Amino acid dipepetide frequency for Streptococcus satellite phage Javan251

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.393AlaAla: 0.393 ± 0.371
1.179AlaCys: 1.179 ± 0.49
4.715AlaAsp: 4.715 ± 1.088
5.894AlaGlu: 5.894 ± 1.306
1.965AlaPhe: 1.965 ± 1.436
2.358AlaGly: 2.358 ± 0.873
0.393AlaHis: 0.393 ± 0.458
5.108AlaIle: 5.108 ± 1.31
6.68AlaLys: 6.68 ± 1.747
5.501AlaLeu: 5.501 ± 1.314
1.572AlaMet: 1.572 ± 0.668
3.536AlaAsn: 3.536 ± 1.277
1.572AlaPro: 1.572 ± 0.613
2.358AlaGln: 2.358 ± 1.046
2.75AlaArg: 2.75 ± 0.742
2.358AlaSer: 2.358 ± 0.637
5.108AlaThr: 5.108 ± 1.325
2.75AlaVal: 2.75 ± 1.209
0.393AlaTrp: 0.393 ± 0.374
3.536AlaTyr: 3.536 ± 0.796
0.0AlaXaa: 0.0 ± 0.0
Cys
0.393CysAla: 0.393 ± 0.371
0.0CysCys: 0.0 ± 0.0
0.393CysAsp: 0.393 ± 0.339
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.786CysGly: 0.786 ± 0.521
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.393CysLys: 0.393 ± 0.454
1.179CysLeu: 1.179 ± 0.536
0.393CysMet: 0.393 ± 0.324
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.786CysArg: 0.786 ± 0.492
0.0CysSer: 0.0 ± 0.0
0.393CysThr: 0.393 ± 0.329
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.393CysTyr: 0.393 ± 0.349
0.0CysXaa: 0.0 ± 0.0
Asp
2.75AspAla: 2.75 ± 1.048
1.572AspCys: 1.572 ± 0.599
4.322AspAsp: 4.322 ± 1.389
4.322AspGlu: 4.322 ± 1.361
3.536AspPhe: 3.536 ± 1.005
1.965AspGly: 1.965 ± 0.927
0.393AspHis: 0.393 ± 0.371
7.073AspIle: 7.073 ± 1.416
3.143AspLys: 3.143 ± 1.053
9.037AspLeu: 9.037 ± 1.7
1.572AspMet: 1.572 ± 0.592
7.073AspAsn: 7.073 ± 1.629
1.179AspPro: 1.179 ± 0.505
1.179AspGln: 1.179 ± 0.693
3.536AspArg: 3.536 ± 1.527
3.929AspSer: 3.929 ± 1.418
4.715AspThr: 4.715 ± 1.392
4.322AspVal: 4.322 ± 1.467
0.786AspTrp: 0.786 ± 0.624
3.536AspTyr: 3.536 ± 1.252
0.0AspXaa: 0.0 ± 0.0
Glu
5.894GluAla: 5.894 ± 2.285
0.0GluCys: 0.0 ± 0.0
7.466GluAsp: 7.466 ± 1.764
3.536GluGlu: 3.536 ± 1.105
1.965GluPhe: 1.965 ± 0.789
1.965GluGly: 1.965 ± 0.771
1.965GluHis: 1.965 ± 1.033
3.929GluIle: 3.929 ± 1.211
6.68GluLys: 6.68 ± 1.25
9.43GluLeu: 9.43 ± 2.067
2.358GluMet: 2.358 ± 1.029
3.929GluAsn: 3.929 ± 0.862
3.536GluPro: 3.536 ± 0.885
3.536GluGln: 3.536 ± 1.017
2.75GluArg: 2.75 ± 1.182
3.929GluSer: 3.929 ± 1.137
3.536GluThr: 3.536 ± 1.166
1.965GluVal: 1.965 ± 0.62
1.179GluTrp: 1.179 ± 0.605
2.358GluTyr: 2.358 ± 0.652
0.0GluXaa: 0.0 ± 0.0
Phe
1.179PheAla: 1.179 ± 0.667
0.0PheCys: 0.0 ± 0.0
2.358PheAsp: 2.358 ± 0.709
2.358PheGlu: 2.358 ± 1.486
1.179PhePhe: 1.179 ± 0.652
1.965PheGly: 1.965 ± 0.737
0.393PheHis: 0.393 ± 0.329
2.358PheIle: 2.358 ± 0.697
2.358PheLys: 2.358 ± 0.747
2.358PheLeu: 2.358 ± 1.181
0.0PheMet: 0.0 ± 0.0
2.358PheAsn: 2.358 ± 0.878
1.572PhePro: 1.572 ± 0.775
2.75PheGln: 2.75 ± 0.998
2.358PheArg: 2.358 ± 0.727
3.536PheSer: 3.536 ± 1.557
2.358PheThr: 2.358 ± 0.817
1.179PheVal: 1.179 ± 0.631
0.0PheTrp: 0.0 ± 0.0
1.965PheTyr: 1.965 ± 0.774
0.0PheXaa: 0.0 ± 0.0
Gly
2.75GlyAla: 2.75 ± 0.835
0.786GlyCys: 0.786 ± 0.658
3.143GlyAsp: 3.143 ± 0.846
2.358GlyGlu: 2.358 ± 0.774
3.536GlyPhe: 3.536 ± 1.089
2.75GlyGly: 2.75 ± 1.35
2.358GlyHis: 2.358 ± 0.692
3.536GlyIle: 3.536 ± 1.266
7.466GlyLys: 7.466 ± 1.443
5.108GlyLeu: 5.108 ± 1.629
0.0GlyMet: 0.0 ± 0.0
1.572GlyAsn: 1.572 ± 0.791
0.0GlyPro: 0.0 ± 0.0
1.179GlyGln: 1.179 ± 0.677
2.75GlyArg: 2.75 ± 0.745
1.179GlySer: 1.179 ± 0.667
2.358GlyThr: 2.358 ± 0.708
3.536GlyVal: 3.536 ± 0.981
1.179GlyTrp: 1.179 ± 0.727
4.322GlyTyr: 4.322 ± 1.065
0.0GlyXaa: 0.0 ± 0.0
His
2.358HisAla: 2.358 ± 1.093
0.0HisCys: 0.0 ± 0.0
0.786HisAsp: 0.786 ± 0.534
0.786HisGlu: 0.786 ± 0.501
0.786HisPhe: 0.786 ± 0.463
0.786HisGly: 0.786 ± 0.499
0.0HisHis: 0.0 ± 0.0
0.393HisIle: 0.393 ± 0.371
0.393HisLys: 0.393 ± 0.458
3.143HisLeu: 3.143 ± 1.448
0.393HisMet: 0.393 ± 0.365
1.572HisAsn: 1.572 ± 0.613
0.393HisPro: 0.393 ± 0.349
1.179HisGln: 1.179 ± 0.612
0.786HisArg: 0.786 ± 0.495
0.786HisSer: 0.786 ± 0.574
1.179HisThr: 1.179 ± 0.987
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.572HisTyr: 1.572 ± 0.716
0.0HisXaa: 0.0 ± 0.0
Ile
6.287IleAla: 6.287 ± 1.135
0.393IleCys: 0.393 ± 0.374
3.929IleAsp: 3.929 ± 1.267
3.929IleGlu: 3.929 ± 0.982
2.358IlePhe: 2.358 ± 0.76
3.143IleGly: 3.143 ± 0.815
0.786IleHis: 0.786 ± 0.574
5.108IleIle: 5.108 ± 0.5
8.251IleLys: 8.251 ± 2.19
2.358IleLeu: 2.358 ± 1.031
1.179IleMet: 1.179 ± 0.553
5.108IleAsn: 5.108 ± 1.407
2.358IlePro: 2.358 ± 0.772
2.358IleGln: 2.358 ± 0.812
3.536IleArg: 3.536 ± 0.862
3.536IleSer: 3.536 ± 0.943
3.536IleThr: 3.536 ± 1.096
3.929IleVal: 3.929 ± 1.17
0.393IleTrp: 0.393 ± 0.324
2.75IleTyr: 2.75 ± 0.59
0.0IleXaa: 0.0 ± 0.0
Lys
5.894LysAla: 5.894 ± 1.284
0.0LysCys: 0.0 ± 0.0
5.108LysAsp: 5.108 ± 1.263
7.859LysGlu: 7.859 ± 1.828
1.572LysPhe: 1.572 ± 0.815
4.322LysGly: 4.322 ± 1.335
3.929LysHis: 3.929 ± 0.966
6.287LysIle: 6.287 ± 1.296
6.68LysLys: 6.68 ± 1.483
9.43LysLeu: 9.43 ± 1.54
1.179LysMet: 1.179 ± 0.668
2.358LysAsn: 2.358 ± 0.777
3.929LysPro: 3.929 ± 1.556
3.143LysGln: 3.143 ± 1.197
5.108LysArg: 5.108 ± 1.658
6.287LysSer: 6.287 ± 1.912
11.002LysThr: 11.002 ± 2.565
4.715LysVal: 4.715 ± 1.073
0.786LysTrp: 0.786 ± 0.436
2.358LysTyr: 2.358 ± 1.103
0.0LysXaa: 0.0 ± 0.0
Leu
7.466LeuAla: 7.466 ± 2.126
0.0LeuCys: 0.0 ± 0.0
9.43LeuAsp: 9.43 ± 1.89
10.609LeuGlu: 10.609 ± 1.81
2.75LeuPhe: 2.75 ± 0.869
3.536LeuGly: 3.536 ± 1.562
1.179LeuHis: 1.179 ± 0.667
4.715LeuIle: 4.715 ± 1.285
13.752LeuLys: 13.752 ± 2.161
8.251LeuLeu: 8.251 ± 2.119
2.358LeuMet: 2.358 ± 0.96
9.037LeuAsn: 9.037 ± 1.475
3.536LeuPro: 3.536 ± 1.234
1.965LeuGln: 1.965 ± 0.822
3.143LeuArg: 3.143 ± 1.137
4.715LeuSer: 4.715 ± 1.248
6.287LeuThr: 6.287 ± 1.567
7.073LeuVal: 7.073 ± 1.334
0.786LeuTrp: 0.786 ± 0.647
2.75LeuTyr: 2.75 ± 1.324
0.0LeuXaa: 0.0 ± 0.0
Met
1.965MetAla: 1.965 ± 0.7
0.0MetCys: 0.0 ± 0.0
0.393MetAsp: 0.393 ± 0.468
0.393MetGlu: 0.393 ± 0.349
0.0MetPhe: 0.0 ± 0.0
0.786MetGly: 0.786 ± 0.525
0.0MetHis: 0.0 ± 0.0
2.358MetIle: 2.358 ± 1.009
1.179MetLys: 1.179 ± 0.572
2.358MetLeu: 2.358 ± 1.088
1.179MetMet: 1.179 ± 0.41
3.143MetAsn: 3.143 ± 0.667
0.786MetPro: 0.786 ± 0.49
0.786MetGln: 0.786 ± 0.357
2.358MetArg: 2.358 ± 0.6
0.393MetSer: 0.393 ± 0.374
3.929MetThr: 3.929 ± 1.476
1.179MetVal: 1.179 ± 0.794
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.715AsnAla: 4.715 ± 1.139
0.0AsnCys: 0.0 ± 0.0
5.501AsnAsp: 5.501 ± 1.294
4.715AsnGlu: 4.715 ± 1.049
0.786AsnPhe: 0.786 ± 0.595
4.715AsnGly: 4.715 ± 0.92
0.0AsnHis: 0.0 ± 0.0
3.929AsnIle: 3.929 ± 0.993
7.073AsnLys: 7.073 ± 1.7
6.287AsnLeu: 6.287 ± 1.29
0.393AsnMet: 0.393 ± 0.454
5.108AsnAsn: 5.108 ± 1.296
2.358AsnPro: 2.358 ± 0.731
2.358AsnGln: 2.358 ± 0.628
3.536AsnArg: 3.536 ± 1.133
2.358AsnSer: 2.358 ± 0.795
3.143AsnThr: 3.143 ± 0.896
1.572AsnVal: 1.572 ± 0.694
0.0AsnTrp: 0.0 ± 0.0
3.143AsnTyr: 3.143 ± 0.779
0.0AsnXaa: 0.0 ± 0.0
Pro
1.572ProAla: 1.572 ± 0.875
0.0ProCys: 0.0 ± 0.0
2.358ProAsp: 2.358 ± 0.817
1.572ProGlu: 1.572 ± 1.026
1.572ProPhe: 1.572 ± 0.619
0.786ProGly: 0.786 ± 0.493
0.0ProHis: 0.0 ± 0.0
0.393ProIle: 0.393 ± 0.324
4.322ProLys: 4.322 ± 1.425
1.179ProLeu: 1.179 ± 0.771
0.786ProMet: 0.786 ± 0.48
1.572ProAsn: 1.572 ± 0.683
1.179ProPro: 1.179 ± 0.798
0.786ProGln: 0.786 ± 0.49
1.965ProArg: 1.965 ± 0.941
1.179ProSer: 1.179 ± 0.556
2.358ProThr: 2.358 ± 0.574
1.965ProVal: 1.965 ± 0.752
0.393ProTrp: 0.393 ± 0.324
2.358ProTyr: 2.358 ± 0.647
0.0ProXaa: 0.0 ± 0.0
Gln
3.536GlnAla: 3.536 ± 1.196
0.0GlnCys: 0.0 ± 0.0
1.965GlnAsp: 1.965 ± 0.833
2.358GlnGlu: 2.358 ± 0.831
1.572GlnPhe: 1.572 ± 0.731
1.179GlnGly: 1.179 ± 0.722
0.786GlnHis: 0.786 ± 0.455
3.143GlnIle: 3.143 ± 1.053
1.965GlnLys: 1.965 ± 0.851
4.715GlnLeu: 4.715 ± 1.799
0.393GlnMet: 0.393 ± 0.55
1.572GlnAsn: 1.572 ± 0.674
0.393GlnPro: 0.393 ± 0.329
0.393GlnGln: 0.393 ± 0.458
3.143GlnArg: 3.143 ± 0.875
1.965GlnSer: 1.965 ± 1.513
1.965GlnThr: 1.965 ± 1.182
3.536GlnVal: 3.536 ± 1.194
0.786GlnTrp: 0.786 ± 0.595
1.179GlnTyr: 1.179 ± 0.566
0.0GlnXaa: 0.0 ± 0.0
Arg
4.322ArgAla: 4.322 ± 1.061
0.0ArgCys: 0.0 ± 0.0
2.75ArgAsp: 2.75 ± 1.293
5.501ArgGlu: 5.501 ± 1.16
1.572ArgPhe: 1.572 ± 0.502
3.536ArgGly: 3.536 ± 1.406
1.965ArgHis: 1.965 ± 0.878
3.143ArgIle: 3.143 ± 0.846
2.75ArgLys: 2.75 ± 1.114
8.644ArgLeu: 8.644 ± 2.368
0.393ArgMet: 0.393 ± 0.349
2.358ArgAsn: 2.358 ± 0.85
1.965ArgPro: 1.965 ± 0.749
2.75ArgGln: 2.75 ± 1.008
2.75ArgArg: 2.75 ± 0.772
1.965ArgSer: 1.965 ± 0.769
3.536ArgThr: 3.536 ± 0.805
1.179ArgVal: 1.179 ± 0.575
0.0ArgTrp: 0.0 ± 0.0
0.786ArgTyr: 0.786 ± 0.436
0.0ArgXaa: 0.0 ± 0.0
Ser
1.179SerAla: 1.179 ± 0.701
0.0SerCys: 0.0 ± 0.0
3.929SerAsp: 3.929 ± 1.226
2.358SerGlu: 2.358 ± 0.96
3.143SerPhe: 3.143 ± 1.172
2.75SerGly: 2.75 ± 0.884
0.393SerHis: 0.393 ± 0.329
3.143SerIle: 3.143 ± 1.048
3.536SerLys: 3.536 ± 1.421
5.108SerLeu: 5.108 ± 1.727
3.536SerMet: 3.536 ± 1.297
1.572SerAsn: 1.572 ± 0.502
0.393SerPro: 0.393 ± 0.371
3.143SerGln: 3.143 ± 1.291
1.965SerArg: 1.965 ± 0.558
2.358SerSer: 2.358 ± 0.914
3.929SerThr: 3.929 ± 1.37
4.322SerVal: 4.322 ± 1.085
0.393SerTrp: 0.393 ± 0.329
3.536SerTyr: 3.536 ± 0.836
0.0SerXaa: 0.0 ± 0.0
Thr
4.322ThrAla: 4.322 ± 1.141
0.0ThrCys: 0.0 ± 0.0
2.75ThrAsp: 2.75 ± 1.075
6.287ThrGlu: 6.287 ± 1.904
3.143ThrPhe: 3.143 ± 0.875
5.894ThrGly: 5.894 ± 1.457
1.965ThrHis: 1.965 ± 1.1
4.715ThrIle: 4.715 ± 1.565
5.894ThrLys: 5.894 ± 2.402
7.073ThrLeu: 7.073 ± 1.593
2.358ThrMet: 2.358 ± 0.728
3.143ThrAsn: 3.143 ± 0.744
1.965ThrPro: 1.965 ± 0.631
2.75ThrGln: 2.75 ± 1.197
1.965ThrArg: 1.965 ± 0.689
3.929ThrSer: 3.929 ± 0.776
5.108ThrThr: 5.108 ± 1.315
5.108ThrVal: 5.108 ± 1.62
1.179ThrTrp: 1.179 ± 0.594
1.965ThrTyr: 1.965 ± 0.983
0.0ThrXaa: 0.0 ± 0.0
Val
1.572ValAla: 1.572 ± 0.735
0.786ValCys: 0.786 ± 0.549
4.715ValAsp: 4.715 ± 1.539
3.536ValGlu: 3.536 ± 1.039
2.75ValPhe: 2.75 ± 0.929
3.536ValGly: 3.536 ± 0.807
0.0ValHis: 0.0 ± 0.0
2.358ValIle: 2.358 ± 1.135
5.108ValLys: 5.108 ± 0.908
5.501ValLeu: 5.501 ± 1.223
1.179ValMet: 1.179 ± 0.697
3.929ValAsn: 3.929 ± 1.006
0.786ValPro: 0.786 ± 0.459
1.572ValGln: 1.572 ± 0.801
2.358ValArg: 2.358 ± 1.435
2.75ValSer: 2.75 ± 0.828
4.322ValThr: 4.322 ± 1.628
1.572ValVal: 1.572 ± 1.2
0.0ValTrp: 0.0 ± 0.0
3.536ValTyr: 3.536 ± 1.525
0.0ValXaa: 0.0 ± 0.0
Trp
0.786TrpAla: 0.786 ± 0.357
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.393TrpGlu: 0.393 ± 0.324
0.0TrpPhe: 0.0 ± 0.0
1.572TrpGly: 1.572 ± 1.295
0.0TrpHis: 0.0 ± 0.0
1.179TrpIle: 1.179 ± 0.683
0.393TrpLys: 0.393 ± 0.329
0.786TrpLeu: 0.786 ± 0.455
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.393TrpGln: 0.393 ± 0.442
0.393TrpArg: 0.393 ± 0.454
0.786TrpSer: 0.786 ± 0.459
0.786TrpThr: 0.786 ± 0.555
0.786TrpVal: 0.786 ± 0.507
0.0TrpTrp: 0.0 ± 0.0
0.393TrpTyr: 0.393 ± 0.324
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.786TyrAla: 0.786 ± 0.549
0.393TyrCys: 0.393 ± 0.324
3.929TyrAsp: 3.929 ± 1.567
3.143TyrGlu: 3.143 ± 1.134
0.393TyrPhe: 0.393 ± 0.371
3.536TyrGly: 3.536 ± 0.898
0.786TyrHis: 0.786 ± 0.357
2.358TyrIle: 2.358 ± 0.891
3.929TyrLys: 3.929 ± 1.518
5.894TyrLeu: 5.894 ± 1.719
1.572TyrMet: 1.572 ± 0.734
2.75TyrAsn: 2.75 ± 1.473
0.393TyrPro: 0.393 ± 0.329
2.358TyrGln: 2.358 ± 1.036
3.929TyrArg: 3.929 ± 0.805
2.75TyrSer: 2.75 ± 0.795
1.965TyrThr: 1.965 ± 0.729
1.179TyrVal: 1.179 ± 0.725
0.393TyrTrp: 0.393 ± 0.324
1.965TyrTyr: 1.965 ± 0.628
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2546 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski