445 ± 0.071
5.223GlySer: 5.223 ± 0.094
6.657GlyThr: 6.657 ± 0.132
6.811GlyVal: 6.811 ± 0.059
1.593GlyTrp: 1.593 ± 0.029
2.427GlyTyr: 2.427 ± 0.032
0.0GlyXaa: 0.0 ± 0.0
His
2.116HisAla: 2.116 ± 0.029
0.261HisCys: 0.261 ± 0.009
1.218HisAsp: 1.218 ± 0.021
1.073HisGlu: 1.073 ± 0.016
0.795HisPhe: 0.795 ± 0.017
1.76HisGly: 1.76 ± 0.023
0.579HisHis: 0.579 ± 0.016
0.648HisIle: 0.648 ± 0.014
0.617HisLys: 0.617 ± 0.015
2.115HisLeu: 2.115 ± 0.031
0.301HisMet: 0.301 ± 0.009
0.515HisAsn: 0.515 ± 0.013
1.601HisPro: 1.601 ± 0.025
0.631HisGln: 0.631 ± 0.014
1.538HisArg: 1.538 ± 0.024
0.865HisSer: 0.865 ± 0.019
1.096HisThr: 1.096 ± 0.018
1.518HisVal: 1.518 ± 0.025
0.362HisTrp: 0.362 ± 0.011
0.54HisTyr: 0.54 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.637IleAla: 4.637 ± 0.037
0.375IleCys: 0.375 ± 0.011
2.687IleAsp: 2.687 ± 0.03
2.511IleGlu: 2.511 ± 0.033
1.111IlePhe: 1.111 ± 0.02
3.502IleGly: 3.502 ± 0.039
0.761IleHis: 0.761 ± 0.016
1.223IleIle: 1.223 ± 0.022
1.325IleLys: 1.325 ± 0.024
3.499IleLeu: 3.499 ± 0.031
0.47IleMet: 0.47 ± 0.011
1.114IleAsn: 1.114 ± 0.026
2.393IlePro: 2.393 ± 0.032
1.172IleGln: 1.172 ± 0.022
2.856IleArg: 2.856 ± 0.037
1.937IleSer: 1.937 ± 0.035
2.498IleThr: 2.498 ± 0.052
3.09IleVal: 3.09 ± 0.033
0.455IleTrp: 0.455 ± 0.013
0.865IleTyr: 0.865 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
4.069LysAla: 4.069 ± 0.066
0.321LysCys: 0.321 ± 0.009
2.294LysAsp: 2.294 ± 0.041
2.167LysGlu: 2.167 ± 0.042
1.163LysPhe: 1.163 ± 0.023
2.606LysGly: 2.606 ± 0.041
0.757LysHis: 0.757 ± 0.014
1.616LysIle: 1.616 ± 0.029
2.271LysLys: 2.271 ± 0.044
3.824LysLeu: 3.824 ± 0.044
0.993LysMet: 0.993 ± 0.02
1.121LysAsn: 1.121 ± 0.024
2.781LysPro: 2.781 ± 0.04
1.39LysGln: 1.39 ± 0.024
2.327LysArg: 2.327 ± 0.034
1.963LysSer: 1.963 ± 0.027
2.437LysThr: 2.437 ± 0.037
2.856LysVal: 2.856 ± 0.038
0.588LysTrp: 0.588 ± 0.015
0.98LysTyr: 0.98 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
12.278LeuAla: 12.278 ± 0.092
0.941LeuCys: 0.941 ± 0.018
5.696LeuAsp: 5.696 ± 0.052
4.42LeuGlu: 4.42 ± 0.045
3.397LeuPhe: 3.397 ± 0.034
7.454LeuGly: 7.454 ± 0.063
1.713LeuHis: 1.713 ± 0.028
3.71LeuIle: 3.71 ± 0.038
3.798LeuLys: 3.798 ± 0.057
8.938LeuLeu: 8.938 ± 0.075
1.422LeuMet: 1.422 ± 0.02
2.656LeuAsn: 2.656 ± 0.037
5.742LeuPro: 5.742 ± 0.051
2.474LeuGln: 2.474 ± 0.03
6.61LeuArg: 6.61 ± 0.064
5.165LeuSer: 5.165 ± 0.045
6.789LeuThr: 6.789 ± 0.067
7.218LeuVal: 7.218 ± 0.054
1.214LeuTrp: 1.214 ± 0.021
2.012LeuTyr: 2.012 ± 0.026
0.0LeuXaa: 0.0 ± 0.0
Met
1.919MetAla: 1.919 ± 0.026
0.165MetCys: 0.165 ± 0.007
0.791MetAsp: 0.791 ± 0.015
0.694MetGlu: 0.694 ± 0.017
0.588MetPhe: 0.588 ± 0.013
1.224MetGly: 1.224 ± 0.024
0.326MetHis: 0.326 ± 0.01
0.841MetIle: 0.841 ± 0.016
0.793MetLys: 0.793 ± 0.017
1.622MetLeu: 1.622 ± 0.022
0.356MetMet: 0.356 ± 0.012
