Amino acid dipepetide frequency for Streptococcus phage P7951

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.985AlaAla: 6.985 ± 2.368
0.283AlaCys: 0.283 ± 0.155
4.248AlaAsp: 4.248 ± 0.901
5.097AlaGlu: 5.097 ± 0.773
3.115AlaPhe: 3.115 ± 1.148
5.569AlaGly: 5.569 ± 1.481
0.566AlaHis: 0.566 ± 0.22
6.419AlaIle: 6.419 ± 1.727
3.965AlaLys: 3.965 ± 0.705
6.513AlaLeu: 6.513 ± 1.374
2.265AlaMet: 2.265 ± 0.871
4.436AlaAsn: 4.436 ± 0.834
1.982AlaPro: 1.982 ± 0.411
4.153AlaGln: 4.153 ± 1.046
3.776AlaArg: 3.776 ± 0.79
6.796AlaSer: 6.796 ± 1.66
4.436AlaThr: 4.436 ± 1.186
4.814AlaVal: 4.814 ± 1.405
0.944AlaTrp: 0.944 ± 0.233
2.832AlaTyr: 2.832 ± 0.526
0.0AlaXaa: 0.0 ± 0.0
Cys
0.094CysAla: 0.094 ± 0.103
0.094CysCys: 0.094 ± 0.084
0.283CysAsp: 0.283 ± 0.181
0.661CysGlu: 0.661 ± 0.308
0.378CysPhe: 0.378 ± 0.271
0.566CysGly: 0.566 ± 0.284
0.189CysHis: 0.189 ± 0.135
0.566CysIle: 0.566 ± 0.222
0.661CysLys: 0.661 ± 0.304
0.189CysLeu: 0.189 ± 0.239
0.0CysMet: 0.0 ± 0.0
0.378CysAsn: 0.378 ± 0.205
0.189CysPro: 0.189 ± 0.185
0.094CysGln: 0.094 ± 0.105
0.094CysArg: 0.094 ± 0.103
0.85CysSer: 0.85 ± 0.258
0.0CysThr: 0.0 ± 0.0
0.472CysVal: 0.472 ± 0.176
0.0CysTrp: 0.0 ± 0.0
0.378CysTyr: 0.378 ± 0.183
0.0CysXaa: 0.0 ± 0.0
Asp
3.304AspAla: 3.304 ± 0.608
0.378AspCys: 0.378 ± 0.188
4.908AspAsp: 4.908 ± 0.736
3.776AspGlu: 3.776 ± 0.749
3.493AspPhe: 3.493 ± 0.581
5.38AspGly: 5.38 ± 0.955
0.566AspHis: 0.566 ± 0.325
2.832AspIle: 2.832 ± 0.54
4.342AspLys: 4.342 ± 0.771
4.908AspLeu: 4.908 ± 0.755
1.133AspMet: 1.133 ± 0.248
4.436AspAsn: 4.436 ± 0.681
0.85AspPro: 0.85 ± 0.323
1.51AspGln: 1.51 ± 0.403
1.793AspArg: 1.793 ± 0.482
4.531AspSer: 4.531 ± 0.663
3.304AspThr: 3.304 ± 0.757
3.587AspVal: 3.587 ± 0.665
0.755AspTrp: 0.755 ± 0.348
3.115AspTyr: 3.115 ± 0.681
0.0AspXaa: 0.0 ± 0.0
Glu
4.814GluAla: 4.814 ± 0.676
0.283GluCys: 0.283 ± 0.181
2.077GluAsp: 2.077 ± 0.461
5.192GluGlu: 5.192 ± 1.149
2.454GluPhe: 2.454 ± 0.52
3.304GluGly: 3.304 ± 0.45
1.322GluHis: 1.322 ± 0.383
5.569GluIle: 5.569 ± 1.096
5.758GluLys: 5.758 ± 1.286
6.608GluLeu: 6.608 ± 1.223
2.926GluMet: 2.926 ± 0.642
3.776GluAsn: 3.776 ± 0.679
1.605GluPro: 1.605 ± 0.541
3.209GluGln: 3.209 ± 0.659
3.776GluArg: 3.776 ± 0.851
2.454GluSer: 2.454 ± 0.689
4.153GluThr: 4.153 ± 0.767
5.947GluVal: 5.947 ± 1.061
1.133GluTrp: 1.133 ± 0.396
3.115GluTyr: 3.115 ± 0.805
0.0GluXaa: 0.0 ± 0.0
Phe
2.454PheAla: 2.454 ± 0.461
0.378PheCys: 0.378 ± 0.201
3.304PheAsp: 3.304 ± 0.562
3.776PheGlu: 3.776 ± 0.79
1.699PhePhe: 1.699 ± 0.621
3.965PheGly: 3.965 ± 0.697
0.378PheHis: 0.378 ± 0.194
3.398PheIle: 3.398 ± 0.524
5.38PheLys: 5.38 ± 0.706
2.643PheLeu: 2.643 ± 0.759
0.755PheMet: 0.755 ± 0.285
3.209PheAsn: 3.209 ± 0.394
0.661PhePro: 0.661 ± 0.292
1.416PheGln: 1.416 ± 0.375
0.661PheArg: 0.661 ± 0.21
3.209PheSer: 3.209 ± 0.747
2.926PheThr: 2.926 ± 0.634
1.793PheVal: 1.793 ± 0.529
0.755PheTrp: 0.755 ± 0.244
0.755PheTyr: 0.755 ± 0.312
0.0PheXaa: 0.0 ± 0.0
Gly
4.531GlyAla: 4.531 ± 1.189
0.283GlyCys: 0.283 ± 0.163
3.398GlyAsp: 3.398 ± 0.564
2.737GlyGlu: 2.737 ± 0.422
3.115GlyPhe: 3.115 ± 0.554
3.115GlyGly: 3.115 ± 0.571
0.85GlyHis: 0.85 ± 0.305
6.985GlyIle: 6.985 ± 1.924
5.192GlyLys: 5.192 ± 0.865
6.891GlyLeu: 6.891 ± 0.957
1.416GlyMet: 1.416 ± 0.699
2.926GlyAsn: 2.926 ± 0.549
0.944GlyPro: 0.944 ± 0.268
3.115GlyGln: 3.115 ± 0.502
2.737GlyArg: 2.737 ± 0.647
4.059GlySer: 4.059 ± 0.774
4.72GlyThr: 4.72 ± 1.059
4.342GlyVal: 4.342 ± 0.672
0.755GlyTrp: 0.755 ± 0.275
3.304GlyTyr: 3.304 ± 0.596
0.0GlyXaa: 0.0 ± 0.0
His
1.038HisAla: 1.038 ± 0.302
0.189HisCys: 0.189 ± 0.162
1.133HisAsp: 1.133 ± 0.307
0.755HisGlu: 0.755 ± 0.351
0.85HisPhe: 0.85 ± 0.373
0.944HisGly: 0.944 ± 0.359
0.378HisHis: 0.378 ± 0.175
0.85HisIle: 0.85 ± 0.321
1.133HisLys: 1.133 ± 0.291
1.322HisLeu: 1.322 ± 0.409
0.378HisMet: 0.378 ± 0.188
0.661HisAsn: 0.661 ± 0.285
0.566HisPro: 0.566 ± 0.281
0.283HisGln: 0.283 ± 0.183
0.566HisArg: 0.566 ± 0.225
0.472HisSer: 0.472 ± 0.225
0.85HisThr: 0.85 ± 0.248
0.944HisVal: 0.944 ± 0.373
0.094HisTrp: 0.094 ± 0.093
0.472HisTyr: 0.472 ± 0.194
0.0HisXaa: 0.0 ± 0.0
Ile
4.908IleAla: 4.908 ± 1.142
0.566IleCys: 0.566 ± 0.253
4.814IleAsp: 4.814 ± 0.557
5.192IleGlu: 5.192 ± 1.202
1.982IlePhe: 1.982 ± 0.455
5.569IleGly: 5.569 ± 1.255
1.416IleHis: 1.416 ± 0.36
4.436IleIle: 4.436 ± 1.055
5.475IleLys: 5.475 ± 0.682
3.398IleLeu: 3.398 ± 0.626
1.982IleMet: 1.982 ± 0.374
2.926IleAsn: 2.926 ± 0.627
2.171IlePro: 2.171 ± 0.577
3.304IleGln: 3.304 ± 0.607
2.926IleArg: 2.926 ± 0.638
6.419IleSer: 6.419 ± 1.443
3.965IleThr: 3.965 ± 0.543
4.342IleVal: 4.342 ± 0.716
0.283IleTrp: 0.283 ± 0.178
2.643IleTyr: 2.643 ± 0.666
0.0IleXaa: 0.0 ± 0.0
Lys
7.363LysAla: 7.363 ± 1.03
0.378LysCys: 0.378 ± 0.268
3.965LysAsp: 3.965 ± 0.621
7.457LysGlu: 7.457 ± 1.563
2.265LysPhe: 2.265 ± 0.542
5.003LysGly: 5.003 ± 0.623
1.133LysHis: 1.133 ± 0.278
4.72LysIle: 4.72 ± 0.759
5.947LysLys: 5.947 ± 1.545
6.324LysLeu: 6.324 ± 1.161
1.699LysMet: 1.699 ± 0.458
3.493LysAsn: 3.493 ± 0.816
3.209LysPro: 3.209 ± 0.621
2.454LysGln: 2.454 ± 0.606
4.153LysArg: 4.153 ± 0.762
4.625LysSer: 4.625 ± 0.44
5.758LysThr: 5.758 ± 0.95
4.153LysVal: 4.153 ± 0.697
0.755LysTrp: 0.755 ± 0.263
3.681LysTyr: 3.681 ± 0.784
0.0LysXaa: 0.0 ± 0.0
Leu
6.702LeuAla: 6.702 ± 0.9
0.378LeuCys: 0.378 ± 0.211
4.153LeuAsp: 4.153 ± 0.646
6.324LeuGlu: 6.324 ± 1.168
3.021LeuPhe: 3.021 ± 0.522
5.852LeuGly: 5.852 ± 0.995
0.85LeuHis: 0.85 ± 0.345
4.248LeuIle: 4.248 ± 0.608
5.569LeuLys: 5.569 ± 0.866
5.475LeuLeu: 5.475 ± 0.891
2.171LeuMet: 2.171 ± 0.4
5.38LeuAsn: 5.38 ± 0.692
2.36LeuPro: 2.36 ± 0.551
2.549LeuGln: 2.549 ± 0.479
3.398LeuArg: 3.398 ± 0.801
5.758LeuSer: 5.758 ± 0.71
7.079LeuThr: 7.079 ± 0.955
4.72LeuVal: 4.72 ± 0.758
0.566LeuTrp: 0.566 ± 0.224
3.115LeuTyr: 3.115 ± 0.579
0.0LeuXaa: 0.0 ± 0.0
Met
3.021MetAla: 3.021 ± 1.011
0.189MetCys: 0.189 ± 0.135
1.133MetAsp: 1.133 ± 0.429
1.133MetGlu: 1.133 ± 0.403
0.85MetPhe: 0.85 ± 0.224
1.227MetGly: 1.227 ± 0.375
0.189MetHis: 0.189 ± 0.115
1.227MetIle: 1.227 ± 0.341
2.171MetLys: 2.171 ± 0.552
1.888MetLeu: 1.888 ± 0.381
0.85MetMet: 0.85 ± 0.558
1.227MetAsn: 1.227 ± 0.337
0.472MetPro: 0.472 ± 0.197
1.227MetGln: 1.227 ± 0.467
0.85MetArg: 0.85 ± 0.255
2.171MetSer: 2.171 ± 0.409
1.888MetThr: 1.888 ± 0.459
2.077MetVal: 2.077 ± 0.55
0.0MetTrp: 0.0 ± 0.0
0.661MetTyr: 0.661 ± 0.343
0.0MetXaa: 0.0 ± 0.0
Asn
4.059AsnAla: 4.059 ± 0.625
0.378AsnCys: 0.378 ± 0.172
3.115AsnAsp: 3.115 ± 0.651
3.776AsnGlu: 3.776 ± 0.882
2.643AsnPhe: 2.643 ± 0.436
4.625AsnGly: 4.625 ± 0.847
1.038AsnHis: 1.038 ± 0.405
3.493AsnIle: 3.493 ± 0.65
3.965AsnLys: 3.965 ± 0.749
3.87AsnLeu: 3.87 ± 0.545
0.944AsnMet: 0.944 ± 0.357
2.832AsnAsn: 2.832 ± 0.508
2.265AsnPro: 2.265 ± 0.454
2.077AsnGln: 2.077 ± 0.537
2.36AsnArg: 2.36 ± 0.477
3.87AsnSer: 3.87 ± 0.772
3.021AsnThr: 3.021 ± 0.702
3.209AsnVal: 3.209 ± 0.613
1.133AsnTrp: 1.133 ± 0.28
1.793AsnTyr: 1.793 ± 0.514
0.0AsnXaa: 0.0 ± 0.0
Pro
1.888ProAla: 1.888 ± 0.556
0.0ProCys: 0.0 ± 0.0
1.888ProAsp: 1.888 ± 0.603
1.322ProGlu: 1.322 ± 0.424
1.227ProPhe: 1.227 ± 0.386
0.755ProGly: 0.755 ± 0.226
0.283ProHis: 0.283 ± 0.143
1.699ProIle: 1.699 ± 0.484
3.115ProLys: 3.115 ± 0.569
1.982ProLeu: 1.982 ± 0.424
0.094ProMet: 0.094 ± 0.093
2.077ProAsn: 2.077 ± 0.508
0.755ProPro: 0.755 ± 0.234
1.51ProGln: 1.51 ± 0.315
1.51ProArg: 1.51 ± 0.405
2.171ProSer: 2.171 ± 0.558
1.322ProThr: 1.322 ± 0.485
1.793ProVal: 1.793 ± 0.42
0.283ProTrp: 0.283 ± 0.166
1.227ProTyr: 1.227 ± 0.351
0.0ProXaa: 0.0 ± 0.0
Gln
4.153GlnAla: 4.153 ± 1.052
0.472GlnCys: 0.472 ± 0.25
2.265GlnAsp: 2.265 ± 0.551
3.304GlnGlu: 3.304 ± 0.737
2.454GlnPhe: 2.454 ± 0.494
2.454GlnGly: 2.454 ± 0.635
0.378GlnHis: 0.378 ± 0.21
2.36GlnIle: 2.36 ± 0.645
2.549GlnLys: 2.549 ± 0.672
4.248GlnLeu: 4.248 ± 0.593
1.133GlnMet: 1.133 ± 0.346
1.322GlnAsn: 1.322 ± 0.333
1.038GlnPro: 1.038 ± 0.259
1.322GlnGln: 1.322 ± 0.431
1.51GlnArg: 1.51 ± 0.346
2.643GlnSer: 2.643 ± 0.558
3.209GlnThr: 3.209 ± 0.467
2.171GlnVal: 2.171 ± 0.315
0.283GlnTrp: 0.283 ± 0.188
1.416GlnTyr: 1.416 ± 0.389
0.0GlnXaa: 0.0 ± 0.0
Arg
3.87ArgAla: 3.87 ± 0.425
0.472ArgCys: 0.472 ± 0.179
2.643ArgAsp: 2.643 ± 0.449
3.209ArgGlu: 3.209 ± 0.84
1.888ArgPhe: 1.888 ± 0.489
1.888ArgGly: 1.888 ± 0.367
0.283ArgHis: 0.283 ± 0.137
2.549ArgIle: 2.549 ± 0.685
3.021ArgLys: 3.021 ± 0.668
3.87ArgLeu: 3.87 ± 0.578
1.605ArgMet: 1.605 ± 0.372
1.51ArgAsn: 1.51 ± 0.459
0.85ArgPro: 0.85 ± 0.207
1.793ArgGln: 1.793 ± 0.424
1.227ArgArg: 1.227 ± 0.495
2.926ArgSer: 2.926 ± 0.493
1.51ArgThr: 1.51 ± 0.407
2.454ArgVal: 2.454 ± 0.505
0.755ArgTrp: 0.755 ± 0.301
2.36ArgTyr: 2.36 ± 0.513
0.0ArgXaa: 0.0 ± 0.0
Ser
6.702SerAla: 6.702 ± 2.474
0.283SerCys: 0.283 ± 0.166
4.436SerAsp: 4.436 ± 0.849
3.115SerGlu: 3.115 ± 0.626
3.209SerPhe: 3.209 ± 0.601
4.625SerGly: 4.625 ± 0.761
1.605SerHis: 1.605 ± 0.456
5.852SerIle: 5.852 ± 1.012
5.569SerLys: 5.569 ± 0.89
4.531SerLeu: 4.531 ± 0.964
1.227SerMet: 1.227 ± 0.316
3.965SerAsn: 3.965 ± 0.671
1.699SerPro: 1.699 ± 0.506
4.342SerGln: 4.342 ± 1.014
2.077SerArg: 2.077 ± 0.408
4.342SerSer: 4.342 ± 0.91
4.531SerThr: 4.531 ± 0.615
5.003SerVal: 5.003 ± 0.846
0.661SerTrp: 0.661 ± 0.204
2.077SerTyr: 2.077 ± 0.449
0.0SerXaa: 0.0 ± 0.0
Thr
5.097ThrAla: 5.097 ± 1.746
0.0ThrCys: 0.0 ± 0.0
2.832ThrAsp: 2.832 ± 0.57
4.059ThrGlu: 4.059 ± 0.719
3.493ThrPhe: 3.493 ± 0.637
4.153ThrGly: 4.153 ± 0.802
0.85ThrHis: 0.85 ± 0.281
4.814ThrIle: 4.814 ± 1.147
6.136ThrLys: 6.136 ± 0.814
5.852ThrLeu: 5.852 ± 0.655
1.793ThrMet: 1.793 ± 0.854
3.493ThrAsn: 3.493 ± 0.72
1.982ThrPro: 1.982 ± 0.422
2.549ThrGln: 2.549 ± 0.485
2.454ThrArg: 2.454 ± 0.494
3.493ThrSer: 3.493 ± 0.803
4.059ThrThr: 4.059 ± 0.728
5.38ThrVal: 5.38 ± 0.829
0.378ThrTrp: 0.378 ± 0.196
2.077ThrTyr: 2.077 ± 0.658
0.0ThrXaa: 0.0 ± 0.0
Val
5.003ValAla: 5.003 ± 1.326
0.566ValCys: 0.566 ± 0.269
4.908ValAsp: 4.908 ± 0.834
5.192ValGlu: 5.192 ± 0.884
3.021ValPhe: 3.021 ± 0.586
3.304ValGly: 3.304 ± 0.628
0.661ValHis: 0.661 ± 0.277
3.587ValIle: 3.587 ± 0.547
5.097ValLys: 5.097 ± 0.614
4.908ValLeu: 4.908 ± 0.568
0.661ValMet: 0.661 ± 0.268
3.87ValAsn: 3.87 ± 0.799
2.171ValPro: 2.171 ± 0.351
2.077ValGln: 2.077 ± 0.551
2.171ValArg: 2.171 ± 0.338
5.475ValSer: 5.475 ± 0.769
5.097ValThr: 5.097 ± 0.729
4.625ValVal: 4.625 ± 0.67
0.755ValTrp: 0.755 ± 0.263
1.793ValTyr: 1.793 ± 0.534
0.0ValXaa: 0.0 ± 0.0
Trp
0.566TrpAla: 0.566 ± 0.207
0.0TrpCys: 0.0 ± 0.0
0.661TrpAsp: 0.661 ± 0.223
0.944TrpGlu: 0.944 ± 0.346
0.189TrpPhe: 0.189 ± 0.141
0.661TrpGly: 0.661 ± 0.261
0.094TrpHis: 0.094 ± 0.115
0.472TrpIle: 0.472 ± 0.222
0.755TrpLys: 0.755 ± 0.203
0.85TrpLeu: 0.85 ± 0.262
0.189TrpMet: 0.189 ± 0.14
0.566TrpAsn: 0.566 ± 0.338
0.094TrpPro: 0.094 ± 0.104
0.283TrpGln: 0.283 ± 0.139
0.378TrpArg: 0.378 ± 0.182
1.133TrpSer: 1.133 ± 0.452
1.038TrpThr: 1.038 ± 0.287
0.944TrpVal: 0.944 ± 0.234
0.378TrpTrp: 0.378 ± 0.219
0.661TrpTyr: 0.661 ± 0.3
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.643TyrAla: 2.643 ± 0.451
0.566TyrCys: 0.566 ± 0.214
2.737TyrAsp: 2.737 ± 0.724
2.454TyrGlu: 2.454 ± 0.597
2.171TyrPhe: 2.171 ± 0.586
2.454TyrGly: 2.454 ± 0.505
0.85TyrHis: 0.85 ± 0.39
2.643TyrIle: 2.643 ± 0.66
2.832TyrLys: 2.832 ± 0.505
3.398TyrLeu: 3.398 ± 0.748
1.133TyrMet: 1.133 ± 0.312
1.982TyrAsn: 1.982 ± 0.445
1.038TyrPro: 1.038 ± 0.41
1.416TyrGln: 1.416 ± 0.406
2.265TyrArg: 2.265 ± 0.63
2.454TyrSer: 2.454 ± 0.466
2.077TyrThr: 2.077 ± 0.604
2.171TyrVal: 2.171 ± 0.443
0.189TyrTrp: 0.189 ± 0.13
1.322TyrTyr: 1.322 ± 0.4
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 47 proteins (10595 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski