Amino acid dipepetide frequency for Corynebacterium renale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.635AlaAla: 15.635 ± 0.24
0.915AlaCys: 0.915 ± 0.039
7.057AlaAsp: 7.057 ± 0.12
7.901AlaGlu: 7.901 ± 0.12
3.492AlaPhe: 3.492 ± 0.079
10.349AlaGly: 10.349 ± 0.144
2.775AlaHis: 2.775 ± 0.065
5.515AlaIle: 5.515 ± 0.101
3.335AlaLys: 3.335 ± 0.091
11.918AlaLeu: 11.918 ± 0.162
2.722AlaMet: 2.722 ± 0.064
2.632AlaAsn: 2.632 ± 0.071
5.508AlaPro: 5.508 ± 0.119
4.688AlaGln: 4.688 ± 0.101
7.264AlaArg: 7.264 ± 0.115
5.811AlaSer: 5.811 ± 0.101
7.215AlaThr: 7.215 ± 0.121
9.799AlaVal: 9.799 ± 0.135
1.588AlaTrp: 1.588 ± 0.054
2.462AlaTyr: 2.462 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.932CysAla: 0.932 ± 0.042
0.068CysCys: 0.068 ± 0.011
0.39CysAsp: 0.39 ± 0.021
0.369CysGlu: 0.369 ± 0.025
0.226CysPhe: 0.226 ± 0.016
0.82CysGly: 0.82 ± 0.035
0.17CysHis: 0.17 ± 0.014
0.313CysIle: 0.313 ± 0.019
0.16CysLys: 0.16 ± 0.017
0.555CysLeu: 0.555 ± 0.028
0.158CysMet: 0.158 ± 0.015
0.179CysAsn: 0.179 ± 0.016
0.398CysPro: 0.398 ± 0.027
0.205CysGln: 0.205 ± 0.018
0.334CysArg: 0.334 ± 0.022
0.468CysSer: 0.468 ± 0.025
0.465CysThr: 0.465 ± 0.031
0.628CysVal: 0.628 ± 0.034
0.085CysTrp: 0.085 ± 0.012
0.121CysTyr: 0.121 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.194AspAla: 7.194 ± 0.118
0.379AspCys: 0.379 ± 0.024
3.546AspAsp: 3.546 ± 0.093
3.828AspGlu: 3.828 ± 0.083
2.004AspPhe: 2.004 ± 0.055
5.08AspGly: 5.08 ± 0.11
1.341AspHis: 1.341 ± 0.048
3.19AspIle: 3.19 ± 0.067
2.039AspLys: 2.039 ± 0.062
5.345AspLeu: 5.345 ± 0.099
1.215AspMet: 1.215 ± 0.037
1.64AspAsn: 1.64 ± 0.05
3.68AspPro: 3.68 ± 0.076
1.792AspGln: 1.792 ± 0.055
3.289AspArg: 3.289 ± 0.075
3.122AspSer: 3.122 ± 0.071
3.348AspThr: 3.348 ± 0.076
5.246AspVal: 5.246 ± 0.086
0.749AspTrp: 0.749 ± 0.039
1.586AspTyr: 1.586 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
7.168GluAla: 7.168 ± 0.134
0.346GluCys: 0.346 ± 0.024
3.562GluAsp: 3.562 ± 0.071
4.546GluGlu: 4.546 ± 0.109
2.112GluPhe: 2.112 ± 0.053
4.455GluGly: 4.455 ± 0.084
1.608GluHis: 1.608 ± 0.05
3.436GluIle: 3.436 ± 0.075
2.684GluLys: 2.684 ± 0.066
6.594GluLeu: 6.594 ± 0.118
1.274GluMet: 1.274 ± 0.043
2.075GluAsn: 2.075 ± 0.054
3.04GluPro: 3.04 ± 0.071
2.469GluGln: 2.469 ± 0.072
3.814GluArg: 3.814 ± 0.075
3.171GluSer: 3.171 ± 0.067
3.415GluThr: 3.415 ± 0.078
4.961GluVal: 4.961 ± 0.102
0.751GluTrp: 0.751 ± 0.036
1.529GluTyr: 1.529 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.765PheAla: 3.765 ± 0.071
0.278PheCys: 0.278 ± 0.021
2.204PheAsp: 2.204 ± 0.056
1.726PheGlu: 1.726 ± 0.06
1.225PhePhe: 1.225 ± 0.052
3.256PheGly: 3.256 ± 0.084
0.719PheHis: 0.719 ± 0.032
1.72PheIle: 1.72 ± 0.056
0.771PheLys: 0.771 ± 0.034
2.85PheLeu: 2.85 ± 0.07
0.72PheMet: 0.72 ± 0.036
0.961PheAsn: 0.961 ± 0.037
1.447PhePro: 1.447 ± 0.047
0.892PheGln: 0.892 ± 0.039
1.576PheArg: 1.576 ± 0.051
2.039PheSer: 2.039 ± 0.062
2.297PheThr: 2.297 ± 0.062
2.58PheVal: 2.58 ± 0.061
0.409PheTrp: 0.409 ± 0.028
0.787PheTyr: 0.787 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
8.969GlyAla: 8.969 ± 0.13
0.654GlyCys: 0.654 ± 0.035
4.348GlyAsp: 4.348 ± 0.074
5.021GlyGlu: 5.021 ± 0.105
2.967GlyPhe: 2.967 ± 0.066
6.836GlyGly: 6.836 ± 0.126
2.124GlyHis: 2.124 ± 0.056
4.733GlyIle: 4.733 ± 0.095
3.263GlyLys: 3.263 ± 0.079
8.019GlyLeu: 8.019 ± 0.129
2.154GlyMet: 2.154 ± 0.056
2.423GlyAsn: 2.423 ± 0.072
3.488GlyPro: 3.488 ± 0.072
2.86GlyGln: 2.86 ± 0.07
4.832GlyArg: 4.832 ± 0.092
4.756GlySer: 4.756 ± 0.091
5.41GlyThr: 5.41 ± 0.103
7.46GlyVal: 7.46 ± 0.111
1.514GlyTrp: 1.514 ± 0.051
2.199GlyTyr: 2.199 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
2.461HisAla: 2.461 ± 0.056
0.192HisCys: 0.192 ± 0.019
1.496HisAsp: 1.496 ± 0.047
1.33HisGlu: 1.33 ± 0.049
0.656HisPhe: 0.656 ± 0.035
1.988HisGly: 1.988 ± 0.061
0.618HisHis: 0.618 ± 0.031
1.147HisIle: 1.147 ± 0.041
0.581HisLys: 0.581 ± 0.027
1.968HisLeu: 1.968 ± 0.065
0.425HisMet: 0.425 ± 0.024
0.729HisAsn: 0.729 ± 0.038
1.532HisPro: 1.532 ± 0.059
0.709HisGln: 0.709 ± 0.034
1.373HisArg: 1.373 ± 0.044
1.272HisSer: 1.272 ± 0.041
1.48HisThr: 1.48 ± 0.049
1.857HisVal: 1.857 ± 0.055
0.313HisTrp: 0.313 ± 0.021
0.579HisTyr: 0.579 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.731IleAla: 6.731 ± 0.111
0.392IleCys: 0.392 ± 0.025
3.59IleAsp: 3.59 ± 0.075
2.992IleGlu: 2.992 ± 0.075
1.689IlePhe: 1.689 ± 0.057
4.462IleGly: 4.462 ± 0.101
1.009IleHis: 1.009 ± 0.037
2.802IleIle: 2.802 ± 0.081
1.392IleLys: 1.392 ± 0.048
4.172IleLeu: 4.172 ± 0.086
1.111IleMet: 1.111 ± 0.039
1.485IleAsn: 1.485 ± 0.048
2.897IlePro: 2.897 ± 0.072
1.323IleGln: 1.323 ± 0.043
2.616IleArg: 2.616 ± 0.062
3.018IleSer: 3.018 ± 0.079
3.479IleThr: 3.479 ± 0.075
4.716IleVal: 4.716 ± 0.091
0.473IleTrp: 0.473 ± 0.026
1.066IleTyr: 1.066 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
3.567LysAla: 3.567 ± 0.085
0.163LysCys: 0.163 ± 0.016
2.086LysAsp: 2.086 ± 0.08
2.095LysGlu: 2.095 ± 0.064
0.813LysPhe: 0.813 ± 0.033
2.151LysGly: 2.151 ± 0.076
0.73LysHis: 0.73 ± 0.035
1.691LysIle: 1.691 ± 0.051
1.801LysLys: 1.801 ± 0.077
2.835LysLeu: 2.835 ± 0.075
0.768LysMet: 0.768 ± 0.033
1.239LysAsn: 1.239 ± 0.047
1.915LysPro: 1.915 ± 0.088
1.187LysGln: 1.187 ± 0.042
1.993LysArg: 1.993 ± 0.06
1.614LysSer: 1.614 ± 0.052
1.926LysThr: 1.926 ± 0.062
2.518LysVal: 2.518 ± 0.077
0.386LysTrp: 0.386 ± 0.025
0.785LysTyr: 0.785 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
11.503LeuAla: 11.503 ± 0.169
0.67LeuCys: 0.67 ± 0.031
5.945LeuAsp: 5.945 ± 0.096
5.23LeuGlu: 5.23 ± 0.105
2.91LeuPhe: 2.91 ± 0.085
8.191LeuGly: 8.191 ± 0.12
2.178LeuHis: 2.178 ± 0.064
5.122LeuIle: 5.122 ± 0.11
2.758LeuLys: 2.758 ± 0.065
8.512LeuLeu: 8.512 ± 0.142
1.804LeuMet: 1.804 ± 0.058
2.601LeuAsn: 2.601 ± 0.066
5.187LeuPro: 5.187 ± 0.09
2.709LeuGln: 2.709 ± 0.062
6.054LeuArg: 6.054 ± 0.091
5.531LeuSer: 5.531 ± 0.107
5.754LeuThr: 5.754 ± 0.099
7.463LeuVal: 7.463 ± 0.119
1.193LeuTrp: 1.193 ± 0.043
1.742LeuTyr: 1.742 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.716MetAla: 2.716 ± 0.057
0.147MetCys: 0.147 ± 0.014
1.18MetAsp: 1.18 ± 0.038
1.098MetGlu: 1.098 ± 0.042
0.712MetPhe: 0.712 ± 0.032
1.676MetGly: 1.676 ± 0.056
0.457MetHis: 0.457 ± 0.025
1.112MetIle: 1.112 ± 0.038
0.735MetLys: 0.735 ± 0.032
2.02MetLeu: 2.02 ± 0.063
0.484MetMet: 0.484 ± 0.028
0.67MetAsn: 0.67 ± 0.031
1.166MetPro: 1.166 ± 0.037
0.703MetGln: 0.703 ± 0.029
1.396MetArg: 1.396 ± 0.047
1.654MetSer: 1.654 ± 0.045
1.599MetThr: 1.599 ± 0.045
1.691MetVal: 1.691 ± 0.06
0.291MetTrp: 0.291 ± 0.019
0.425MetTyr: 0.425 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.131AsnAla: 3.131 ± 0.062
0.184AsnCys: 0.184 ± 0.017
1.448AsnAsp: 1.448 ± 0.044
1.526AsnGlu: 1.526 ± 0.054
0.895AsnPhe: 0.895 ± 0.034
2.138AsnGly: 2.138 ± 0.065
0.628AsnHis: 0.628 ± 0.03
1.439AsnIle: 1.439 ± 0.047
0.961AsnLys: 0.961 ± 0.04
2.667AsnLeu: 2.667 ± 0.063
0.632AsnMet: 0.632 ± 0.033
0.918AsnAsn: 0.918 ± 0.044
2.19AsnPro: 2.19 ± 0.063
1.053AsnGln: 1.053 ± 0.048
1.582AsnArg: 1.582 ± 0.054
1.595AsnSer: 1.595 ± 0.047
1.736AsnThr: 1.736 ± 0.061
2.299AsnVal: 2.299 ± 0.058
0.385AsnTrp: 0.385 ± 0.023
0.692AsnTyr: 0.692 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
6.322ProAla: 6.322 ± 0.131
0.267ProCys: 0.267 ± 0.024
3.536ProAsp: 3.536 ± 0.073
4.814ProGlu: 4.814 ± 0.1
1.592ProPhe: 1.592 ± 0.053
4.806ProGly: 4.806 ± 0.108
1.209ProHis: 1.209 ± 0.049
2.168ProIle: 2.168 ± 0.057
1.677ProLys: 1.677 ± 0.062
4.373ProLeu: 4.373 ± 0.074
0.964ProMet: 0.964 ± 0.032
1.464ProAsn: 1.464 ± 0.054
1.83ProPro: 1.83 ± 0.065
1.998ProGln: 1.998 ± 0.069
2.834ProArg: 2.834 ± 0.063
2.611ProSer: 2.611 ± 0.06
3.432ProThr: 3.432 ± 0.083
4.606ProVal: 4.606 ± 0.093
0.748ProTrp: 0.748 ± 0.032
1.171ProTyr: 1.171 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.995GlnAla: 3.995 ± 0.116
0.196GlnCys: 0.196 ± 0.016
1.651GlnAsp: 1.651 ± 0.049
2.22GlnGlu: 2.22 ± 0.059
1.058GlnPhe: 1.058 ± 0.042
2.405GlnGly: 2.405 ± 0.065
0.748GlnHis: 0.748 ± 0.036
1.647GlnIle: 1.647 ± 0.047
1.122GlnLys: 1.122 ± 0.04
3.556GlnLeu: 3.556 ± 0.08
0.794GlnMet: 0.794 ± 0.035
0.882GlnAsn: 0.882 ± 0.04
1.909GlnPro: 1.909 ± 0.063
1.54GlnGln: 1.54 ± 0.053
2.674GlnArg: 2.674 ± 0.065
1.595GlnSer: 1.595 ± 0.055
1.581GlnThr: 1.581 ± 0.049
2.72GlnVal: 2.72 ± 0.066
0.733GlnTrp: 0.733 ± 0.034
0.687GlnTyr: 0.687 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
6.622ArgAla: 6.622 ± 0.105
0.385ArgCys: 0.385 ± 0.024
3.619ArgAsp: 3.619 ± 0.078
4.16ArgGlu: 4.16 ± 0.084
2.036ArgPhe: 2.036 ± 0.053
4.703ArgGly: 4.703 ± 0.09
1.357ArgHis: 1.357 ± 0.044
3.235ArgIle: 3.235 ± 0.073
2.174ArgLys: 2.174 ± 0.066
5.299ArgLeu: 5.299 ± 0.099
1.625ArgMet: 1.625 ± 0.042
1.655ArgAsn: 1.655 ± 0.05
2.941ArgPro: 2.941 ± 0.072
1.945ArgGln: 1.945 ± 0.052
4.507ArgArg: 4.507 ± 0.103
3.227ArgSer: 3.227 ± 0.073
3.809ArgThr: 3.809 ± 0.08
4.456ArgVal: 4.456 ± 0.073
0.922ArgTrp: 0.922 ± 0.034
1.526ArgTyr: 1.526 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
6.285SerAla: 6.285 ± 0.12
0.328SerCys: 0.328 ± 0.023
2.939SerAsp: 2.939 ± 0.075
3.21SerGlu: 3.21 ± 0.06
1.903SerPhe: 1.903 ± 0.066
5.26SerGly: 5.26 ± 0.094
1.196SerHis: 1.196 ± 0.044
2.624SerIle: 2.624 ± 0.075
1.527SerLys: 1.527 ± 0.052
4.9SerLeu: 4.9 ± 0.089
1.331SerMet: 1.331 ± 0.047
1.475SerAsn: 1.475 ± 0.048
2.969SerPro: 2.969 ± 0.069
1.977SerGln: 1.977 ± 0.051
3.448SerArg: 3.448 ± 0.073
3.451SerSer: 3.451 ± 0.089
3.76SerThr: 3.76 ± 0.08
4.504SerVal: 4.504 ± 0.093
0.971SerTrp: 0.971 ± 0.036
1.314SerTyr: 1.314 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
7.09ThrAla: 7.09 ± 0.11
0.415ThrCys: 0.415 ± 0.025
3.41ThrAsp: 3.41 ± 0.085
3.436ThrGlu: 3.436 ± 0.073
2.007ThrPhe: 2.007 ± 0.055
5.53ThrGly: 5.53 ± 0.095
1.389ThrHis: 1.389 ± 0.042
3.291ThrIle: 3.291 ± 0.065
1.81ThrLys: 1.81 ± 0.065
5.776ThrLeu: 5.776 ± 0.093
1.253ThrMet: 1.253 ± 0.044
1.606ThrAsn: 1.606 ± 0.053
4.105ThrPro: 4.105 ± 0.076
2.08ThrGln: 2.08 ± 0.06
3.304ThrArg: 3.304 ± 0.07
3.564ThrSer: 3.564 ± 0.078
4.311ThrThr: 4.311 ± 0.118
5.969ThrVal: 5.969 ± 0.098
1.011ThrTrp: 1.011 ± 0.036
1.477ThrTyr: 1.477 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
10.477ValAla: 10.477 ± 0.142
0.751ValCys: 0.751 ± 0.035
5.391ValAsp: 5.391 ± 0.096
5.378ValGlu: 5.378 ± 0.11
2.553ValPhe: 2.553 ± 0.066
6.883ValGly: 6.883 ± 0.113
1.725ValHis: 1.725 ± 0.054
4.458ValIle: 4.458 ± 0.088
2.347ValLys: 2.347 ± 0.071
7.897ValLeu: 7.897 ± 0.142
1.729ValMet: 1.729 ± 0.059
2.32ValAsn: 2.32 ± 0.059
4.33ValPro: 4.33 ± 0.09
2.161ValGln: 2.161 ± 0.06
4.897ValArg: 4.897 ± 0.085
4.691ValSer: 4.691 ± 0.089
5.638ValThr: 5.638 ± 0.11
7.854ValVal: 7.854 ± 0.141
1.181ValTrp: 1.181 ± 0.044
1.671ValTyr: 1.671 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.617TrpAla: 1.617 ± 0.053
0.137TrpCys: 0.137 ± 0.015
0.86TrpAsp: 0.86 ± 0.032
0.82TrpGlu: 0.82 ± 0.035
0.506TrpPhe: 0.506 ± 0.028
0.961TrpGly: 0.961 ± 0.043
0.287TrpHis: 0.287 ± 0.019
0.823TrpIle: 0.823 ± 0.04
0.483TrpLys: 0.483 ± 0.027
1.542TrpLeu: 1.542 ± 0.056
0.354TrpMet: 0.354 ± 0.026
0.46TrpAsn: 0.46 ± 0.025
0.641TrpPro: 0.641 ± 0.033
0.553TrpGln: 0.553 ± 0.028
0.908TrpArg: 0.908 ± 0.036
0.779TrpSer: 0.779 ± 0.038
0.778TrpThr: 0.778 ± 0.034
1.232TrpVal: 1.232 ± 0.04
0.403TrpTrp: 0.403 ± 0.024
0.31TrpTyr: 0.31 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.403TyrAla: 2.403 ± 0.055
0.179TyrCys: 0.179 ± 0.018
1.354TyrAsp: 1.354 ± 0.042
1.308TyrGlu: 1.308 ± 0.044
0.867TyrPhe: 0.867 ± 0.037
2.082TyrGly: 2.082 ± 0.055
0.437TyrHis: 0.437 ± 0.025
0.951TyrIle: 0.951 ± 0.041
0.645TyrLys: 0.645 ± 0.03
2.258TyrLeu: 2.258 ± 0.06
0.412TyrMet: 0.412 ± 0.024
0.686TyrAsn: 0.686 ± 0.032
1.251TyrPro: 1.251 ± 0.048
0.867TyrGln: 0.867 ± 0.038
1.507TyrArg: 1.507 ± 0.052
1.403TyrSer: 1.403 ± 0.04
1.402TyrThr: 1.402 ± 0.051
1.771TyrVal: 1.771 ± 0.048
0.346TyrTrp: 0.346 ± 0.025
0.569TyrTyr: 0.569 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2134 proteins (694073 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski