Amino acid dipepetide frequency for Cronobacter phage ESSI-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.859AlaAla: 12.859 ± 1.229
0.559AlaCys: 0.559 ± 0.221
7.548AlaAsp: 7.548 ± 0.845
6.523AlaGlu: 6.523 ± 0.802
4.752AlaPhe: 4.752 ± 0.63
10.157AlaGly: 10.157 ± 1.028
1.957AlaHis: 1.957 ± 0.499
5.218AlaIle: 5.218 ± 0.832
4.286AlaLys: 4.286 ± 0.606
9.97AlaLeu: 9.97 ± 0.975
2.329AlaMet: 2.329 ± 0.434
3.541AlaAsn: 3.541 ± 0.705
4.286AlaPro: 4.286 ± 0.624
5.311AlaGln: 5.311 ± 0.643
7.361AlaArg: 7.361 ± 0.746
7.082AlaSer: 7.082 ± 0.866
5.963AlaThr: 5.963 ± 0.673
9.691AlaVal: 9.691 ± 0.919
2.143AlaTrp: 2.143 ± 0.484
2.516AlaTyr: 2.516 ± 0.606
0.0AlaXaa: 0.0 ± 0.0
Cys
2.329CysAla: 2.329 ± 0.621
0.373CysCys: 0.373 ± 0.257
0.932CysAsp: 0.932 ± 0.3
0.373CysGlu: 0.373 ± 0.224
0.373CysPhe: 0.373 ± 0.169
0.932CysGly: 0.932 ± 0.306
0.466CysHis: 0.466 ± 0.253
0.373CysIle: 0.373 ± 0.204
0.28CysLys: 0.28 ± 0.164
1.491CysLeu: 1.491 ± 0.446
0.186CysMet: 0.186 ± 0.14
0.373CysAsn: 0.373 ± 0.194
0.745CysPro: 0.745 ± 0.265
0.652CysGln: 0.652 ± 0.237
1.118CysArg: 1.118 ± 0.378
0.839CysSer: 0.839 ± 0.252
0.373CysThr: 0.373 ± 0.176
0.652CysVal: 0.652 ± 0.24
0.28CysTrp: 0.28 ± 0.164
0.093CysTyr: 0.093 ± 0.079
0.0CysXaa: 0.0 ± 0.0
Asp
6.802AspAla: 6.802 ± 0.732
0.186AspCys: 0.186 ± 0.15
1.584AspAsp: 1.584 ± 0.394
3.448AspGlu: 3.448 ± 0.584
2.329AspPhe: 2.329 ± 0.378
5.218AspGly: 5.218 ± 0.863
0.839AspHis: 0.839 ± 0.234
2.423AspIle: 2.423 ± 0.502
2.329AspLys: 2.329 ± 0.494
3.634AspLeu: 3.634 ± 0.739
1.211AspMet: 1.211 ± 0.414
1.584AspAsn: 1.584 ± 0.289
2.05AspPro: 2.05 ± 0.508
1.77AspGln: 1.77 ± 0.381
2.329AspArg: 2.329 ± 0.5
2.05AspSer: 2.05 ± 0.333
1.77AspThr: 1.77 ± 0.392
5.032AspVal: 5.032 ± 0.688
0.932AspTrp: 0.932 ± 0.262
2.143AspTyr: 2.143 ± 0.608
0.0AspXaa: 0.0 ± 0.0
Glu
5.498GluAla: 5.498 ± 0.67
0.373GluCys: 0.373 ± 0.308
1.398GluAsp: 1.398 ± 0.344
1.77GluGlu: 1.77 ± 0.478
1.77GluPhe: 1.77 ± 0.406
3.448GluGly: 3.448 ± 0.686
1.677GluHis: 1.677 ± 0.383
2.516GluIle: 2.516 ± 0.39
3.448GluLys: 3.448 ± 0.665
5.125GluLeu: 5.125 ± 0.784
2.143GluMet: 2.143 ± 0.545
2.423GluAsn: 2.423 ± 0.396
1.584GluPro: 1.584 ± 0.39
1.864GluGln: 1.864 ± 0.412
3.168GluArg: 3.168 ± 0.559
2.982GluSer: 2.982 ± 0.697
3.261GluThr: 3.261 ± 0.56
2.795GluVal: 2.795 ± 0.544
0.745GluTrp: 0.745 ± 0.247
1.305GluTyr: 1.305 ± 0.335
0.0GluXaa: 0.0 ± 0.0
Phe
4.286PheAla: 4.286 ± 0.657
0.466PheCys: 0.466 ± 0.227
1.957PheAsp: 1.957 ± 0.373
1.864PheGlu: 1.864 ± 0.402
1.211PhePhe: 1.211 ± 0.314
3.261PheGly: 3.261 ± 0.486
0.839PheHis: 0.839 ± 0.345
1.864PheIle: 1.864 ± 0.356
1.025PheLys: 1.025 ± 0.246
1.864PheLeu: 1.864 ± 0.386
1.398PheMet: 1.398 ± 0.322
2.329PheAsn: 2.329 ± 0.51
1.864PhePro: 1.864 ± 0.339
1.211PheGln: 1.211 ± 0.442
2.05PheArg: 2.05 ± 0.444
3.541PheSer: 3.541 ± 0.565
3.168PheThr: 3.168 ± 0.536
3.168PheVal: 3.168 ± 0.402
1.025PheTrp: 1.025 ± 0.323
1.118PheTyr: 1.118 ± 0.315
0.0PheXaa: 0.0 ± 0.0
Gly
8.013GlyAla: 8.013 ± 1.282
0.745GlyCys: 0.745 ± 0.223
3.82GlyAsp: 3.82 ± 0.664
4.1GlyGlu: 4.1 ± 0.678
4.659GlyPhe: 4.659 ± 0.749
5.591GlyGly: 5.591 ± 0.787
1.77GlyHis: 1.77 ± 0.555
4.286GlyIle: 4.286 ± 0.685
4.566GlyLys: 4.566 ± 0.664
5.404GlyLeu: 5.404 ± 0.898
2.423GlyMet: 2.423 ± 0.432
3.075GlyAsn: 3.075 ± 0.462
1.118GlyPro: 1.118 ± 0.387
5.032GlyGln: 5.032 ± 0.659
5.218GlyArg: 5.218 ± 0.613
3.634GlySer: 3.634 ± 0.781
3.727GlyThr: 3.727 ± 0.809
5.125GlyVal: 5.125 ± 0.783
1.584GlyTrp: 1.584 ± 0.355
1.677GlyTyr: 1.677 ± 0.378
0.0GlyXaa: 0.0 ± 0.0
His
2.423HisAla: 2.423 ± 0.513
0.28HisCys: 0.28 ± 0.207
0.373HisAsp: 0.373 ± 0.169
0.932HisGlu: 0.932 ± 0.253
1.211HisPhe: 1.211 ± 0.364
1.584HisGly: 1.584 ± 0.586
0.932HisHis: 0.932 ± 0.328
1.305HisIle: 1.305 ± 0.468
0.839HisLys: 0.839 ± 0.28
1.77HisLeu: 1.77 ± 0.405
0.466HisMet: 0.466 ± 0.208
0.745HisAsn: 0.745 ± 0.253
1.211HisPro: 1.211 ± 0.305
0.839HisGln: 0.839 ± 0.317
1.77HisArg: 1.77 ± 0.581
1.77HisSer: 1.77 ± 0.419
1.211HisThr: 1.211 ± 0.392
1.77HisVal: 1.77 ± 0.465
0.559HisTrp: 0.559 ± 0.216
0.466HisTyr: 0.466 ± 0.28
0.0HisXaa: 0.0 ± 0.0
Ile
5.218IleAla: 5.218 ± 0.658
1.118IleCys: 1.118 ± 0.435
2.795IleAsp: 2.795 ± 0.511
1.957IleGlu: 1.957 ± 0.529
1.584IlePhe: 1.584 ± 0.347
3.634IleGly: 3.634 ± 0.518
1.025IleHis: 1.025 ± 0.346
1.677IleIle: 1.677 ± 0.46
1.77IleLys: 1.77 ± 0.382
3.448IleLeu: 3.448 ± 0.693
0.373IleMet: 0.373 ± 0.181
2.609IleAsn: 2.609 ± 0.484
2.423IlePro: 2.423 ± 0.484
2.423IleGln: 2.423 ± 0.49
3.727IleArg: 3.727 ± 0.665
2.982IleSer: 2.982 ± 0.518
4.1IleThr: 4.1 ± 0.563
3.075IleVal: 3.075 ± 0.598
0.28IleTrp: 0.28 ± 0.157
1.398IleTyr: 1.398 ± 0.406
0.0IleXaa: 0.0 ± 0.0
Lys
6.523LysAla: 6.523 ± 0.677
0.466LysCys: 0.466 ± 0.23
1.491LysAsp: 1.491 ± 0.295
2.143LysGlu: 2.143 ± 0.466
1.491LysPhe: 1.491 ± 0.314
4.007LysGly: 4.007 ± 0.599
0.559LysHis: 0.559 ± 0.237
2.329LysIle: 2.329 ± 0.462
3.075LysLys: 3.075 ± 0.701
3.448LysLeu: 3.448 ± 0.631
1.211LysMet: 1.211 ± 0.404
2.05LysAsn: 2.05 ± 0.418
2.982LysPro: 2.982 ± 0.371
1.864LysGln: 1.864 ± 0.451
4.193LysArg: 4.193 ± 0.66
1.77LysSer: 1.77 ± 0.444
3.914LysThr: 3.914 ± 0.553
1.957LysVal: 1.957 ± 0.408
0.839LysTrp: 0.839 ± 0.316
1.584LysTyr: 1.584 ± 0.439
0.0LysXaa: 0.0 ± 0.0
Leu
11.554LeuAla: 11.554 ± 1.087
1.77LeuCys: 1.77 ± 0.367
4.007LeuAsp: 4.007 ± 0.616
3.448LeuGlu: 3.448 ± 0.595
2.329LeuPhe: 2.329 ± 0.491
4.007LeuGly: 4.007 ± 0.743
2.329LeuHis: 2.329 ± 0.684
4.007LeuIle: 4.007 ± 0.619
5.032LeuLys: 5.032 ± 0.849
7.361LeuLeu: 7.361 ± 0.838
2.795LeuMet: 2.795 ± 0.483
4.379LeuAsn: 4.379 ± 0.562
4.007LeuPro: 4.007 ± 0.534
2.329LeuGln: 2.329 ± 0.487
8.479LeuArg: 8.479 ± 1.04
6.988LeuSer: 6.988 ± 0.905
5.404LeuThr: 5.404 ± 0.572
5.591LeuVal: 5.591 ± 0.717
0.932LeuTrp: 0.932 ± 0.268
2.609LeuTyr: 2.609 ± 0.458
0.0LeuXaa: 0.0 ± 0.0
Met
3.075MetAla: 3.075 ± 0.589
0.28MetCys: 0.28 ± 0.143
0.652MetAsp: 0.652 ± 0.287
1.118MetGlu: 1.118 ± 0.339
0.745MetPhe: 0.745 ± 0.28
0.839MetGly: 0.839 ± 0.298
0.28MetHis: 0.28 ± 0.17
1.025MetIle: 1.025 ± 0.275
1.305MetLys: 1.305 ± 0.402
1.957MetLeu: 1.957 ± 0.355
1.025MetMet: 1.025 ± 0.29
1.025MetAsn: 1.025 ± 0.261
1.305MetPro: 1.305 ± 0.381
1.677MetGln: 1.677 ± 0.404
2.236MetArg: 2.236 ± 0.437
2.05MetSer: 2.05 ± 0.387
1.398MetThr: 1.398 ± 0.336
1.491MetVal: 1.491 ± 0.382
0.466MetTrp: 0.466 ± 0.188
0.652MetTyr: 0.652 ± 0.242
0.0MetXaa: 0.0 ± 0.0
Asn
3.82AsnAla: 3.82 ± 0.541
0.466AsnCys: 0.466 ± 0.188
1.677AsnAsp: 1.677 ± 0.408
2.516AsnGlu: 2.516 ± 0.503
1.957AsnPhe: 1.957 ± 0.513
3.727AsnGly: 3.727 ± 0.544
1.025AsnHis: 1.025 ± 0.303
3.168AsnIle: 3.168 ± 0.815
1.305AsnLys: 1.305 ± 0.483
4.1AsnLeu: 4.1 ± 0.642
1.398AsnMet: 1.398 ± 0.339
1.491AsnAsn: 1.491 ± 0.381
1.864AsnPro: 1.864 ± 0.424
1.491AsnGln: 1.491 ± 0.457
2.423AsnArg: 2.423 ± 0.577
2.143AsnSer: 2.143 ± 0.456
2.143AsnThr: 2.143 ± 0.359
1.398AsnVal: 1.398 ± 0.305
0.652AsnTrp: 0.652 ± 0.23
0.932AsnTyr: 0.932 ± 0.321
0.0AsnXaa: 0.0 ± 0.0
Pro
4.845ProAla: 4.845 ± 0.64
0.745ProCys: 0.745 ± 0.271
2.795ProAsp: 2.795 ± 0.465
2.889ProGlu: 2.889 ± 0.641
1.957ProPhe: 1.957 ± 0.466
3.82ProGly: 3.82 ± 0.651
0.839ProHis: 0.839 ± 0.341
2.143ProIle: 2.143 ± 0.499
1.677ProLys: 1.677 ± 0.369
4.379ProLeu: 4.379 ± 0.618
0.466ProMet: 0.466 ± 0.199
1.211ProAsn: 1.211 ± 0.337
1.77ProPro: 1.77 ± 0.34
1.957ProGln: 1.957 ± 0.424
2.609ProArg: 2.609 ± 0.449
2.05ProSer: 2.05 ± 0.398
1.118ProThr: 1.118 ± 0.423
4.939ProVal: 4.939 ± 0.792
0.466ProTrp: 0.466 ± 0.164
0.745ProTyr: 0.745 ± 0.259
0.0ProXaa: 0.0 ± 0.0
Gln
4.193GlnAla: 4.193 ± 0.519
0.652GlnCys: 0.652 ± 0.222
2.236GlnAsp: 2.236 ± 0.452
1.398GlnGlu: 1.398 ± 0.417
1.305GlnPhe: 1.305 ± 0.289
2.982GlnGly: 2.982 ± 0.419
1.398GlnHis: 1.398 ± 0.456
3.075GlnIle: 3.075 ± 0.655
1.677GlnLys: 1.677 ± 0.411
5.963GlnLeu: 5.963 ± 0.74
1.118GlnMet: 1.118 ± 0.285
0.652GlnAsn: 0.652 ± 0.246
2.236GlnPro: 2.236 ± 0.481
2.795GlnGln: 2.795 ± 0.688
4.286GlnArg: 4.286 ± 0.748
1.584GlnSer: 1.584 ± 0.425
2.329GlnThr: 2.329 ± 0.623
2.795GlnVal: 2.795 ± 0.531
0.559GlnTrp: 0.559 ± 0.215
1.398GlnTyr: 1.398 ± 0.388
0.0GlnXaa: 0.0 ± 0.0
Arg
7.268ArgAla: 7.268 ± 1.145
0.932ArgCys: 0.932 ± 0.281
4.007ArgAsp: 4.007 ± 0.668
3.541ArgGlu: 3.541 ± 0.675
3.168ArgPhe: 3.168 ± 0.73
4.1ArgGly: 4.1 ± 0.939
1.957ArgHis: 1.957 ± 0.589
3.448ArgIle: 3.448 ± 0.507
3.541ArgLys: 3.541 ± 0.624
7.268ArgLeu: 7.268 ± 0.71
1.957ArgMet: 1.957 ± 0.449
3.727ArgAsn: 3.727 ± 0.64
2.329ArgPro: 2.329 ± 0.524
3.727ArgGln: 3.727 ± 0.665
7.175ArgArg: 7.175 ± 1.435
3.541ArgSer: 3.541 ± 0.587
2.889ArgThr: 2.889 ± 0.528
4.473ArgVal: 4.473 ± 0.596
1.491ArgTrp: 1.491 ± 0.337
2.609ArgTyr: 2.609 ± 0.547
0.0ArgXaa: 0.0 ± 0.0
Ser
8.386SerAla: 8.386 ± 1.164
1.118SerCys: 1.118 ± 0.326
3.261SerAsp: 3.261 ± 0.574
2.702SerGlu: 2.702 ± 0.59
2.236SerPhe: 2.236 ± 0.529
5.125SerGly: 5.125 ± 0.88
0.932SerHis: 0.932 ± 0.269
1.957SerIle: 1.957 ± 0.585
2.795SerLys: 2.795 ± 0.561
5.498SerLeu: 5.498 ± 0.818
1.305SerMet: 1.305 ± 0.338
1.584SerAsn: 1.584 ± 0.472
2.143SerPro: 2.143 ± 0.513
2.423SerGln: 2.423 ± 0.563
3.261SerArg: 3.261 ± 0.515
2.143SerSer: 2.143 ± 0.427
2.609SerThr: 2.609 ± 0.57
4.659SerVal: 4.659 ± 0.619
1.491SerTrp: 1.491 ± 0.357
1.118SerTyr: 1.118 ± 0.354
0.0SerXaa: 0.0 ± 0.0
Thr
6.336ThrAla: 6.336 ± 0.743
0.745ThrCys: 0.745 ± 0.277
4.007ThrAsp: 4.007 ± 0.623
2.795ThrGlu: 2.795 ± 0.509
2.609ThrPhe: 2.609 ± 0.438
6.802ThrGly: 6.802 ± 0.664
0.932ThrHis: 0.932 ± 0.31
2.609ThrIle: 2.609 ± 0.551
2.795ThrLys: 2.795 ± 0.472
5.684ThrLeu: 5.684 ± 0.904
0.559ThrMet: 0.559 ± 0.229
1.211ThrAsn: 1.211 ± 0.276
2.982ThrPro: 2.982 ± 0.482
2.05ThrGln: 2.05 ± 0.393
2.982ThrArg: 2.982 ± 0.596
2.236ThrSer: 2.236 ± 0.505
2.795ThrThr: 2.795 ± 0.546
3.82ThrVal: 3.82 ± 0.857
0.839ThrTrp: 0.839 ± 0.279
0.839ThrTyr: 0.839 ± 0.253
0.0ThrXaa: 0.0 ± 0.0
Val
6.709ValAla: 6.709 ± 0.788
0.839ValCys: 0.839 ± 0.342
3.168ValAsp: 3.168 ± 0.495
4.286ValGlu: 4.286 ± 0.78
1.957ValPhe: 1.957 ± 0.493
3.168ValGly: 3.168 ± 0.516
1.677ValHis: 1.677 ± 0.428
2.516ValIle: 2.516 ± 0.477
4.193ValLys: 4.193 ± 0.694
5.963ValLeu: 5.963 ± 0.796
1.398ValMet: 1.398 ± 0.492
4.193ValAsn: 4.193 ± 0.516
4.193ValPro: 4.193 ± 0.509
2.795ValGln: 2.795 ± 0.582
4.286ValArg: 4.286 ± 0.631
5.032ValSer: 5.032 ± 0.769
5.032ValThr: 5.032 ± 0.753
4.1ValVal: 4.1 ± 0.461
1.584ValTrp: 1.584 ± 0.316
1.864ValTyr: 1.864 ± 0.42
0.0ValXaa: 0.0 ± 0.0
Trp
1.677TrpAla: 1.677 ± 0.563
0.373TrpCys: 0.373 ± 0.168
0.932TrpAsp: 0.932 ± 0.298
0.373TrpGlu: 0.373 ± 0.163
0.466TrpPhe: 0.466 ± 0.197
0.652TrpGly: 0.652 ± 0.215
0.466TrpHis: 0.466 ± 0.168
0.652TrpIle: 0.652 ± 0.239
0.652TrpLys: 0.652 ± 0.236
2.05TrpLeu: 2.05 ± 0.397
0.466TrpMet: 0.466 ± 0.196
0.466TrpAsn: 0.466 ± 0.17
1.305TrpPro: 1.305 ± 0.32
1.118TrpGln: 1.118 ± 0.295
1.957TrpArg: 1.957 ± 0.449
1.025TrpSer: 1.025 ± 0.259
0.745TrpThr: 0.745 ± 0.229
1.118TrpVal: 1.118 ± 0.282
0.28TrpTrp: 0.28 ± 0.157
1.118TrpTyr: 1.118 ± 0.246
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.236TyrAla: 2.236 ± 0.438
0.745TyrCys: 0.745 ± 0.275
1.025TyrAsp: 1.025 ± 0.318
1.118TyrGlu: 1.118 ± 0.289
1.398TyrPhe: 1.398 ± 0.418
2.516TyrGly: 2.516 ± 0.448
0.559TyrHis: 0.559 ± 0.258
1.025TyrIle: 1.025 ± 0.315
1.305TyrLys: 1.305 ± 0.374
2.982TyrLeu: 2.982 ± 0.544
0.28TyrMet: 0.28 ± 0.146
1.025TyrAsn: 1.025 ± 0.299
1.025TyrPro: 1.025 ± 0.267
1.305TyrGln: 1.305 ± 0.289
2.516TyrArg: 2.516 ± 0.595
1.305TyrSer: 1.305 ± 0.354
1.677TyrThr: 1.677 ± 0.453
1.398TyrVal: 1.398 ± 0.451
0.745TyrTrp: 0.745 ± 0.292
0.466TyrTyr: 0.466 ± 0.197
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (10733 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski