Amino acid dipepetide frequency for Adelie penguin polyomavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.483AlaAla: 13.483 ± 6.273
0.0AlaCys: 0.0 ± 0.0
1.685AlaAsp: 1.685 ± 0.854
6.18AlaGlu: 6.18 ± 1.711
1.124AlaPhe: 1.124 ± 0.554
4.494AlaGly: 4.494 ± 2.743
0.0AlaHis: 0.0 ± 0.0
6.742AlaIle: 6.742 ± 3.012
5.056AlaLys: 5.056 ± 1.319
10.112AlaLeu: 10.112 ± 2.158
1.685AlaMet: 1.685 ± 0.854
2.809AlaAsn: 2.809 ± 0.901
3.371AlaPro: 3.371 ± 1.324
3.933AlaGln: 3.933 ± 1.924
6.18AlaArg: 6.18 ± 1.626
3.371AlaSer: 3.371 ± 1.22
5.056AlaThr: 5.056 ± 1.188
6.18AlaVal: 6.18 ± 2.298
0.0AlaTrp: 0.0 ± 0.0
3.933AlaTyr: 3.933 ± 2.005
0.0AlaXaa: 0.0 ± 0.0
Cys
1.685CysAla: 1.685 ± 0.757
0.0CysCys: 0.0 ± 0.0
0.562CysAsp: 0.562 ± 0.396
1.124CysGlu: 1.124 ± 0.732
1.124CysPhe: 1.124 ± 0.793
0.562CysGly: 0.562 ± 0.396
1.124CysHis: 1.124 ± 0.497
0.562CysIle: 0.562 ± 0.396
1.124CysLys: 1.124 ± 0.497
0.562CysLeu: 0.562 ± 0.396
1.124CysMet: 1.124 ± 0.793
0.0CysAsn: 0.0 ± 0.0
2.247CysPro: 2.247 ± 1.185
1.124CysGln: 1.124 ± 0.793
1.685CysArg: 1.685 ± 0.901
0.0CysSer: 0.0 ± 0.0
1.685CysThr: 1.685 ± 0.757
0.562CysVal: 0.562 ± 0.396
0.562CysTrp: 0.562 ± 0.484
1.685CysTyr: 1.685 ± 0.897
0.0CysXaa: 0.0 ± 0.0
Asp
3.371AspAla: 3.371 ± 0.646
2.247AspCys: 2.247 ± 1.585
4.494AspAsp: 4.494 ± 1.966
2.247AspGlu: 2.247 ± 0.83
0.0AspPhe: 0.0 ± 0.0
4.494AspGly: 4.494 ± 0.976
1.124AspHis: 1.124 ± 0.793
1.124AspIle: 1.124 ± 0.497
1.124AspLys: 1.124 ± 0.732
4.494AspLeu: 4.494 ± 1.371
1.685AspMet: 1.685 ± 0.51
1.124AspAsn: 1.124 ± 0.968
8.989AspPro: 8.989 ± 1.76
1.685AspGln: 1.685 ± 0.901
4.494AspArg: 4.494 ± 1.386
5.056AspSer: 5.056 ± 1.392
5.618AspThr: 5.618 ± 2.962
3.933AspVal: 3.933 ± 0.442
1.124AspTrp: 1.124 ± 0.83
2.809AspTyr: 2.809 ± 1.432
0.0AspXaa: 0.0 ± 0.0
Glu
9.551GluAla: 9.551 ± 3.624
1.124GluCys: 1.124 ± 0.968
3.933GluAsp: 3.933 ± 1.664
9.551GluGlu: 9.551 ± 3.351
2.247GluPhe: 2.247 ± 0.807
2.809GluGly: 2.809 ± 0.965
0.0GluHis: 0.0 ± 0.0
3.371GluIle: 3.371 ± 0.811
2.809GluLys: 2.809 ± 1.065
6.18GluLeu: 6.18 ± 3.042
0.0GluMet: 0.0 ± 0.0
2.809GluAsn: 2.809 ± 0.455
3.933GluPro: 3.933 ± 2.166
3.371GluGln: 3.371 ± 1.428
2.809GluArg: 2.809 ± 0.822
3.371GluSer: 3.371 ± 1.878
4.494GluThr: 4.494 ± 0.455
4.494GluVal: 4.494 ± 1.553
1.124GluTrp: 1.124 ± 0.83
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
0.562PheAla: 0.562 ± 0.396
1.124PheCys: 1.124 ± 0.497
0.562PheAsp: 0.562 ± 0.396
1.124PheGlu: 1.124 ± 0.793
0.0PhePhe: 0.0 ± 0.0
2.247PheGly: 2.247 ± 0.826
0.562PheHis: 0.562 ± 0.484
1.685PheIle: 1.685 ± 0.644
1.124PheLys: 1.124 ± 0.497
2.247PheLeu: 2.247 ± 0.807
1.124PheMet: 1.124 ± 0.793
0.562PheAsn: 0.562 ± 0.758
2.247PhePro: 2.247 ± 0.807
1.124PheGln: 1.124 ± 0.497
1.685PheArg: 1.685 ± 0.747
0.562PheSer: 0.562 ± 0.396
2.809PheThr: 2.809 ± 0.938
0.562PheVal: 0.562 ± 0.396
0.0PheTrp: 0.0 ± 0.0
0.562PheTyr: 0.562 ± 0.484
0.0PheXaa: 0.0 ± 0.0
Gly
7.303GlyAla: 7.303 ± 2.112
2.809GlyCys: 2.809 ± 1.519
5.618GlyAsp: 5.618 ± 2.234
3.933GlyGlu: 3.933 ± 1.44
1.685GlyPhe: 1.685 ± 0.994
8.427GlyGly: 8.427 ± 1.819
1.124GlyHis: 1.124 ± 0.497
3.371GlyIle: 3.371 ± 1.006
3.933GlyLys: 3.933 ± 1.26
8.989GlyLeu: 8.989 ± 4.368
2.247GlyMet: 2.247 ± 0.693
0.562GlyAsn: 0.562 ± 0.484
5.056GlyPro: 5.056 ± 1.429
3.371GlyGln: 3.371 ± 1.945
1.685GlyArg: 1.685 ± 0.644
3.933GlySer: 3.933 ± 1.698
4.494GlyThr: 4.494 ± 0.45
5.056GlyVal: 5.056 ± 1.375
0.0GlyTrp: 0.0 ± 0.0
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
0.562HisAla: 0.562 ± 0.396
1.124HisCys: 1.124 ± 0.793
1.124HisAsp: 1.124 ± 0.554
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
1.685HisHis: 1.685 ± 0.731
0.0HisIle: 0.0 ± 0.0
0.562HisLys: 0.562 ± 0.484
2.247HisLeu: 2.247 ± 0.643
0.0HisMet: 0.0 ± 0.0
1.685HisAsn: 1.685 ± 0.644
2.247HisPro: 2.247 ± 1.464
0.562HisGln: 0.562 ± 0.396
0.562HisArg: 0.562 ± 0.484
0.562HisSer: 0.562 ± 0.484
1.124HisThr: 1.124 ± 0.83
1.124HisVal: 1.124 ± 0.732
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.809IleAla: 2.809 ± 1.536
0.562IleCys: 0.562 ± 0.396
2.247IleAsp: 2.247 ± 0.676
3.371IleGlu: 3.371 ± 1.025
1.685IlePhe: 1.685 ± 0.901
2.809IleGly: 2.809 ± 1.519
0.562IleHis: 0.562 ± 0.569
1.124IleIle: 1.124 ± 0.793
2.247IleLys: 2.247 ± 0.993
4.494IleLeu: 4.494 ± 1.451
0.0IleMet: 0.0 ± 0.0
1.124IleAsn: 1.124 ± 0.793
2.247IlePro: 2.247 ± 0.83
1.685IleGln: 1.685 ± 0.897
1.124IleArg: 1.124 ± 0.732
2.247IleSer: 2.247 ± 1.597
1.685IleThr: 1.685 ± 0.757
1.124IleVal: 1.124 ± 0.554
0.0IleTrp: 0.0 ± 0.0
2.247IleTyr: 2.247 ± 1.102
0.0IleXaa: 0.0 ± 0.0
Lys
5.056LysAla: 5.056 ± 0.622
0.562LysCys: 0.562 ± 0.396
3.371LysAsp: 3.371 ± 0.646
1.685LysGlu: 1.685 ± 0.757
0.0LysPhe: 0.0 ± 0.0
3.933LysGly: 3.933 ± 1.77
1.685LysHis: 1.685 ± 0.901
1.685LysIle: 1.685 ± 0.757
5.618LysLys: 5.618 ± 2.108
5.618LysLeu: 5.618 ± 2.435
2.247LysMet: 2.247 ± 0.596
1.685LysAsn: 1.685 ± 0.644
0.562LysPro: 0.562 ± 0.484
3.371LysGln: 3.371 ± 1.485
6.18LysArg: 6.18 ± 1.058
1.685LysSer: 1.685 ± 1.189
1.124LysThr: 1.124 ± 0.497
3.371LysVal: 3.371 ± 1.377
2.247LysTrp: 2.247 ± 0.807
1.124LysTyr: 1.124 ± 0.497
0.0LysXaa: 0.0 ± 0.0
Leu
2.809LeuAla: 2.809 ± 0.938
1.124LeuCys: 1.124 ± 0.497
5.056LeuAsp: 5.056 ± 1.429
8.427LeuGlu: 8.427 ± 2.689
2.247LeuPhe: 2.247 ± 1.024
5.056LeuGly: 5.056 ± 2.39
1.685LeuHis: 1.685 ± 0.901
3.371LeuIle: 3.371 ± 1.377
4.494LeuLys: 4.494 ± 1.91
15.169LeuLeu: 15.169 ± 1.826
2.809LeuMet: 2.809 ± 1.217
4.494LeuAsn: 4.494 ± 1.573
10.674LeuPro: 10.674 ± 2.713
6.18LeuGln: 6.18 ± 0.644
3.933LeuArg: 3.933 ± 0.442
5.056LeuSer: 5.056 ± 1.961
5.056LeuThr: 5.056 ± 1.608
5.056LeuVal: 5.056 ± 1.957
1.124LeuTrp: 1.124 ± 0.83
7.865LeuTyr: 7.865 ± 1.593
0.0LeuXaa: 0.0 ± 0.0
Met
3.371MetAla: 3.371 ± 1.708
0.0MetCys: 0.0 ± 0.0
3.371MetAsp: 3.371 ± 0.424
1.124MetGlu: 1.124 ± 0.497
1.124MetPhe: 1.124 ± 0.968
2.247MetGly: 2.247 ± 0.643
0.0MetHis: 0.0 ± 0.0
0.562MetIle: 0.562 ± 0.396
2.809MetLys: 2.809 ± 1.519
2.809MetLeu: 2.809 ± 0.901
0.0MetMet: 0.0 ± 0.0
1.124MetAsn: 1.124 ± 0.497
0.562MetPro: 0.562 ± 0.396
0.0MetGln: 0.0 ± 0.0
1.124MetArg: 1.124 ± 0.83
1.124MetSer: 1.124 ± 0.968
0.0MetThr: 0.0 ± 0.0
0.562MetVal: 0.562 ± 0.396
0.562MetTrp: 0.562 ± 0.484
0.562MetTyr: 0.562 ± 0.396
0.0MetXaa: 0.0 ± 0.0
Asn
2.809AsnAla: 2.809 ± 0.705
0.562AsnCys: 0.562 ± 0.396
1.685AsnAsp: 1.685 ± 0.897
2.247AsnGlu: 2.247 ± 0.993
1.124AsnPhe: 1.124 ± 0.497
2.809AsnGly: 2.809 ± 0.822
1.124AsnHis: 1.124 ± 0.732
1.685AsnIle: 1.685 ± 0.747
2.247AsnLys: 2.247 ± 0.676
2.247AsnLeu: 2.247 ± 1.185
1.124AsnMet: 1.124 ± 0.8
2.247AsnAsn: 2.247 ± 0.83
2.809AsnPro: 2.809 ± 0.455
1.685AsnGln: 1.685 ± 1.229
2.247AsnArg: 2.247 ± 1.659
1.685AsnSer: 1.685 ± 0.757
3.933AsnThr: 3.933 ± 1.104
1.124AsnVal: 1.124 ± 0.968
0.562AsnTrp: 0.562 ± 0.396
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
2.809ProAla: 2.809 ± 0.907
0.562ProCys: 0.562 ± 0.484
6.18ProAsp: 6.18 ± 2.429
6.18ProGlu: 6.18 ± 2.676
1.124ProPhe: 1.124 ± 0.793
6.18ProGly: 6.18 ± 0.853
0.0ProHis: 0.0 ± 0.0
1.685ProIle: 1.685 ± 0.747
4.494ProLys: 4.494 ± 1.018
6.18ProLeu: 6.18 ± 1.532
0.562ProMet: 0.562 ± 0.484
3.371ProAsn: 3.371 ± 1.679
6.18ProPro: 6.18 ± 1.046
2.809ProGln: 2.809 ± 1.432
6.18ProArg: 6.18 ± 2.495
5.618ProSer: 5.618 ± 2.088
2.247ProThr: 2.247 ± 1.354
5.618ProVal: 5.618 ± 1.644
0.562ProTrp: 0.562 ± 0.758
2.809ProTyr: 2.809 ± 1.612
0.0ProXaa: 0.0 ± 0.0
Gln
6.742GlnAla: 6.742 ± 1.884
0.0GlnCys: 0.0 ± 0.0
2.809GlnAsp: 2.809 ± 0.705
1.685GlnGlu: 1.685 ± 0.901
1.685GlnPhe: 1.685 ± 0.757
2.809GlnGly: 2.809 ± 1.825
2.247GlnHis: 2.247 ± 1.031
1.685GlnIle: 1.685 ± 0.51
2.247GlnLys: 2.247 ± 1.185
5.056GlnLeu: 5.056 ± 1.462
0.562GlnMet: 0.562 ± 0.396
1.685GlnAsn: 1.685 ± 0.901
2.247GlnPro: 2.247 ± 0.558
6.18GlnGln: 6.18 ± 1.467
5.618GlnArg: 5.618 ± 1.189
1.685GlnSer: 1.685 ± 0.747
4.494GlnThr: 4.494 ± 0.721
0.562GlnVal: 0.562 ± 0.484
1.685GlnTrp: 1.685 ± 0.854
2.809GlnTyr: 2.809 ± 1.743
0.0GlnXaa: 0.0 ± 0.0
Arg
5.618ArgAla: 5.618 ± 3.042
1.124ArgCys: 1.124 ± 0.793
3.933ArgAsp: 3.933 ± 2.067
1.685ArgGlu: 1.685 ± 0.901
1.685ArgPhe: 1.685 ± 0.644
3.933ArgGly: 3.933 ± 1.26
0.0ArgHis: 0.0 ± 0.0
1.124ArgIle: 1.124 ± 0.968
5.618ArgLys: 5.618 ± 1.212
6.742ArgLeu: 6.742 ± 2.42
2.247ArgMet: 2.247 ± 0.558
3.933ArgAsn: 3.933 ± 0.792
1.685ArgPro: 1.685 ± 0.644
4.494ArgGln: 4.494 ± 1.717
8.427ArgArg: 8.427 ± 2.115
5.056ArgSer: 5.056 ± 1.899
3.371ArgThr: 3.371 ± 1.324
2.809ArgVal: 2.809 ± 1.473
1.685ArgTrp: 1.685 ± 0.644
3.371ArgTyr: 3.371 ± 1.36
0.0ArgXaa: 0.0 ± 0.0
Ser
5.618SerAla: 5.618 ± 2.193
2.247SerCys: 2.247 ± 0.993
1.124SerAsp: 1.124 ± 0.732
2.809SerGlu: 2.809 ± 1.017
2.247SerPhe: 2.247 ± 0.676
5.618SerGly: 5.618 ± 1.813
0.0SerHis: 0.0 ± 0.0
0.0SerIle: 0.0 ± 0.0
2.247SerLys: 2.247 ± 0.83
4.494SerLeu: 4.494 ± 1.052
1.124SerMet: 1.124 ± 0.497
2.809SerAsn: 2.809 ± 0.705
1.685SerPro: 1.685 ± 0.897
3.371SerGln: 3.371 ± 1.377
2.809SerArg: 2.809 ± 1.743
2.809SerSer: 2.809 ± 1.217
5.056SerThr: 5.056 ± 1.081
3.371SerVal: 3.371 ± 1.36
0.0SerTrp: 0.0 ± 0.0
0.562SerTyr: 0.562 ± 0.484
0.0SerXaa: 0.0 ± 0.0
Thr
5.056ThrAla: 5.056 ± 1.093
1.124ThrCys: 1.124 ± 0.793
4.494ThrAsp: 4.494 ± 1.66
4.494ThrGlu: 4.494 ± 1.623
1.124ThrPhe: 1.124 ± 0.793
5.056ThrGly: 5.056 ± 2.041
0.0ThrHis: 0.0 ± 0.0
2.809ThrIle: 2.809 ± 0.455
2.247ThrLys: 2.247 ± 0.993
5.618ThrLeu: 5.618 ± 0.994
0.562ThrMet: 0.562 ± 0.396
0.562ThrAsn: 0.562 ± 0.484
6.742ThrPro: 6.742 ± 0.982
5.056ThrGln: 5.056 ± 1.969
3.933ThrArg: 3.933 ± 1.064
1.685ThrSer: 1.685 ± 0.757
3.933ThrThr: 3.933 ± 1.27
3.933ThrVal: 3.933 ± 1.698
1.124ThrTrp: 1.124 ± 0.83
0.562ThrTyr: 0.562 ± 0.396
0.0ThrXaa: 0.0 ± 0.0
Val
3.933ValAla: 3.933 ± 1.237
1.124ValCys: 1.124 ± 0.793
3.371ValAsp: 3.371 ± 0.646
5.056ValGlu: 5.056 ± 0.622
1.124ValPhe: 1.124 ± 0.732
3.933ValGly: 3.933 ± 2.407
2.247ValHis: 2.247 ± 0.558
1.685ValIle: 1.685 ± 0.778
1.124ValLys: 1.124 ± 0.793
3.933ValLeu: 3.933 ± 1.698
3.371ValMet: 3.371 ± 0.654
2.809ValAsn: 2.809 ± 0.455
5.618ValPro: 5.618 ± 1.823
2.809ValGln: 2.809 ± 0.692
3.933ValArg: 3.933 ± 1.698
2.809ValSer: 2.809 ± 1.027
3.371ValThr: 3.371 ± 1.621
0.562ValVal: 0.562 ± 0.484
0.562ValTrp: 0.562 ± 0.396
0.562ValTyr: 0.562 ± 0.484
0.0ValXaa: 0.0 ± 0.0
Trp
1.124TrpAla: 1.124 ± 0.83
0.0TrpCys: 0.0 ± 0.0
1.685TrpAsp: 1.685 ± 1.058
1.124TrpGlu: 1.124 ± 0.497
0.0TrpPhe: 0.0 ± 0.0
2.809TrpGly: 2.809 ± 1.432
0.0TrpHis: 0.0 ± 0.0
0.562TrpIle: 0.562 ± 0.396
0.562TrpLys: 0.562 ± 0.484
2.809TrpLeu: 2.809 ± 1.432
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.562TrpSer: 0.562 ± 0.758
0.0TrpThr: 0.0 ± 0.0
0.562TrpVal: 0.562 ± 0.484
0.562TrpTrp: 0.562 ± 0.484
1.124TrpTyr: 1.124 ± 0.83
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.124TyrAla: 1.124 ± 0.732
1.685TyrCys: 1.685 ± 1.436
3.933TyrAsp: 3.933 ± 1.839
3.933TyrGlu: 3.933 ± 1.77
1.124TyrPhe: 1.124 ± 0.497
3.371TyrGly: 3.371 ± 0.654
0.0TyrHis: 0.0 ± 0.0
0.562TyrIle: 0.562 ± 0.396
1.685TyrLys: 1.685 ± 0.901
1.685TyrLeu: 1.685 ± 0.897
0.0TyrMet: 0.0 ± 0.0
0.562TyrAsn: 0.562 ± 0.484
2.247TyrPro: 2.247 ± 1.113
1.685TyrGln: 1.685 ± 0.854
3.933TyrArg: 3.933 ± 1.248
1.124TyrSer: 1.124 ± 0.497
0.562TyrThr: 0.562 ± 0.396
3.371TyrVal: 3.371 ± 0.654
0.0TyrTrp: 0.0 ± 0.0
1.685TyrTyr: 1.685 ± 0.854
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1781 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski