Amino acid dipepetide frequency for Mesorhizobium soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.131AlaAla: 16.131 ± 0.135	0.964AlaCys: 0.964 ± 0.024	6.574AlaAsp: 6.574 ± 0.058	7.664AlaGlu: 7.664 ± 0.089	4.614AlaPhe: 4.614 ± 0.046	10.483AlaGly: 10.483 ± 0.093	2.15AlaHis: 2.15 ± 0.035	6.727AlaIle: 6.727 ± 0.067	4.519AlaLys: 4.519 ± 0.069	12.592AlaLeu: 12.592 ± 0.096	3.521AlaMet: 3.521 ± 0.042	3.1AlaAsn: 3.1 ± 0.046	5.141AlaPro: 5.141 ± 0.068	3.513AlaGln: 3.513 ± 0.057	7.91AlaArg: 7.91 ± 0.069	6.602AlaSer: 6.602 ± 0.075	5.947AlaThr: 5.947 ± 0.07	8.682AlaVal: 8.682 ± 0.071	1.433AlaTrp: 1.433 ± 0.032	2.784AlaTyr: 2.784 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.841CysAla: 0.841 ± 0.02	0.096CysCys: 0.096 ± 0.009	0.501CysAsp: 0.501 ± 0.018	0.418CysGlu: 0.418 ± 0.015	0.346CysPhe: 0.346 ± 0.013	0.9CysGly: 0.9 ± 0.026	0.237CysHis: 0.237 ± 0.011	0.403CysIle: 0.403 ± 0.016	0.19CysLys: 0.19 ± 0.011	0.748CysLeu: 0.748 ± 0.022	0.166CysMet: 0.166 ± 0.009	0.211CysAsn: 0.211 ± 0.011	0.413CysPro: 0.413 ± 0.018	0.208CysGln: 0.208 ± 0.012	0.561CysArg: 0.561 ± 0.017	0.475CysSer: 0.475 ± 0.017	0.414CysThr: 0.414 ± 0.016	0.604CysVal: 0.604 ± 0.019	0.115CysTrp: 0.115 ± 0.008	0.202CysTyr: 0.202 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.369AspAla: 6.369 ± 0.067	0.446AspCys: 0.446 ± 0.016	2.897AspAsp: 2.897 ± 0.049	3.491AspGlu: 3.491 ± 0.05	2.315AspPhe: 2.315 ± 0.039	4.921AspGly: 4.921 ± 0.054	1.212AspHis: 1.212 ± 0.027	3.181AspIle: 3.181 ± 0.043	1.913AspLys: 1.913 ± 0.036	5.562AspLeu: 5.562 ± 0.059	1.389AspMet: 1.389 ± 0.027	1.399AspAsn: 1.399 ± 0.028	3.287AspPro: 3.287 ± 0.046	1.672AspGln: 1.672 ± 0.033	4.127AspArg: 4.127 ± 0.049	2.136AspSer: 2.136 ± 0.034	2.504AspThr: 2.504 ± 0.04	4.042AspVal: 4.042 ± 0.049	0.947AspTrp: 0.947 ± 0.027	1.511AspTyr: 1.511 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.731GluAla: 7.731 ± 0.085	0.358GluCys: 0.358 ± 0.017	2.691GluAsp: 2.691 ± 0.035	3.321GluGlu: 3.321 ± 0.058	1.946GluPhe: 1.946 ± 0.036	4.225GluGly: 4.225 ± 0.058	1.225GluHis: 1.225 ± 0.026	3.748GluIle: 3.748 ± 0.051	2.704GluLys: 2.704 ± 0.044	5.425GluLeu: 5.425 ± 0.058	1.621GluMet: 1.621 ± 0.03	1.752GluAsn: 1.752 ± 0.031	2.806GluPro: 2.806 ± 0.045	2.095GluGln: 2.095 ± 0.039	4.812GluArg: 4.812 ± 0.067	2.347GluSer: 2.347 ± 0.036	3.432GluThr: 3.432 ± 0.054	3.924GluVal: 3.924 ± 0.05	0.775GluTrp: 0.775 ± 0.024	1.03GluTyr: 1.03 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.553PheAla: 4.553 ± 0.062	0.394PheCys: 0.394 ± 0.015	2.724PheAsp: 2.724 ± 0.038	2.243PheGlu: 2.243 ± 0.038	1.556PhePhe: 1.556 ± 0.032	3.943PheGly: 3.943 ± 0.057	0.831PheHis: 0.831 ± 0.027	1.861PheIle: 1.861 ± 0.037	1.044PheLys: 1.044 ± 0.027	3.59PheLeu: 3.59 ± 0.053	0.895PheMet: 0.895 ± 0.025	1.125PheAsn: 1.125 ± 0.027	1.677PhePro: 1.677 ± 0.034	1.145PheGln: 1.145 ± 0.024	2.385PheArg: 2.385 ± 0.032	2.467PheSer: 2.467 ± 0.045	1.956PheThr: 1.956 ± 0.041	3.105PheVal: 3.105 ± 0.043	0.616PheTrp: 0.616 ± 0.022	0.918PheTyr: 0.918 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	8.806GlyAla: 8.806 ± 0.077	0.836GlyCys: 0.836 ± 0.02	4.201GlyAsp: 4.201 ± 0.05	4.701GlyGlu: 4.701 ± 0.056	3.868GlyPhe: 3.868 ± 0.06	7.313GlyGly: 7.313 ± 0.114	1.899GlyHis: 1.899 ± 0.035	4.901GlyIle: 4.901 ± 0.056	3.811GlyLys: 3.811 ± 0.046	8.753GlyLeu: 8.753 ± 0.081	2.424GlyMet: 2.424 ± 0.036	2.405GlyAsn: 2.405 ± 0.048	3.245GlyPro: 3.245 ± 0.042	2.819GlyGln: 2.819 ± 0.048	5.802GlyArg: 5.802 ± 0.058	4.759GlySer: 4.759 ± 0.068	4.716GlyThr: 4.716 ± 0.091	6.175GlyVal: 6.175 ± 0.059	1.372GlyTrp: 1.372 ± 0.037	2.398GlyTyr: 2.398 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.207HisAla: 2.207 ± 0.035	0.215HisCys: 0.215 ± 0.011	1.259HisAsp: 1.259 ± 0.03	1.132HisGlu: 1.132 ± 0.027	0.901HisPhe: 0.901 ± 0.025	1.961HisGly: 1.961 ± 0.035	0.562HisHis: 0.562 ± 0.022	0.999HisIle: 0.999 ± 0.025	0.56HisLys: 0.56 ± 0.018	1.936HisLeu: 1.936 ± 0.037	0.536HisMet: 0.536 ± 0.019	0.499HisAsn: 0.499 ± 0.017	1.269HisPro: 1.269 ± 0.03	0.577HisGln: 0.577 ± 0.021	1.364HisArg: 1.364 ± 0.027	1.011HisSer: 1.011 ± 0.027	0.821HisThr: 0.821 ± 0.024	1.499HisVal: 1.499 ± 0.027	0.332HisTrp: 0.332 ± 0.014	0.559HisTyr: 0.559 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	7.556IleAla: 7.556 ± 0.068	0.542IleCys: 0.542 ± 0.018	3.713IleAsp: 3.713 ± 0.052	3.711IleGlu: 3.711 ± 0.05	1.903IlePhe: 1.903 ± 0.037	5.271IleGly: 5.271 ± 0.056	0.968IleHis: 0.968 ± 0.022	2.651IleIle: 2.651 ± 0.042	1.573IleLys: 1.573 ± 0.036	4.689IleLeu: 4.689 ± 0.056	1.099IleMet: 1.099 ± 0.028	1.544IleAsn: 1.544 ± 0.034	2.39IlePro: 2.39 ± 0.037	1.248IleGln: 1.248 ± 0.024	3.349IleArg: 3.349 ± 0.047	3.293IleSer: 3.293 ± 0.045	2.721IleThr: 2.721 ± 0.042	4.69IleVal: 4.69 ± 0.058	0.64IleTrp: 0.64 ± 0.02	1.214IleTyr: 1.214 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.724LysAla: 4.724 ± 0.061	0.155LysCys: 0.155 ± 0.009	1.887LysAsp: 1.887 ± 0.039	1.858LysGlu: 1.858 ± 0.036	1.062LysPhe: 1.062 ± 0.022	2.827LysGly: 2.827 ± 0.039	0.651LysHis: 0.651 ± 0.018	1.976LysIle: 1.976 ± 0.039	1.542LysLys: 1.542 ± 0.034	3.7LysLeu: 3.7 ± 0.052	0.904LysMet: 0.904 ± 0.022	1.083LysAsn: 1.083 ± 0.027	2.362LysPro: 2.362 ± 0.04	1.182LysGln: 1.182 ± 0.025	2.519LysArg: 2.519 ± 0.039	2.102LysSer: 2.102 ± 0.033	2.114LysThr: 2.114 ± 0.037	2.712LysVal: 2.712 ± 0.04	0.427LysTrp: 0.427 ± 0.017	0.713LysTyr: 0.713 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.124LeuAla: 13.124 ± 0.106	0.856LeuCys: 0.856 ± 0.023	5.804LeuAsp: 5.804 ± 0.06	5.394LeuGlu: 5.394 ± 0.06	3.704LeuPhe: 3.704 ± 0.058	8.196LeuGly: 8.196 ± 0.08	1.75LeuHis: 1.75 ± 0.032	5.198LeuIle: 5.198 ± 0.071	3.937LeuLys: 3.937 ± 0.049	9.276LeuLeu: 9.276 ± 0.112	2.329LeuMet: 2.329 ± 0.036	2.628LeuAsn: 2.628 ± 0.04	5.307LeuPro: 5.307 ± 0.056	2.657LeuGln: 2.657 ± 0.04	6.36LeuArg: 6.36 ± 0.061	6.594LeuSer: 6.594 ± 0.07	5.367LeuThr: 5.367 ± 0.072	7.676LeuVal: 7.676 ± 0.076	1.085LeuTrp: 1.085 ± 0.028	2.094LeuTyr: 2.094 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	3.131MetAla: 3.131 ± 0.044	0.154MetCys: 0.154 ± 0.008	1.123MetAsp: 1.123 ± 0.026	1.218MetGlu: 1.218 ± 0.023	0.77MetPhe: 0.77 ± 0.021	1.865MetGly: 1.865 ± 0.034	0.454MetHis: 0.454 ± 0.014	1.436MetIle: 1.436 ± 0.03	1.086MetLys: 1.086 ± 0.022	2.597MetLeu: 2.597 ± 0.038	0.681MetMet: 0.681 ± 0.021	0.869MetAsn: 0.869 ± 0.022	1.482MetPro: 1.482 ± 0.029	0.876MetGln: 0.876 ± 0.024	1.901MetArg: 1.901 ± 0.032	1.771MetSer: 1.771 ± 0.033	1.902MetThr: 1.902 ± 0.033	1.851MetVal: 1.851 ± 0.033	0.239MetTrp: 0.239 ± 0.011	0.336MetTyr: 0.336 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.286AsnAla: 3.286 ± 0.046	0.238AsnCys: 0.238 ± 0.012	1.488AsnAsp: 1.488 ± 0.034	1.399AsnGlu: 1.399 ± 0.028	1.102AsnPhe: 1.102 ± 0.029	2.728AsnGly: 2.728 ± 0.06	0.534AsnHis: 0.534 ± 0.017	1.501AsnIle: 1.501 ± 0.026	0.829AsnLys: 0.829 ± 0.022	2.63AsnLeu: 2.63 ± 0.041	0.661AsnMet: 0.661 ± 0.018	0.787AsnAsn: 0.787 ± 0.035	1.891AsnPro: 1.891 ± 0.032	0.787AsnGln: 0.787 ± 0.021	1.834AsnArg: 1.834 ± 0.031	1.449AsnSer: 1.449 ± 0.028	1.329AsnThr: 1.329 ± 0.035	2.142AsnVal: 2.142 ± 0.039	0.491AsnTrp: 0.491 ± 0.018	0.734AsnTyr: 0.734 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.965ProAla: 5.965 ± 0.075	0.288ProCys: 0.288 ± 0.013	3.353ProAsp: 3.353 ± 0.047	3.664ProGlu: 3.664 ± 0.048	2.024ProPhe: 2.024 ± 0.037	4.272ProGly: 4.272 ± 0.053	1.103ProHis: 1.103 ± 0.024	2.412ProIle: 2.412 ± 0.032	1.833ProLys: 1.833 ± 0.04	4.606ProLeu: 4.606 ± 0.053	1.176ProMet: 1.176 ± 0.026	1.445ProAsn: 1.445 ± 0.028	2.141ProPro: 2.141 ± 0.042	1.666ProGln: 1.666 ± 0.03	2.727ProArg: 2.727 ± 0.047	2.818ProSer: 2.818 ± 0.038	2.481ProThr: 2.481 ± 0.038	4.107ProVal: 4.107 ± 0.051	0.659ProTrp: 0.659 ± 0.019	1.271ProTyr: 1.271 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.867GlnAla: 3.867 ± 0.048	0.199GlnCys: 0.199 ± 0.01	1.366GlnAsp: 1.366 ± 0.026	1.511GlnGlu: 1.511 ± 0.031	1.085GlnPhe: 1.085 ± 0.026	2.243GlnGly: 2.243 ± 0.035	0.636GlnHis: 0.636 ± 0.019	1.847GlnIle: 1.847 ± 0.035	1.24GlnLys: 1.24 ± 0.026	2.876GlnLeu: 2.876 ± 0.049	0.933GlnMet: 0.933 ± 0.024	0.933GlnAsn: 0.933 ± 0.024	1.811GlnPro: 1.811 ± 0.035	1.24GlnGln: 1.24 ± 0.035	2.274GlnArg: 2.274 ± 0.04	1.744GlnSer: 1.744 ± 0.031	1.634GlnThr: 1.634 ± 0.032	2.161GlnVal: 2.161 ± 0.036	0.387GlnTrp: 0.387 ± 0.014	0.61GlnTyr: 0.61 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.299ArgAla: 7.299 ± 0.075	0.47ArgCys: 0.47 ± 0.019	3.845ArgAsp: 3.845 ± 0.052	4.07ArgGlu: 4.07 ± 0.054	2.885ArgPhe: 2.885 ± 0.038	4.486ArgGly: 4.486 ± 0.054	1.632ArgHis: 1.632 ± 0.027	3.942ArgIle: 3.942 ± 0.05	2.541ArgLys: 2.541 ± 0.04	7.41ArgLeu: 7.41 ± 0.068	1.822ArgMet: 1.822 ± 0.034	2.018ArgAsn: 2.018 ± 0.032	3.278ArgPro: 3.278 ± 0.046	2.538ArgGln: 2.538 ± 0.041	5.237ArgArg: 5.237 ± 0.073	3.686ArgSer: 3.686 ± 0.046	3.209ArgThr: 3.209 ± 0.04	4.541ArgVal: 4.541 ± 0.05	0.952ArgTrp: 0.952 ± 0.025	1.668ArgTyr: 1.668 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.313SerAla: 6.313 ± 0.068	0.417SerCys: 0.417 ± 0.017	2.959SerAsp: 2.959 ± 0.038	3.0SerGlu: 3.0 ± 0.04	2.44SerPhe: 2.44 ± 0.042	5.758SerGly: 5.758 ± 0.076	1.144SerHis: 1.144 ± 0.026	3.087SerIle: 3.087 ± 0.046	1.829SerLys: 1.829 ± 0.034	5.72SerLeu: 5.72 ± 0.063	1.44SerMet: 1.44 ± 0.027	1.506SerAsn: 1.506 ± 0.034	2.825SerPro: 2.825 ± 0.041	1.663SerGln: 1.663 ± 0.035	3.643SerArg: 3.643 ± 0.049	3.177SerSer: 3.177 ± 0.055	2.783SerThr: 2.783 ± 0.045	4.211SerVal: 4.211 ± 0.048	0.843SerTrp: 0.843 ± 0.026	1.403SerTyr: 1.403 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.146ThrAla: 6.146 ± 0.066	0.4ThrCys: 0.4 ± 0.016	2.753ThrAsp: 2.753 ± 0.04	2.691ThrGlu: 2.691 ± 0.041	2.071ThrPhe: 2.071 ± 0.035	4.91ThrGly: 4.91 ± 0.073	1.024ThrHis: 1.024 ± 0.023	3.209ThrIle: 3.209 ± 0.049	1.606ThrLys: 1.606 ± 0.028	5.671ThrLeu: 5.671 ± 0.073	1.307ThrMet: 1.307 ± 0.03	1.379ThrAsn: 1.379 ± 0.034	3.063ThrPro: 3.063 ± 0.052	1.41ThrGln: 1.41 ± 0.026	3.102ThrArg: 3.102 ± 0.047	2.858ThrSer: 2.858 ± 0.043	2.915ThrThr: 2.915 ± 0.053	4.456ThrVal: 4.456 ± 0.06	0.622ThrTrp: 0.622 ± 0.023	1.199ThrTyr: 1.199 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.274ValAla: 9.274 ± 0.071	0.635ValCys: 0.635 ± 0.021	4.133ValAsp: 4.133 ± 0.046	4.639ValGlu: 4.639 ± 0.056	2.934ValPhe: 2.934 ± 0.045	5.853ValGly: 5.853 ± 0.054	1.354ValHis: 1.354 ± 0.031	4.045ValIle: 4.045 ± 0.051	2.51ValLys: 2.51 ± 0.046	7.51ValLeu: 7.51 ± 0.077	1.975ValMet: 1.975 ± 0.034	2.025ValAsn: 2.025 ± 0.041	3.734ValPro: 3.734 ± 0.045	1.999ValGln: 1.999 ± 0.036	4.793ValArg: 4.793 ± 0.051	4.684ValSer: 4.684 ± 0.049	4.613ValThr: 4.613 ± 0.063	6.196ValVal: 6.196 ± 0.063	0.903ValTrp: 0.903 ± 0.025	1.52ValTyr: 1.52 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.223TrpAla: 1.223 ± 0.028	0.14TrpCys: 0.14 ± 0.008	0.622TrpAsp: 0.622 ± 0.018	0.553TrpGlu: 0.553 ± 0.017	0.561TrpPhe: 0.561 ± 0.021	0.888TrpGly: 0.888 ± 0.024	0.356TrpHis: 0.356 ± 0.016	0.69TrpIle: 0.69 ± 0.019	0.519TrpLys: 0.519 ± 0.016	1.68TrpLeu: 1.68 ± 0.032	0.374TrpMet: 0.374 ± 0.016	0.491TrpAsn: 0.491 ± 0.018	0.729TrpPro: 0.729 ± 0.023	0.581TrpGln: 0.581 ± 0.021	1.095TrpArg: 1.095 ± 0.029	0.862TrpSer: 0.862 ± 0.025	0.734TrpThr: 0.734 ± 0.021	0.826TrpVal: 0.826 ± 0.024	0.236TrpTrp: 0.236 ± 0.013	0.314TrpTyr: 0.314 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.506TyrAla: 2.506 ± 0.044	0.248TyrCys: 0.248 ± 0.012	1.43TyrAsp: 1.43 ± 0.03	1.287TyrGlu: 1.287 ± 0.031	0.941TyrPhe: 0.941 ± 0.022	2.16TyrGly: 2.16 ± 0.041	0.478TyrHis: 0.478 ± 0.017	0.954TyrIle: 0.954 ± 0.021	0.714TyrLys: 0.714 ± 0.022	2.364TyrLeu: 2.364 ± 0.038	0.49TyrMet: 0.49 ± 0.017	0.641TyrAsn: 0.641 ± 0.021	1.163TyrPro: 1.163 ± 0.028	0.722TyrGln: 0.722 ± 0.024	1.734TyrArg: 1.734 ± 0.033	1.326TyrSer: 1.326 ± 0.028	1.199TyrThr: 1.199 ± 0.027	1.727TyrVal: 1.727 ± 0.028	0.399TyrTrp: 0.399 ± 0.016	0.627TyrTyr: 0.627 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5837 proteins (1783834 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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