0.599MetAsn: 0.599 ± 0.013
1.142MetPro: 1.142 ± 0.022
0.454MetGln: 0.454 ± 0.012
1.194MetArg: 1.194 ± 0.021
1.166MetSer: 1.166 ± 0.016
1.515MetThr: 1.515 ± 0.022
1.17MetVal: 1.17 ± 0.021
0.215MetTrp: 0.215 ± 0.008
0.342MetTyr: 0.342 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.703AsnAla: 2.703 ± 0.04
0.27AsnCys: 0.27 ± 0.01
1.542AsnAsp: 1.542 ± 0.024
1.268AsnGlu: 1.268 ± 0.022
0.956AsnPhe: 0.956 ± 0.019
3.072AsnGly: 3.072 ± 0.061
0.571AsnHis: 0.571 ± 0.013
1.014AsnIle: 1.014 ± 0.022
0.885AsnLys: 0.885 ± 0.015
2.75AsnLeu: 2.75 ± 0.038
0.413AsnMet: 0.413 ± 0.011
1.001AsnAsn: 1.001 ± 0.027
2.308AsnPro: 2.308 ± 0.035
1.003AsnGln: 1.003 ± 0.022
1.892AsnArg: 1.892 ± 0.023
1.441AsnSer: 1.441 ± 0.033
1.721AsnThr: 1.721 ± 0.044
2.003AsnVal: 2.003 ± 0.035
0.442AsnTrp: 0.442 ± 0.011
0.758AsnTyr: 0.758 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
8.327ProAla: 8.327 ± 0.079
0.435ProCys: 0.435 ± 0.013
4.731ProAsp: 4.731 ± 0.049
3.546ProGlu: 3.546 ± 0.038
2.019ProPhe: 2.019 ± 0.028
5.785ProGly: 5.785 ± 0.066
1.152ProHis: 1.152 ± 0.02
2.138ProIle: 2.138 ± 0.025
2.382ProLys: 2.382 ± 0.033
4.739ProLeu: 4.739 ± 0.046
0.921ProMet: 0.921 ± 0.019
1.824ProAsn: 1.824 ± 0.027
4.904ProPro: 4.904 ± 0.072
1.564ProGln: 1.564 ± 0.024
3.567ProArg: 3.567 ± 0.042
3.306ProSer: 3.306 ± 0.035
4.293ProThr: 4.293 ± 0.05
5.279ProVal: 5.279 ± 0.054
0.747ProTrp: 0.747 ± 0.018
1.174ProTyr: 1.174 ± 0.022
0.0ProXaa: 0.0 ± 0.0
Gln
3.38GlnAla: 3.38 ± 0.039
0.264GlnCys: 0.264 ± 0.009
1.288GlnAsp: 1.288 ± 0.022
1.392GlnGlu: 1.392 ± 0.024
1.319GlnPhe: 1.319 ± 0.017
2.004GlnGly: 2.004 ± 0.034
0.625GlnHis: 0.625 ± 0.012
1.636GlnIle: 1.636 ± 0.026
1.361GlnLys: 1.361 ± 0.025
3.007GlnLeu: 3.007 ± 0.032
0.658GlnMet: 0.658 ± 0.015
0.922GlnAsn: 0.922 ± 0.021
1.968GlnPro: 1.968 ± 0.028
1.245GlnGln: 1.245 ± 0.026
2.053GlnArg: 2.053 ± 0.033
1.728GlnSer: 1.728 ± 0.027
2.137GlnThr: 2.137 ± 0.033
2.542GlnVal: 2.542 ± 0.031
0.46GlnTrp: 0.46 ± 0.013
0.814GlnTyr: 0.814 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
7.623ArgAla: 7.623 ± 0.079
0.718ArgCys: 0.718 ± 0.016
4.046ArgAsp: 4.046 ± 0.048
4.076ArgGlu: 4.076 ± 0.049
2.85ArgPhe: 2.85 ± 0.032
5.1ArgGly: 5.1 ± 0.051
1.592ArgHis: 1.592 ± 0.024
2.766ArgIle: 2.766 ± 0.034
2.666ArgLys: 2.666 ± 0.038
7.364ArgLeu: 7.364 ± 0.065
1.481ArgMet: 1.481 ± 0.022
1.784ArgAsn: 1.784 ± 0.028
4.448ArgPro: 4.448 ± 0.048
2.532ArgGln: 2.532 ± 0.034
5.773ArgArg: 5.773 ± 0.066
3.432ArgSer: 3.432 ± 0.039
4.061ArgThr: 4.061 ± 0.047
5.938ArgVal: 5.938 ± 0.061
1.261ArgTrp: 1.261 ± 0.025
1.803ArgTyr: 1.803 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
5.486SerAla: 5.486 ± 0.058
0.477SerCys: 0.477 ± 0.011
2.838SerAsp: 2.838 ± 0.039
2.412SerGlu: 2.412 ± 0.031
1.863SerPhe: 1.863 ± 0.027
5.713SerGly: 5.713 ± 0.095
1.073SerHis: 1.073 ± 0.019
1.955SerIle: 1.955 ± 0.034
1.592SerLys: 1.592 ± 0.025
4.708SerLeu: 4.708 ± 0.041
0.887SerMet: 0.887 ± 0.017
1.52SerAsn: 1.52 ± 0.032
3.763SerPro: 3.763 ± 0.046
1.516SerGln: 1.516 ± 0.02
3.491SerArg: 3.491 ± 0.035
3.031SerSer: 3.031 ± 0.063
3.317SerThr: 3.317 ± 0.069
4.071SerVal: 4.071 ± 0.049
0.749SerTrp: 0.749 ± 0.016
1.243SerTyr: 1.243 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
7.938ThrAla: 7.938 ± 0.1
0.551ThrCys: 0.551 ± 0.015
3.905ThrAsp: 3.905 ± 0.06
2.825ThrGlu: 2.825 ± 0.035
2.498ThrPhe: 2.498 ± 0.041
6.869ThrGly: 6.869 ± 0.11
1.219ThrHis: 1.219 ± 0.018
2.754ThrIle: 2.754 ± 0.049
1.964ThrLys: 1.964 ± 0.027
6.112ThrLeu: 6.112 ± 0.072
0.89ThrMet: 0.89 ± 0.019
1.883ThrAsn: 1.883 ± 0.048
4.634ThrPro: 4.634 ± 0.05
1.702ThrGln: 1.702 ± 0.03
3.757ThrArg: 3.757 ± 0.042
3.373ThrSer: 3.373 ± 0.059
4.602ThrThr: 4.602 ± 0.099
5.691ThrVal: 5.691 ± 0.085
0.923ThrTrp: 0.923 ± 0.022
1.557ThrTyr: 1.557 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.617ValAla: 9.617 ± 0.069
0.903ValCys: 0.903 ± 0.019
4.196ValAsp: 4.196 ± 0.048
4.099ValGlu: 4.099 ± 0.041
2.861ValPhe: 2.861 ± 0.031
6.342ValGly: 6.342 ± 0.056
1.465ValHis: 1.465 ± 0.021
3.286ValIle: 3.286 ± 0.035
2.757ValLys: 2.757 ± 0.038
7.223ValLeu: 7.223 ± 0.054
1.376ValMet: 1.376 ± 0.021
2.247ValAsn: 2.247 ± 0.037
4.677ValPro: 4.677 ± 0.049
2.215ValGln: 2.215 ± 0.025
6.335ValArg: 6.335 ± 0.058
4.451ValSer: 4.451 ± 0.058
6.026ValThr: 6.026 ± 0.096
7.445ValVal: 7.445 ± 0.052
1.335ValTrp: 1.335 ± 0.023
2.062ValTyr: 2.062 ± 0.026
0.0ValXaa: 0.0 ± 0.0
Trp
1.606TrpAla: 1.606 ± 0.03
0.206TrpCys: 0.206 ± 0.009
0.978TrpAsp: 0.978 ± 0.023
0.77TrpGlu: 0.77 ± 0.017
0.55TrpPhe: 0.55 ± 0.016
0.958TrpGly: 0.958 ± 0.018
0.354TrpHis: 0.354 ± 0.012
0.473TrpIle: 0.473 ± 0.011
0.639TrpLys: 0.639 ± 0.018
1.675TrpLeu: 1.675 ± 0.023
0.306TrpMet: 0.306 ± 0.011
0.484TrpAsn: 0.484 ± 0.012
0.738TrpPro: 0.738 ± 0.016
0.614TrpGln: 0.614 ± 0.015
1.108TrpArg: 1.108 ± 0.02
0.859TrpSer: 0.859 ± 0.018
0.872TrpThr: 0.872 ± 0.018
1.333TrpVal: 1.333 ± 0.023
0.303TrpTrp: 0.303 ± 0.011
0.414TrpTyr: 0.414 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.477TyrAla: 2.477 ± 0.03
0.275TyrCys: 0.275 ± 0.009
1.633TyrAsp: 1.633 ± 0.042
1.326TyrGlu: 1.326 ± 0.024
0.951TyrPhe: 0.951 ± 0.019
1.999TyrGly: 1.999 ± 0.03
0.631TyrHis: 0.631 ± 0.016
0.697TyrIle: 0.697 ± 0.016
0.707TyrLys: 0.707 ± 0.014
2.458TyrLeu: 2.458 ± 0.03
0.334TyrMet: 0.334 ± 0.011
0.713TyrAsn: 0.713 ± 0.015
1.306TyrPro: 1.306 ± 0.024
0.974TyrGln: 0.974 ± 0.021
2.043TyrArg: 2.043 ± 0.031
1.232TyrSer: 1.232 ± 0.023
1.534TyrThr: 1.534 ± 0.034
1.745TyrVal: 1.745 ± 0.027
0.381TyrTrp: 0.381 ± 0.013
0.7TyrTyr: 0.7 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10212 proteins (3250331 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski