Amino acid dipepetide frequency for Blueberry necrotic ring blotch virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.119AlaAla: 4.119 ± 0.944
0.727AlaCys: 0.727 ± 0.417
3.392AlaAsp: 3.392 ± 1.307
2.423AlaGlu: 2.423 ± 0.757
3.15AlaPhe: 3.15 ± 1.093
3.635AlaGly: 3.635 ± 0.73
0.969AlaHis: 0.969 ± 0.562
3.15AlaIle: 3.15 ± 0.683
3.15AlaLys: 3.15 ± 0.89
5.088AlaLeu: 5.088 ± 0.56
1.454AlaMet: 1.454 ± 0.357
2.665AlaAsn: 2.665 ± 0.96
3.15AlaPro: 3.15 ± 2.179
1.212AlaGln: 1.212 ± 0.582
2.423AlaArg: 2.423 ± 1.104
4.604AlaSer: 4.604 ± 1.419
2.423AlaThr: 2.423 ± 0.571
3.877AlaVal: 3.877 ± 0.561
0.485AlaTrp: 0.485 ± 0.328
2.665AlaTyr: 2.665 ± 0.556
0.0AlaXaa: 0.0 ± 0.0
Cys
1.212CysAla: 1.212 ± 0.891
0.0CysCys: 0.0 ± 0.0
0.969CysAsp: 0.969 ± 0.467
2.423CysGlu: 2.423 ± 0.945
1.454CysPhe: 1.454 ± 0.741
0.242CysGly: 0.242 ± 0.162
0.727CysHis: 0.727 ± 0.572
1.212CysIle: 1.212 ± 0.449
1.212CysLys: 1.212 ± 0.394
1.454CysLeu: 1.454 ± 0.543
1.696CysMet: 1.696 ± 0.432
0.727CysAsn: 0.727 ± 0.27
1.696CysPro: 1.696 ± 0.835
0.242CysGln: 0.242 ± 0.162
1.212CysArg: 1.212 ± 0.605
0.727CysSer: 0.727 ± 0.36
0.727CysThr: 0.727 ± 0.485
1.696CysVal: 1.696 ± 0.389
0.485CysTrp: 0.485 ± 0.328
0.727CysTyr: 0.727 ± 0.27
0.0CysXaa: 0.0 ± 0.0
Asp
3.392AspAla: 3.392 ± 0.937
0.969AspCys: 0.969 ± 0.31
2.665AspAsp: 2.665 ± 1.19
3.635AspGlu: 3.635 ± 0.688
3.635AspPhe: 3.635 ± 1.048
2.908AspGly: 2.908 ± 0.489
2.665AspHis: 2.665 ± 0.962
4.119AspIle: 4.119 ± 0.787
2.908AspLys: 2.908 ± 0.879
3.15AspLeu: 3.15 ± 0.596
1.212AspMet: 1.212 ± 0.421
2.423AspAsn: 2.423 ± 1.075
2.665AspPro: 2.665 ± 0.428
1.454AspGln: 1.454 ± 0.337
3.15AspArg: 3.15 ± 0.873
5.573AspSer: 5.573 ± 0.989
4.119AspThr: 4.119 ± 1.212
6.058AspVal: 6.058 ± 0.813
0.242AspTrp: 0.242 ± 0.212
2.181AspTyr: 2.181 ± 0.874
0.0AspXaa: 0.0 ± 0.0
Glu
2.181GluAla: 2.181 ± 0.918
1.938GluCys: 1.938 ± 0.679
3.635GluAsp: 3.635 ± 1.387
2.665GluGlu: 2.665 ± 0.72
2.423GluPhe: 2.423 ± 1.07
0.969GluGly: 0.969 ± 0.63
1.696GluHis: 1.696 ± 0.496
2.423GluIle: 2.423 ± 0.743
4.604GluLys: 4.604 ± 1.592
5.331GluLeu: 5.331 ± 1.119
0.727GluMet: 0.727 ± 0.36
0.727GluAsn: 0.727 ± 0.417
1.454GluPro: 1.454 ± 0.719
1.696GluGln: 1.696 ± 0.61
3.15GluArg: 3.15 ± 0.849
3.15GluSer: 3.15 ± 0.696
3.15GluThr: 3.15 ± 1.078
4.362GluVal: 4.362 ± 1.032
0.0GluTrp: 0.0 ± 0.0
2.908GluTyr: 2.908 ± 0.77
0.0GluXaa: 0.0 ± 0.0
Phe
2.665PheAla: 2.665 ± 0.785
1.454PheCys: 1.454 ± 0.356
3.15PheAsp: 3.15 ± 1.021
3.635PheGlu: 3.635 ± 1.481
3.15PhePhe: 3.15 ± 1.333
2.908PheGly: 2.908 ± 1.223
1.212PheHis: 1.212 ± 0.561
2.423PheIle: 2.423 ± 0.796
2.181PheLys: 2.181 ± 0.422
6.542PheLeu: 6.542 ± 1.504
0.727PheMet: 0.727 ± 0.273
1.938PheAsn: 1.938 ± 0.762
2.665PhePro: 2.665 ± 0.606
1.212PheGln: 1.212 ± 0.77
2.908PheArg: 2.908 ± 1.192
4.362PheSer: 4.362 ± 1.071
2.423PheThr: 2.423 ± 0.691
3.15PheVal: 3.15 ± 1.558
0.727PheTrp: 0.727 ± 0.468
1.938PheTyr: 1.938 ± 0.695
0.0PheXaa: 0.0 ± 0.0
Gly
2.423GlyAla: 2.423 ± 1.065
0.969GlyCys: 0.969 ± 0.406
2.908GlyAsp: 2.908 ± 0.662
1.696GlyGlu: 1.696 ± 0.61
2.423GlyPhe: 2.423 ± 0.484
1.454GlyGly: 1.454 ± 0.479
0.969GlyHis: 0.969 ± 1.068
2.665GlyIle: 2.665 ± 0.833
3.15GlyLys: 3.15 ± 1.004
3.392GlyLeu: 3.392 ± 0.744
0.485GlyMet: 0.485 ± 0.181
2.423GlyAsn: 2.423 ± 0.543
3.392GlyPro: 3.392 ± 1.334
0.727GlyGln: 0.727 ± 0.36
1.454GlyArg: 1.454 ± 0.481
4.604GlySer: 4.604 ± 0.616
2.908GlyThr: 2.908 ± 1.191
3.877GlyVal: 3.877 ± 1.462
0.242GlyTrp: 0.242 ± 0.162
0.969GlyTyr: 0.969 ± 0.32
0.0GlyXaa: 0.0 ± 0.0
His
2.181HisAla: 2.181 ± 1.157
1.212HisCys: 1.212 ± 0.428
1.212HisAsp: 1.212 ± 0.6
1.696HisGlu: 1.696 ± 0.67
1.696HisPhe: 1.696 ± 0.377
0.727HisGly: 0.727 ± 0.36
1.454HisHis: 1.454 ± 0.666
3.635HisIle: 3.635 ± 0.888
0.969HisLys: 0.969 ± 0.646
3.15HisLeu: 3.15 ± 1.124
0.485HisMet: 0.485 ± 0.577
1.454HisAsn: 1.454 ± 0.481
1.212HisPro: 1.212 ± 0.696
0.727HisGln: 0.727 ± 0.316
0.969HisArg: 0.969 ± 0.93
2.181HisSer: 2.181 ± 0.968
1.454HisThr: 1.454 ± 0.495
3.15HisVal: 3.15 ± 1.002
0.485HisTrp: 0.485 ± 0.395
1.696HisTyr: 1.696 ± 0.501
0.0HisXaa: 0.0 ± 0.0
Ile
3.15IleAla: 3.15 ± 0.958
1.212IleCys: 1.212 ± 0.561
4.604IleAsp: 4.604 ± 1.776
2.908IleGlu: 2.908 ± 0.489
2.665IlePhe: 2.665 ± 0.902
2.908IleGly: 2.908 ± 0.892
1.696IleHis: 1.696 ± 0.737
1.212IleIle: 1.212 ± 0.43
2.423IleLys: 2.423 ± 0.671
6.542IleLeu: 6.542 ± 2.403
0.727IleMet: 0.727 ± 0.476
2.908IleAsn: 2.908 ± 0.469
4.846IlePro: 4.846 ± 0.752
2.181IleGln: 2.181 ± 0.96
2.423IleArg: 2.423 ± 1.057
6.058IleSer: 6.058 ± 1.217
2.181IleThr: 2.181 ± 1.286
5.573IleVal: 5.573 ± 0.767
0.242IleTrp: 0.242 ± 0.162
2.665IleTyr: 2.665 ± 0.88
0.0IleXaa: 0.0 ± 0.0
Lys
1.212LysAla: 1.212 ± 0.582
1.938LysCys: 1.938 ± 0.756
4.362LysAsp: 4.362 ± 1.409
2.423LysGlu: 2.423 ± 0.76
4.362LysPhe: 4.362 ± 0.703
1.938LysGly: 1.938 ± 0.562
0.727LysHis: 0.727 ± 0.27
3.635LysIle: 3.635 ± 0.934
2.423LysLys: 2.423 ± 0.651
5.088LysLeu: 5.088 ± 0.713
0.969LysMet: 0.969 ± 0.438
3.635LysAsn: 3.635 ± 1.198
2.423LysPro: 2.423 ± 0.946
1.454LysGln: 1.454 ± 0.741
2.423LysArg: 2.423 ± 1.093
3.15LysSer: 3.15 ± 0.746
2.665LysThr: 2.665 ± 0.962
3.635LysVal: 3.635 ± 0.898
0.485LysTrp: 0.485 ± 0.323
4.604LysTyr: 4.604 ± 0.839
0.0LysXaa: 0.0 ± 0.0
Leu
4.362LeuAla: 4.362 ± 0.67
2.665LeuCys: 2.665 ± 0.728
4.846LeuAsp: 4.846 ± 1.058
3.392LeuGlu: 3.392 ± 0.571
3.392LeuPhe: 3.392 ± 0.688
3.15LeuGly: 3.15 ± 0.941
2.423LeuHis: 2.423 ± 1.008
2.665LeuIle: 2.665 ± 1.204
5.088LeuLys: 5.088 ± 1.717
8.965LeuLeu: 8.965 ± 2.282
2.423LeuMet: 2.423 ± 0.86
6.3LeuAsn: 6.3 ± 0.835
4.604LeuPro: 4.604 ± 0.561
2.665LeuGln: 2.665 ± 0.781
3.877LeuArg: 3.877 ± 0.906
9.692LeuSer: 9.692 ± 1.254
7.512LeuThr: 7.512 ± 0.955
8.723LeuVal: 8.723 ± 2.798
1.212LeuTrp: 1.212 ± 0.936
2.908LeuTyr: 2.908 ± 0.965
0.0LeuXaa: 0.0 ± 0.0
Met
0.969MetAla: 0.969 ± 0.367
0.485MetCys: 0.485 ± 0.181
1.696MetAsp: 1.696 ± 0.448
0.969MetGlu: 0.969 ± 0.562
0.242MetPhe: 0.242 ± 0.162
0.727MetGly: 0.727 ± 0.476
1.212MetHis: 1.212 ± 0.553
0.969MetIle: 0.969 ± 0.406
1.454MetLys: 1.454 ± 0.481
0.969MetLeu: 0.969 ± 0.238
0.485MetMet: 0.485 ± 0.181
0.485MetAsn: 0.485 ± 0.424
1.212MetPro: 1.212 ± 0.541
0.727MetGln: 0.727 ± 0.405
0.242MetArg: 0.242 ± 0.212
2.423MetSer: 2.423 ± 0.706
1.696MetThr: 1.696 ± 0.736
1.454MetVal: 1.454 ± 0.463
0.242MetTrp: 0.242 ± 0.162
1.454MetTyr: 1.454 ± 0.54
0.0MetXaa: 0.0 ± 0.0
Asn
2.181AsnAla: 2.181 ± 0.298
1.212AsnCys: 1.212 ± 0.988
1.938AsnAsp: 1.938 ± 0.48
2.423AsnGlu: 2.423 ± 1.112
2.181AsnPhe: 2.181 ± 0.748
1.696AsnGly: 1.696 ± 0.674
0.969AsnHis: 0.969 ± 0.362
2.908AsnIle: 2.908 ± 0.753
1.696AsnLys: 1.696 ± 0.444
5.088AsnLeu: 5.088 ± 0.9
1.696AsnMet: 1.696 ± 0.62
2.181AsnAsn: 2.181 ± 0.401
3.635AsnPro: 3.635 ± 0.639
0.727AsnGln: 0.727 ± 0.36
1.938AsnArg: 1.938 ± 0.626
5.088AsnSer: 5.088 ± 1.246
2.908AsnThr: 2.908 ± 0.66
3.877AsnVal: 3.877 ± 0.548
0.0AsnTrp: 0.0 ± 0.0
2.423AsnTyr: 2.423 ± 0.703
0.0AsnXaa: 0.0 ± 0.0
Pro
3.15ProAla: 3.15 ± 2.02
0.969ProCys: 0.969 ± 0.31
3.15ProAsp: 3.15 ± 1.365
2.908ProGlu: 2.908 ± 0.501
1.212ProPhe: 1.212 ± 0.677
2.423ProGly: 2.423 ± 0.697
1.454ProHis: 1.454 ± 0.424
4.119ProIle: 4.119 ± 0.523
1.938ProLys: 1.938 ± 0.604
5.815ProLeu: 5.815 ± 1.888
0.485ProMet: 0.485 ± 0.312
1.696ProAsn: 1.696 ± 0.628
2.181ProPro: 2.181 ± 1.54
1.454ProGln: 1.454 ± 0.814
4.119ProArg: 4.119 ± 0.655
4.119ProSer: 4.119 ± 1.387
3.877ProThr: 3.877 ± 1.413
5.815ProVal: 5.815 ± 1.85
0.242ProTrp: 0.242 ± 0.505
1.454ProTyr: 1.454 ± 0.986
0.0ProXaa: 0.0 ± 0.0
Gln
1.938GlnAla: 1.938 ± 0.366
1.212GlnCys: 1.212 ± 0.529
0.485GlnAsp: 0.485 ± 0.323
1.454GlnGlu: 1.454 ± 0.429
2.181GlnPhe: 2.181 ± 0.618
1.212GlnGly: 1.212 ± 0.315
0.727GlnHis: 0.727 ± 0.468
1.454GlnIle: 1.454 ± 0.543
1.454GlnLys: 1.454 ± 0.726
2.665GlnLeu: 2.665 ± 0.822
0.727GlnMet: 0.727 ± 0.27
1.938GlnAsn: 1.938 ± 0.955
0.969GlnPro: 0.969 ± 0.438
0.969GlnGln: 0.969 ± 0.31
2.181GlnArg: 2.181 ± 0.662
2.181GlnSer: 2.181 ± 0.605
0.485GlnThr: 0.485 ± 0.323
2.181GlnVal: 2.181 ± 0.71
0.0GlnTrp: 0.0 ± 0.0
1.212GlnTyr: 1.212 ± 0.38
0.0GlnXaa: 0.0 ± 0.0
Arg
4.119ArgAla: 4.119 ± 1.253
0.485ArgCys: 0.485 ± 0.312
3.392ArgAsp: 3.392 ± 0.788
1.454ArgGlu: 1.454 ± 0.543
3.392ArgPhe: 3.392 ± 1.237
1.696ArgGly: 1.696 ± 1.045
2.908ArgHis: 2.908 ± 0.583
4.362ArgIle: 4.362 ± 0.502
2.665ArgLys: 2.665 ± 1.156
4.604ArgLeu: 4.604 ± 0.642
0.485ArgMet: 0.485 ± 0.378
4.362ArgAsn: 4.362 ± 1.053
1.938ArgPro: 1.938 ± 1.03
0.969ArgGln: 0.969 ± 0.238
3.15ArgArg: 3.15 ± 1.076
1.696ArgSer: 1.696 ± 1.151
4.362ArgThr: 4.362 ± 0.736
4.362ArgVal: 4.362 ± 0.982
0.485ArgTrp: 0.485 ± 0.455
2.665ArgTyr: 2.665 ± 0.893
0.0ArgXaa: 0.0 ± 0.0
Ser
6.542SerAla: 6.542 ± 1.271
0.969SerCys: 0.969 ± 0.507
4.604SerAsp: 4.604 ± 1.719
2.665SerGlu: 2.665 ± 0.399
4.604SerPhe: 4.604 ± 0.665
5.088SerGly: 5.088 ± 0.848
2.908SerHis: 2.908 ± 0.31
5.331SerIle: 5.331 ± 1.092
5.331SerLys: 5.331 ± 1.221
5.815SerLeu: 5.815 ± 1.043
0.969SerMet: 0.969 ± 0.375
2.665SerAsn: 2.665 ± 0.991
3.392SerPro: 3.392 ± 0.836
2.665SerGln: 2.665 ± 0.295
4.846SerArg: 4.846 ± 1.233
10.177SerSer: 10.177 ± 2.201
4.362SerThr: 4.362 ± 1.128
7.512SerVal: 7.512 ± 1.802
0.485SerTrp: 0.485 ± 0.181
2.181SerTyr: 2.181 ± 0.541
0.0SerXaa: 0.0 ± 0.0
Thr
3.635ThrAla: 3.635 ± 0.665
0.242ThrCys: 0.242 ± 0.162
1.938ThrAsp: 1.938 ± 0.467
1.938ThrGlu: 1.938 ± 0.796
3.635ThrPhe: 3.635 ± 1.863
2.423ThrGly: 2.423 ± 0.768
3.15ThrHis: 3.15 ± 1.123
5.331ThrIle: 5.331 ± 2.199
2.665ThrLys: 2.665 ± 0.383
3.877ThrLeu: 3.877 ± 1.224
0.485ThrMet: 0.485 ± 0.181
2.181ThrAsn: 2.181 ± 0.442
4.362ThrPro: 4.362 ± 0.778
0.969ThrGln: 0.969 ± 0.406
4.604ThrArg: 4.604 ± 1.144
3.635ThrSer: 3.635 ± 1.04
4.119ThrThr: 4.119 ± 1.381
7.269ThrVal: 7.269 ± 0.915
0.727ThrTrp: 0.727 ± 0.323
2.423ThrTyr: 2.423 ± 0.455
0.0ThrXaa: 0.0 ± 0.0
Val
2.908ValAla: 2.908 ± 1.919
0.485ValCys: 0.485 ± 0.323
5.815ValAsp: 5.815 ± 1.457
5.573ValGlu: 5.573 ± 1.392
3.392ValPhe: 3.392 ± 1.003
4.604ValGly: 4.604 ± 1.24
2.665ValHis: 2.665 ± 0.911
4.362ValIle: 4.362 ± 1.789
5.815ValLys: 5.815 ± 1.261
8.965ValLeu: 8.965 ± 1.916
2.181ValMet: 2.181 ± 0.412
3.15ValAsn: 3.15 ± 0.798
5.088ValPro: 5.088 ± 1.56
3.635ValGln: 3.635 ± 0.805
4.604ValArg: 4.604 ± 0.805
6.3ValSer: 6.3 ± 1.332
6.3ValThr: 6.3 ± 1.678
10.661ValVal: 10.661 ± 2.995
0.242ValTrp: 0.242 ± 0.162
4.846ValTyr: 4.846 ± 1.398
0.0ValXaa: 0.0 ± 0.0
Trp
0.242TrpAla: 0.242 ± 0.162
0.0TrpCys: 0.0 ± 0.0
0.242TrpAsp: 0.242 ± 0.28
0.485TrpGlu: 0.485 ± 0.181
0.242TrpPhe: 0.242 ± 0.505
0.485TrpGly: 0.485 ± 0.323
0.0TrpHis: 0.0 ± 0.0
0.242TrpIle: 0.242 ± 0.162
0.485TrpLys: 0.485 ± 0.181
0.242TrpLeu: 0.242 ± 0.28
0.727TrpMet: 0.727 ± 0.756
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.242TrpGln: 0.242 ± 0.339
1.212TrpArg: 1.212 ± 0.456
0.242TrpSer: 0.242 ± 0.162
0.0TrpThr: 0.0 ± 0.0
1.696TrpVal: 1.696 ± 0.495
0.0TrpTrp: 0.0 ± 0.0
0.485TrpTyr: 0.485 ± 0.312
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.181TyrAla: 2.181 ± 0.605
1.696TyrCys: 1.696 ± 0.596
4.119TyrAsp: 4.119 ± 0.523
2.423TyrGlu: 2.423 ± 0.512
1.938TyrPhe: 1.938 ± 0.486
1.938TyrGly: 1.938 ± 0.598
1.212TyrHis: 1.212 ± 0.529
2.908TyrIle: 2.908 ± 1.35
1.938TyrLys: 1.938 ± 1.117
4.119TyrLeu: 4.119 ± 1.053
0.727TyrMet: 0.727 ± 0.27
2.908TyrAsn: 2.908 ± 0.774
1.938TyrPro: 1.938 ± 0.724
1.696TyrGln: 1.696 ± 0.516
2.665TyrArg: 2.665 ± 0.709
3.15TyrSer: 3.15 ± 0.525
1.938TyrThr: 1.938 ± 1.025
2.665TyrVal: 2.665 ± 1.015
0.242TyrTrp: 0.242 ± 0.404
1.696TyrTyr: 1.696 ± 0.526
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4128 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski