Amino acid dipepetide frequency for Acinetobacter phage Petty

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.715AlaAla: 8.715 ± 1.164
1.049AlaCys: 1.049 ± 0.315
5.084AlaAsp: 5.084 ± 0.585
5.487AlaGlu: 5.487 ± 0.761
3.066AlaPhe: 3.066 ± 0.61
5.487AlaGly: 5.487 ± 0.681
1.372AlaHis: 1.372 ± 0.418
3.793AlaIle: 3.793 ± 0.42
5.165AlaLys: 5.165 ± 0.862
9.845AlaLeu: 9.845 ± 1.087
3.066AlaMet: 3.066 ± 0.737
4.277AlaAsn: 4.277 ± 0.534
2.582AlaPro: 2.582 ± 0.389
4.923AlaGln: 4.923 ± 0.728
3.389AlaArg: 3.389 ± 0.456
4.116AlaSer: 4.116 ± 0.498
4.196AlaThr: 4.196 ± 0.681
6.214AlaVal: 6.214 ± 0.865
0.807AlaTrp: 0.807 ± 0.201
3.309AlaTyr: 3.309 ± 0.544
0.0AlaXaa: 0.0 ± 0.0
Cys
0.888CysAla: 0.888 ± 0.29
0.242CysCys: 0.242 ± 0.114
0.403CysAsp: 0.403 ± 0.208
0.646CysGlu: 0.646 ± 0.213
0.081CysPhe: 0.081 ± 0.072
0.968CysGly: 0.968 ± 0.367
0.323CysHis: 0.323 ± 0.166
0.888CysIle: 0.888 ± 0.266
0.807CysLys: 0.807 ± 0.312
0.726CysLeu: 0.726 ± 0.249
0.403CysMet: 0.403 ± 0.185
0.242CysAsn: 0.242 ± 0.177
0.565CysPro: 0.565 ± 0.238
0.323CysGln: 0.323 ± 0.179
0.403CysArg: 0.403 ± 0.173
0.807CysSer: 0.807 ± 0.304
0.807CysThr: 0.807 ± 0.347
0.968CysVal: 0.968 ± 0.269
0.323CysTrp: 0.323 ± 0.156
0.968CysTyr: 0.968 ± 0.354
0.0CysXaa: 0.0 ± 0.0
Asp
6.375AspAla: 6.375 ± 0.908
0.968AspCys: 0.968 ± 0.266
3.631AspAsp: 3.631 ± 0.636
4.438AspGlu: 4.438 ± 0.591
2.34AspPhe: 2.34 ± 0.335
4.116AspGly: 4.116 ± 0.666
1.291AspHis: 1.291 ± 0.353
4.116AspIle: 4.116 ± 0.524
3.309AspLys: 3.309 ± 0.54
5.003AspLeu: 5.003 ± 0.443
1.695AspMet: 1.695 ± 0.41
2.744AspAsn: 2.744 ± 0.546
1.775AspPro: 1.775 ± 0.282
1.533AspGln: 1.533 ± 0.334
2.421AspArg: 2.421 ± 0.508
2.26AspSer: 2.26 ± 0.421
3.631AspThr: 3.631 ± 0.536
4.358AspVal: 4.358 ± 0.573
1.049AspTrp: 1.049 ± 0.268
2.905AspTyr: 2.905 ± 0.541
0.0AspXaa: 0.0 ± 0.0
Glu
5.73GluAla: 5.73 ± 0.638
0.646GluCys: 0.646 ± 0.214
3.631GluAsp: 3.631 ± 0.599
4.035GluGlu: 4.035 ± 0.634
2.663GluPhe: 2.663 ± 0.535
3.631GluGly: 3.631 ± 0.618
1.775GluHis: 1.775 ± 0.38
3.066GluIle: 3.066 ± 0.419
2.986GluLys: 2.986 ± 0.691
6.214GluLeu: 6.214 ± 0.993
1.614GluMet: 1.614 ± 0.411
3.228GluAsn: 3.228 ± 0.608
1.775GluPro: 1.775 ± 0.517
3.793GluGln: 3.793 ± 0.575
3.309GluArg: 3.309 ± 0.572
3.309GluSer: 3.309 ± 0.574
2.179GluThr: 2.179 ± 0.415
4.6GluVal: 4.6 ± 0.51
0.646GluTrp: 0.646 ± 0.202
3.309GluTyr: 3.309 ± 0.496
0.0GluXaa: 0.0 ± 0.0
Phe
2.744PheAla: 2.744 ± 0.477
0.403PheCys: 0.403 ± 0.18
2.744PheAsp: 2.744 ± 0.575
2.34PheGlu: 2.34 ± 0.498
0.888PhePhe: 0.888 ± 0.227
1.856PheGly: 1.856 ± 0.364
0.081PheHis: 0.081 ± 0.084
2.017PheIle: 2.017 ± 0.534
2.905PheLys: 2.905 ± 0.472
2.502PheLeu: 2.502 ± 0.431
1.049PheMet: 1.049 ± 0.331
2.34PheAsn: 2.34 ± 0.382
1.13PhePro: 1.13 ± 0.319
1.775PheGln: 1.775 ± 0.406
1.533PheArg: 1.533 ± 0.341
2.421PheSer: 2.421 ± 0.453
2.26PheThr: 2.26 ± 0.292
2.26PheVal: 2.26 ± 0.41
0.403PheTrp: 0.403 ± 0.177
0.968PheTyr: 0.968 ± 0.326
0.0PheXaa: 0.0 ± 0.0
Gly
5.649GlyAla: 5.649 ± 0.827
0.807GlyCys: 0.807 ± 0.24
4.358GlyAsp: 4.358 ± 0.497
3.631GlyGlu: 3.631 ± 0.472
2.179GlyPhe: 2.179 ± 0.782
5.73GlyGly: 5.73 ± 0.91
1.13GlyHis: 1.13 ± 0.306
4.6GlyIle: 4.6 ± 0.545
4.116GlyLys: 4.116 ± 0.704
5.326GlyLeu: 5.326 ± 0.722
1.695GlyMet: 1.695 ± 0.356
3.309GlyAsn: 3.309 ± 0.506
0.0GlyPro: 0.0 ± 0.0
2.582GlyGln: 2.582 ± 0.432
4.196GlyArg: 4.196 ± 0.54
3.389GlySer: 3.389 ± 0.453
5.81GlyThr: 5.81 ± 0.709
6.294GlyVal: 6.294 ± 0.691
1.13GlyTrp: 1.13 ± 0.339
2.905GlyTyr: 2.905 ± 0.46
0.0GlyXaa: 0.0 ± 0.0
His
1.049HisAla: 1.049 ± 0.389
0.323HisCys: 0.323 ± 0.189
1.775HisAsp: 1.775 ± 0.474
1.13HisGlu: 1.13 ± 0.3
0.968HisPhe: 0.968 ± 0.244
1.533HisGly: 1.533 ± 0.287
0.323HisHis: 0.323 ± 0.169
1.614HisIle: 1.614 ± 0.262
2.098HisLys: 2.098 ± 0.429
1.453HisLeu: 1.453 ± 0.397
0.484HisMet: 0.484 ± 0.195
1.21HisAsn: 1.21 ± 0.244
0.807HisPro: 0.807 ± 0.25
0.646HisGln: 0.646 ± 0.233
0.888HisArg: 0.888 ± 0.21
1.291HisSer: 1.291 ± 0.4
1.13HisThr: 1.13 ± 0.341
1.049HisVal: 1.049 ± 0.279
0.565HisTrp: 0.565 ± 0.198
1.372HisTyr: 1.372 ± 0.345
0.0HisXaa: 0.0 ± 0.0
Ile
3.712IleAla: 3.712 ± 0.493
0.484IleCys: 0.484 ± 0.185
4.277IleAsp: 4.277 ± 0.614
4.438IleGlu: 4.438 ± 0.642
1.533IlePhe: 1.533 ± 0.36
4.277IleGly: 4.277 ± 0.647
1.372IleHis: 1.372 ± 0.325
2.421IleIle: 2.421 ± 0.558
3.551IleLys: 3.551 ± 0.48
3.47IleLeu: 3.47 ± 0.657
1.21IleMet: 1.21 ± 0.299
3.47IleAsn: 3.47 ± 0.551
2.34IlePro: 2.34 ± 0.408
2.017IleGln: 2.017 ± 0.361
2.986IleArg: 2.986 ± 0.55
2.582IleSer: 2.582 ± 0.413
2.824IleThr: 2.824 ± 0.454
4.196IleVal: 4.196 ± 0.622
0.242IleTrp: 0.242 ± 0.13
2.26IleTyr: 2.26 ± 0.304
0.0IleXaa: 0.0 ± 0.0
Lys
4.923LysAla: 4.923 ± 0.803
1.049LysCys: 1.049 ± 0.333
4.116LysAsp: 4.116 ± 0.431
3.147LysGlu: 3.147 ± 0.531
1.775LysPhe: 1.775 ± 0.443
5.487LysGly: 5.487 ± 0.765
2.017LysHis: 2.017 ± 0.492
3.309LysIle: 3.309 ± 0.535
3.228LysLys: 3.228 ± 0.519
4.842LysLeu: 4.842 ± 0.608
1.049LysMet: 1.049 ± 0.226
2.34LysAsn: 2.34 ± 0.555
2.582LysPro: 2.582 ± 0.487
2.744LysGln: 2.744 ± 0.441
3.47LysArg: 3.47 ± 0.605
3.873LysSer: 3.873 ± 0.529
2.824LysThr: 2.824 ± 0.474
3.954LysVal: 3.954 ± 0.441
1.372LysTrp: 1.372 ± 0.31
3.147LysTyr: 3.147 ± 0.36
0.0LysXaa: 0.0 ± 0.0
Leu
7.747LeuAla: 7.747 ± 1.223
1.049LeuCys: 1.049 ± 0.349
5.81LeuAsp: 5.81 ± 0.596
6.375LeuGlu: 6.375 ± 0.787
2.744LeuPhe: 2.744 ± 0.542
5.568LeuGly: 5.568 ± 0.655
2.098LeuHis: 2.098 ± 0.478
3.309LeuIle: 3.309 ± 0.39
4.761LeuLys: 4.761 ± 0.775
7.021LeuLeu: 7.021 ± 0.887
1.937LeuMet: 1.937 ± 0.398
4.761LeuAsn: 4.761 ± 0.632
3.066LeuPro: 3.066 ± 0.554
4.438LeuGln: 4.438 ± 0.592
4.6LeuArg: 4.6 ± 0.526
6.94LeuSer: 6.94 ± 0.842
4.761LeuThr: 4.761 ± 0.632
4.923LeuVal: 4.923 ± 0.722
0.968LeuTrp: 0.968 ± 0.372
3.631LeuTyr: 3.631 ± 0.545
0.0LeuXaa: 0.0 ± 0.0
Met
2.502MetAla: 2.502 ± 0.405
0.323MetCys: 0.323 ± 0.143
1.453MetAsp: 1.453 ± 0.302
0.807MetGlu: 0.807 ± 0.428
0.968MetPhe: 0.968 ± 0.252
2.26MetGly: 2.26 ± 0.453
0.323MetHis: 0.323 ± 0.164
1.372MetIle: 1.372 ± 0.351
1.533MetLys: 1.533 ± 0.336
2.905MetLeu: 2.905 ± 0.389
0.807MetMet: 0.807 ± 0.309
1.533MetAsn: 1.533 ± 0.315
0.565MetPro: 0.565 ± 0.237
1.453MetGln: 1.453 ± 0.415
1.775MetArg: 1.775 ± 0.417
1.856MetSer: 1.856 ± 0.393
1.937MetThr: 1.937 ± 0.358
0.968MetVal: 0.968 ± 0.307
0.484MetTrp: 0.484 ± 0.169
1.372MetTyr: 1.372 ± 0.332
0.0MetXaa: 0.0 ± 0.0
Asn
3.389AsnAla: 3.389 ± 0.488
0.807AsnCys: 0.807 ± 0.285
2.582AsnAsp: 2.582 ± 0.707
2.421AsnGlu: 2.421 ± 0.402
1.695AsnPhe: 1.695 ± 0.367
4.519AsnGly: 4.519 ± 0.864
1.291AsnHis: 1.291 ± 0.359
2.34AsnIle: 2.34 ± 0.448
3.228AsnLys: 3.228 ± 0.492
4.842AsnLeu: 4.842 ± 0.644
1.453AsnMet: 1.453 ± 0.359
2.744AsnAsn: 2.744 ± 0.62
3.066AsnPro: 3.066 ± 0.37
1.533AsnGln: 1.533 ± 0.321
1.614AsnArg: 1.614 ± 0.261
3.309AsnSer: 3.309 ± 0.39
3.389AsnThr: 3.389 ± 0.698
2.905AsnVal: 2.905 ± 0.515
1.13AsnTrp: 1.13 ± 0.327
2.017AsnTyr: 2.017 ± 0.325
0.0AsnXaa: 0.0 ± 0.0
Pro
2.744ProAla: 2.744 ± 0.556
0.323ProCys: 0.323 ± 0.154
2.744ProAsp: 2.744 ± 0.431
3.389ProGlu: 3.389 ± 0.521
1.21ProPhe: 1.21 ± 0.259
0.0ProGly: 0.0 ± 0.0
0.807ProHis: 0.807 ± 0.228
2.663ProIle: 2.663 ± 0.416
3.066ProLys: 3.066 ± 0.613
2.179ProLeu: 2.179 ± 0.38
1.049ProMet: 1.049 ± 0.333
2.017ProAsn: 2.017 ± 0.326
1.21ProPro: 1.21 ± 0.392
1.937ProGln: 1.937 ± 0.509
1.21ProArg: 1.21 ± 0.348
2.26ProSer: 2.26 ± 0.371
2.421ProThr: 2.421 ± 0.605
3.873ProVal: 3.873 ± 0.775
0.0ProTrp: 0.0 ± 0.0
1.614ProTyr: 1.614 ± 0.478
0.0ProXaa: 0.0 ± 0.0
Gln
4.438GlnAla: 4.438 ± 0.688
0.403GlnCys: 0.403 ± 0.167
1.695GlnAsp: 1.695 ± 0.3
2.905GlnGlu: 2.905 ± 0.556
1.533GlnPhe: 1.533 ± 0.338
2.663GlnGly: 2.663 ± 0.5
0.968GlnHis: 0.968 ± 0.249
2.421GlnIle: 2.421 ± 0.369
2.098GlnLys: 2.098 ± 0.492
3.954GlnLeu: 3.954 ± 0.571
0.726GlnMet: 0.726 ± 0.301
2.26GlnAsn: 2.26 ± 0.387
1.614GlnPro: 1.614 ± 0.431
3.551GlnGln: 3.551 ± 0.805
2.744GlnArg: 2.744 ± 0.551
1.775GlnSer: 1.775 ± 0.344
2.179GlnThr: 2.179 ± 0.47
3.309GlnVal: 3.309 ± 0.629
0.323GlnTrp: 0.323 ± 0.106
2.502GlnTyr: 2.502 ± 0.582
0.0GlnXaa: 0.0 ± 0.0
Arg
4.438ArgAla: 4.438 ± 0.643
0.242ArgCys: 0.242 ± 0.144
2.34ArgAsp: 2.34 ± 0.345
2.502ArgGlu: 2.502 ± 0.433
1.775ArgPhe: 1.775 ± 0.443
2.502ArgGly: 2.502 ± 0.464
0.888ArgHis: 0.888 ± 0.246
2.824ArgIle: 2.824 ± 0.347
3.631ArgLys: 3.631 ± 0.491
4.519ArgLeu: 4.519 ± 0.488
1.775ArgMet: 1.775 ± 0.434
2.179ArgAsn: 2.179 ± 0.444
1.372ArgPro: 1.372 ± 0.309
1.695ArgGln: 1.695 ± 0.346
3.389ArgArg: 3.389 ± 0.511
3.551ArgSer: 3.551 ± 0.55
3.066ArgThr: 3.066 ± 0.521
4.277ArgVal: 4.277 ± 0.569
0.646ArgTrp: 0.646 ± 0.214
2.34ArgTyr: 2.34 ± 0.4
0.0ArgXaa: 0.0 ± 0.0
Ser
6.052SerAla: 6.052 ± 0.558
0.646SerCys: 0.646 ± 0.231
3.228SerAsp: 3.228 ± 0.415
3.389SerGlu: 3.389 ± 0.66
2.26SerPhe: 2.26 ± 0.444
4.438SerGly: 4.438 ± 0.637
1.049SerHis: 1.049 ± 0.303
2.986SerIle: 2.986 ± 0.379
3.147SerLys: 3.147 ± 0.565
5.326SerLeu: 5.326 ± 0.717
2.582SerMet: 2.582 ± 0.607
2.179SerAsn: 2.179 ± 0.31
2.824SerPro: 2.824 ± 0.479
1.937SerGln: 1.937 ± 0.509
2.663SerArg: 2.663 ± 0.392
2.986SerSer: 2.986 ± 0.683
4.842SerThr: 4.842 ± 0.918
3.631SerVal: 3.631 ± 0.53
0.565SerTrp: 0.565 ± 0.246
2.017SerTyr: 2.017 ± 0.374
0.0SerXaa: 0.0 ± 0.0
Thr
5.245ThrAla: 5.245 ± 0.662
0.403ThrCys: 0.403 ± 0.159
2.824ThrAsp: 2.824 ± 0.62
4.035ThrGlu: 4.035 ± 0.695
2.663ThrPhe: 2.663 ± 0.368
5.326ThrGly: 5.326 ± 0.498
1.13ThrHis: 1.13 ± 0.273
3.228ThrIle: 3.228 ± 0.402
3.712ThrLys: 3.712 ± 0.591
4.358ThrLeu: 4.358 ± 0.488
1.291ThrMet: 1.291 ± 0.36
2.421ThrAsn: 2.421 ± 0.51
4.116ThrPro: 4.116 ± 0.446
2.098ThrGln: 2.098 ± 0.343
2.905ThrArg: 2.905 ± 0.546
3.066ThrSer: 3.066 ± 0.625
3.389ThrThr: 3.389 ± 0.644
4.116ThrVal: 4.116 ± 0.527
0.565ThrTrp: 0.565 ± 0.236
2.744ThrTyr: 2.744 ± 0.441
0.0ThrXaa: 0.0 ± 0.0
Val
5.891ValAla: 5.891 ± 0.833
0.646ValCys: 0.646 ± 0.234
3.228ValAsp: 3.228 ± 0.512
3.793ValGlu: 3.793 ± 0.429
2.098ValPhe: 2.098 ± 0.399
5.084ValGly: 5.084 ± 0.849
1.856ValHis: 1.856 ± 0.31
3.551ValIle: 3.551 ± 0.511
4.196ValLys: 4.196 ± 0.613
6.617ValLeu: 6.617 ± 0.8
1.695ValMet: 1.695 ± 0.407
4.196ValAsn: 4.196 ± 0.591
3.47ValPro: 3.47 ± 0.644
3.47ValGln: 3.47 ± 0.513
3.793ValArg: 3.793 ± 0.49
4.6ValSer: 4.6 ± 0.753
4.277ValThr: 4.277 ± 0.788
4.6ValVal: 4.6 ± 0.75
1.13ValTrp: 1.13 ± 0.342
2.179ValTyr: 2.179 ± 0.472
0.0ValXaa: 0.0 ± 0.0
Trp
0.646TrpAla: 0.646 ± 0.22
0.242TrpCys: 0.242 ± 0.13
0.888TrpAsp: 0.888 ± 0.286
1.13TrpGlu: 1.13 ± 0.309
0.726TrpPhe: 0.726 ± 0.223
0.403TrpGly: 0.403 ± 0.187
0.161TrpHis: 0.161 ± 0.122
0.646TrpIle: 0.646 ± 0.243
0.968TrpLys: 0.968 ± 0.259
1.453TrpLeu: 1.453 ± 0.53
0.242TrpMet: 0.242 ± 0.145
0.888TrpAsn: 0.888 ± 0.239
0.0TrpPro: 0.0 ± 0.0
0.323TrpGln: 0.323 ± 0.15
0.242TrpArg: 0.242 ± 0.158
0.968TrpSer: 0.968 ± 0.289
0.968TrpThr: 0.968 ± 0.333
1.049TrpVal: 1.049 ± 0.35
0.161TrpTrp: 0.161 ± 0.115
0.565TrpTyr: 0.565 ± 0.286
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.066TyrAla: 3.066 ± 0.468
0.726TyrCys: 0.726 ± 0.249
3.147TyrAsp: 3.147 ± 0.459
2.098TyrGlu: 2.098 ± 0.427
1.453TyrPhe: 1.453 ± 0.375
2.986TyrGly: 2.986 ± 0.398
1.453TyrHis: 1.453 ± 0.415
2.502TyrIle: 2.502 ± 0.429
2.744TyrLys: 2.744 ± 0.367
3.954TyrLeu: 3.954 ± 0.468
1.291TyrMet: 1.291 ± 0.329
1.937TyrAsn: 1.937 ± 0.383
1.856TyrPro: 1.856 ± 0.421
1.291TyrGln: 1.291 ± 0.383
2.421TyrArg: 2.421 ± 0.417
3.389TyrSer: 3.389 ± 0.631
2.744TyrThr: 2.744 ± 0.415
2.905TyrVal: 2.905 ± 0.451
0.161TyrTrp: 0.161 ± 0.105
1.856TyrTyr: 1.856 ± 0.335
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 45 proteins (12393 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski