Amino acid dipepetide frequency for Klebsiella phage KPP5665-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.996AlaAla: 11.996 ± 1.356
1.083AlaCys: 1.083 ± 0.388
5.332AlaAsp: 5.332 ± 0.541
6.498AlaGlu: 6.498 ± 0.988
2.582AlaPhe: 2.582 ± 0.519
7.747AlaGly: 7.747 ± 0.846
1.999AlaHis: 1.999 ± 0.462
6.831AlaIle: 6.831 ± 0.724
5.332AlaLys: 5.332 ± 0.635
9.33AlaLeu: 9.33 ± 0.946
2.749AlaMet: 2.749 ± 0.566
3.832AlaAsn: 3.832 ± 0.601
3.499AlaPro: 3.499 ± 0.648
4.165AlaGln: 4.165 ± 0.932
4.998AlaArg: 4.998 ± 0.687
6.331AlaSer: 6.331 ± 0.702
5.498AlaThr: 5.498 ± 0.69
5.415AlaVal: 5.415 ± 0.994
1.333AlaTrp: 1.333 ± 0.397
2.666AlaTyr: 2.666 ± 0.555
0.0AlaXaa: 0.0 ± 0.0
Cys
1.166CysAla: 1.166 ± 0.263
0.25CysCys: 0.25 ± 0.159
0.833CysAsp: 0.833 ± 0.224
0.916CysGlu: 0.916 ± 0.306
0.333CysPhe: 0.333 ± 0.161
0.833CysGly: 0.833 ± 0.296
0.167CysHis: 0.167 ± 0.122
0.333CysIle: 0.333 ± 0.166
0.583CysLys: 0.583 ± 0.191
0.5CysLeu: 0.5 ± 0.189
0.167CysMet: 0.167 ± 0.112
0.333CysAsn: 0.333 ± 0.131
0.666CysPro: 0.666 ± 0.219
0.333CysGln: 0.333 ± 0.138
1.0CysArg: 1.0 ± 0.315
0.583CysSer: 0.583 ± 0.221
0.417CysThr: 0.417 ± 0.165
0.5CysVal: 0.5 ± 0.199
0.25CysTrp: 0.25 ± 0.147
0.417CysTyr: 0.417 ± 0.229
0.0CysXaa: 0.0 ± 0.0
Asp
4.915AspAla: 4.915 ± 0.81
0.417AspCys: 0.417 ± 0.178
3.166AspAsp: 3.166 ± 0.809
2.999AspGlu: 2.999 ± 0.419
2.083AspPhe: 2.083 ± 0.427
5.165AspGly: 5.165 ± 0.575
0.833AspHis: 0.833 ± 0.275
3.582AspIle: 3.582 ± 0.663
3.166AspLys: 3.166 ± 0.479
5.498AspLeu: 5.498 ± 0.788
1.416AspMet: 1.416 ± 0.303
3.499AspAsn: 3.499 ± 0.431
2.083AspPro: 2.083 ± 0.49
1.916AspGln: 1.916 ± 0.339
3.166AspArg: 3.166 ± 0.402
4.415AspSer: 4.415 ± 0.584
3.166AspThr: 3.166 ± 0.501
3.832AspVal: 3.832 ± 0.647
0.75AspTrp: 0.75 ± 0.209
1.749AspTyr: 1.749 ± 0.367
0.0AspXaa: 0.0 ± 0.0
Glu
5.748GluAla: 5.748 ± 0.7
0.916GluCys: 0.916 ± 0.344
1.916GluAsp: 1.916 ± 0.368
3.416GluGlu: 3.416 ± 0.792
3.082GluPhe: 3.082 ± 0.589
3.665GluGly: 3.665 ± 0.586
0.75GluHis: 0.75 ± 0.211
3.582GluIle: 3.582 ± 0.57
2.333GluLys: 2.333 ± 0.612
5.332GluLeu: 5.332 ± 0.703
1.583GluMet: 1.583 ± 0.394
2.666GluAsn: 2.666 ± 0.555
2.166GluPro: 2.166 ± 0.378
2.832GluGln: 2.832 ± 0.618
4.249GluArg: 4.249 ± 0.675
2.916GluSer: 2.916 ± 0.455
3.416GluThr: 3.416 ± 0.508
3.749GluVal: 3.749 ± 0.514
1.166GluTrp: 1.166 ± 0.287
2.249GluTyr: 2.249 ± 0.353
0.0GluXaa: 0.0 ± 0.0
Phe
3.082PheAla: 3.082 ± 0.489
0.417PheCys: 0.417 ± 0.191
2.416PheAsp: 2.416 ± 0.452
1.833PheGlu: 1.833 ± 0.305
1.5PhePhe: 1.5 ± 0.318
2.582PheGly: 2.582 ± 0.377
0.417PheHis: 0.417 ± 0.225
2.249PheIle: 2.249 ± 0.568
1.25PheLys: 1.25 ± 0.337
1.999PheLeu: 1.999 ± 0.309
1.083PheMet: 1.083 ± 0.28
2.416PheAsn: 2.416 ± 0.486
1.416PhePro: 1.416 ± 0.407
1.25PheGln: 1.25 ± 0.294
1.583PheArg: 1.583 ± 0.439
2.582PheSer: 2.582 ± 0.408
2.832PheThr: 2.832 ± 0.576
1.999PheVal: 1.999 ± 0.463
0.417PheTrp: 0.417 ± 0.163
0.583PheTyr: 0.583 ± 0.229
0.0PheXaa: 0.0 ± 0.0
Gly
6.831GlyAla: 6.831 ± 0.836
0.333GlyCys: 0.333 ± 0.211
5.415GlyAsp: 5.415 ± 0.766
3.499GlyGlu: 3.499 ± 0.382
3.915GlyPhe: 3.915 ± 0.497
5.248GlyGly: 5.248 ± 0.785
1.083GlyHis: 1.083 ± 0.266
3.999GlyIle: 3.999 ± 0.575
4.582GlyLys: 4.582 ± 0.627
7.414GlyLeu: 7.414 ± 0.816
2.416GlyMet: 2.416 ± 0.368
3.166GlyAsn: 3.166 ± 0.431
1.999GlyPro: 1.999 ± 0.494
1.999GlyGln: 1.999 ± 0.504
4.499GlyArg: 4.499 ± 0.594
4.415GlySer: 4.415 ± 0.715
5.248GlyThr: 5.248 ± 0.578
5.581GlyVal: 5.581 ± 0.753
1.25GlyTrp: 1.25 ± 0.311
3.082GlyTyr: 3.082 ± 0.542
0.0GlyXaa: 0.0 ± 0.0
His
1.416HisAla: 1.416 ± 0.462
0.25HisCys: 0.25 ± 0.167
1.166HisAsp: 1.166 ± 0.333
0.833HisGlu: 0.833 ± 0.217
0.417HisPhe: 0.417 ± 0.179
1.416HisGly: 1.416 ± 0.283
0.417HisHis: 0.417 ± 0.172
1.25HisIle: 1.25 ± 0.416
0.417HisLys: 0.417 ± 0.201
1.416HisLeu: 1.416 ± 0.416
0.333HisMet: 0.333 ± 0.143
0.75HisAsn: 0.75 ± 0.276
0.75HisPro: 0.75 ± 0.219
0.75HisGln: 0.75 ± 0.193
1.25HisArg: 1.25 ± 0.362
0.167HisSer: 0.167 ± 0.126
0.666HisThr: 0.666 ± 0.338
1.25HisVal: 1.25 ± 0.323
0.333HisTrp: 0.333 ± 0.167
1.166HisTyr: 1.166 ± 0.291
0.0HisXaa: 0.0 ± 0.0
Ile
5.498IleAla: 5.498 ± 0.776
1.0IleCys: 1.0 ± 0.287
3.416IleAsp: 3.416 ± 0.433
3.999IleGlu: 3.999 ± 0.7
1.833IlePhe: 1.833 ± 0.358
3.582IleGly: 3.582 ± 0.439
0.666IleHis: 0.666 ± 0.22
3.249IleIle: 3.249 ± 0.471
2.582IleLys: 2.582 ± 0.559
3.499IleLeu: 3.499 ± 0.617
1.583IleMet: 1.583 ± 0.391
2.916IleAsn: 2.916 ± 0.597
1.749IlePro: 1.749 ± 0.318
1.833IleGln: 1.833 ± 0.372
3.999IleArg: 3.999 ± 0.594
4.665IleSer: 4.665 ± 0.546
4.415IleThr: 4.415 ± 0.625
3.166IleVal: 3.166 ± 0.51
0.75IleTrp: 0.75 ± 0.222
1.999IleTyr: 1.999 ± 0.325
0.0IleXaa: 0.0 ± 0.0
Lys
5.248LysAla: 5.248 ± 1.0
0.5LysCys: 0.5 ± 0.172
1.999LysAsp: 1.999 ± 0.567
4.249LysGlu: 4.249 ± 0.811
1.583LysPhe: 1.583 ± 0.47
3.082LysGly: 3.082 ± 0.556
1.416LysHis: 1.416 ± 0.432
1.833LysIle: 1.833 ± 0.424
1.999LysLys: 1.999 ± 0.431
4.165LysLeu: 4.165 ± 0.516
1.25LysMet: 1.25 ± 0.298
3.416LysAsn: 3.416 ± 0.479
2.249LysPro: 2.249 ± 0.584
2.166LysGln: 2.166 ± 0.477
3.082LysArg: 3.082 ± 0.627
3.915LysSer: 3.915 ± 0.622
2.832LysThr: 2.832 ± 0.386
2.582LysVal: 2.582 ± 0.479
0.583LysTrp: 0.583 ± 0.282
1.083LysTyr: 1.083 ± 0.312
0.0LysXaa: 0.0 ± 0.0
Leu
8.83LeuAla: 8.83 ± 0.917
1.166LeuCys: 1.166 ± 0.336
5.082LeuAsp: 5.082 ± 0.703
3.832LeuGlu: 3.832 ± 0.709
1.916LeuPhe: 1.916 ± 0.272
4.832LeuGly: 4.832 ± 0.427
1.333LeuHis: 1.333 ± 0.318
5.332LeuIle: 5.332 ± 0.91
4.915LeuLys: 4.915 ± 0.63
7.498LeuLeu: 7.498 ± 0.856
1.666LeuMet: 1.666 ± 0.342
4.832LeuAsn: 4.832 ± 0.613
4.582LeuPro: 4.582 ± 0.669
3.582LeuGln: 3.582 ± 0.638
4.998LeuArg: 4.998 ± 0.882
6.914LeuSer: 6.914 ± 0.673
5.915LeuThr: 5.915 ± 0.545
5.998LeuVal: 5.998 ± 0.645
1.0LeuTrp: 1.0 ± 0.259
1.999LeuTyr: 1.999 ± 0.346
0.0LeuXaa: 0.0 ± 0.0
Met
3.249MetAla: 3.249 ± 0.578
0.25MetCys: 0.25 ± 0.163
0.583MetAsp: 0.583 ± 0.259
1.333MetGlu: 1.333 ± 0.362
0.833MetPhe: 0.833 ± 0.222
1.166MetGly: 1.166 ± 0.302
0.417MetHis: 0.417 ± 0.193
0.833MetIle: 0.833 ± 0.251
2.083MetLys: 2.083 ± 0.415
2.666MetLeu: 2.666 ± 0.451
1.166MetMet: 1.166 ± 0.327
1.166MetAsn: 1.166 ± 0.369
1.083MetPro: 1.083 ± 0.255
1.749MetGln: 1.749 ± 0.336
1.166MetArg: 1.166 ± 0.268
2.333MetSer: 2.333 ± 0.342
2.499MetThr: 2.499 ± 0.491
1.25MetVal: 1.25 ± 0.314
0.083MetTrp: 0.083 ± 0.09
0.916MetTyr: 0.916 ± 0.284
0.0MetXaa: 0.0 ± 0.0
Asn
4.582AsnAla: 4.582 ± 0.865
0.25AsnCys: 0.25 ± 0.146
2.249AsnAsp: 2.249 ± 0.343
2.416AsnGlu: 2.416 ± 0.397
1.25AsnPhe: 1.25 ± 0.276
3.832AsnGly: 3.832 ± 0.566
0.583AsnHis: 0.583 ± 0.21
3.582AsnIle: 3.582 ± 0.617
1.916AsnLys: 1.916 ± 0.421
3.999AsnLeu: 3.999 ± 0.583
1.083AsnMet: 1.083 ± 0.293
1.5AsnAsn: 1.5 ± 0.381
2.832AsnPro: 2.832 ± 0.493
2.166AsnGln: 2.166 ± 0.485
1.749AsnArg: 1.749 ± 0.328
3.166AsnSer: 3.166 ± 0.389
1.999AsnThr: 1.999 ± 0.335
2.832AsnVal: 2.832 ± 0.46
0.583AsnTrp: 0.583 ± 0.221
1.5AsnTyr: 1.5 ± 0.265
0.0AsnXaa: 0.0 ± 0.0
Pro
4.165ProAla: 4.165 ± 0.591
0.25ProCys: 0.25 ± 0.13
3.416ProAsp: 3.416 ± 0.404
2.916ProGlu: 2.916 ± 0.545
1.416ProPhe: 1.416 ± 0.355
3.332ProGly: 3.332 ± 0.754
0.75ProHis: 0.75 ± 0.236
1.833ProIle: 1.833 ± 0.314
1.083ProLys: 1.083 ± 0.357
3.915ProLeu: 3.915 ± 0.592
0.75ProMet: 0.75 ± 0.2
1.416ProAsn: 1.416 ± 0.393
2.416ProPro: 2.416 ± 0.45
1.749ProGln: 1.749 ± 0.309
2.083ProArg: 2.083 ± 0.456
3.166ProSer: 3.166 ± 0.585
2.166ProThr: 2.166 ± 0.506
3.749ProVal: 3.749 ± 0.653
0.583ProTrp: 0.583 ± 0.211
1.25ProTyr: 1.25 ± 0.273
0.0ProXaa: 0.0 ± 0.0
Gln
3.915GlnAla: 3.915 ± 0.58
0.25GlnCys: 0.25 ± 0.125
1.916GlnAsp: 1.916 ± 0.476
1.666GlnGlu: 1.666 ± 0.435
0.916GlnPhe: 0.916 ± 0.343
3.249GlnGly: 3.249 ± 0.482
0.583GlnHis: 0.583 ± 0.212
2.666GlnIle: 2.666 ± 0.572
2.749GlnLys: 2.749 ± 0.724
3.416GlnLeu: 3.416 ± 0.492
1.666GlnMet: 1.666 ± 0.404
1.25GlnAsn: 1.25 ± 0.321
1.583GlnPro: 1.583 ± 0.318
1.999GlnGln: 1.999 ± 0.436
2.999GlnArg: 2.999 ± 0.699
2.416GlnSer: 2.416 ± 0.447
2.333GlnThr: 2.333 ± 0.407
2.333GlnVal: 2.333 ± 0.568
0.25GlnTrp: 0.25 ± 0.183
1.749GlnTyr: 1.749 ± 0.34
0.0GlnXaa: 0.0 ± 0.0
Arg
4.499ArgAla: 4.499 ± 0.618
1.083ArgCys: 1.083 ± 0.451
3.249ArgAsp: 3.249 ± 0.474
4.082ArgGlu: 4.082 ± 0.942
2.416ArgPhe: 2.416 ± 0.441
3.749ArgGly: 3.749 ± 0.524
1.583ArgHis: 1.583 ± 0.413
3.499ArgIle: 3.499 ± 0.583
3.082ArgLys: 3.082 ± 0.57
5.915ArgLeu: 5.915 ± 0.731
2.249ArgMet: 2.249 ± 0.406
1.999ArgAsn: 1.999 ± 0.479
1.666ArgPro: 1.666 ± 0.396
2.333ArgGln: 2.333 ± 0.465
4.499ArgArg: 4.499 ± 0.914
2.749ArgSer: 2.749 ± 0.558
2.499ArgThr: 2.499 ± 0.454
3.416ArgVal: 3.416 ± 0.615
1.5ArgTrp: 1.5 ± 0.407
2.749ArgTyr: 2.749 ± 0.554
0.0ArgXaa: 0.0 ± 0.0
Ser
7.164SerAla: 7.164 ± 0.899
0.417SerCys: 0.417 ± 0.187
5.248SerAsp: 5.248 ± 0.696
3.166SerGlu: 3.166 ± 0.549
2.749SerPhe: 2.749 ± 0.374
7.248SerGly: 7.248 ± 0.825
0.833SerHis: 0.833 ± 0.256
2.916SerIle: 2.916 ± 0.513
3.166SerLys: 3.166 ± 0.502
5.665SerLeu: 5.665 ± 0.798
1.833SerMet: 1.833 ± 0.319
2.249SerAsn: 2.249 ± 0.421
3.166SerPro: 3.166 ± 0.465
2.582SerGln: 2.582 ± 0.41
3.332SerArg: 3.332 ± 0.472
4.748SerSer: 4.748 ± 0.866
4.415SerThr: 4.415 ± 0.811
4.998SerVal: 4.998 ± 0.569
1.666SerTrp: 1.666 ± 0.303
1.583SerTyr: 1.583 ± 0.36
0.0SerXaa: 0.0 ± 0.0
Thr
6.998ThrAla: 6.998 ± 0.797
0.333ThrCys: 0.333 ± 0.131
4.082ThrAsp: 4.082 ± 0.542
3.582ThrGlu: 3.582 ± 0.562
2.166ThrPhe: 2.166 ± 0.312
6.581ThrGly: 6.581 ± 0.834
0.75ThrHis: 0.75 ± 0.329
3.332ThrIle: 3.332 ± 0.537
2.666ThrLys: 2.666 ± 0.665
4.332ThrLeu: 4.332 ± 0.571
1.0ThrMet: 1.0 ± 0.227
1.583ThrAsn: 1.583 ± 0.389
3.249ThrPro: 3.249 ± 0.642
2.166ThrGln: 2.166 ± 0.433
3.082ThrArg: 3.082 ± 0.66
4.748ThrSer: 4.748 ± 0.566
4.665ThrThr: 4.665 ± 0.609
4.332ThrVal: 4.332 ± 0.762
1.583ThrTrp: 1.583 ± 0.345
1.749ThrTyr: 1.749 ± 0.342
0.0ThrXaa: 0.0 ± 0.0
Val
6.165ValAla: 6.165 ± 0.727
0.75ValCys: 0.75 ± 0.236
3.915ValAsp: 3.915 ± 0.564
4.499ValGlu: 4.499 ± 1.009
2.249ValPhe: 2.249 ± 0.324
5.082ValGly: 5.082 ± 0.68
0.666ValHis: 0.666 ± 0.243
3.166ValIle: 3.166 ± 0.667
3.082ValLys: 3.082 ± 0.467
4.249ValLeu: 4.249 ± 0.664
1.583ValMet: 1.583 ± 0.417
3.499ValAsn: 3.499 ± 0.537
2.666ValPro: 2.666 ± 0.506
1.749ValGln: 1.749 ± 0.357
3.582ValArg: 3.582 ± 0.534
5.165ValSer: 5.165 ± 0.627
4.915ValThr: 4.915 ± 0.905
4.082ValVal: 4.082 ± 0.552
1.083ValTrp: 1.083 ± 0.271
1.999ValTyr: 1.999 ± 0.413
0.0ValXaa: 0.0 ± 0.0
Trp
1.333TrpAla: 1.333 ± 0.284
0.5TrpCys: 0.5 ± 0.188
0.666TrpAsp: 0.666 ± 0.291
1.0TrpGlu: 1.0 ± 0.303
0.333TrpPhe: 0.333 ± 0.18
1.0TrpGly: 1.0 ± 0.248
0.417TrpHis: 0.417 ± 0.169
1.0TrpIle: 1.0 ± 0.277
0.583TrpLys: 0.583 ± 0.207
2.499TrpLeu: 2.499 ± 0.388
0.583TrpMet: 0.583 ± 0.204
0.25TrpAsn: 0.25 ± 0.142
0.666TrpPro: 0.666 ± 0.226
0.583TrpGln: 0.583 ± 0.219
0.916TrpArg: 0.916 ± 0.253
1.0TrpSer: 1.0 ± 0.316
0.833TrpThr: 0.833 ± 0.227
1.166TrpVal: 1.166 ± 0.319
0.167TrpTrp: 0.167 ± 0.11
0.666TrpTyr: 0.666 ± 0.199
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.416TyrAla: 2.416 ± 0.382
0.167TyrCys: 0.167 ± 0.138
1.749TyrAsp: 1.749 ± 0.308
1.0TyrGlu: 1.0 ± 0.257
0.333TyrPhe: 0.333 ± 0.19
2.582TyrGly: 2.582 ± 0.525
0.75TyrHis: 0.75 ± 0.229
1.333TyrIle: 1.333 ± 0.306
1.666TyrLys: 1.666 ± 0.375
2.916TyrLeu: 2.916 ± 0.463
0.583TyrMet: 0.583 ± 0.23
1.333TyrAsn: 1.333 ± 0.302
1.916TyrPro: 1.916 ± 0.547
1.999TyrGln: 1.999 ± 0.413
2.666TyrArg: 2.666 ± 0.392
2.749TyrSer: 2.749 ± 0.742
2.249TyrThr: 2.249 ± 0.42
1.916TyrVal: 1.916 ± 0.299
0.833TyrTrp: 0.833 ± 0.23
0.916TyrTyr: 0.916 ± 0.276
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (12005 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski