Amino acid dipepetide frequency for Mycobacterium phage Zerg

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.841AlaAla: 13.841 ± 1.96
1.244AlaCys: 1.244 ± 0.299
6.758AlaAsp: 6.758 ± 0.671
7.083AlaGlu: 7.083 ± 0.735
2.811AlaPhe: 2.811 ± 0.406
9.57AlaGly: 9.57 ± 1.437
2.595AlaHis: 2.595 ± 0.371
4.433AlaIle: 4.433 ± 0.543
4.379AlaLys: 4.379 ± 0.425
7.84AlaLeu: 7.84 ± 0.806
2.054AlaMet: 2.054 ± 0.328
2.811AlaAsn: 2.811 ± 0.425
5.136AlaPro: 5.136 ± 0.492
3.406AlaGln: 3.406 ± 0.514
7.191AlaArg: 7.191 ± 0.78
5.082AlaSer: 5.082 ± 0.658
5.731AlaThr: 5.731 ± 0.456
6.92AlaVal: 6.92 ± 0.651
2.433AlaTrp: 2.433 ± 0.411
2.433AlaTyr: 2.433 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.973CysAla: 0.973 ± 0.288
0.054CysCys: 0.054 ± 0.063
1.46CysAsp: 1.46 ± 0.36
0.973CysGlu: 0.973 ± 0.238
0.216CysPhe: 0.216 ± 0.106
1.784CysGly: 1.784 ± 0.438
0.324CysHis: 0.324 ± 0.134
0.054CysIle: 0.054 ± 0.053
0.433CysLys: 0.433 ± 0.16
0.649CysLeu: 0.649 ± 0.243
0.216CysMet: 0.216 ± 0.139
0.324CysAsn: 0.324 ± 0.134
1.189CysPro: 1.189 ± 0.26
0.433CysGln: 0.433 ± 0.151
0.811CysArg: 0.811 ± 0.24
0.919CysSer: 0.919 ± 0.321
0.919CysThr: 0.919 ± 0.249
0.811CysVal: 0.811 ± 0.171
0.378CysTrp: 0.378 ± 0.132
0.27CysTyr: 0.27 ± 0.117
0.0CysXaa: 0.0 ± 0.0
Asp
6.974AspAla: 6.974 ± 0.705
0.919AspCys: 0.919 ± 0.218
4.325AspAsp: 4.325 ± 0.525
3.893AspGlu: 3.893 ± 0.484
1.622AspPhe: 1.622 ± 0.238
6.163AspGly: 6.163 ± 0.536
1.406AspHis: 1.406 ± 0.292
2.109AspIle: 2.109 ± 0.338
1.73AspLys: 1.73 ± 0.277
6.055AspLeu: 6.055 ± 0.484
1.081AspMet: 1.081 ± 0.288
1.784AspAsn: 1.784 ± 0.347
4.487AspPro: 4.487 ± 0.548
2.379AspGln: 2.379 ± 0.32
4.866AspArg: 4.866 ± 0.557
3.136AspSer: 3.136 ± 0.509
4.217AspThr: 4.217 ± 0.507
4.325AspVal: 4.325 ± 0.526
1.514AspTrp: 1.514 ± 0.23
1.838AspTyr: 1.838 ± 0.324
0.0AspXaa: 0.0 ± 0.0
Glu
6.866GluAla: 6.866 ± 0.719
0.811GluCys: 0.811 ± 0.24
2.703GluAsp: 2.703 ± 0.364
2.811GluGlu: 2.811 ± 0.523
2.109GluPhe: 2.109 ± 0.331
3.676GluGly: 3.676 ± 0.428
1.838GluHis: 1.838 ± 0.359
2.325GluIle: 2.325 ± 0.329
1.946GluLys: 1.946 ± 0.323
6.055GluLeu: 6.055 ± 0.594
1.514GluMet: 1.514 ± 0.299
1.838GluAsn: 1.838 ± 0.293
3.406GluPro: 3.406 ± 0.587
2.703GluGln: 2.703 ± 0.359
5.298GluArg: 5.298 ± 0.688
2.703GluSer: 2.703 ± 0.431
4.433GluThr: 4.433 ± 0.628
3.676GluVal: 3.676 ± 0.489
1.46GluTrp: 1.46 ± 0.34
1.784GluTyr: 1.784 ± 0.339
0.0GluXaa: 0.0 ± 0.0
Phe
3.028PheAla: 3.028 ± 0.378
0.216PheCys: 0.216 ± 0.109
2.649PheAsp: 2.649 ± 0.454
1.676PheGlu: 1.676 ± 0.284
0.973PhePhe: 0.973 ± 0.266
3.136PheGly: 3.136 ± 0.606
0.757PheHis: 0.757 ± 0.215
1.568PheIle: 1.568 ± 0.384
1.298PheLys: 1.298 ± 0.272
1.568PheLeu: 1.568 ± 0.222
0.703PheMet: 0.703 ± 0.205
1.244PheAsn: 1.244 ± 0.351
1.568PhePro: 1.568 ± 0.303
1.298PheGln: 1.298 ± 0.279
1.298PheArg: 1.298 ± 0.261
1.784PheSer: 1.784 ± 0.327
2.487PheThr: 2.487 ± 0.383
2.271PheVal: 2.271 ± 0.323
0.703PheTrp: 0.703 ± 0.194
0.865PheTyr: 0.865 ± 0.253
0.0PheXaa: 0.0 ± 0.0
Gly
8.434GlyAla: 8.434 ± 1.322
1.244GlyCys: 1.244 ± 0.297
5.623GlyAsp: 5.623 ± 0.519
4.542GlyGlu: 4.542 ± 0.51
2.703GlyPhe: 2.703 ± 0.474
10.651GlyGly: 10.651 ± 2.125
1.838GlyHis: 1.838 ± 0.31
4.163GlyIle: 4.163 ± 0.532
2.649GlyLys: 2.649 ± 0.398
6.055GlyLeu: 6.055 ± 0.464
2.217GlyMet: 2.217 ± 0.419
3.028GlyAsn: 3.028 ± 0.423
4.055GlyPro: 4.055 ± 0.532
2.541GlyGln: 2.541 ± 0.502
5.19GlyArg: 5.19 ± 0.625
6.055GlySer: 6.055 ± 0.854
5.947GlyThr: 5.947 ± 0.81
6.488GlyVal: 6.488 ± 0.733
2.433GlyTrp: 2.433 ± 0.361
2.379GlyTyr: 2.379 ± 0.454
0.0GlyXaa: 0.0 ± 0.0
His
1.946HisAla: 1.946 ± 0.327
0.433HisCys: 0.433 ± 0.189
0.865HisAsp: 0.865 ± 0.223
1.568HisGlu: 1.568 ± 0.294
0.595HisPhe: 0.595 ± 0.135
1.784HisGly: 1.784 ± 0.268
0.973HisHis: 0.973 ± 0.29
1.46HisIle: 1.46 ± 0.306
1.027HisLys: 1.027 ± 0.261
1.514HisLeu: 1.514 ± 0.298
0.378HisMet: 0.378 ± 0.105
1.027HisAsn: 1.027 ± 0.219
1.298HisPro: 1.298 ± 0.227
0.811HisGln: 0.811 ± 0.238
2.109HisArg: 2.109 ± 0.381
1.027HisSer: 1.027 ± 0.207
1.298HisThr: 1.298 ± 0.304
1.892HisVal: 1.892 ± 0.409
0.595HisTrp: 0.595 ± 0.175
0.973HisTyr: 0.973 ± 0.201
0.0HisXaa: 0.0 ± 0.0
Ile
4.812IleAla: 4.812 ± 0.575
0.541IleCys: 0.541 ± 0.203
3.46IleAsp: 3.46 ± 0.488
3.298IleGlu: 3.298 ± 0.344
0.757IlePhe: 0.757 ± 0.192
4.001IleGly: 4.001 ± 0.494
1.568IleHis: 1.568 ± 0.325
1.46IleIle: 1.46 ± 0.271
1.244IleLys: 1.244 ± 0.25
2.163IleLeu: 2.163 ± 0.35
0.378IleMet: 0.378 ± 0.124
2.054IleAsn: 2.054 ± 0.302
2.649IlePro: 2.649 ± 0.339
1.568IleGln: 1.568 ± 0.278
2.379IleArg: 2.379 ± 0.393
2.325IleSer: 2.325 ± 0.492
3.406IleThr: 3.406 ± 0.409
3.406IleVal: 3.406 ± 0.384
1.027IleTrp: 1.027 ± 0.259
0.919IleTyr: 0.919 ± 0.182
0.0IleXaa: 0.0 ± 0.0
Lys
3.622LysAla: 3.622 ± 0.5
0.378LysCys: 0.378 ± 0.141
2.054LysAsp: 2.054 ± 0.317
1.352LysGlu: 1.352 ± 0.252
1.189LysPhe: 1.189 ± 0.201
2.487LysGly: 2.487 ± 0.359
1.244LysHis: 1.244 ± 0.311
0.973LysIle: 0.973 ± 0.236
1.298LysLys: 1.298 ± 0.376
2.487LysLeu: 2.487 ± 0.471
0.757LysMet: 0.757 ± 0.174
0.919LysAsn: 0.919 ± 0.213
2.487LysPro: 2.487 ± 0.386
1.514LysGln: 1.514 ± 0.226
2.649LysArg: 2.649 ± 0.521
2.109LysSer: 2.109 ± 0.317
2.0LysThr: 2.0 ± 0.337
2.541LysVal: 2.541 ± 0.373
0.865LysTrp: 0.865 ± 0.199
0.973LysTyr: 0.973 ± 0.215
0.0LysXaa: 0.0 ± 0.0
Leu
7.731LeuAla: 7.731 ± 0.888
0.595LeuCys: 0.595 ± 0.171
4.65LeuAsp: 4.65 ± 0.46
4.217LeuGlu: 4.217 ± 0.483
2.649LeuPhe: 2.649 ± 0.338
5.461LeuGly: 5.461 ± 0.567
0.973LeuHis: 0.973 ± 0.188
3.028LeuIle: 3.028 ± 0.503
2.163LeuLys: 2.163 ± 0.346
4.812LeuLeu: 4.812 ± 0.627
1.406LeuMet: 1.406 ± 0.264
2.703LeuAsn: 2.703 ± 0.378
5.298LeuPro: 5.298 ± 0.56
3.082LeuGln: 3.082 ± 0.469
5.028LeuArg: 5.028 ± 0.633
5.136LeuSer: 5.136 ± 0.489
5.569LeuThr: 5.569 ± 0.588
4.866LeuVal: 4.866 ± 0.483
1.244LeuTrp: 1.244 ± 0.308
2.325LeuTyr: 2.325 ± 0.392
0.0LeuXaa: 0.0 ± 0.0
Met
2.217MetAla: 2.217 ± 0.357
0.216MetCys: 0.216 ± 0.129
1.352MetAsp: 1.352 ± 0.277
0.757MetGlu: 0.757 ± 0.195
0.541MetPhe: 0.541 ± 0.21
1.838MetGly: 1.838 ± 0.264
0.162MetHis: 0.162 ± 0.098
1.081MetIle: 1.081 ± 0.247
0.649MetLys: 0.649 ± 0.175
1.73MetLeu: 1.73 ± 0.262
0.487MetMet: 0.487 ± 0.201
0.811MetAsn: 0.811 ± 0.194
1.135MetPro: 1.135 ± 0.26
0.487MetGln: 0.487 ± 0.136
1.298MetArg: 1.298 ± 0.273
2.811MetSer: 2.811 ± 0.385
2.163MetThr: 2.163 ± 0.288
1.352MetVal: 1.352 ± 0.32
0.378MetTrp: 0.378 ± 0.138
0.27MetTyr: 0.27 ± 0.11
0.0MetXaa: 0.0 ± 0.0
Asn
3.676AsnAla: 3.676 ± 0.436
0.216AsnCys: 0.216 ± 0.108
1.784AsnAsp: 1.784 ± 0.307
1.73AsnGlu: 1.73 ± 0.322
0.811AsnPhe: 0.811 ± 0.254
4.271AsnGly: 4.271 ± 0.629
0.811AsnHis: 0.811 ± 0.141
1.622AsnIle: 1.622 ± 0.388
0.973AsnLys: 0.973 ± 0.22
2.271AsnLeu: 2.271 ± 0.394
0.703AsnMet: 0.703 ± 0.187
1.784AsnAsn: 1.784 ± 0.401
3.136AsnPro: 3.136 ± 0.344
1.081AsnGln: 1.081 ± 0.269
2.487AsnArg: 2.487 ± 0.429
1.46AsnSer: 1.46 ± 0.298
2.163AsnThr: 2.163 ± 0.274
2.0AsnVal: 2.0 ± 0.333
0.595AsnTrp: 0.595 ± 0.149
0.757AsnTyr: 0.757 ± 0.181
0.0AsnXaa: 0.0 ± 0.0
Pro
5.461ProAla: 5.461 ± 0.683
0.811ProCys: 0.811 ± 0.27
4.325ProAsp: 4.325 ± 0.479
4.65ProGlu: 4.65 ± 0.513
2.163ProPhe: 2.163 ± 0.35
6.109ProGly: 6.109 ± 0.722
1.46ProHis: 1.46 ± 0.26
2.054ProIle: 2.054 ± 0.311
2.325ProLys: 2.325 ± 0.369
4.433ProLeu: 4.433 ± 0.546
1.352ProMet: 1.352 ± 0.28
1.946ProAsn: 1.946 ± 0.296
4.163ProPro: 4.163 ± 0.591
2.379ProGln: 2.379 ± 0.362
3.028ProArg: 3.028 ± 0.535
3.028ProSer: 3.028 ± 0.446
3.19ProThr: 3.19 ± 0.465
4.596ProVal: 4.596 ± 0.564
1.189ProTrp: 1.189 ± 0.209
1.514ProTyr: 1.514 ± 0.234
0.0ProXaa: 0.0 ± 0.0
Gln
3.893GlnAla: 3.893 ± 0.518
0.541GlnCys: 0.541 ± 0.228
1.406GlnAsp: 1.406 ± 0.278
1.676GlnGlu: 1.676 ± 0.322
1.298GlnPhe: 1.298 ± 0.178
2.595GlnGly: 2.595 ± 0.433
1.135GlnHis: 1.135 ± 0.264
1.838GlnIle: 1.838 ± 0.335
1.244GlnLys: 1.244 ± 0.213
2.974GlnLeu: 2.974 ± 0.389
0.757GlnMet: 0.757 ± 0.238
0.865GlnAsn: 0.865 ± 0.231
2.217GlnPro: 2.217 ± 0.459
1.189GlnGln: 1.189 ± 0.26
2.811GlnArg: 2.811 ± 0.462
2.433GlnSer: 2.433 ± 0.363
1.73GlnThr: 1.73 ± 0.361
2.541GlnVal: 2.541 ± 0.363
0.811GlnTrp: 0.811 ± 0.183
0.865GlnTyr: 0.865 ± 0.249
0.0GlnXaa: 0.0 ± 0.0
Arg
7.245ArgAla: 7.245 ± 0.664
1.081ArgCys: 1.081 ± 0.334
5.028ArgAsp: 5.028 ± 0.624
5.028ArgGlu: 5.028 ± 0.651
2.271ArgPhe: 2.271 ± 0.389
3.893ArgGly: 3.893 ± 0.41
1.406ArgHis: 1.406 ± 0.339
4.163ArgIle: 4.163 ± 0.618
2.271ArgLys: 2.271 ± 0.387
4.974ArgLeu: 4.974 ± 0.601
2.595ArgMet: 2.595 ± 0.377
2.379ArgAsn: 2.379 ± 0.4
3.352ArgPro: 3.352 ± 0.453
1.784ArgGln: 1.784 ± 0.314
5.947ArgArg: 5.947 ± 0.953
4.055ArgSer: 4.055 ± 0.463
3.19ArgThr: 3.19 ± 0.558
4.596ArgVal: 4.596 ± 0.541
2.054ArgTrp: 2.054 ± 0.336
1.946ArgTyr: 1.946 ± 0.326
0.0ArgXaa: 0.0 ± 0.0
Ser
5.136SerAla: 5.136 ± 0.622
0.703SerCys: 0.703 ± 0.251
4.001SerAsp: 4.001 ± 0.49
2.92SerGlu: 2.92 ± 0.394
2.054SerPhe: 2.054 ± 0.435
5.893SerGly: 5.893 ± 0.882
1.081SerHis: 1.081 ± 0.221
2.92SerIle: 2.92 ± 0.33
2.325SerLys: 2.325 ± 0.362
4.055SerLeu: 4.055 ± 0.468
1.298SerMet: 1.298 ± 0.28
2.595SerAsn: 2.595 ± 0.502
3.19SerPro: 3.19 ± 0.395
1.622SerGln: 1.622 ± 0.262
3.352SerArg: 3.352 ± 0.415
3.676SerSer: 3.676 ± 0.598
3.46SerThr: 3.46 ± 0.51
4.704SerVal: 4.704 ± 0.798
1.135SerTrp: 1.135 ± 0.228
1.46SerTyr: 1.46 ± 0.279
0.0SerXaa: 0.0 ± 0.0
Thr
6.272ThrAla: 6.272 ± 0.629
0.865ThrCys: 0.865 ± 0.305
4.217ThrAsp: 4.217 ± 0.646
4.001ThrGlu: 4.001 ± 0.439
2.109ThrPhe: 2.109 ± 0.35
6.434ThrGly: 6.434 ± 0.743
1.622ThrHis: 1.622 ± 0.336
3.298ThrIle: 3.298 ± 0.46
1.892ThrLys: 1.892 ± 0.338
4.109ThrLeu: 4.109 ± 0.489
1.244ThrMet: 1.244 ± 0.27
2.379ThrAsn: 2.379 ± 0.374
4.542ThrPro: 4.542 ± 0.672
1.73ThrGln: 1.73 ± 0.261
4.055ThrArg: 4.055 ± 0.496
3.46ThrSer: 3.46 ± 0.428
4.866ThrThr: 4.866 ± 0.821
5.839ThrVal: 5.839 ± 0.524
0.973ThrTrp: 0.973 ± 0.235
1.676ThrTyr: 1.676 ± 0.305
0.0ThrXaa: 0.0 ± 0.0
Val
7.137ValAla: 7.137 ± 0.663
1.46ValCys: 1.46 ± 0.302
5.136ValAsp: 5.136 ± 0.583
4.812ValGlu: 4.812 ± 0.611
2.757ValPhe: 2.757 ± 0.497
5.407ValGly: 5.407 ± 0.695
1.352ValHis: 1.352 ± 0.277
2.757ValIle: 2.757 ± 0.376
2.703ValLys: 2.703 ± 0.363
5.407ValLeu: 5.407 ± 0.523
1.298ValMet: 1.298 ± 0.238
2.217ValAsn: 2.217 ± 0.368
4.271ValPro: 4.271 ± 0.414
2.974ValGln: 2.974 ± 0.339
5.028ValArg: 5.028 ± 0.619
4.163ValSer: 4.163 ± 0.781
5.298ValThr: 5.298 ± 0.624
6.218ValVal: 6.218 ± 0.61
1.568ValTrp: 1.568 ± 0.293
1.244ValTyr: 1.244 ± 0.262
0.0ValXaa: 0.0 ± 0.0
Trp
2.054TrpAla: 2.054 ± 0.3
0.378TrpCys: 0.378 ± 0.153
1.135TrpAsp: 1.135 ± 0.253
1.135TrpGlu: 1.135 ± 0.318
0.595TrpPhe: 0.595 ± 0.152
0.973TrpGly: 0.973 ± 0.234
0.811TrpHis: 0.811 ± 0.203
1.027TrpIle: 1.027 ± 0.223
0.811TrpLys: 0.811 ± 0.165
1.784TrpLeu: 1.784 ± 0.328
1.027TrpMet: 1.027 ± 0.272
0.649TrpAsn: 0.649 ± 0.229
1.298TrpPro: 1.298 ± 0.276
1.027TrpGln: 1.027 ± 0.269
2.109TrpArg: 2.109 ± 0.403
1.244TrpSer: 1.244 ± 0.271
1.676TrpThr: 1.676 ± 0.348
1.784TrpVal: 1.784 ± 0.425
0.865TrpTrp: 0.865 ± 0.208
0.487TrpTyr: 0.487 ± 0.181
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.433TyrAla: 2.433 ± 0.384
0.487TyrCys: 0.487 ± 0.198
1.892TyrAsp: 1.892 ± 0.394
1.838TyrGlu: 1.838 ± 0.334
0.865TyrPhe: 0.865 ± 0.212
2.109TyrGly: 2.109 ± 0.404
0.216TyrHis: 0.216 ± 0.087
1.081TyrIle: 1.081 ± 0.197
0.541TyrLys: 0.541 ± 0.176
2.0TyrLeu: 2.0 ± 0.31
0.216TyrMet: 0.216 ± 0.099
0.973TyrAsn: 0.973 ± 0.225
1.298TyrPro: 1.298 ± 0.215
0.811TyrGln: 0.811 ± 0.184
2.325TyrArg: 2.325 ± 0.365
0.973TyrSer: 0.973 ± 0.24
1.892TyrThr: 1.892 ± 0.364
2.379TyrVal: 2.379 ± 0.297
0.649TyrTrp: 0.649 ± 0.157
0.595TyrTyr: 0.595 ± 0.143
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 104 proteins (18497 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski