Amino acid dipepetide frequency for Streptococcus phage Javan457

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.677AlaAla: 3.677 ± 0.752
0.315AlaCys: 0.315 ± 0.2
5.463AlaAsp: 5.463 ± 0.698
6.619AlaGlu: 6.619 ± 0.877
1.891AlaPhe: 1.891 ± 0.456
3.152AlaGly: 3.152 ± 0.621
0.946AlaHis: 0.946 ± 0.269
6.409AlaIle: 6.409 ± 1.577
8.405AlaLys: 8.405 ± 0.938
5.884AlaLeu: 5.884 ± 0.756
2.206AlaMet: 2.206 ± 0.475
3.572AlaAsn: 3.572 ± 0.588
1.366AlaPro: 1.366 ± 0.444
3.257AlaGln: 3.257 ± 0.434
2.732AlaArg: 2.732 ± 0.566
4.518AlaSer: 4.518 ± 0.853
4.203AlaThr: 4.203 ± 0.97
5.358AlaVal: 5.358 ± 0.711
0.63AlaTrp: 0.63 ± 0.234
2.627AlaTyr: 2.627 ± 0.646
0.0AlaXaa: 0.0 ± 0.0
Cys
0.525CysAla: 0.525 ± 0.229
0.0CysCys: 0.0 ± 0.0
0.21CysAsp: 0.21 ± 0.135
0.525CysGlu: 0.525 ± 0.255
0.21CysPhe: 0.21 ± 0.128
0.21CysGly: 0.21 ± 0.146
0.21CysHis: 0.21 ± 0.143
0.21CysIle: 0.21 ± 0.153
0.315CysLys: 0.315 ± 0.181
0.315CysLeu: 0.315 ± 0.168
0.21CysMet: 0.21 ± 0.144
0.105CysAsn: 0.105 ± 0.099
0.105CysPro: 0.105 ± 0.105
0.105CysGln: 0.105 ± 0.105
0.315CysArg: 0.315 ± 0.173
0.63CysSer: 0.63 ± 0.327
0.315CysThr: 0.315 ± 0.189
0.42CysVal: 0.42 ± 0.207
0.105CysTrp: 0.105 ± 0.091
0.42CysTyr: 0.42 ± 0.201
0.0CysXaa: 0.0 ± 0.0
Asp
3.362AspAla: 3.362 ± 0.695
0.42AspCys: 0.42 ± 0.252
5.358AspAsp: 5.358 ± 0.785
4.203AspGlu: 4.203 ± 0.731
3.467AspPhe: 3.467 ± 0.565
4.308AspGly: 4.308 ± 0.853
0.525AspHis: 0.525 ± 0.254
5.463AspIle: 5.463 ± 0.72
6.514AspLys: 6.514 ± 0.857
4.833AspLeu: 4.833 ± 0.643
2.206AspMet: 2.206 ± 0.429
4.728AspAsn: 4.728 ± 0.604
2.206AspPro: 2.206 ± 0.523
1.471AspGln: 1.471 ± 0.294
2.101AspArg: 2.101 ± 0.437
3.887AspSer: 3.887 ± 0.638
3.572AspThr: 3.572 ± 0.536
3.152AspVal: 3.152 ± 0.446
1.576AspTrp: 1.576 ± 0.492
3.257AspTyr: 3.257 ± 0.64
0.0AspXaa: 0.0 ± 0.0
Glu
3.677GluAla: 3.677 ± 0.714
0.42GluCys: 0.42 ± 0.22
3.047GluAsp: 3.047 ± 0.558
6.724GluGlu: 6.724 ± 1.012
1.996GluPhe: 1.996 ± 0.542
3.677GluGly: 3.677 ± 0.557
1.366GluHis: 1.366 ± 0.395
5.148GluIle: 5.148 ± 0.647
6.409GluLys: 6.409 ± 1.122
9.351GluLeu: 9.351 ± 1.014
1.996GluMet: 1.996 ± 0.6
3.782GluAsn: 3.782 ± 0.805
1.786GluPro: 1.786 ± 0.618
3.992GluGln: 3.992 ± 0.589
2.522GluArg: 2.522 ± 0.54
4.413GluSer: 4.413 ± 0.538
4.728GluThr: 4.728 ± 0.718
4.518GluVal: 4.518 ± 0.713
0.946GluTrp: 0.946 ± 0.311
1.996GluTyr: 1.996 ± 0.522
0.0GluXaa: 0.0 ± 0.0
Phe
1.786PheAla: 1.786 ± 0.429
0.105PheCys: 0.105 ± 0.096
3.572PheAsp: 3.572 ± 0.653
3.467PheGlu: 3.467 ± 0.501
1.051PhePhe: 1.051 ± 0.4
2.101PheGly: 2.101 ± 0.454
0.525PheHis: 0.525 ± 0.218
2.627PheIle: 2.627 ± 0.553
3.992PheLys: 3.992 ± 0.727
2.311PheLeu: 2.311 ± 0.589
1.261PheMet: 1.261 ± 0.387
2.837PheAsn: 2.837 ± 0.489
0.525PhePro: 0.525 ± 0.308
0.841PheGln: 0.841 ± 0.305
1.261PheArg: 1.261 ± 0.391
2.206PheSer: 2.206 ± 0.451
2.732PheThr: 2.732 ± 0.632
1.576PheVal: 1.576 ± 0.5
0.42PheTrp: 0.42 ± 0.192
1.786PheTyr: 1.786 ± 0.43
0.0PheXaa: 0.0 ± 0.0
Gly
5.568GlyAla: 5.568 ± 1.298
0.42GlyCys: 0.42 ± 0.207
3.467GlyAsp: 3.467 ± 0.577
3.362GlyGlu: 3.362 ± 0.487
3.257GlyPhe: 3.257 ± 0.751
3.362GlyGly: 3.362 ± 0.68
1.051GlyHis: 1.051 ± 0.336
5.043GlyIle: 5.043 ± 0.681
5.358GlyLys: 5.358 ± 0.824
4.413GlyLeu: 4.413 ± 0.884
1.681GlyMet: 1.681 ± 0.601
2.942GlyAsn: 2.942 ± 0.728
1.051GlyPro: 1.051 ± 0.803
2.732GlyGln: 2.732 ± 0.66
2.206GlyArg: 2.206 ± 0.648
3.677GlySer: 3.677 ± 0.557
3.152GlyThr: 3.152 ± 0.701
3.362GlyVal: 3.362 ± 0.521
0.735GlyTrp: 0.735 ± 0.287
2.311GlyTyr: 2.311 ± 0.428
0.0GlyXaa: 0.0 ± 0.0
His
0.841HisAla: 0.841 ± 0.308
0.105HisCys: 0.105 ± 0.099
1.156HisAsp: 1.156 ± 0.412
1.366HisGlu: 1.366 ± 0.391
1.156HisPhe: 1.156 ± 0.247
0.63HisGly: 0.63 ± 0.253
0.525HisHis: 0.525 ± 0.212
1.681HisIle: 1.681 ± 0.368
1.051HisLys: 1.051 ± 0.348
1.891HisLeu: 1.891 ± 0.497
0.315HisMet: 0.315 ± 0.203
0.525HisAsn: 0.525 ± 0.243
0.315HisPro: 0.315 ± 0.183
0.315HisGln: 0.315 ± 0.174
0.42HisArg: 0.42 ± 0.233
0.42HisSer: 0.42 ± 0.193
1.261HisThr: 1.261 ± 0.376
0.946HisVal: 0.946 ± 0.264
0.21HisTrp: 0.21 ± 0.144
0.946HisTyr: 0.946 ± 0.342
0.0HisXaa: 0.0 ± 0.0
Ile
6.514IleAla: 6.514 ± 1.117
0.735IleCys: 0.735 ± 0.419
6.514IleAsp: 6.514 ± 0.841
4.833IleGlu: 4.833 ± 0.625
2.732IlePhe: 2.732 ± 0.624
3.782IleGly: 3.782 ± 0.807
1.366IleHis: 1.366 ± 0.375
3.782IleIle: 3.782 ± 0.741
7.039IleLys: 7.039 ± 1.012
4.833IleLeu: 4.833 ± 0.829
1.366IleMet: 1.366 ± 0.288
5.463IleAsn: 5.463 ± 0.679
2.206IlePro: 2.206 ± 0.558
2.732IleGln: 2.732 ± 0.627
1.996IleArg: 1.996 ± 0.393
3.992IleSer: 3.992 ± 0.621
5.043IleThr: 5.043 ± 0.923
3.257IleVal: 3.257 ± 0.589
0.735IleTrp: 0.735 ± 0.289
1.471IleTyr: 1.471 ± 0.368
0.0IleXaa: 0.0 ± 0.0
Lys
6.724LysAla: 6.724 ± 0.76
0.21LysCys: 0.21 ± 0.134
4.518LysAsp: 4.518 ± 0.818
7.565LysGlu: 7.565 ± 0.761
2.416LysPhe: 2.416 ± 0.36
4.308LysGly: 4.308 ± 0.717
1.366LysHis: 1.366 ± 0.441
6.934LysIle: 6.934 ± 1.127
7.46LysLys: 7.46 ± 0.994
7.354LysLeu: 7.354 ± 0.933
3.152LysMet: 3.152 ± 0.662
4.728LysAsn: 4.728 ± 0.682
2.837LysPro: 2.837 ± 0.69
3.467LysGln: 3.467 ± 0.556
3.257LysArg: 3.257 ± 0.745
6.409LysSer: 6.409 ± 0.615
6.304LysThr: 6.304 ± 0.961
5.148LysVal: 5.148 ± 0.783
0.63LysTrp: 0.63 ± 0.3
3.467LysTyr: 3.467 ± 0.723
0.0LysXaa: 0.0 ± 0.0
Leu
6.409LeuAla: 6.409 ± 0.731
0.315LeuCys: 0.315 ± 0.158
5.568LeuAsp: 5.568 ± 0.67
6.619LeuGlu: 6.619 ± 0.96
3.257LeuPhe: 3.257 ± 0.458
5.358LeuGly: 5.358 ± 0.924
0.841LeuHis: 0.841 ± 0.307
6.094LeuIle: 6.094 ± 0.788
8.405LeuLys: 8.405 ± 0.872
5.779LeuLeu: 5.779 ± 0.786
1.891LeuMet: 1.891 ± 0.427
5.043LeuAsn: 5.043 ± 0.694
2.416LeuPro: 2.416 ± 0.618
2.522LeuGln: 2.522 ± 0.643
4.308LeuArg: 4.308 ± 0.811
6.514LeuSer: 6.514 ± 0.835
6.409LeuThr: 6.409 ± 0.752
4.203LeuVal: 4.203 ± 0.741
0.946LeuTrp: 0.946 ± 0.527
2.942LeuTyr: 2.942 ± 0.644
0.0LeuXaa: 0.0 ± 0.0
Met
1.786MetAla: 1.786 ± 0.415
0.315MetCys: 0.315 ± 0.205
1.576MetAsp: 1.576 ± 0.467
1.681MetGlu: 1.681 ± 0.392
0.841MetPhe: 0.841 ± 0.314
0.946MetGly: 0.946 ± 0.285
0.315MetHis: 0.315 ± 0.204
1.681MetIle: 1.681 ± 0.434
2.311MetLys: 2.311 ± 0.419
2.101MetLeu: 2.101 ± 0.52
0.42MetMet: 0.42 ± 0.226
1.471MetAsn: 1.471 ± 0.466
0.735MetPro: 0.735 ± 0.335
0.42MetGln: 0.42 ± 0.21
1.261MetArg: 1.261 ± 0.348
2.416MetSer: 2.416 ± 0.669
1.996MetThr: 1.996 ± 0.496
1.576MetVal: 1.576 ± 0.449
0.21MetTrp: 0.21 ± 0.152
0.315MetTyr: 0.315 ± 0.168
0.0MetXaa: 0.0 ± 0.0
Asn
5.253AsnAla: 5.253 ± 1.023
0.21AsnCys: 0.21 ± 0.18
2.206AsnAsp: 2.206 ± 0.708
3.677AsnGlu: 3.677 ± 0.427
2.206AsnPhe: 2.206 ± 0.462
4.413AsnGly: 4.413 ± 0.654
1.051AsnHis: 1.051 ± 0.299
3.257AsnIle: 3.257 ± 0.596
3.677AsnLys: 3.677 ± 0.47
5.043AsnLeu: 5.043 ± 0.947
0.946AsnMet: 0.946 ± 0.272
3.047AsnAsn: 3.047 ± 0.554
2.101AsnPro: 2.101 ± 0.387
2.206AsnGln: 2.206 ± 0.44
3.257AsnArg: 3.257 ± 0.463
3.362AsnSer: 3.362 ± 0.838
3.467AsnThr: 3.467 ± 0.522
3.152AsnVal: 3.152 ± 0.47
0.735AsnTrp: 0.735 ± 0.336
2.311AsnTyr: 2.311 ± 0.516
0.0AsnXaa: 0.0 ± 0.0
Pro
1.471ProAla: 1.471 ± 0.442
0.21ProCys: 0.21 ± 0.16
2.416ProAsp: 2.416 ± 0.476
1.156ProGlu: 1.156 ± 0.354
0.946ProPhe: 0.946 ± 0.279
0.735ProGly: 0.735 ± 0.3
0.42ProHis: 0.42 ± 0.226
2.416ProIle: 2.416 ± 0.595
2.732ProLys: 2.732 ± 0.639
1.996ProLeu: 1.996 ± 0.511
0.63ProMet: 0.63 ± 0.236
1.051ProAsn: 1.051 ± 0.356
0.105ProPro: 0.105 ± 0.107
1.366ProGln: 1.366 ± 0.343
1.261ProArg: 1.261 ± 0.336
1.576ProSer: 1.576 ± 0.542
1.366ProThr: 1.366 ± 0.324
1.786ProVal: 1.786 ± 0.626
0.315ProTrp: 0.315 ± 0.184
1.051ProTyr: 1.051 ± 0.334
0.0ProXaa: 0.0 ± 0.0
Gln
4.833GlnAla: 4.833 ± 0.746
0.315GlnCys: 0.315 ± 0.186
1.996GlnAsp: 1.996 ± 0.41
2.101GlnGlu: 2.101 ± 0.418
1.471GlnPhe: 1.471 ± 0.442
1.996GlnGly: 1.996 ± 0.485
0.315GlnHis: 0.315 ± 0.185
2.627GlnIle: 2.627 ± 0.43
3.572GlnLys: 3.572 ± 0.702
4.623GlnLeu: 4.623 ± 0.635
0.63GlnMet: 0.63 ± 0.223
2.101GlnAsn: 2.101 ± 0.442
0.946GlnPro: 0.946 ± 0.288
1.366GlnGln: 1.366 ± 0.319
2.101GlnArg: 2.101 ± 0.463
2.732GlnSer: 2.732 ± 0.488
2.311GlnThr: 2.311 ± 0.702
1.996GlnVal: 1.996 ± 0.508
0.21GlnTrp: 0.21 ± 0.125
1.156GlnTyr: 1.156 ± 0.329
0.0GlnXaa: 0.0 ± 0.0
Arg
3.152ArgAla: 3.152 ± 0.511
0.525ArgCys: 0.525 ± 0.231
3.047ArgAsp: 3.047 ± 0.585
2.522ArgGlu: 2.522 ± 0.446
1.681ArgPhe: 1.681 ± 0.479
2.101ArgGly: 2.101 ± 0.48
1.156ArgHis: 1.156 ± 0.385
2.416ArgIle: 2.416 ± 0.423
2.416ArgLys: 2.416 ± 0.406
4.203ArgLeu: 4.203 ± 0.723
1.051ArgMet: 1.051 ± 0.304
1.786ArgAsn: 1.786 ± 0.479
1.156ArgPro: 1.156 ± 0.39
2.627ArgGln: 2.627 ± 0.495
1.786ArgArg: 1.786 ± 0.584
2.732ArgSer: 2.732 ± 0.664
2.311ArgThr: 2.311 ± 0.529
2.732ArgVal: 2.732 ± 0.556
0.735ArgTrp: 0.735 ± 0.21
1.471ArgTyr: 1.471 ± 0.349
0.0ArgXaa: 0.0 ± 0.0
Ser
4.833SerAla: 4.833 ± 1.118
0.315SerCys: 0.315 ± 0.183
4.097SerAsp: 4.097 ± 0.68
3.782SerGlu: 3.782 ± 0.503
2.732SerPhe: 2.732 ± 0.612
5.043SerGly: 5.043 ± 0.881
0.735SerHis: 0.735 ± 0.33
3.782SerIle: 3.782 ± 0.564
5.253SerLys: 5.253 ± 1.045
5.779SerLeu: 5.779 ± 0.726
0.735SerMet: 0.735 ± 0.277
4.518SerAsn: 4.518 ± 0.808
1.366SerPro: 1.366 ± 0.396
3.152SerGln: 3.152 ± 0.623
3.257SerArg: 3.257 ± 0.875
5.884SerSer: 5.884 ± 1.297
4.413SerThr: 4.413 ± 0.863
3.677SerVal: 3.677 ± 0.629
0.315SerTrp: 0.315 ± 0.193
2.522SerTyr: 2.522 ± 0.74
0.0SerXaa: 0.0 ± 0.0
Thr
5.043ThrAla: 5.043 ± 0.706
0.315ThrCys: 0.315 ± 0.174
5.358ThrAsp: 5.358 ± 0.717
3.677ThrGlu: 3.677 ± 0.624
2.206ThrPhe: 2.206 ± 0.589
5.884ThrGly: 5.884 ± 1.276
1.156ThrHis: 1.156 ± 0.321
4.308ThrIle: 4.308 ± 0.578
6.514ThrLys: 6.514 ± 0.677
4.938ThrLeu: 4.938 ± 0.908
0.841ThrMet: 0.841 ± 0.252
3.257ThrAsn: 3.257 ± 0.548
1.051ThrPro: 1.051 ± 0.375
2.416ThrGln: 2.416 ± 0.482
1.891ThrArg: 1.891 ± 0.47
3.572ThrSer: 3.572 ± 0.748
3.992ThrThr: 3.992 ± 0.652
6.514ThrVal: 6.514 ± 0.814
0.946ThrTrp: 0.946 ± 0.414
2.311ThrTyr: 2.311 ± 0.48
0.0ThrXaa: 0.0 ± 0.0
Val
3.572ValAla: 3.572 ± 0.549
0.0ValCys: 0.0 ± 0.0
3.782ValAsp: 3.782 ± 0.705
4.833ValGlu: 4.833 ± 0.609
1.891ValPhe: 1.891 ± 0.543
3.782ValGly: 3.782 ± 0.846
1.051ValHis: 1.051 ± 0.285
3.887ValIle: 3.887 ± 0.622
4.308ValLys: 4.308 ± 0.616
5.043ValLeu: 5.043 ± 0.693
1.576ValMet: 1.576 ± 0.419
2.522ValAsn: 2.522 ± 0.466
1.366ValPro: 1.366 ± 0.43
2.206ValGln: 2.206 ± 0.558
2.837ValArg: 2.837 ± 0.638
3.782ValSer: 3.782 ± 0.537
6.094ValThr: 6.094 ± 0.771
4.413ValVal: 4.413 ± 0.919
0.841ValTrp: 0.841 ± 0.275
1.681ValTyr: 1.681 ± 0.471
0.0ValXaa: 0.0 ± 0.0
Trp
0.42TrpAla: 0.42 ± 0.19
0.105TrpCys: 0.105 ± 0.106
0.63TrpAsp: 0.63 ± 0.229
0.63TrpGlu: 0.63 ± 0.242
0.42TrpPhe: 0.42 ± 0.197
1.471TrpGly: 1.471 ± 0.467
0.21TrpHis: 0.21 ± 0.143
0.525TrpIle: 0.525 ± 0.245
0.42TrpLys: 0.42 ± 0.229
1.156TrpLeu: 1.156 ± 0.455
0.42TrpMet: 0.42 ± 0.231
0.735TrpAsn: 0.735 ± 0.334
0.21TrpPro: 0.21 ± 0.142
0.525TrpGln: 0.525 ± 0.222
0.525TrpArg: 0.525 ± 0.227
1.261TrpSer: 1.261 ± 0.61
1.051TrpThr: 1.051 ± 0.268
0.21TrpVal: 0.21 ± 0.127
0.0TrpTrp: 0.0 ± 0.0
0.63TrpTyr: 0.63 ± 0.208
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.782TyrAla: 3.782 ± 0.686
0.105TyrCys: 0.105 ± 0.087
2.627TyrAsp: 2.627 ± 0.606
3.257TyrGlu: 3.257 ± 0.701
1.156TyrPhe: 1.156 ± 0.333
1.891TyrGly: 1.891 ± 0.431
0.946TyrHis: 0.946 ± 0.283
2.101TyrIle: 2.101 ± 0.513
2.101TyrLys: 2.101 ± 0.621
3.992TyrLeu: 3.992 ± 0.643
0.735TyrMet: 0.735 ± 0.284
1.366TyrAsn: 1.366 ± 0.443
1.156TyrPro: 1.156 ± 0.472
1.681TyrGln: 1.681 ± 0.393
2.311TyrArg: 2.311 ± 0.551
2.206TyrSer: 2.206 ± 0.582
1.471TyrThr: 1.471 ± 0.442
1.471TyrVal: 1.471 ± 0.391
0.315TyrTrp: 0.315 ± 0.183
1.471TyrTyr: 1.471 ± 0.386
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 44 proteins (9519 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski