Amino acid dipepetide frequency for halophilic archaeon J07HX64

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.58AlaAla: 11.58 ± 0.181	0.674AlaCys: 0.674 ± 0.032	8.499AlaAsp: 8.499 ± 0.116	7.917AlaGlu: 7.917 ± 0.112	3.261AlaPhe: 3.261 ± 0.071	10.103AlaGly: 10.103 ± 0.14	1.802AlaHis: 1.802 ± 0.049	3.581AlaIle: 3.581 ± 0.072	1.271AlaLys: 1.271 ± 0.038	9.537AlaLeu: 9.537 ± 0.123	1.667AlaMet: 1.667 ± 0.049	2.178AlaAsn: 2.178 ± 0.057	3.656AlaPro: 3.656 ± 0.07	2.298AlaGln: 2.298 ± 0.058	6.347AlaArg: 6.347 ± 0.102	4.835AlaSer: 4.835 ± 0.078	6.785AlaThr: 6.785 ± 0.115	10.597AlaVal: 10.597 ± 0.139	0.826AlaTrp: 0.826 ± 0.04	2.268AlaTyr: 2.268 ± 0.063	0.053AlaXaa: 0.053 ± 0.008
Cys	0.686CysAla: 0.686 ± 0.032	0.106CysCys: 0.106 ± 0.014	0.577CysAsp: 0.577 ± 0.029	0.675CysGlu: 0.675 ± 0.03	0.189CysPhe: 0.189 ± 0.016	0.907CysGly: 0.907 ± 0.04	0.197CysHis: 0.197 ± 0.016	0.265CysIle: 0.265 ± 0.018	0.089CysLys: 0.089 ± 0.01	0.656CysLeu: 0.656 ± 0.032	0.115CysMet: 0.115 ± 0.012	0.192CysAsn: 0.192 ± 0.017	0.616CysPro: 0.616 ± 0.032	0.189CysGln: 0.189 ± 0.015	0.709CysArg: 0.709 ± 0.037	0.523CysSer: 0.523 ± 0.029	0.456CysThr: 0.456 ± 0.028	0.632CysVal: 0.632 ± 0.03	0.096CysTrp: 0.096 ± 0.013	0.162CysTyr: 0.162 ± 0.014	0.004CysXaa: 0.004 ± 0.002
Asp	7.546AspAla: 7.546 ± 0.106	0.761AspCys: 0.761 ± 0.035	6.294AspAsp: 6.294 ± 0.125	6.678AspGlu: 6.678 ± 0.109	1.282AspPhe: 1.282 ± 0.036	7.957AspGly: 7.957 ± 0.115	1.653AspHis: 1.653 ± 0.047	3.954AspIle: 3.954 ± 0.077	0.736AspLys: 0.736 ± 0.031	6.157AspLeu: 6.157 ± 0.113	1.056AspMet: 1.056 ± 0.043	1.662AspAsn: 1.662 ± 0.051	5.078AspPro: 5.078 ± 0.091	1.976AspGln: 1.976 ± 0.056	6.988AspArg: 6.988 ± 0.107	4.921AspSer: 4.921 ± 0.078	5.59AspThr: 5.59 ± 0.097	5.955AspVal: 5.955 ± 0.089	1.007AspTrp: 1.007 ± 0.037	1.371AspTyr: 1.371 ± 0.045	0.031AspXaa: 0.031 ± 0.006
Glu	7.532GluAla: 7.532 ± 0.115	0.602GluCys: 0.602 ± 0.034	4.623GluAsp: 4.623 ± 0.088	6.02GluGlu: 6.02 ± 0.122	3.25GluPhe: 3.25 ± 0.066	5.444GluGly: 5.444 ± 0.089	2.199GluHis: 2.199 ± 0.05	3.312GluIle: 3.312 ± 0.086	1.294GluLys: 1.294 ± 0.046	7.655GluLeu: 7.655 ± 0.119	1.713GluMet: 1.713 ± 0.049	2.205GluAsn: 2.205 ± 0.055	3.739GluPro: 3.739 ± 0.079	3.972GluGln: 3.972 ± 0.078	8.056GluArg: 8.056 ± 0.14	5.347GluSer: 5.347 ± 0.085	7.536GluThr: 7.536 ± 0.098	5.538GluVal: 5.538 ± 0.088	0.907GluTrp: 0.907 ± 0.039	2.462GluTyr: 2.462 ± 0.062	0.029GluXaa: 0.029 ± 0.006
Phe	3.022PheAla: 3.022 ± 0.067	0.257PheCys: 0.257 ± 0.016	3.279PheAsp: 3.279 ± 0.073	3.279PheGlu: 3.279 ± 0.063	0.877PhePhe: 0.877 ± 0.042	3.013PheGly: 3.013 ± 0.067	0.49PheHis: 0.49 ± 0.028	0.884PheIle: 0.884 ± 0.039	0.352PheLys: 0.352 ± 0.021	2.551PheLeu: 2.551 ± 0.059	0.388PheMet: 0.388 ± 0.023	0.649PheAsn: 0.649 ± 0.033	1.226PhePro: 1.226 ± 0.046	0.779PheGln: 0.779 ± 0.036	1.727PheArg: 1.727 ± 0.043	1.72PheSer: 1.72 ± 0.051	1.827PheThr: 1.827 ± 0.055	3.084PheVal: 3.084 ± 0.071	0.344PheTrp: 0.344 ± 0.023	0.739PheTyr: 0.739 ± 0.032	0.008PheXaa: 0.008 ± 0.004
Gly	8.155GlyAla: 8.155 ± 0.12	0.775GlyCys: 0.775 ± 0.033	7.176GlyAsp: 7.176 ± 0.132	7.901GlyGlu: 7.901 ± 0.111	3.12GlyPhe: 3.12 ± 0.064	8.264GlyGly: 8.264 ± 0.146	1.835GlyHis: 1.835 ± 0.05	3.632GlyIle: 3.632 ± 0.062	1.474GlyLys: 1.474 ± 0.049	7.437GlyLeu: 7.437 ± 0.113	1.679GlyMet: 1.679 ± 0.049	2.201GlyAsn: 2.201 ± 0.062	3.723GlyPro: 3.723 ± 0.083	2.672GlyGln: 2.672 ± 0.066	5.785GlyArg: 5.785 ± 0.097	5.804GlySer: 5.804 ± 0.113	6.677GlyThr: 6.677 ± 0.106	8.305GlyVal: 8.305 ± 0.109	1.066GlyTrp: 1.066 ± 0.04	2.575GlyTyr: 2.575 ± 0.048	0.061GlyXaa: 0.061 ± 0.01
His	1.838HisAla: 1.838 ± 0.054	0.229HisCys: 0.229 ± 0.017	1.698HisAsp: 1.698 ± 0.044	1.686HisGlu: 1.686 ± 0.049	0.34HisPhe: 0.34 ± 0.022	1.905HisGly: 1.905 ± 0.053	0.542HisHis: 0.542 ± 0.029	0.764HisIle: 0.764 ± 0.035	0.252HisLys: 0.252 ± 0.016	1.684HisLeu: 1.684 ± 0.042	0.229HisMet: 0.229 ± 0.018	0.49HisAsn: 0.49 ± 0.034	1.378HisPro: 1.378 ± 0.048	0.512HisGln: 0.512 ± 0.025	1.668HisArg: 1.668 ± 0.046	1.101HisSer: 1.101 ± 0.04	1.353HisThr: 1.353 ± 0.054	1.602HisVal: 1.602 ± 0.048	0.19HisTrp: 0.19 ± 0.014	0.455HisTyr: 0.455 ± 0.025	0.01HisXaa: 0.01 ± 0.004
Ile	3.71IleAla: 3.71 ± 0.081	0.267IleCys: 0.267 ± 0.017	3.564IleAsp: 3.564 ± 0.077	3.933IleGlu: 3.933 ± 0.09	0.851IlePhe: 0.851 ± 0.036	3.223IleGly: 3.223 ± 0.076	0.753IleHis: 0.753 ± 0.032	1.23IleIle: 1.23 ± 0.048	0.532IleLys: 0.532 ± 0.026	2.527IleLeu: 2.527 ± 0.061	0.408IleMet: 0.408 ± 0.025	0.884IleAsn: 0.884 ± 0.038	1.796IlePro: 1.796 ± 0.049	1.138IleGln: 1.138 ± 0.038	2.338IleArg: 2.338 ± 0.06	1.926IleSer: 1.926 ± 0.054	2.102IleThr: 2.102 ± 0.057	2.974IleVal: 2.974 ± 0.07	0.282IleTrp: 0.282 ± 0.019	0.692IleTyr: 0.692 ± 0.031	0.001IleXaa: 0.001 ± 0.001
Lys	1.11LysAla: 1.11 ± 0.045	0.085LysCys: 0.085 ± 0.011	0.622LysAsp: 0.622 ± 0.027	0.89LysGlu: 0.89 ± 0.036	0.399LysPhe: 0.399 ± 0.025	0.975LysGly: 0.975 ± 0.038	0.403LysHis: 0.403 ± 0.025	0.576LysIle: 0.576 ± 0.029	0.46LysLys: 0.46 ± 0.031	1.481LysLeu: 1.481 ± 0.045	0.305LysMet: 0.305 ± 0.022	0.463LysAsn: 0.463 ± 0.028	0.712LysPro: 0.712 ± 0.035	0.865LysGln: 0.865 ± 0.036	1.393LysArg: 1.393 ± 0.045	0.882LysSer: 0.882 ± 0.04	1.079LysThr: 1.079 ± 0.041	0.731LysVal: 0.731 ± 0.032	0.132LysTrp: 0.132 ± 0.012	0.405LysTyr: 0.405 ± 0.022	0.007LysXaa: 0.007 ± 0.003
Leu	10.486LeuAla: 10.486 ± 0.135	0.716LeuCys: 0.716 ± 0.029	7.738LeuAsp: 7.738 ± 0.109	6.661LeuGlu: 6.661 ± 0.112	2.973LeuPhe: 2.973 ± 0.068	7.858LeuGly: 7.858 ± 0.114	1.423LeuHis: 1.423 ± 0.044	2.109LeuIle: 2.109 ± 0.059	1.139LeuLys: 1.139 ± 0.046	8.466LeuLeu: 8.466 ± 0.151	1.297LeuMet: 1.297 ± 0.043	1.77LeuAsn: 1.77 ± 0.049	4.018LeuPro: 4.018 ± 0.081	2.044LeuGln: 2.044 ± 0.051	5.896LeuArg: 5.896 ± 0.102	5.905LeuSer: 5.905 ± 0.096	5.568LeuThr: 5.568 ± 0.09	8.565LeuVal: 8.565 ± 0.147	0.807LeuTrp: 0.807 ± 0.034	2.045LeuTyr: 2.045 ± 0.058	0.039LeuXaa: 0.039 ± 0.007
Met	1.542MetAla: 1.542 ± 0.052	0.142MetCys: 0.142 ± 0.015	1.05MetAsp: 1.05 ± 0.037	1.002MetGlu: 1.002 ± 0.038	0.52MetPhe: 0.52 ± 0.029	1.272MetGly: 1.272 ± 0.045	0.33MetHis: 0.33 ± 0.021	0.566MetIle: 0.566 ± 0.029	0.27MetLys: 0.27 ± 0.019	1.591MetLeu: 1.591 ± 0.043	0.272MetMet: 0.272 ± 0.019	0.562MetAsn: 0.562 ± 0.026	0.755MetPro: 0.755 ± 0.031	0.517MetGln: 0.517 ± 0.023	1.123MetArg: 1.123 ± 0.036	1.505MetSer: 1.505 ± 0.048	1.508MetThr: 1.508 ± 0.044	1.161MetVal: 1.161 ± 0.04	0.143MetTrp: 0.143 ± 0.014	0.373MetTyr: 0.373 ± 0.02	0.016MetXaa: 0.016 ± 0.004
Asn	2.149AsnAla: 2.149 ± 0.052	0.236AsnCys: 0.236 ± 0.019	1.509AsnAsp: 1.509 ± 0.048	1.675AsnGlu: 1.675 ± 0.049	0.635AsnPhe: 0.635 ± 0.028	2.334AsnGly: 2.334 ± 0.076	0.484AsnHis: 0.484 ± 0.023	1.02AsnIle: 1.02 ± 0.037	0.412AsnLys: 0.412 ± 0.025	1.954AsnLeu: 1.954 ± 0.054	0.375AsnMet: 0.375 ± 0.019	0.796AsnAsn: 0.796 ± 0.032	1.52AsnPro: 1.52 ± 0.038	0.636AsnGln: 0.636 ± 0.029	1.954AsnArg: 1.954 ± 0.053	1.319AsnSer: 1.319 ± 0.046	1.569AsnThr: 1.569 ± 0.054	1.969AsnVal: 1.969 ± 0.061	0.315AsnTrp: 0.315 ± 0.022	0.57AsnTyr: 0.57 ± 0.027	0.005AsnXaa: 0.005 ± 0.003
Pro	5.1ProAla: 5.1 ± 0.091	0.268ProCys: 0.268 ± 0.02	4.967ProAsp: 4.967 ± 0.082	4.631ProGlu: 4.631 ± 0.081	1.367ProPhe: 1.367 ± 0.042	4.995ProGly: 4.995 ± 0.095	0.828ProHis: 0.828 ± 0.034	1.381ProIle: 1.381 ± 0.043	0.613ProLys: 0.613 ± 0.028	3.637ProLeu: 3.637 ± 0.076	0.756ProMet: 0.756 ± 0.035	0.977ProAsn: 0.977 ± 0.035	2.399ProPro: 2.399 ± 0.068	1.074ProGln: 1.074 ± 0.036	2.608ProArg: 2.608 ± 0.062	2.543ProSer: 2.543 ± 0.058	3.217ProThr: 3.217 ± 0.066	4.979ProVal: 4.979 ± 0.09	0.431ProTrp: 0.431 ± 0.027	0.977ProTyr: 0.977 ± 0.039	0.023ProXaa: 0.023 ± 0.006
Gln	2.66GlnAla: 2.66 ± 0.062	0.211GlnCys: 0.211 ± 0.017	1.414GlnAsp: 1.414 ± 0.045	1.998GlnGlu: 1.998 ± 0.063	1.427GlnPhe: 1.427 ± 0.047	1.864GlnGly: 1.864 ± 0.048	0.645GlnHis: 0.645 ± 0.028	1.129GlnIle: 1.129 ± 0.036	0.542GlnLys: 0.542 ± 0.03	2.702GlnLeu: 2.702 ± 0.058	0.631GlnMet: 0.631 ± 0.027	0.787GlnAsn: 0.787 ± 0.034	1.413GlnPro: 1.413 ± 0.045	1.34GlnGln: 1.34 ± 0.053	2.317GlnArg: 2.317 ± 0.061	1.895GlnSer: 1.895 ± 0.058	2.266GlnThr: 2.266 ± 0.056	2.42GlnVal: 2.42 ± 0.053	0.288GlnTrp: 0.288 ± 0.022	0.779GlnTyr: 0.779 ± 0.034	0.008GlnXaa: 0.008 ± 0.003
Arg	6.957ArgAla: 6.957 ± 0.118	0.653ArgCys: 0.653 ± 0.035	4.807ArgAsp: 4.807 ± 0.097	7.129ArgGlu: 7.129 ± 0.13	2.338ArgPhe: 2.338 ± 0.057	5.209ArgGly: 5.209 ± 0.098	1.409ArgHis: 1.409 ± 0.049	2.566ArgIle: 2.566 ± 0.06	1.177ArgLys: 1.177 ± 0.041	6.868ArgLeu: 6.868 ± 0.105	1.477ArgMet: 1.477 ± 0.045	1.731ArgAsn: 1.731 ± 0.049	3.15ArgPro: 3.15 ± 0.074	2.48ArgGln: 2.48 ± 0.068	6.095ArgArg: 6.095 ± 0.123	4.09ArgSer: 4.09 ± 0.078	4.505ArgThr: 4.505 ± 0.091	6.154ArgVal: 6.154 ± 0.089	0.839ArgTrp: 0.839 ± 0.036	1.972ArgTyr: 1.972 ± 0.055	0.044ArgXaa: 0.044 ± 0.008
Ser	5.317SerAla: 5.317 ± 0.086	0.401SerCys: 0.401 ± 0.026	4.174SerAsp: 4.174 ± 0.081	4.489SerGlu: 4.489 ± 0.093	1.989SerPhe: 1.989 ± 0.052	6.325SerGly: 6.325 ± 0.112	1.121SerHis: 1.121 ± 0.037	2.111SerIle: 2.111 ± 0.055	0.959SerLys: 0.959 ± 0.038	5.092SerLeu: 5.092 ± 0.098	1.086SerMet: 1.086 ± 0.038	1.555SerAsn: 1.555 ± 0.047	3.072SerPro: 3.072 ± 0.077	1.431SerGln: 1.431 ± 0.046	3.847SerArg: 3.847 ± 0.071	3.287SerSer: 3.287 ± 0.082	4.061SerThr: 4.061 ± 0.09	5.642SerVal: 5.642 ± 0.098	0.538SerTrp: 0.538 ± 0.028	1.458SerTyr: 1.458 ± 0.05	0.036SerXaa: 0.036 ± 0.007
Thr	7.697ThrAla: 7.697 ± 0.098	0.443ThrCys: 0.443 ± 0.026	6.296ThrAsp: 6.296 ± 0.097	5.349ThrGlu: 5.349 ± 0.102	1.929ThrPhe: 1.929 ± 0.054	7.785ThrGly: 7.785 ± 0.128	1.406ThrHis: 1.406 ± 0.041	2.246ThrIle: 2.246 ± 0.053	0.825ThrLys: 0.825 ± 0.036	6.144ThrLeu: 6.144 ± 0.099	0.937ThrMet: 0.937 ± 0.031	1.465ThrAsn: 1.465 ± 0.052	3.544ThrPro: 3.544 ± 0.066	1.612ThrGln: 1.612 ± 0.051	4.056ThrArg: 4.056 ± 0.096	3.077ThrSer: 3.077 ± 0.072	4.932ThrThr: 4.932 ± 0.101	8.84ThrVal: 8.84 ± 0.153	0.55ThrTrp: 0.55 ± 0.032	1.445ThrTyr: 1.445 ± 0.043	0.047ThrXaa: 0.047 ± 0.008
Val	9.531ValAla: 9.531 ± 0.146	0.88ValCys: 0.88 ± 0.04	7.579ValAsp: 7.579 ± 0.099	8.525ValGlu: 8.525 ± 0.12	2.754ValPhe: 2.754 ± 0.061	8.093ValGly: 8.093 ± 0.127	1.634ValHis: 1.634 ± 0.056	2.687ValIle: 2.687 ± 0.074	1.06ValLys: 1.06 ± 0.041	8.015ValLeu: 8.015 ± 0.138	1.288ValMet: 1.288 ± 0.041	1.879ValAsn: 1.879 ± 0.061	4.32ValPro: 4.32 ± 0.067	2.165ValGln: 2.165 ± 0.052	5.811ValArg: 5.811 ± 0.094	5.406ValSer: 5.406 ± 0.095	7.232ValThr: 7.232 ± 0.13	9.12ValVal: 9.12 ± 0.156	0.851ValTrp: 0.851 ± 0.029	2.079ValTyr: 2.079 ± 0.051	0.039ValXaa: 0.039 ± 0.007
Trp	0.82TrpAla: 0.82 ± 0.036	0.093TrpCys: 0.093 ± 0.012	0.576TrpAsp: 0.576 ± 0.031	0.769TrpGlu: 0.769 ± 0.033	0.335TrpPhe: 0.335 ± 0.019	0.701TrpGly: 0.701 ± 0.028	0.18TrpHis: 0.18 ± 0.015	0.297TrpIle: 0.297 ± 0.021	0.205TrpLys: 0.205 ± 0.016	1.138TrpLeu: 1.138 ± 0.047	0.21TrpMet: 0.21 ± 0.017	0.288TrpAsn: 0.288 ± 0.018	0.447TrpPro: 0.447 ± 0.025	0.392TrpGln: 0.392 ± 0.026	0.891TrpArg: 0.891 ± 0.034	0.62TrpSer: 0.62 ± 0.031	0.77TrpThr: 0.77 ± 0.034	0.873TrpVal: 0.873 ± 0.036	0.143TrpTrp: 0.143 ± 0.015	0.302TrpTyr: 0.302 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.255TyrAla: 2.255 ± 0.06	0.232TyrCys: 0.232 ± 0.017	2.171TyrAsp: 2.171 ± 0.06	2.208TyrGlu: 2.208 ± 0.056	0.653TyrPhe: 0.653 ± 0.029	2.042TyrGly: 2.042 ± 0.05	0.592TyrHis: 0.592 ± 0.029	0.815TyrIle: 0.815 ± 0.033	0.313TyrLys: 0.313 ± 0.023	2.192TyrLeu: 2.192 ± 0.059	0.321TyrMet: 0.321 ± 0.022	0.688TyrAsn: 0.688 ± 0.033	1.174TyrPro: 1.174 ± 0.04	0.637TyrGln: 0.637 ± 0.029	1.984TyrArg: 1.984 ± 0.054	1.242TyrSer: 1.242 ± 0.039	1.554TyrThr: 1.554 ± 0.045	1.774TyrVal: 1.774 ± 0.053	0.287TyrTrp: 0.287 ± 0.02	0.696TyrTyr: 0.696 ± 0.035	0.01TyrXaa: 0.01 ± 0.003
Xaa	0.043XaaAla: 0.043 ± 0.007	0.008XaaCys: 0.008 ± 0.003	0.039XaaAsp: 0.039 ± 0.008	0.021XaaGlu: 0.021 ± 0.005	0.007XaaPhe: 0.007 ± 0.003	0.047XaaGly: 0.047 ± 0.007	0.003XaaHis: 0.003 ± 0.002	0.008XaaIle: 0.008 ± 0.003	0.001XaaLys: 0.001 ± 0.001	0.038XaaLeu: 0.038 ± 0.007	0.012XaaMet: 0.012 ± 0.004	0.014XaaAsn: 0.014 ± 0.004	0.036XaaPro: 0.036 ± 0.007	0.007XaaGln: 0.007 ± 0.003	0.056XaaArg: 0.056 ± 0.009	0.043XaaSer: 0.043 ± 0.008	0.038XaaThr: 0.038 ± 0.008	0.034XaaVal: 0.034 ± 0.006	0.007XaaTrp: 0.007 ± 0.003	0.013XaaTyr: 0.013 ± 0.004	11.032XaaXaa: 11.032 ± 1.279

Statistics based on 3025 proteins (767293 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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