Amino acid dipepetide frequency for Salmonella phage SW5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.006AlaAla: 14.006 ± 2.043
1.053AlaCys: 1.053 ± 0.405
6.845AlaAsp: 6.845 ± 0.962
7.582AlaGlu: 7.582 ± 0.917
3.686AlaPhe: 3.686 ± 0.541
8.425AlaGly: 8.425 ± 1.001
1.474AlaHis: 1.474 ± 0.464
4.318AlaIle: 4.318 ± 0.514
4.528AlaLys: 4.528 ± 0.827
8.109AlaLeu: 8.109 ± 0.909
4.002AlaMet: 4.002 ± 0.703
4.739AlaAsn: 4.739 ± 0.618
3.896AlaPro: 3.896 ± 0.637
4.528AlaGln: 4.528 ± 0.625
4.423AlaArg: 4.423 ± 0.616
7.687AlaSer: 7.687 ± 0.656
6.003AlaThr: 6.003 ± 0.695
8.319AlaVal: 8.319 ± 0.744
2.001AlaTrp: 2.001 ± 0.565
3.159AlaTyr: 3.159 ± 0.689
0.0AlaXaa: 0.0 ± 0.0
Cys
0.842CysAla: 0.842 ± 0.323
0.105CysCys: 0.105 ± 0.095
0.737CysAsp: 0.737 ± 0.275
0.948CysGlu: 0.948 ± 0.321
0.105CysPhe: 0.105 ± 0.105
0.948CysGly: 0.948 ± 0.431
0.105CysHis: 0.105 ± 0.105
0.316CysIle: 0.316 ± 0.193
0.316CysLys: 0.316 ± 0.203
0.737CysLeu: 0.737 ± 0.315
0.0CysMet: 0.0 ± 0.0
0.316CysAsn: 0.316 ± 0.168
0.737CysPro: 0.737 ± 0.248
0.316CysGln: 0.316 ± 0.227
0.842CysArg: 0.842 ± 0.216
0.632CysSer: 0.632 ± 0.265
0.421CysThr: 0.421 ± 0.249
0.421CysVal: 0.421 ± 0.206
0.211CysTrp: 0.211 ± 0.136
0.105CysTyr: 0.105 ± 0.098
0.0CysXaa: 0.0 ± 0.0
Asp
6.424AspAla: 6.424 ± 0.777
0.421AspCys: 0.421 ± 0.246
2.527AspAsp: 2.527 ± 0.473
4.107AspGlu: 4.107 ± 0.679
2.317AspPhe: 2.317 ± 0.494
4.318AspGly: 4.318 ± 0.649
0.737AspHis: 0.737 ± 0.248
2.738AspIle: 2.738 ± 0.626
3.37AspLys: 3.37 ± 0.756
4.528AspLeu: 4.528 ± 0.61
1.58AspMet: 1.58 ± 0.32
1.79AspAsn: 1.79 ± 0.389
2.738AspPro: 2.738 ± 0.861
1.158AspGln: 1.158 ± 0.329
2.211AspArg: 2.211 ± 0.43
2.949AspSer: 2.949 ± 0.626
2.633AspThr: 2.633 ± 0.503
6.108AspVal: 6.108 ± 0.73
1.474AspTrp: 1.474 ± 0.414
2.211AspTyr: 2.211 ± 0.613
0.0AspXaa: 0.0 ± 0.0
Glu
5.476GluAla: 5.476 ± 0.765
0.527GluCys: 0.527 ± 0.29
3.265GluAsp: 3.265 ± 0.687
2.527GluGlu: 2.527 ± 0.509
2.527GluPhe: 2.527 ± 0.746
3.37GluGly: 3.37 ± 0.593
0.948GluHis: 0.948 ± 0.31
4.002GluIle: 4.002 ± 0.727
5.16GluLys: 5.16 ± 0.668
5.265GluLeu: 5.265 ± 0.845
2.422GluMet: 2.422 ± 0.646
2.527GluAsn: 2.527 ± 0.442
3.054GluPro: 3.054 ± 0.567
2.422GluGln: 2.422 ± 0.531
4.002GluArg: 4.002 ± 0.715
2.738GluSer: 2.738 ± 0.574
3.37GluThr: 3.37 ± 0.655
3.159GluVal: 3.159 ± 0.66
1.369GluTrp: 1.369 ± 0.431
1.58GluTyr: 1.58 ± 0.366
0.0GluXaa: 0.0 ± 0.0
Phe
4.844PheAla: 4.844 ± 0.961
0.527PheCys: 0.527 ± 0.242
2.001PheAsp: 2.001 ± 0.429
1.685PheGlu: 1.685 ± 0.399
1.369PhePhe: 1.369 ± 0.312
2.633PheGly: 2.633 ± 0.537
0.316PheHis: 0.316 ± 0.241
2.317PheIle: 2.317 ± 0.433
1.685PheLys: 1.685 ± 0.539
2.001PheLeu: 2.001 ± 0.45
0.948PheMet: 0.948 ± 0.312
2.527PheAsn: 2.527 ± 0.489
1.369PhePro: 1.369 ± 0.359
1.369PheGln: 1.369 ± 0.388
1.158PheArg: 1.158 ± 0.437
3.58PheSer: 3.58 ± 0.714
2.738PheThr: 2.738 ± 0.481
2.738PheVal: 2.738 ± 0.574
0.632PheTrp: 0.632 ± 0.25
0.421PheTyr: 0.421 ± 0.214
0.0PheXaa: 0.0 ± 0.0
Gly
6.424GlyAla: 6.424 ± 1.171
0.737GlyCys: 0.737 ± 0.268
4.949GlyAsp: 4.949 ± 0.641
4.318GlyGlu: 4.318 ± 0.638
2.527GlyPhe: 2.527 ± 0.576
4.739GlyGly: 4.739 ± 0.748
2.001GlyHis: 2.001 ± 0.323
4.107GlyIle: 4.107 ± 0.536
4.107GlyLys: 4.107 ± 0.641
6.108GlyLeu: 6.108 ± 0.755
1.369GlyMet: 1.369 ± 0.345
4.002GlyAsn: 4.002 ± 0.71
1.79GlyPro: 1.79 ± 0.345
3.37GlyGln: 3.37 ± 0.539
5.055GlyArg: 5.055 ± 0.757
4.318GlySer: 4.318 ± 0.779
4.002GlyThr: 4.002 ± 0.873
6.74GlyVal: 6.74 ± 0.993
1.474GlyTrp: 1.474 ± 0.406
2.949GlyTyr: 2.949 ± 0.512
0.0GlyXaa: 0.0 ± 0.0
His
1.158HisAla: 1.158 ± 0.369
0.211HisCys: 0.211 ± 0.147
1.053HisAsp: 1.053 ± 0.336
1.474HisGlu: 1.474 ± 0.346
0.948HisPhe: 0.948 ± 0.291
1.369HisGly: 1.369 ± 0.462
0.527HisHis: 0.527 ± 0.226
0.948HisIle: 0.948 ± 0.265
0.527HisLys: 0.527 ± 0.237
1.369HisLeu: 1.369 ± 0.373
0.211HisMet: 0.211 ± 0.184
0.527HisAsn: 0.527 ± 0.201
1.158HisPro: 1.158 ± 0.373
0.527HisGln: 0.527 ± 0.196
0.842HisArg: 0.842 ± 0.249
1.053HisSer: 1.053 ± 0.287
1.896HisThr: 1.896 ± 0.465
0.527HisVal: 0.527 ± 0.182
0.527HisTrp: 0.527 ± 0.188
0.211HisTyr: 0.211 ± 0.135
0.0HisXaa: 0.0 ± 0.0
Ile
6.213IleAla: 6.213 ± 0.841
0.421IleCys: 0.421 ± 0.236
3.686IleAsp: 3.686 ± 0.483
2.422IleGlu: 2.422 ± 0.559
1.58IlePhe: 1.58 ± 0.336
4.423IleGly: 4.423 ± 0.799
0.737IleHis: 0.737 ± 0.249
1.474IleIle: 1.474 ± 0.289
2.422IleLys: 2.422 ± 0.463
3.159IleLeu: 3.159 ± 0.761
1.158IleMet: 1.158 ± 0.296
2.843IleAsn: 2.843 ± 0.55
3.475IlePro: 3.475 ± 0.668
1.79IleGln: 1.79 ± 0.392
3.791IleArg: 3.791 ± 0.681
2.527IleSer: 2.527 ± 0.488
5.265IleThr: 5.265 ± 0.723
2.738IleVal: 2.738 ± 0.544
0.842IleTrp: 0.842 ± 0.24
1.685IleTyr: 1.685 ± 0.507
0.0IleXaa: 0.0 ± 0.0
Lys
5.687LysAla: 5.687 ± 0.648
0.211LysCys: 0.211 ± 0.143
2.527LysAsp: 2.527 ± 0.637
2.106LysGlu: 2.106 ± 0.556
2.106LysPhe: 2.106 ± 0.537
4.107LysGly: 4.107 ± 0.826
0.316LysHis: 0.316 ± 0.167
3.475LysIle: 3.475 ± 0.686
2.949LysLys: 2.949 ± 0.582
5.687LysLeu: 5.687 ± 1.088
2.106LysMet: 2.106 ± 0.344
2.422LysAsn: 2.422 ± 0.469
3.896LysPro: 3.896 ± 0.84
0.948LysGln: 0.948 ± 0.325
3.686LysArg: 3.686 ± 0.81
2.949LysSer: 2.949 ± 0.709
3.054LysThr: 3.054 ± 0.605
2.527LysVal: 2.527 ± 0.444
1.264LysTrp: 1.264 ± 0.478
1.474LysTyr: 1.474 ± 0.378
0.0LysXaa: 0.0 ± 0.0
Leu
9.688LeuAla: 9.688 ± 1.084
0.527LeuCys: 0.527 ± 0.229
4.423LeuAsp: 4.423 ± 0.551
3.054LeuGlu: 3.054 ± 0.64
2.317LeuPhe: 2.317 ± 0.434
6.318LeuGly: 6.318 ± 0.86
1.158LeuHis: 1.158 ± 0.314
4.528LeuIle: 4.528 ± 0.602
4.423LeuLys: 4.423 ± 0.915
8.319LeuLeu: 8.319 ± 1.119
2.527LeuMet: 2.527 ± 0.567
3.58LeuAsn: 3.58 ± 0.613
5.16LeuPro: 5.16 ± 0.651
2.527LeuGln: 2.527 ± 0.623
6.74LeuArg: 6.74 ± 0.997
5.371LeuSer: 5.371 ± 0.973
5.055LeuThr: 5.055 ± 0.699
5.055LeuVal: 5.055 ± 0.826
1.58LeuTrp: 1.58 ± 0.387
2.317LeuTyr: 2.317 ± 0.54
0.0LeuXaa: 0.0 ± 0.0
Met
2.738MetAla: 2.738 ± 0.697
0.105MetCys: 0.105 ± 0.101
1.474MetAsp: 1.474 ± 0.347
1.474MetGlu: 1.474 ± 0.313
0.948MetPhe: 0.948 ± 0.273
1.896MetGly: 1.896 ± 0.373
0.105MetHis: 0.105 ± 0.096
1.474MetIle: 1.474 ± 0.317
1.158MetLys: 1.158 ± 0.355
2.001MetLeu: 2.001 ± 0.355
0.737MetMet: 0.737 ± 0.319
1.369MetAsn: 1.369 ± 0.4
1.474MetPro: 1.474 ± 0.423
1.369MetGln: 1.369 ± 0.446
1.58MetArg: 1.58 ± 0.387
2.317MetSer: 2.317 ± 0.606
2.001MetThr: 2.001 ± 0.553
1.474MetVal: 1.474 ± 0.406
0.316MetTrp: 0.316 ± 0.207
0.421MetTyr: 0.421 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
5.476AsnAla: 5.476 ± 0.673
0.316AsnCys: 0.316 ± 0.23
2.317AsnAsp: 2.317 ± 0.459
2.843AsnGlu: 2.843 ± 0.692
1.264AsnPhe: 1.264 ± 0.313
4.423AsnGly: 4.423 ± 0.761
0.948AsnHis: 0.948 ± 0.397
3.159AsnIle: 3.159 ± 0.619
2.527AsnLys: 2.527 ± 0.568
2.633AsnLeu: 2.633 ± 0.652
1.264AsnMet: 1.264 ± 0.425
1.369AsnAsn: 1.369 ± 0.462
1.474AsnPro: 1.474 ± 0.405
1.896AsnGln: 1.896 ± 0.38
2.738AsnArg: 2.738 ± 0.599
1.79AsnSer: 1.79 ± 0.346
2.422AsnThr: 2.422 ± 0.485
2.633AsnVal: 2.633 ± 0.563
0.421AsnTrp: 0.421 ± 0.183
1.369AsnTyr: 1.369 ± 0.306
0.0AsnXaa: 0.0 ± 0.0
Pro
7.056ProAla: 7.056 ± 0.937
0.316ProCys: 0.316 ± 0.168
4.002ProAsp: 4.002 ± 0.524
3.791ProGlu: 3.791 ± 0.785
1.79ProPhe: 1.79 ± 0.495
3.58ProGly: 3.58 ± 0.587
1.053ProHis: 1.053 ± 0.305
1.79ProIle: 1.79 ± 0.443
2.317ProLys: 2.317 ± 0.503
3.896ProLeu: 3.896 ± 0.656
0.737ProMet: 0.737 ± 0.298
1.685ProAsn: 1.685 ± 0.465
2.633ProPro: 2.633 ± 0.565
0.842ProGln: 0.842 ± 0.334
3.159ProArg: 3.159 ± 0.666
2.527ProSer: 2.527 ± 0.424
1.79ProThr: 1.79 ± 0.379
3.791ProVal: 3.791 ± 0.678
0.632ProTrp: 0.632 ± 0.275
1.474ProTyr: 1.474 ± 0.366
0.0ProXaa: 0.0 ± 0.0
Gln
4.844GlnAla: 4.844 ± 0.832
0.316GlnCys: 0.316 ± 0.167
1.264GlnAsp: 1.264 ± 0.353
1.474GlnGlu: 1.474 ± 0.391
2.001GlnPhe: 2.001 ± 0.414
1.79GlnGly: 1.79 ± 0.389
0.527GlnHis: 0.527 ± 0.202
3.159GlnIle: 3.159 ± 0.674
1.58GlnLys: 1.58 ± 0.377
3.791GlnLeu: 3.791 ± 0.571
0.842GlnMet: 0.842 ± 0.409
1.053GlnAsn: 1.053 ± 0.292
2.001GlnPro: 2.001 ± 0.506
2.738GlnGln: 2.738 ± 0.617
2.738GlnArg: 2.738 ± 0.55
2.527GlnSer: 2.527 ± 0.583
2.001GlnThr: 2.001 ± 0.541
1.896GlnVal: 1.896 ± 0.364
0.316GlnTrp: 0.316 ± 0.176
0.632GlnTyr: 0.632 ± 0.248
0.0GlnXaa: 0.0 ± 0.0
Arg
5.055ArgAla: 5.055 ± 0.969
0.842ArgCys: 0.842 ± 0.309
2.633ArgAsp: 2.633 ± 0.558
4.949ArgGlu: 4.949 ± 1.004
2.422ArgPhe: 2.422 ± 0.472
3.054ArgGly: 3.054 ± 0.452
1.053ArgHis: 1.053 ± 0.391
3.159ArgIle: 3.159 ± 0.659
4.318ArgLys: 4.318 ± 0.807
7.372ArgLeu: 7.372 ± 0.949
1.474ArgMet: 1.474 ± 0.435
2.843ArgAsn: 2.843 ± 0.56
2.317ArgPro: 2.317 ± 0.434
3.58ArgGln: 3.58 ± 0.89
4.002ArgArg: 4.002 ± 0.755
2.738ArgSer: 2.738 ± 0.385
2.633ArgThr: 2.633 ± 0.519
3.37ArgVal: 3.37 ± 0.659
1.474ArgTrp: 1.474 ± 0.356
1.896ArgTyr: 1.896 ± 0.377
0.0ArgXaa: 0.0 ± 0.0
Ser
5.897SerAla: 5.897 ± 0.8
0.316SerCys: 0.316 ± 0.177
2.422SerAsp: 2.422 ± 0.385
3.791SerGlu: 3.791 ± 0.649
2.211SerPhe: 2.211 ± 0.379
6.845SerGly: 6.845 ± 0.868
1.474SerHis: 1.474 ± 0.369
2.211SerIle: 2.211 ± 0.62
4.002SerLys: 4.002 ± 0.653
5.16SerLeu: 5.16 ± 0.631
1.264SerMet: 1.264 ± 0.333
1.685SerAsn: 1.685 ± 0.373
3.265SerPro: 3.265 ± 0.623
2.211SerGln: 2.211 ± 0.429
4.107SerArg: 4.107 ± 0.602
2.106SerSer: 2.106 ± 0.425
2.738SerThr: 2.738 ± 0.594
3.791SerVal: 3.791 ± 0.664
1.053SerTrp: 1.053 ± 0.335
0.842SerTyr: 0.842 ± 0.259
0.0SerXaa: 0.0 ± 0.0
Thr
6.529ThrAla: 6.529 ± 0.758
0.737ThrCys: 0.737 ± 0.268
4.002ThrAsp: 4.002 ± 1.059
3.58ThrGlu: 3.58 ± 0.596
2.106ThrPhe: 2.106 ± 0.558
5.581ThrGly: 5.581 ± 0.685
1.264ThrHis: 1.264 ± 0.353
2.106ThrIle: 2.106 ± 0.45
2.211ThrLys: 2.211 ± 0.565
5.476ThrLeu: 5.476 ± 0.969
1.369ThrMet: 1.369 ± 0.378
2.211ThrAsn: 2.211 ± 0.463
3.686ThrPro: 3.686 ± 0.457
2.317ThrGln: 2.317 ± 0.539
3.686ThrArg: 3.686 ± 0.728
2.422ThrSer: 2.422 ± 0.478
3.37ThrThr: 3.37 ± 0.647
3.58ThrVal: 3.58 ± 0.649
0.842ThrTrp: 0.842 ± 0.308
2.001ThrTyr: 2.001 ± 0.386
0.0ThrXaa: 0.0 ± 0.0
Val
6.529ValAla: 6.529 ± 0.761
0.737ValCys: 0.737 ± 0.289
4.107ValAsp: 4.107 ± 0.584
5.055ValGlu: 5.055 ± 0.72
2.738ValPhe: 2.738 ± 0.655
4.212ValGly: 4.212 ± 0.713
1.158ValHis: 1.158 ± 0.31
3.475ValIle: 3.475 ± 0.701
4.318ValLys: 4.318 ± 0.51
4.739ValLeu: 4.739 ± 0.83
1.474ValMet: 1.474 ± 0.407
3.475ValAsn: 3.475 ± 0.55
2.527ValPro: 2.527 ± 0.534
1.474ValGln: 1.474 ± 0.372
2.738ValArg: 2.738 ± 0.653
4.002ValSer: 4.002 ± 0.454
5.055ValThr: 5.055 ± 1.134
4.423ValVal: 4.423 ± 0.869
1.474ValTrp: 1.474 ± 0.435
2.001ValTyr: 2.001 ± 0.322
0.0ValXaa: 0.0 ± 0.0
Trp
1.685TrpAla: 1.685 ± 0.534
0.105TrpCys: 0.105 ± 0.109
0.527TrpAsp: 0.527 ± 0.197
1.264TrpGlu: 1.264 ± 0.346
0.737TrpPhe: 0.737 ± 0.286
1.053TrpGly: 1.053 ± 0.274
0.316TrpHis: 0.316 ± 0.178
1.053TrpIle: 1.053 ± 0.288
0.632TrpLys: 0.632 ± 0.224
1.685TrpLeu: 1.685 ± 0.435
0.421TrpMet: 0.421 ± 0.226
0.632TrpAsn: 0.632 ± 0.313
1.474TrpPro: 1.474 ± 0.422
1.158TrpGln: 1.158 ± 0.326
1.896TrpArg: 1.896 ± 0.522
1.264TrpSer: 1.264 ± 0.344
1.158TrpThr: 1.158 ± 0.371
0.737TrpVal: 0.737 ± 0.25
0.211TrpTrp: 0.211 ± 0.141
0.737TrpTyr: 0.737 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.211TyrAla: 2.211 ± 0.372
0.632TyrCys: 0.632 ± 0.257
1.58TyrAsp: 1.58 ± 0.611
1.264TyrGlu: 1.264 ± 0.384
1.158TyrPhe: 1.158 ± 0.359
2.106TyrGly: 2.106 ± 0.422
0.842TyrHis: 0.842 ± 0.306
2.843TyrIle: 2.843 ± 0.618
0.948TyrLys: 0.948 ± 0.291
2.633TyrLeu: 2.633 ± 0.459
0.421TyrMet: 0.421 ± 0.186
1.685TyrAsn: 1.685 ± 0.453
0.737TyrPro: 0.737 ± 0.291
0.948TyrGln: 0.948 ± 0.322
1.79TyrArg: 1.79 ± 0.522
1.896TyrSer: 1.896 ± 0.464
1.474TyrThr: 1.474 ± 0.461
1.685TyrVal: 1.685 ± 0.445
0.632TyrTrp: 0.632 ± 0.233
0.527TyrTyr: 0.527 ± 0.22
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 38 proteins (9497 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski