Amino acid dipepetide frequency for Mycobacterium virus Babsiella

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.337AlaAla: 15.337 ± 1.401
0.82AlaCys: 0.82 ± 0.254
8.521AlaAsp: 8.521 ± 0.73
9.215AlaGlu: 9.215 ± 1.125
2.398AlaPhe: 2.398 ± 0.386
11.235AlaGly: 11.235 ± 1.655
1.704AlaHis: 1.704 ± 0.352
5.87AlaIle: 5.87 ± 0.722
4.607AlaLys: 4.607 ± 0.605
9.152AlaLeu: 9.152 ± 0.772
2.209AlaMet: 2.209 ± 0.349
2.651AlaAsn: 2.651 ± 0.452
5.491AlaPro: 5.491 ± 0.688
5.239AlaGln: 5.239 ± 0.755
6.943AlaArg: 6.943 ± 0.661
5.996AlaSer: 5.996 ± 0.722
5.996AlaThr: 5.996 ± 0.674
6.88AlaVal: 6.88 ± 0.714
2.146AlaTrp: 2.146 ± 0.411
3.219AlaTyr: 3.219 ± 0.333
0.0AlaXaa: 0.0 ± 0.0
Cys
0.694CysAla: 0.694 ± 0.216
0.126CysCys: 0.126 ± 0.087
0.442CysAsp: 0.442 ± 0.18
0.442CysGlu: 0.442 ± 0.204
0.126CysPhe: 0.126 ± 0.081
1.199CysGly: 1.199 ± 0.272
0.442CysHis: 0.442 ± 0.179
0.505CysIle: 0.505 ± 0.165
0.316CysLys: 0.316 ± 0.142
0.568CysLeu: 0.568 ± 0.177
0.379CysMet: 0.379 ± 0.147
0.252CysAsn: 0.252 ± 0.126
1.073CysPro: 1.073 ± 0.363
0.379CysGln: 0.379 ± 0.186
1.136CysArg: 1.136 ± 0.267
0.252CysSer: 0.252 ± 0.164
0.442CysThr: 0.442 ± 0.18
0.379CysVal: 0.379 ± 0.162
0.189CysTrp: 0.189 ± 0.111
0.126CysTyr: 0.126 ± 0.098
0.0CysXaa: 0.0 ± 0.0
Asp
6.69AspAla: 6.69 ± 0.744
0.757AspCys: 0.757 ± 0.272
5.617AspAsp: 5.617 ± 0.581
5.491AspGlu: 5.491 ± 0.725
1.83AspPhe: 1.83 ± 0.407
6.88AspGly: 6.88 ± 0.689
1.262AspHis: 1.262 ± 0.302
2.651AspIle: 2.651 ± 0.4
1.199AspLys: 1.199 ± 0.322
7.132AspLeu: 7.132 ± 0.588
1.389AspMet: 1.389 ± 0.26
1.704AspAsn: 1.704 ± 0.324
3.408AspPro: 3.408 ± 0.405
1.641AspGln: 1.641 ± 0.298
4.86AspArg: 4.86 ± 0.748
3.534AspSer: 3.534 ± 0.63
4.355AspThr: 4.355 ± 0.567
4.292AspVal: 4.292 ± 0.457
1.893AspTrp: 1.893 ± 0.353
1.957AspTyr: 1.957 ± 0.318
0.0AspXaa: 0.0 ± 0.0
Glu
7.574GluAla: 7.574 ± 0.816
0.947GluCys: 0.947 ± 0.269
2.903GluAsp: 2.903 ± 0.443
2.966GluGlu: 2.966 ± 0.554
2.651GluPhe: 2.651 ± 0.514
4.229GluGly: 4.229 ± 0.415
1.893GluHis: 1.893 ± 0.397
2.461GluIle: 2.461 ± 0.438
1.893GluLys: 1.893 ± 0.351
6.059GluLeu: 6.059 ± 0.592
1.389GluMet: 1.389 ± 0.267
1.515GluAsn: 1.515 ± 0.269
3.471GluPro: 3.471 ± 0.568
2.146GluGln: 2.146 ± 0.31
4.229GluArg: 4.229 ± 0.454
3.093GluSer: 3.093 ± 0.399
3.282GluThr: 3.282 ± 0.435
4.418GluVal: 4.418 ± 0.521
1.262GluTrp: 1.262 ± 0.261
1.767GluTyr: 1.767 ± 0.365
0.0GluXaa: 0.0 ± 0.0
Phe
2.966PheAla: 2.966 ± 0.478
0.252PheCys: 0.252 ± 0.119
2.588PheAsp: 2.588 ± 0.358
1.199PheGlu: 1.199 ± 0.305
0.82PhePhe: 0.82 ± 0.2
3.976PheGly: 3.976 ± 0.536
0.379PheHis: 0.379 ± 0.168
1.83PheIle: 1.83 ± 0.376
1.136PheLys: 1.136 ± 0.251
1.893PheLeu: 1.893 ± 0.411
0.631PheMet: 0.631 ± 0.185
0.947PheAsn: 0.947 ± 0.301
1.199PhePro: 1.199 ± 0.275
1.199PheGln: 1.199 ± 0.234
1.83PheArg: 1.83 ± 0.308
1.515PheSer: 1.515 ± 0.241
1.641PheThr: 1.641 ± 0.329
2.461PheVal: 2.461 ± 0.334
0.757PheTrp: 0.757 ± 0.221
0.568PheTyr: 0.568 ± 0.159
0.0PheXaa: 0.0 ± 0.0
Gly
9.72GlyAla: 9.72 ± 1.111
0.568GlyCys: 0.568 ± 0.166
5.743GlyAsp: 5.743 ± 0.649
5.112GlyGlu: 5.112 ± 0.573
2.903GlyPhe: 2.903 ± 0.449
8.836GlyGly: 8.836 ± 1.46
1.767GlyHis: 1.767 ± 0.354
4.102GlyIle: 4.102 ± 0.725
3.282GlyLys: 3.282 ± 0.441
6.564GlyLeu: 6.564 ± 0.975
1.767GlyMet: 1.767 ± 0.364
3.471GlyAsn: 3.471 ± 0.534
5.049GlyPro: 5.049 ± 0.595
4.544GlyGln: 4.544 ± 0.72
5.933GlyArg: 5.933 ± 0.676
5.554GlySer: 5.554 ± 0.937
6.248GlyThr: 6.248 ± 0.592
5.743GlyVal: 5.743 ± 0.751
2.146GlyTrp: 2.146 ± 0.379
2.777GlyTyr: 2.777 ± 0.397
0.0GlyXaa: 0.0 ± 0.0
His
1.83HisAla: 1.83 ± 0.357
0.316HisCys: 0.316 ± 0.145
1.578HisAsp: 1.578 ± 0.298
1.452HisGlu: 1.452 ± 0.287
0.568HisPhe: 0.568 ± 0.231
1.515HisGly: 1.515 ± 0.295
0.379HisHis: 0.379 ± 0.168
1.199HisIle: 1.199 ± 0.28
0.505HisLys: 0.505 ± 0.186
1.83HisLeu: 1.83 ± 0.392
0.442HisMet: 0.442 ± 0.169
0.505HisAsn: 0.505 ± 0.168
1.389HisPro: 1.389 ± 0.32
1.073HisGln: 1.073 ± 0.24
1.389HisArg: 1.389 ± 0.289
0.631HisSer: 0.631 ± 0.21
1.136HisThr: 1.136 ± 0.247
1.578HisVal: 1.578 ± 0.312
0.568HisTrp: 0.568 ± 0.219
0.694HisTyr: 0.694 ± 0.202
0.0HisXaa: 0.0 ± 0.0
Ile
5.428IleAla: 5.428 ± 0.514
0.316IleCys: 0.316 ± 0.126
2.777IleAsp: 2.777 ± 0.404
3.408IleGlu: 3.408 ± 0.433
0.757IlePhe: 0.757 ± 0.283
4.544IleGly: 4.544 ± 0.62
0.884IleHis: 0.884 ± 0.205
1.073IleIle: 1.073 ± 0.274
1.641IleLys: 1.641 ± 0.315
2.02IleLeu: 2.02 ± 0.373
0.505IleMet: 0.505 ± 0.174
1.767IleAsn: 1.767 ± 0.294
3.282IlePro: 3.282 ± 0.441
1.199IleGln: 1.199 ± 0.266
3.913IleArg: 3.913 ± 0.537
2.083IleSer: 2.083 ± 0.401
3.219IleThr: 3.219 ± 0.386
3.408IleVal: 3.408 ± 0.394
0.379IleTrp: 0.379 ± 0.189
1.01IleTyr: 1.01 ± 0.265
0.0IleXaa: 0.0 ± 0.0
Lys
3.661LysAla: 3.661 ± 0.437
0.126LysCys: 0.126 ± 0.078
2.209LysAsp: 2.209 ± 0.452
1.83LysGlu: 1.83 ± 0.356
1.83LysPhe: 1.83 ± 0.369
2.588LysGly: 2.588 ± 0.451
1.073LysHis: 1.073 ± 0.306
1.262LysIle: 1.262 ± 0.31
0.631LysLys: 0.631 ± 0.176
2.777LysLeu: 2.777 ± 0.384
0.947LysMet: 0.947 ± 0.254
1.136LysAsn: 1.136 ± 0.217
2.714LysPro: 2.714 ± 0.439
0.757LysGln: 0.757 ± 0.227
2.146LysArg: 2.146 ± 0.485
1.515LysSer: 1.515 ± 0.275
1.389LysThr: 1.389 ± 0.291
2.525LysVal: 2.525 ± 0.481
0.757LysTrp: 0.757 ± 0.206
0.505LysTyr: 0.505 ± 0.159
0.0LysXaa: 0.0 ± 0.0
Leu
10.477LeuAla: 10.477 ± 0.941
0.884LeuCys: 0.884 ± 0.26
6.059LeuAsp: 6.059 ± 0.717
3.471LeuGlu: 3.471 ± 0.533
2.083LeuPhe: 2.083 ± 0.371
7.889LeuGly: 7.889 ± 0.605
1.136LeuHis: 1.136 ± 0.292
3.471LeuIle: 3.471 ± 0.394
3.282LeuLys: 3.282 ± 0.535
6.753LeuLeu: 6.753 ± 0.737
1.199LeuMet: 1.199 ± 0.295
2.903LeuAsn: 2.903 ± 0.523
6.185LeuPro: 6.185 ± 0.759
2.272LeuGln: 2.272 ± 0.4
5.239LeuArg: 5.239 ± 0.591
4.166LeuSer: 4.166 ± 0.542
4.166LeuThr: 4.166 ± 0.512
4.797LeuVal: 4.797 ± 0.599
1.073LeuTrp: 1.073 ± 0.239
1.389LeuTyr: 1.389 ± 0.238
0.0LeuXaa: 0.0 ± 0.0
Met
3.093MetAla: 3.093 ± 0.436
0.252MetCys: 0.252 ± 0.13
0.631MetAsp: 0.631 ± 0.211
1.262MetGlu: 1.262 ± 0.324
0.505MetPhe: 0.505 ± 0.159
1.199MetGly: 1.199 ± 0.321
0.568MetHis: 0.568 ± 0.188
1.01MetIle: 1.01 ± 0.325
0.884MetLys: 0.884 ± 0.21
1.515MetLeu: 1.515 ± 0.281
0.505MetMet: 0.505 ± 0.179
0.757MetAsn: 0.757 ± 0.177
1.704MetPro: 1.704 ± 0.294
0.947MetGln: 0.947 ± 0.244
1.389MetArg: 1.389 ± 0.296
2.209MetSer: 2.209 ± 0.343
1.578MetThr: 1.578 ± 0.267
0.757MetVal: 0.757 ± 0.218
0.252MetTrp: 0.252 ± 0.117
0.505MetTyr: 0.505 ± 0.194
0.0MetXaa: 0.0 ± 0.0
Asn
3.282AsnAla: 3.282 ± 0.428
0.316AsnCys: 0.316 ± 0.133
1.704AsnAsp: 1.704 ± 0.325
1.073AsnGlu: 1.073 ± 0.284
0.568AsnPhe: 0.568 ± 0.177
4.039AsnGly: 4.039 ± 0.617
0.568AsnHis: 0.568 ± 0.192
0.884AsnIle: 0.884 ± 0.268
0.568AsnLys: 0.568 ± 0.175
3.345AsnLeu: 3.345 ± 0.56
0.568AsnMet: 0.568 ± 0.161
1.01AsnAsn: 1.01 ± 0.265
3.093AsnPro: 3.093 ± 0.403
0.82AsnGln: 0.82 ± 0.176
2.398AsnArg: 2.398 ± 0.586
1.957AsnSer: 1.957 ± 0.374
1.073AsnThr: 1.073 ± 0.276
1.957AsnVal: 1.957 ± 0.315
0.82AsnTrp: 0.82 ± 0.211
0.757AsnTyr: 0.757 ± 0.21
0.0AsnXaa: 0.0 ± 0.0
Pro
5.996ProAla: 5.996 ± 0.721
0.252ProCys: 0.252 ± 0.159
5.049ProAsp: 5.049 ± 0.718
4.229ProGlu: 4.229 ± 0.627
2.398ProPhe: 2.398 ± 0.362
6.438ProGly: 6.438 ± 0.878
0.884ProHis: 0.884 ± 0.277
2.588ProIle: 2.588 ± 0.389
2.146ProLys: 2.146 ± 0.352
4.607ProLeu: 4.607 ± 0.754
1.325ProMet: 1.325 ± 0.323
1.83ProAsn: 1.83 ± 0.427
3.598ProPro: 3.598 ± 0.707
3.093ProGln: 3.093 ± 0.412
3.345ProArg: 3.345 ± 0.516
3.724ProSer: 3.724 ± 0.389
3.408ProThr: 3.408 ± 0.653
4.544ProVal: 4.544 ± 0.581
1.136ProTrp: 1.136 ± 0.247
1.262ProTyr: 1.262 ± 0.31
0.0ProXaa: 0.0 ± 0.0
Gln
4.86GlnAla: 4.86 ± 0.644
0.126GlnCys: 0.126 ± 0.087
1.578GlnAsp: 1.578 ± 0.315
0.884GlnGlu: 0.884 ± 0.248
1.452GlnPhe: 1.452 ± 0.349
3.03GlnGly: 3.03 ± 0.63
0.694GlnHis: 0.694 ± 0.227
2.335GlnIle: 2.335 ± 0.38
1.01GlnLys: 1.01 ± 0.255
3.093GlnLeu: 3.093 ± 0.499
1.325GlnMet: 1.325 ± 0.303
1.199GlnAsn: 1.199 ± 0.27
2.209GlnPro: 2.209 ± 0.286
1.957GlnGln: 1.957 ± 0.557
3.976GlnArg: 3.976 ± 0.461
2.272GlnSer: 2.272 ± 0.408
2.083GlnThr: 2.083 ± 0.348
2.903GlnVal: 2.903 ± 0.403
0.694GlnTrp: 0.694 ± 0.182
0.442GlnTyr: 0.442 ± 0.154
0.0GlnXaa: 0.0 ± 0.0
Arg
7.953ArgAla: 7.953 ± 0.829
0.631ArgCys: 0.631 ± 0.213
5.365ArgAsp: 5.365 ± 0.522
4.229ArgGlu: 4.229 ± 0.479
2.083ArgPhe: 2.083 ± 0.389
5.302ArgGly: 5.302 ± 0.609
2.02ArgHis: 2.02 ± 0.333
2.777ArgIle: 2.777 ± 0.465
2.461ArgLys: 2.461 ± 0.389
5.112ArgLeu: 5.112 ± 0.584
2.461ArgMet: 2.461 ± 0.474
2.461ArgAsn: 2.461 ± 0.383
3.724ArgPro: 3.724 ± 0.463
2.525ArgGln: 2.525 ± 0.487
7.258ArgArg: 7.258 ± 1.165
3.408ArgSer: 3.408 ± 0.58
4.102ArgThr: 4.102 ± 0.534
3.976ArgVal: 3.976 ± 0.497
2.02ArgTrp: 2.02 ± 0.337
1.893ArgTyr: 1.893 ± 0.43
0.0ArgXaa: 0.0 ± 0.0
Ser
6.185SerAla: 6.185 ± 0.692
0.757SerCys: 0.757 ± 0.23
3.598SerAsp: 3.598 ± 0.494
2.461SerGlu: 2.461 ± 0.443
1.578SerPhe: 1.578 ± 0.32
5.428SerGly: 5.428 ± 0.904
0.694SerHis: 0.694 ± 0.239
2.209SerIle: 2.209 ± 0.307
1.767SerLys: 1.767 ± 0.319
3.724SerLeu: 3.724 ± 0.596
2.02SerMet: 2.02 ± 0.29
1.767SerAsn: 1.767 ± 0.295
3.219SerPro: 3.219 ± 0.423
2.272SerGln: 2.272 ± 0.437
3.787SerArg: 3.787 ± 0.481
2.335SerSer: 2.335 ± 0.451
3.661SerThr: 3.661 ± 0.517
3.408SerVal: 3.408 ± 0.563
1.073SerTrp: 1.073 ± 0.219
1.136SerTyr: 1.136 ± 0.218
0.0SerXaa: 0.0 ± 0.0
Thr
7.069ThrAla: 7.069 ± 0.647
0.442ThrCys: 0.442 ± 0.226
3.724ThrAsp: 3.724 ± 0.621
3.219ThrGlu: 3.219 ± 0.436
1.957ThrPhe: 1.957 ± 0.339
4.86ThrGly: 4.86 ± 0.524
1.262ThrHis: 1.262 ± 0.217
3.156ThrIle: 3.156 ± 0.535
2.083ThrLys: 2.083 ± 0.302
4.544ThrLeu: 4.544 ± 0.498
0.505ThrMet: 0.505 ± 0.228
1.893ThrAsn: 1.893 ± 0.353
4.671ThrPro: 4.671 ± 0.571
1.83ThrGln: 1.83 ± 0.359
3.219ThrArg: 3.219 ± 0.508
3.093ThrSer: 3.093 ± 0.417
3.598ThrThr: 3.598 ± 0.462
4.986ThrVal: 4.986 ± 0.644
1.452ThrTrp: 1.452 ± 0.352
1.641ThrTyr: 1.641 ± 0.346
0.0ThrXaa: 0.0 ± 0.0
Val
7.953ValAla: 7.953 ± 0.845
0.884ValCys: 0.884 ± 0.282
5.175ValAsp: 5.175 ± 0.629
5.302ValGlu: 5.302 ± 0.479
1.578ValPhe: 1.578 ± 0.292
5.175ValGly: 5.175 ± 0.665
1.452ValHis: 1.452 ± 0.269
2.903ValIle: 2.903 ± 0.404
2.083ValLys: 2.083 ± 0.355
4.86ValLeu: 4.86 ± 0.593
1.199ValMet: 1.199 ± 0.302
1.893ValAsn: 1.893 ± 0.298
4.229ValPro: 4.229 ± 0.526
2.335ValGln: 2.335 ± 0.361
4.923ValArg: 4.923 ± 0.448
3.345ValSer: 3.345 ± 0.565
5.175ValThr: 5.175 ± 0.73
5.807ValVal: 5.807 ± 0.6
1.01ValTrp: 1.01 ± 0.227
1.073ValTyr: 1.073 ± 0.238
0.0ValXaa: 0.0 ± 0.0
Trp
1.83TrpAla: 1.83 ± 0.317
0.379TrpCys: 0.379 ± 0.116
1.452TrpAsp: 1.452 ± 0.322
1.073TrpGlu: 1.073 ± 0.246
1.073TrpPhe: 1.073 ± 0.306
1.073TrpGly: 1.073 ± 0.265
0.757TrpHis: 0.757 ± 0.176
0.757TrpIle: 0.757 ± 0.219
0.505TrpLys: 0.505 ± 0.145
1.515TrpLeu: 1.515 ± 0.241
0.442TrpMet: 0.442 ± 0.176
0.505TrpAsn: 0.505 ± 0.144
0.947TrpPro: 0.947 ± 0.197
1.073TrpGln: 1.073 ± 0.254
2.02TrpArg: 2.02 ± 0.494
1.136TrpSer: 1.136 ± 0.237
1.389TrpThr: 1.389 ± 0.333
1.578TrpVal: 1.578 ± 0.353
0.442TrpTrp: 0.442 ± 0.161
0.505TrpTyr: 0.505 ± 0.15
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.03TyrAla: 3.03 ± 0.475
0.316TyrCys: 0.316 ± 0.127
1.83TyrAsp: 1.83 ± 0.309
1.83TyrGlu: 1.83 ± 0.286
0.631TyrPhe: 0.631 ± 0.183
2.398TyrGly: 2.398 ± 0.457
0.757TyrHis: 0.757 ± 0.223
0.568TyrIle: 0.568 ± 0.186
0.379TyrLys: 0.379 ± 0.158
1.83TyrLeu: 1.83 ± 0.457
0.252TyrMet: 0.252 ± 0.108
0.631TyrAsn: 0.631 ± 0.238
1.262TyrPro: 1.262 ± 0.313
0.82TyrGln: 0.82 ± 0.217
1.83TyrArg: 1.83 ± 0.278
1.262TyrSer: 1.262 ± 0.281
1.262TyrThr: 1.262 ± 0.271
1.957TyrVal: 1.957 ± 0.349
0.379TyrTrp: 0.379 ± 0.141
0.757TyrTyr: 0.757 ± 0.225
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (15845 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski