Amino acid dipepetide frequency for Mycobacterium virus Alma

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.256AlaAla: 11.256 ± 0.963
0.843AlaCys: 0.843 ± 0.246
5.116AlaAsp: 5.116 ± 0.531
6.742AlaGlu: 6.742 ± 0.74
3.612AlaPhe: 3.612 ± 0.474
9.029AlaGly: 9.029 ± 0.803
1.926AlaHis: 1.926 ± 0.3
4.635AlaIle: 4.635 ± 0.583
5.839AlaLys: 5.839 ± 0.64
9.21AlaLeu: 9.21 ± 0.721
2.528AlaMet: 2.528 ± 0.353
3.311AlaAsn: 3.311 ± 0.504
4.755AlaPro: 4.755 ± 0.636
4.153AlaGln: 4.153 ± 0.639
6.2AlaArg: 6.2 ± 0.714
5.839AlaSer: 5.839 ± 0.564
6.019AlaThr: 6.019 ± 0.696
6.561AlaVal: 6.561 ± 0.583
1.324AlaTrp: 1.324 ± 0.291
2.287AlaTyr: 2.287 ± 0.404
0.0AlaXaa: 0.0 ± 0.0
Cys
0.542CysAla: 0.542 ± 0.177
0.0CysCys: 0.0 ± 0.0
0.602CysAsp: 0.602 ± 0.165
0.421CysGlu: 0.421 ± 0.17
0.361CysPhe: 0.361 ± 0.122
0.602CysGly: 0.602 ± 0.191
0.421CysHis: 0.421 ± 0.167
0.241CysIle: 0.241 ± 0.105
0.301CysLys: 0.301 ± 0.13
0.542CysLeu: 0.542 ± 0.188
0.181CysMet: 0.181 ± 0.105
0.542CysAsn: 0.542 ± 0.174
0.542CysPro: 0.542 ± 0.196
0.301CysGln: 0.301 ± 0.135
0.662CysArg: 0.662 ± 0.188
0.843CysSer: 0.843 ± 0.224
0.301CysThr: 0.301 ± 0.121
0.662CysVal: 0.662 ± 0.166
0.482CysTrp: 0.482 ± 0.187
0.181CysTyr: 0.181 ± 0.109
0.0CysXaa: 0.0 ± 0.0
Asp
6.26AspAla: 6.26 ± 0.48
0.421AspCys: 0.421 ± 0.181
3.612AspAsp: 3.612 ± 0.472
4.515AspGlu: 4.515 ± 0.628
2.107AspPhe: 2.107 ± 0.357
5.538AspGly: 5.538 ± 0.498
1.324AspHis: 1.324 ± 0.347
3.371AspIle: 3.371 ± 0.472
2.949AspLys: 2.949 ± 0.443
5.478AspLeu: 5.478 ± 0.647
1.023AspMet: 1.023 ± 0.246
1.746AspAsn: 1.746 ± 0.326
4.033AspPro: 4.033 ± 0.549
1.986AspGln: 1.986 ± 0.31
3.25AspArg: 3.25 ± 0.412
3.732AspSer: 3.732 ± 0.455
3.913AspThr: 3.913 ± 0.488
4.394AspVal: 4.394 ± 0.54
1.204AspTrp: 1.204 ± 0.291
2.348AspTyr: 2.348 ± 0.375
0.0AspXaa: 0.0 ± 0.0
Glu
6.682GluAla: 6.682 ± 0.674
0.06GluCys: 0.06 ± 0.064
4.153GluAsp: 4.153 ± 0.571
4.996GluGlu: 4.996 ± 0.686
2.769GluPhe: 2.769 ± 0.368
4.816GluGly: 4.816 ± 0.598
1.746GluHis: 1.746 ± 0.316
3.431GluIle: 3.431 ± 0.449
2.769GluLys: 2.769 ± 0.568
5.959GluLeu: 5.959 ± 0.558
2.408GluMet: 2.408 ± 0.502
1.986GluAsn: 1.986 ± 0.371
3.07GluPro: 3.07 ± 0.448
2.588GluGln: 2.588 ± 0.329
4.214GluArg: 4.214 ± 0.565
3.19GluSer: 3.19 ± 0.445
3.371GluThr: 3.371 ± 0.542
4.755GluVal: 4.755 ± 0.529
1.324GluTrp: 1.324 ± 0.313
1.986GluTyr: 1.986 ± 0.301
0.0GluXaa: 0.0 ± 0.0
Phe
3.431PheAla: 3.431 ± 0.412
0.421PheCys: 0.421 ± 0.141
2.167PheAsp: 2.167 ± 0.334
2.348PheGlu: 2.348 ± 0.47
0.722PhePhe: 0.722 ± 0.233
3.07PheGly: 3.07 ± 0.424
0.602PheHis: 0.602 ± 0.188
1.806PheIle: 1.806 ± 0.311
1.324PheLys: 1.324 ± 0.264
2.348PheLeu: 2.348 ± 0.443
0.482PheMet: 0.482 ± 0.169
1.806PheAsn: 1.806 ± 0.28
1.806PhePro: 1.806 ± 0.352
0.963PheGln: 0.963 ± 0.256
1.445PheArg: 1.445 ± 0.282
2.227PheSer: 2.227 ± 0.306
2.047PheThr: 2.047 ± 0.378
1.806PheVal: 1.806 ± 0.324
0.361PheTrp: 0.361 ± 0.139
0.963PheTyr: 0.963 ± 0.196
0.0PheXaa: 0.0 ± 0.0
Gly
7.464GlyAla: 7.464 ± 0.892
1.083GlyCys: 1.083 ± 0.263
6.742GlyAsp: 6.742 ± 0.86
5.357GlyGlu: 5.357 ± 0.471
2.769GlyPhe: 2.769 ± 0.383
9.21GlyGly: 9.21 ± 1.455
1.746GlyHis: 1.746 ± 0.331
4.454GlyIle: 4.454 ± 0.542
4.394GlyLys: 4.394 ± 0.601
6.862GlyLeu: 6.862 ± 0.824
2.769GlyMet: 2.769 ± 0.45
3.551GlyAsn: 3.551 ± 0.574
5.237GlyPro: 5.237 ± 1.499
2.769GlyGln: 2.769 ± 0.451
3.732GlyArg: 3.732 ± 0.433
4.755GlySer: 4.755 ± 0.647
5.417GlyThr: 5.417 ± 0.586
6.381GlyVal: 6.381 ± 0.605
1.565GlyTrp: 1.565 ± 0.265
2.408GlyTyr: 2.408 ± 0.415
0.0GlyXaa: 0.0 ± 0.0
His
1.384HisAla: 1.384 ± 0.292
0.181HisCys: 0.181 ± 0.107
1.324HisAsp: 1.324 ± 0.307
0.843HisGlu: 0.843 ± 0.252
0.722HisPhe: 0.722 ± 0.185
1.746HisGly: 1.746 ± 0.456
0.602HisHis: 0.602 ± 0.189
0.843HisIle: 0.843 ± 0.235
0.783HisLys: 0.783 ± 0.203
1.324HisLeu: 1.324 ± 0.348
0.482HisMet: 0.482 ± 0.16
0.662HisAsn: 0.662 ± 0.178
1.324HisPro: 1.324 ± 0.273
0.903HisGln: 0.903 ± 0.254
1.505HisArg: 1.505 ± 0.294
0.482HisSer: 0.482 ± 0.146
1.204HisThr: 1.204 ± 0.237
1.144HisVal: 1.144 ± 0.277
0.542HisTrp: 0.542 ± 0.169
0.602HisTyr: 0.602 ± 0.242
0.0HisXaa: 0.0 ± 0.0
Ile
5.116IleAla: 5.116 ± 0.4
0.421IleCys: 0.421 ± 0.146
4.093IleAsp: 4.093 ± 0.4
3.852IleGlu: 3.852 ± 0.482
1.625IlePhe: 1.625 ± 0.317
3.612IleGly: 3.612 ± 0.453
0.843IleHis: 0.843 ± 0.235
1.565IleIle: 1.565 ± 0.283
2.528IleLys: 2.528 ± 0.421
3.852IleLeu: 3.852 ± 0.423
0.602IleMet: 0.602 ± 0.207
1.866IleAsn: 1.866 ± 0.33
3.973IlePro: 3.973 ± 0.404
1.264IleGln: 1.264 ± 0.301
3.371IleArg: 3.371 ± 0.458
2.588IleSer: 2.588 ± 0.305
3.13IleThr: 3.13 ± 0.375
3.07IleVal: 3.07 ± 0.431
0.843IleTrp: 0.843 ± 0.266
1.023IleTyr: 1.023 ± 0.22
0.0IleXaa: 0.0 ± 0.0
Lys
5.116LysAla: 5.116 ± 0.665
0.241LysCys: 0.241 ± 0.107
2.348LysAsp: 2.348 ± 0.269
2.468LysGlu: 2.468 ± 0.462
1.204LysPhe: 1.204 ± 0.27
4.695LysGly: 4.695 ± 0.82
0.722LysHis: 0.722 ± 0.245
2.528LysIle: 2.528 ± 0.408
2.107LysLys: 2.107 ± 0.412
4.033LysLeu: 4.033 ± 0.483
1.144LysMet: 1.144 ± 0.253
0.963LysAsn: 0.963 ± 0.256
2.588LysPro: 2.588 ± 0.463
1.806LysGln: 1.806 ± 0.312
3.732LysArg: 3.732 ± 0.541
2.348LysSer: 2.348 ± 0.306
2.287LysThr: 2.287 ± 0.312
4.394LysVal: 4.394 ± 0.504
1.023LysTrp: 1.023 ± 0.284
1.505LysTyr: 1.505 ± 0.334
0.0LysXaa: 0.0 ± 0.0
Leu
9.45LeuAla: 9.45 ± 0.767
1.023LeuCys: 1.023 ± 0.206
4.695LeuAsp: 4.695 ± 0.519
5.357LeuGlu: 5.357 ± 0.546
2.348LeuPhe: 2.348 ± 0.338
6.682LeuGly: 6.682 ± 0.804
1.144LeuHis: 1.144 ± 0.283
4.033LeuIle: 4.033 ± 0.59
3.25LeuLys: 3.25 ± 0.354
5.056LeuLeu: 5.056 ± 0.607
2.348LeuMet: 2.348 ± 0.375
2.769LeuAsn: 2.769 ± 0.353
4.394LeuPro: 4.394 ± 0.469
2.588LeuGln: 2.588 ± 0.52
5.598LeuArg: 5.598 ± 0.571
4.334LeuSer: 4.334 ± 0.488
5.718LeuThr: 5.718 ± 0.655
4.695LeuVal: 4.695 ± 0.499
1.926LeuTrp: 1.926 ± 0.32
1.866LeuTyr: 1.866 ± 0.34
0.0LeuXaa: 0.0 ± 0.0
Met
3.25MetAla: 3.25 ± 0.392
0.241MetCys: 0.241 ± 0.116
0.843MetAsp: 0.843 ± 0.199
2.047MetGlu: 2.047 ± 0.419
0.542MetPhe: 0.542 ± 0.161
1.926MetGly: 1.926 ± 0.328
0.241MetHis: 0.241 ± 0.129
1.264MetIle: 1.264 ± 0.293
1.324MetLys: 1.324 ± 0.291
1.565MetLeu: 1.565 ± 0.316
0.903MetMet: 0.903 ± 0.201
0.542MetAsn: 0.542 ± 0.205
1.144MetPro: 1.144 ± 0.25
1.144MetGln: 1.144 ± 0.204
1.625MetArg: 1.625 ± 0.304
2.408MetSer: 2.408 ± 0.417
2.287MetThr: 2.287 ± 0.376
1.264MetVal: 1.264 ± 0.267
0.241MetTrp: 0.241 ± 0.108
0.662MetTyr: 0.662 ± 0.207
0.0MetXaa: 0.0 ± 0.0
Asn
3.913AsnAla: 3.913 ± 0.523
0.361AsnCys: 0.361 ± 0.152
1.685AsnAsp: 1.685 ± 0.334
1.926AsnGlu: 1.926 ± 0.385
1.264AsnPhe: 1.264 ± 0.355
3.25AsnGly: 3.25 ± 0.481
0.662AsnHis: 0.662 ± 0.19
1.625AsnIle: 1.625 ± 0.283
1.384AsnLys: 1.384 ± 0.264
2.769AsnLeu: 2.769 ± 0.352
0.722AsnMet: 0.722 ± 0.157
0.843AsnAsn: 0.843 ± 0.28
2.227AsnPro: 2.227 ± 0.271
0.843AsnGln: 0.843 ± 0.24
1.866AsnArg: 1.866 ± 0.315
1.565AsnSer: 1.565 ± 0.353
1.685AsnThr: 1.685 ± 0.215
2.468AsnVal: 2.468 ± 0.346
0.903AsnTrp: 0.903 ± 0.216
0.843AsnTyr: 0.843 ± 0.176
0.0AsnXaa: 0.0 ± 0.0
Pro
5.658ProAla: 5.658 ± 0.546
0.421ProCys: 0.421 ± 0.164
3.431ProAsp: 3.431 ± 0.507
4.214ProGlu: 4.214 ± 0.506
1.746ProPhe: 1.746 ± 0.355
5.297ProGly: 5.297 ± 0.564
0.903ProHis: 0.903 ± 0.233
2.769ProIle: 2.769 ± 0.334
2.408ProLys: 2.408 ± 0.594
3.25ProLeu: 3.25 ± 0.518
1.445ProMet: 1.445 ± 0.312
2.227ProAsn: 2.227 ± 0.376
2.047ProPro: 2.047 ± 0.359
2.348ProGln: 2.348 ± 0.641
3.01ProArg: 3.01 ± 0.508
2.709ProSer: 2.709 ± 0.343
4.033ProThr: 4.033 ± 0.435
4.274ProVal: 4.274 ± 0.421
0.843ProTrp: 0.843 ± 0.296
1.264ProTyr: 1.264 ± 0.241
0.0ProXaa: 0.0 ± 0.0
Gln
4.153GlnAla: 4.153 ± 0.517
0.12GlnCys: 0.12 ± 0.079
1.565GlnAsp: 1.565 ± 0.262
2.227GlnGlu: 2.227 ± 0.43
1.083GlnPhe: 1.083 ± 0.223
4.334GlnGly: 4.334 ± 1.023
0.843GlnHis: 0.843 ± 0.24
2.107GlnIle: 2.107 ± 0.367
1.324GlnLys: 1.324 ± 0.332
2.769GlnLeu: 2.769 ± 0.662
0.903GlnMet: 0.903 ± 0.271
1.324GlnAsn: 1.324 ± 0.249
1.384GlnPro: 1.384 ± 0.277
1.986GlnGln: 1.986 ± 0.382
2.107GlnArg: 2.107 ± 0.38
1.806GlnSer: 1.806 ± 0.294
1.986GlnThr: 1.986 ± 0.341
2.588GlnVal: 2.588 ± 0.37
0.662GlnTrp: 0.662 ± 0.192
1.083GlnTyr: 1.083 ± 0.275
0.0GlnXaa: 0.0 ± 0.0
Arg
5.237ArgAla: 5.237 ± 0.643
0.722ArgCys: 0.722 ± 0.228
4.033ArgAsp: 4.033 ± 0.539
4.816ArgGlu: 4.816 ± 0.559
2.287ArgPhe: 2.287 ± 0.408
4.153ArgGly: 4.153 ± 0.526
1.384ArgHis: 1.384 ± 0.361
3.612ArgIle: 3.612 ± 0.415
3.371ArgLys: 3.371 ± 0.424
5.658ArgLeu: 5.658 ± 0.551
1.685ArgMet: 1.685 ± 0.324
1.565ArgAsn: 1.565 ± 0.25
2.709ArgPro: 2.709 ± 0.375
2.348ArgGln: 2.348 ± 0.432
4.876ArgArg: 4.876 ± 0.762
3.07ArgSer: 3.07 ± 0.37
2.709ArgThr: 2.709 ± 0.4
4.515ArgVal: 4.515 ± 0.533
1.023ArgTrp: 1.023 ± 0.219
1.565ArgTyr: 1.565 ± 0.35
0.0ArgXaa: 0.0 ± 0.0
Ser
4.996SerAla: 4.996 ± 0.582
0.421SerCys: 0.421 ± 0.167
3.973SerAsp: 3.973 ± 0.451
3.732SerGlu: 3.732 ± 0.523
1.625SerPhe: 1.625 ± 0.334
5.779SerGly: 5.779 ± 0.656
0.843SerHis: 0.843 ± 0.211
2.528SerIle: 2.528 ± 0.391
2.468SerLys: 2.468 ± 0.41
4.394SerLeu: 4.394 ± 0.609
1.565SerMet: 1.565 ± 0.232
1.144SerAsn: 1.144 ± 0.252
2.528SerPro: 2.528 ± 0.359
1.986SerGln: 1.986 ± 0.293
3.672SerArg: 3.672 ± 0.458
3.792SerSer: 3.792 ± 0.504
3.07SerThr: 3.07 ± 0.397
4.033SerVal: 4.033 ± 0.502
1.384SerTrp: 1.384 ± 0.327
1.505SerTyr: 1.505 ± 0.239
0.0SerXaa: 0.0 ± 0.0
Thr
6.26ThrAla: 6.26 ± 0.575
0.482ThrCys: 0.482 ± 0.174
4.033ThrAsp: 4.033 ± 0.461
3.01ThrGlu: 3.01 ± 0.389
1.986ThrPhe: 1.986 ± 0.342
6.501ThrGly: 6.501 ± 1.087
1.204ThrHis: 1.204 ± 0.237
2.227ThrIle: 2.227 ± 0.361
3.371ThrLys: 3.371 ± 0.492
5.478ThrLeu: 5.478 ± 0.6
1.685ThrMet: 1.685 ± 0.338
1.806ThrAsn: 1.806 ± 0.339
3.913ThrPro: 3.913 ± 0.508
2.107ThrGln: 2.107 ± 0.321
2.949ThrArg: 2.949 ± 0.413
3.01ThrSer: 3.01 ± 0.567
3.07ThrThr: 3.07 ± 0.397
4.755ThrVal: 4.755 ± 0.49
0.843ThrTrp: 0.843 ± 0.276
2.287ThrTyr: 2.287 ± 0.321
0.0ThrXaa: 0.0 ± 0.0
Val
6.862ValAla: 6.862 ± 0.626
0.602ValCys: 0.602 ± 0.208
5.598ValAsp: 5.598 ± 0.538
4.695ValGlu: 4.695 ± 0.569
2.107ValPhe: 2.107 ± 0.37
5.237ValGly: 5.237 ± 0.457
0.783ValHis: 0.783 ± 0.218
3.732ValIle: 3.732 ± 0.446
3.913ValLys: 3.913 ± 0.356
5.177ValLeu: 5.177 ± 0.567
1.204ValMet: 1.204 ± 0.233
2.528ValAsn: 2.528 ± 0.452
3.792ValPro: 3.792 ± 0.484
2.167ValGln: 2.167 ± 0.321
4.454ValArg: 4.454 ± 0.544
3.672ValSer: 3.672 ± 0.566
5.357ValThr: 5.357 ± 0.529
6.019ValVal: 6.019 ± 0.568
1.746ValTrp: 1.746 ± 0.293
1.986ValTyr: 1.986 ± 0.312
0.0ValXaa: 0.0 ± 0.0
Trp
1.445TrpAla: 1.445 ± 0.372
0.361TrpCys: 0.361 ± 0.159
1.384TrpAsp: 1.384 ± 0.25
1.324TrpGlu: 1.324 ± 0.245
0.482TrpPhe: 0.482 ± 0.15
1.384TrpGly: 1.384 ± 0.31
0.421TrpHis: 0.421 ± 0.175
1.264TrpIle: 1.264 ± 0.252
0.602TrpLys: 0.602 ± 0.185
0.963TrpLeu: 0.963 ± 0.192
0.783TrpMet: 0.783 ± 0.24
0.602TrpAsn: 0.602 ± 0.221
1.083TrpPro: 1.083 ± 0.265
1.144TrpGln: 1.144 ± 0.235
0.963TrpArg: 0.963 ± 0.253
1.445TrpSer: 1.445 ± 0.305
1.445TrpThr: 1.445 ± 0.299
1.204TrpVal: 1.204 ± 0.253
0.542TrpTrp: 0.542 ± 0.204
0.482TrpTyr: 0.482 ± 0.145
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.709TyrAla: 2.709 ± 0.426
0.301TyrCys: 0.301 ± 0.15
1.806TyrAsp: 1.806 ± 0.296
1.384TyrGlu: 1.384 ± 0.321
0.783TyrPhe: 0.783 ± 0.193
1.866TyrGly: 1.866 ± 0.306
0.241TyrHis: 0.241 ± 0.132
1.204TyrIle: 1.204 ± 0.215
0.843TyrLys: 0.843 ± 0.235
2.588TyrLeu: 2.588 ± 0.401
0.542TyrMet: 0.542 ± 0.155
1.023TyrAsn: 1.023 ± 0.224
1.746TyrPro: 1.746 ± 0.344
0.963TyrGln: 0.963 ± 0.258
2.107TyrArg: 2.107 ± 0.436
1.625TyrSer: 1.625 ± 0.228
1.926TyrThr: 1.926 ± 0.316
2.649TyrVal: 2.649 ± 0.424
0.542TyrTrp: 0.542 ± 0.159
0.963TyrTyr: 0.963 ± 0.287
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 96 proteins (16614 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski