Amino acid dipepetide frequency for Zymoseptoria brevis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.022AlaAla: 10.022 ± 0.065	1.047AlaCys: 1.047 ± 0.015	4.675AlaAsp: 4.675 ± 0.03	5.796AlaGlu: 5.796 ± 0.044	3.225AlaPhe: 3.225 ± 0.027	6.373AlaGly: 6.373 ± 0.046	1.847AlaHis: 1.847 ± 0.022	4.151AlaIle: 4.151 ± 0.032	4.558AlaLys: 4.558 ± 0.038	7.818AlaLeu: 7.818 ± 0.044	2.191AlaMet: 2.191 ± 0.023	3.179AlaAsn: 3.179 ± 0.023	5.234AlaPro: 5.234 ± 0.043	3.77AlaGln: 3.77 ± 0.031	5.322AlaArg: 5.322 ± 0.035	7.65AlaSer: 7.65 ± 0.051	5.676AlaThr: 5.676 ± 0.041	5.625AlaVal: 5.625 ± 0.033	1.186AlaTrp: 1.186 ± 0.016	2.228AlaTyr: 2.228 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.942CysAla: 0.942 ± 0.015	0.219CysCys: 0.219 ± 0.007	0.644CysAsp: 0.644 ± 0.014	0.602CysGlu: 0.602 ± 0.012	0.487CysPhe: 0.487 ± 0.01	0.921CysGly: 0.921 ± 0.016	0.305CysHis: 0.305 ± 0.009	0.631CysIle: 0.631 ± 0.012	0.516CysLys: 0.516 ± 0.01	1.097CysLeu: 1.097 ± 0.016	0.252CysMet: 0.252 ± 0.008	0.395CysAsn: 0.395 ± 0.009	0.609CysPro: 0.609 ± 0.013	0.416CysGln: 0.416 ± 0.01	0.724CysArg: 0.724 ± 0.012	0.833CysSer: 0.833 ± 0.012	0.687CysThr: 0.687 ± 0.013	0.76CysVal: 0.76 ± 0.013	0.175CysTrp: 0.175 ± 0.006	0.343CysTyr: 0.343 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.193AspAla: 5.193 ± 0.037	0.625AspCys: 0.625 ± 0.012	4.644AspAsp: 4.644 ± 0.041	4.814AspGlu: 4.814 ± 0.039	2.292AspPhe: 2.292 ± 0.022	4.408AspGly: 4.408 ± 0.036	1.33AspHis: 1.33 ± 0.017	2.793AspIle: 2.793 ± 0.026	2.291AspLys: 2.291 ± 0.026	5.117AspLeu: 5.117 ± 0.034	1.337AspMet: 1.337 ± 0.02	1.86AspAsn: 1.86 ± 0.021	3.231AspPro: 3.231 ± 0.026	1.951AspGln: 1.951 ± 0.02	3.151AspArg: 3.151 ± 0.033	4.188AspSer: 4.188 ± 0.03	2.991AspThr: 2.991 ± 0.026	3.892AspVal: 3.892 ± 0.034	0.887AspTrp: 0.887 ± 0.014	1.532AspTyr: 1.532 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.69GluAla: 5.69 ± 0.034	0.625GluCys: 0.625 ± 0.012	4.656GluAsp: 4.656 ± 0.043	5.894GluGlu: 5.894 ± 0.055	1.806GluPhe: 1.806 ± 0.019	4.113GluGly: 4.113 ± 0.034	1.499GluHis: 1.499 ± 0.017	2.792GluIle: 2.792 ± 0.025	3.814GluLys: 3.814 ± 0.031	5.223GluLeu: 5.223 ± 0.045	1.609GluMet: 1.609 ± 0.018	2.099GluAsn: 2.099 ± 0.02	2.707GluPro: 2.707 ± 0.027	2.788GluGln: 2.788 ± 0.03	4.211GluArg: 4.211 ± 0.04	4.115GluSer: 4.115 ± 0.031	3.404GluThr: 3.404 ± 0.029	3.952GluVal: 3.952 ± 0.031	0.902GluTrp: 0.902 ± 0.015	1.594GluTyr: 1.594 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.252PheAla: 3.252 ± 0.029	0.504PheCys: 0.504 ± 0.01	2.302PheAsp: 2.302 ± 0.021	2.122PheGlu: 2.122 ± 0.019	1.463PhePhe: 1.463 ± 0.022	2.835PheGly: 2.835 ± 0.032	0.859PheHis: 0.859 ± 0.013	1.544PheIle: 1.544 ± 0.021	1.437PheLys: 1.437 ± 0.017	3.117PheLeu: 3.117 ± 0.027	0.728PheMet: 0.728 ± 0.01	1.371PheAsn: 1.371 ± 0.017	1.787PhePro: 1.787 ± 0.019	1.28PheGln: 1.28 ± 0.015	1.858PheArg: 1.858 ± 0.019	2.74PheSer: 2.74 ± 0.023	2.181PheThr: 2.181 ± 0.022	2.299PheVal: 2.299 ± 0.023	0.593PheTrp: 0.593 ± 0.011	0.99PheTyr: 0.99 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.53GlyAla: 5.53 ± 0.044	0.834GlyCys: 0.834 ± 0.015	3.812GlyAsp: 3.812 ± 0.03	4.085GlyGlu: 4.085 ± 0.03	2.708GlyPhe: 2.708 ± 0.029	6.627GlyGly: 6.627 ± 0.07	1.682GlyHis: 1.682 ± 0.018	3.251GlyIle: 3.251 ± 0.03	3.711GlyLys: 3.711 ± 0.035	5.958GlyLeu: 5.958 ± 0.041	1.837GlyMet: 1.837 ± 0.021	2.587GlyAsn: 2.587 ± 0.026	3.255GlyPro: 3.255 ± 0.027	2.684GlyGln: 2.684 ± 0.026	4.332GlyArg: 4.332 ± 0.036	5.692GlySer: 5.692 ± 0.037	4.061GlyThr: 4.061 ± 0.031	4.437GlyVal: 4.437 ± 0.032	1.161GlyTrp: 1.161 ± 0.017	2.079GlyTyr: 2.079 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	2.062HisAla: 2.062 ± 0.022	0.324HisCys: 0.324 ± 0.008	1.424HisAsp: 1.424 ± 0.019	1.358HisGlu: 1.358 ± 0.017	0.93HisPhe: 0.93 ± 0.016	1.721HisGly: 1.721 ± 0.022	0.868HisHis: 0.868 ± 0.019	1.138HisIle: 1.138 ± 0.016	0.907HisLys: 0.907 ± 0.015	2.231HisLeu: 2.231 ± 0.026	0.476HisMet: 0.476 ± 0.009	0.87HisAsn: 0.87 ± 0.013	1.604HisPro: 1.604 ± 0.02	0.989HisGln: 0.989 ± 0.015	1.526HisArg: 1.526 ± 0.02	1.833HisSer: 1.833 ± 0.023	1.32HisThr: 1.32 ± 0.017	1.415HisVal: 1.415 ± 0.018	0.352HisTrp: 0.352 ± 0.009	0.663HisTyr: 0.663 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.241IleAla: 4.241 ± 0.025	0.658IleCys: 0.658 ± 0.013	2.771IleAsp: 2.771 ± 0.025	2.788IleGlu: 2.788 ± 0.03	1.776IlePhe: 1.776 ± 0.02	3.027IleGly: 3.027 ± 0.031	1.077IleHis: 1.077 ± 0.016	2.099IleIle: 2.099 ± 0.022	2.029IleLys: 2.029 ± 0.022	4.013IleLeu: 4.013 ± 0.036	0.949IleMet: 0.949 ± 0.014	1.643IleAsn: 1.643 ± 0.019	2.762IlePro: 2.762 ± 0.02	1.625IleGln: 1.625 ± 0.017	2.576IleArg: 2.576 ± 0.023	3.512IleSer: 3.512 ± 0.028	2.746IleThr: 2.746 ± 0.025	3.017IleVal: 3.017 ± 0.023	0.641IleTrp: 0.641 ± 0.013	1.251IleTyr: 1.251 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.651LysAla: 4.651 ± 0.034	0.482LysCys: 0.482 ± 0.011	2.942LysAsp: 2.942 ± 0.027	3.486LysGlu: 3.486 ± 0.033	1.397LysPhe: 1.397 ± 0.017	3.037LysGly: 3.037 ± 0.027	1.153LysHis: 1.153 ± 0.016	2.109LysIle: 2.109 ± 0.022	3.515LysLys: 3.515 ± 0.049	3.982LysLeu: 3.982 ± 0.033	1.091LysMet: 1.091 ± 0.016	1.637LysAsn: 1.637 ± 0.021	2.73LysPro: 2.73 ± 0.026	1.984LysGln: 1.984 ± 0.022	3.563LysArg: 3.563 ± 0.033	3.564LysSer: 3.564 ± 0.027	2.858LysThr: 2.858 ± 0.026	2.929LysVal: 2.929 ± 0.024	0.68LysTrp: 0.68 ± 0.013	1.245LysTyr: 1.245 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.918LeuAla: 7.918 ± 0.047	1.099LeuCys: 1.099 ± 0.016	5.026LeuAsp: 5.026 ± 0.032	5.331LeuGlu: 5.331 ± 0.043	2.995LeuPhe: 2.995 ± 0.026	5.56LeuGly: 5.56 ± 0.039	2.228LeuHis: 2.228 ± 0.024	3.568LeuIle: 3.568 ± 0.029	4.126LeuLys: 4.126 ± 0.034	7.79LeuLeu: 7.79 ± 0.056	1.734LeuMet: 1.734 ± 0.019	2.982LeuAsn: 2.982 ± 0.027	5.594LeuPro: 5.594 ± 0.039	3.816LeuGln: 3.816 ± 0.035	5.698LeuArg: 5.698 ± 0.048	6.828LeuSer: 6.828 ± 0.039	4.827LeuThr: 4.827 ± 0.033	5.039LeuVal: 5.039 ± 0.042	1.123LeuTrp: 1.123 ± 0.018	2.137LeuTyr: 2.137 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.318MetAla: 2.318 ± 0.024	0.246MetCys: 0.246 ± 0.007	1.311MetAsp: 1.311 ± 0.018	1.36MetGlu: 1.36 ± 0.017	0.745MetPhe: 0.745 ± 0.012	1.5MetGly: 1.5 ± 0.019	0.516MetHis: 0.516 ± 0.011	0.945MetIle: 0.945 ± 0.016	1.056MetLys: 1.056 ± 0.013	1.912MetLeu: 1.912 ± 0.021	0.589MetMet: 0.589 ± 0.011	0.804MetAsn: 0.804 ± 0.012	1.429MetPro: 1.429 ± 0.019	0.984MetGln: 0.984 ± 0.018	1.392MetArg: 1.392 ± 0.015	1.949MetSer: 1.949 ± 0.019	1.3MetThr: 1.3 ± 0.017	1.286MetVal: 1.286 ± 0.017	0.265MetTrp: 0.265 ± 0.008	0.549MetTyr: 0.549 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.409AsnAla: 3.409 ± 0.026	0.404AsnCys: 0.404 ± 0.009	2.107AsnAsp: 2.107 ± 0.02	2.024AsnGlu: 2.024 ± 0.018	1.323AsnPhe: 1.323 ± 0.018	3.252AsnGly: 3.252 ± 0.035	0.826AsnHis: 0.826 ± 0.012	1.845AsnIle: 1.845 ± 0.019	1.499AsnLys: 1.499 ± 0.018	3.0AsnLeu: 3.0 ± 0.024	0.831AsnMet: 0.831 ± 0.014	1.459AsnAsn: 1.459 ± 0.021	2.278AsnPro: 2.278 ± 0.022	1.204AsnGln: 1.204 ± 0.017	1.853AsnArg: 1.853 ± 0.018	2.616AsnSer: 2.616 ± 0.024	2.26AsnThr: 2.26 ± 0.025	2.331AsnVal: 2.331 ± 0.021	0.495AsnTrp: 0.495 ± 0.009	0.969AsnTyr: 0.969 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.83ProAla: 5.83 ± 0.045	0.485ProCys: 0.485 ± 0.011	3.103ProAsp: 3.103 ± 0.025	3.619ProGlu: 3.619 ± 0.031	1.941ProPhe: 1.941 ± 0.02	3.936ProGly: 3.936 ± 0.033	1.349ProHis: 1.349 ± 0.02	2.45ProIle: 2.45 ± 0.025	2.649ProLys: 2.649 ± 0.025	4.505ProLeu: 4.505 ± 0.034	1.119ProMet: 1.119 ± 0.017	2.16ProAsn: 2.16 ± 0.023	5.445ProPro: 5.445 ± 0.064	2.561ProGln: 2.561 ± 0.034	3.404ProArg: 3.404 ± 0.033	5.99ProSer: 5.99 ± 0.047	4.293ProThr: 4.293 ± 0.036	3.384ProVal: 3.384 ± 0.031	0.681ProTrp: 0.681 ± 0.011	1.436ProTyr: 1.436 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.769GlnAla: 3.769 ± 0.038	0.441GlnCys: 0.441 ± 0.009	2.233GlnAsp: 2.233 ± 0.024	2.404GlnGlu: 2.404 ± 0.025	1.197GlnPhe: 1.197 ± 0.015	2.402GlnGly: 2.402 ± 0.022	1.224GlnHis: 1.224 ± 0.019	1.754GlnIle: 1.754 ± 0.02	1.987GlnLys: 1.987 ± 0.019	3.367GlnLeu: 3.367 ± 0.03	0.935GlnMet: 0.935 ± 0.016	1.539GlnAsn: 1.539 ± 0.019	2.641GlnPro: 2.641 ± 0.029	2.855GlnGln: 2.855 ± 0.054	2.842GlnArg: 2.842 ± 0.028	3.26GlnSer: 3.26 ± 0.032	2.479GlnThr: 2.479 ± 0.024	2.149GlnVal: 2.149 ± 0.021	0.554GlnTrp: 0.554 ± 0.01	1.207GlnTyr: 1.207 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	5.035ArgAla: 5.035 ± 0.038	0.681ArgCys: 0.681 ± 0.014	3.392ArgAsp: 3.392 ± 0.034	4.046ArgGlu: 4.046 ± 0.033	2.035ArgPhe: 2.035 ± 0.019	3.829ArgGly: 3.829 ± 0.035	1.539ArgHis: 1.539 ± 0.019	2.777ArgIle: 2.777 ± 0.025	3.673ArgLys: 3.673 ± 0.031	5.3ArgLeu: 5.3 ± 0.042	1.444ArgMet: 1.444 ± 0.016	2.282ArgAsn: 2.282 ± 0.021	3.666ArgPro: 3.666 ± 0.033	2.769ArgGln: 2.769 ± 0.028	5.172ArgArg: 5.172 ± 0.049	4.974ArgSer: 4.974 ± 0.042	3.57ArgThr: 3.57 ± 0.028	3.286ArgVal: 3.286 ± 0.029	0.891ArgTrp: 0.891 ± 0.014	1.553ArgTyr: 1.553 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	7.194SerAla: 7.194 ± 0.047	0.789SerCys: 0.789 ± 0.015	4.328SerAsp: 4.328 ± 0.032	4.146SerGlu: 4.146 ± 0.034	2.769SerPhe: 2.769 ± 0.028	5.691SerGly: 5.691 ± 0.042	1.884SerHis: 1.884 ± 0.024	3.739SerIle: 3.739 ± 0.029	3.73SerLys: 3.73 ± 0.037	6.607SerLeu: 6.607 ± 0.043	1.8SerMet: 1.8 ± 0.022	3.061SerAsn: 3.061 ± 0.025	5.416SerPro: 5.416 ± 0.043	3.204SerGln: 3.204 ± 0.03	4.978SerArg: 4.978 ± 0.041	8.769SerSer: 8.769 ± 0.08	6.11SerThr: 6.11 ± 0.055	4.337SerVal: 4.337 ± 0.031	1.02SerTrp: 1.02 ± 0.017	1.952SerTyr: 1.952 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.855ThrAla: 5.855 ± 0.045	0.741ThrCys: 0.741 ± 0.013	2.933ThrAsp: 2.933 ± 0.027	3.094ThrGlu: 3.094 ± 0.026	2.325ThrPhe: 2.325 ± 0.023	4.186ThrGly: 4.186 ± 0.033	1.348ThrHis: 1.348 ± 0.018	3.106ThrIle: 3.106 ± 0.027	2.717ThrLys: 2.717 ± 0.026	5.267ThrLeu: 5.267 ± 0.038	1.271ThrMet: 1.271 ± 0.016	2.194ThrAsn: 2.194 ± 0.022	4.453ThrPro: 4.453 ± 0.038	2.188ThrGln: 2.188 ± 0.025	3.204ThrArg: 3.204 ± 0.028	5.793ThrSer: 5.793 ± 0.049	4.929ThrThr: 4.929 ± 0.072	3.648ThrVal: 3.648 ± 0.034	0.809ThrTrp: 0.809 ± 0.013	1.584ThrTyr: 1.584 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.38ValAla: 5.38 ± 0.033	0.768ValCys: 0.768 ± 0.013	3.738ValAsp: 3.738 ± 0.027	4.207ValGlu: 4.207 ± 0.033	2.257ValPhe: 2.257 ± 0.023	4.057ValGly: 4.057 ± 0.029	1.384ValHis: 1.384 ± 0.018	2.563ValIle: 2.563 ± 0.024	3.061ValLys: 3.061 ± 0.027	5.45ValLeu: 5.45 ± 0.036	1.333ValMet: 1.333 ± 0.015	2.178ValAsn: 2.178 ± 0.02	3.502ValPro: 3.502 ± 0.028	2.478ValGln: 2.478 ± 0.021	3.616ValArg: 3.616 ± 0.027	4.287ValSer: 4.287 ± 0.032	3.386ValThr: 3.386 ± 0.035	4.281ValVal: 4.281 ± 0.035	0.842ValTrp: 0.842 ± 0.013	1.614ValTyr: 1.614 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.06TrpAla: 1.06 ± 0.016	0.194TrpCys: 0.194 ± 0.006	0.829TrpAsp: 0.829 ± 0.013	0.819TrpGlu: 0.819 ± 0.014	0.509TrpPhe: 0.509 ± 0.011	0.802TrpGly: 0.802 ± 0.013	0.366TrpHis: 0.366 ± 0.008	0.694TrpIle: 0.694 ± 0.013	0.748TrpLys: 0.748 ± 0.012	1.291TrpLeu: 1.291 ± 0.015	0.365TrpMet: 0.365 ± 0.008	0.599TrpAsn: 0.599 ± 0.01	0.598TrpPro: 0.598 ± 0.011	0.618TrpGln: 0.618 ± 0.012	0.989TrpArg: 0.989 ± 0.015	1.051TrpSer: 1.051 ± 0.014	0.942TrpThr: 0.942 ± 0.014	0.795TrpVal: 0.795 ± 0.014	0.247TrpTrp: 0.247 ± 0.007	0.402TrpTyr: 0.402 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.221TyrAla: 2.221 ± 0.022	0.391TyrCys: 0.391 ± 0.009	1.659TyrAsp: 1.659 ± 0.018	1.498TyrGlu: 1.498 ± 0.017	1.085TyrPhe: 1.085 ± 0.014	2.046TyrGly: 2.046 ± 0.021	0.725TyrHis: 0.725 ± 0.013	1.25TyrIle: 1.25 ± 0.017	1.012TyrLys: 1.012 ± 0.015	2.372TyrLeu: 2.372 ± 0.025	0.567TyrMet: 0.567 ± 0.011	1.086TyrAsn: 1.086 ± 0.017	1.399TyrPro: 1.399 ± 0.018	1.073TyrGln: 1.073 ± 0.015	1.507TyrArg: 1.507 ± 0.02	1.88TyrSer: 1.88 ± 0.022	1.626TyrThr: 1.626 ± 0.019	1.521TyrVal: 1.521 ± 0.018	0.412TyrTrp: 0.412 ± 0.009	0.86TyrTyr: 0.86 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10566 proteins (5141735 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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