Amino acid dipepetide frequency for Streptococcus satellite phage Javan289

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.434AlaAla: 0.434 ± 0.421
0.434AlaCys: 0.434 ± 0.341
5.208AlaAsp: 5.208 ± 1.475
3.038AlaGlu: 3.038 ± 1.242
3.472AlaPhe: 3.472 ± 0.659
1.302AlaGly: 1.302 ± 0.733
0.434AlaHis: 0.434 ± 0.5
3.906AlaIle: 3.906 ± 1.03
3.906AlaLys: 3.906 ± 1.412
7.378AlaLeu: 7.378 ± 1.663
2.17AlaMet: 2.17 ± 0.727
3.038AlaAsn: 3.038 ± 1.242
0.868AlaPro: 0.868 ± 0.657
2.17AlaGln: 2.17 ± 0.783
2.17AlaArg: 2.17 ± 0.759
2.17AlaSer: 2.17 ± 1.009
2.604AlaThr: 2.604 ± 1.34
1.736AlaVal: 1.736 ± 0.82
0.0AlaTrp: 0.0 ± 0.0
1.736AlaTyr: 1.736 ± 0.554
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.434CysGlu: 0.434 ± 0.421
1.302CysPhe: 1.302 ± 0.534
0.0CysGly: 0.0 ± 0.0
0.434CysHis: 0.434 ± 0.467
1.736CysIle: 1.736 ± 0.968
0.434CysLys: 0.434 ± 0.467
0.868CysLeu: 0.868 ± 0.549
0.434CysMet: 0.434 ± 0.452
0.434CysAsn: 0.434 ± 0.341
0.434CysPro: 0.434 ± 0.421
0.0CysGln: 0.0 ± 0.0
1.302CysArg: 1.302 ± 0.65
0.434CysSer: 0.434 ± 0.467
0.0CysThr: 0.0 ± 0.0
0.868CysVal: 0.868 ± 0.474
0.0CysTrp: 0.0 ± 0.0
0.434CysTyr: 0.434 ± 0.341
0.0CysXaa: 0.0 ± 0.0
Asp
1.736AspAla: 1.736 ± 0.606
0.434AspCys: 0.434 ± 0.421
3.472AspAsp: 3.472 ± 1.243
3.038AspGlu: 3.038 ± 0.926
3.472AspPhe: 3.472 ± 1.289
4.774AspGly: 4.774 ± 1.992
0.0AspHis: 0.0 ± 0.0
3.472AspIle: 3.472 ± 0.916
4.34AspLys: 4.34 ± 1.498
3.906AspLeu: 3.906 ± 0.622
1.302AspMet: 1.302 ± 0.649
3.906AspAsn: 3.906 ± 1.29
1.736AspPro: 1.736 ± 0.877
0.868AspGln: 0.868 ± 0.521
1.302AspArg: 1.302 ± 0.712
2.604AspSer: 2.604 ± 1.487
2.17AspThr: 2.17 ± 0.973
4.34AspVal: 4.34 ± 1.629
1.736AspTrp: 1.736 ± 0.849
4.34AspTyr: 4.34 ± 1.204
0.0AspXaa: 0.0 ± 0.0
Glu
3.038GluAla: 3.038 ± 1.262
0.868GluCys: 0.868 ± 0.47
1.736GluAsp: 1.736 ± 1.315
6.076GluGlu: 6.076 ± 3.012
3.472GluPhe: 3.472 ± 1.93
0.868GluGly: 0.868 ± 0.476
0.868GluHis: 0.868 ± 0.47
5.208GluIle: 5.208 ± 1.269
3.472GluLys: 3.472 ± 2.018
14.757GluLeu: 14.757 ± 1.782
2.604GluMet: 2.604 ± 0.866
4.34GluAsn: 4.34 ± 1.147
3.472GluPro: 3.472 ± 1.418
1.736GluGln: 1.736 ± 0.749
2.604GluArg: 2.604 ± 0.969
3.472GluSer: 3.472 ± 1.048
4.34GluThr: 4.34 ± 1.282
3.472GluVal: 3.472 ± 1.15
0.868GluTrp: 0.868 ± 0.64
4.34GluTyr: 4.34 ± 1.279
0.0GluXaa: 0.0 ± 0.0
Phe
3.906PheAla: 3.906 ± 1.077
1.302PheCys: 1.302 ± 1.4
2.604PheAsp: 2.604 ± 0.829
5.642PheGlu: 5.642 ± 1.637
5.208PhePhe: 5.208 ± 1.635
2.604PheGly: 2.604 ± 1.046
1.302PheHis: 1.302 ± 0.956
4.774PheIle: 4.774 ± 1.082
3.472PheLys: 3.472 ± 1.107
7.378PheLeu: 7.378 ± 2.017
0.0PheMet: 0.0 ± 0.0
2.17PheAsn: 2.17 ± 0.72
0.868PhePro: 0.868 ± 0.841
1.736PheGln: 1.736 ± 0.879
2.604PheArg: 2.604 ± 1.354
2.604PheSer: 2.604 ± 0.556
2.17PheThr: 2.17 ± 0.87
5.642PheVal: 5.642 ± 1.571
1.736PheTrp: 1.736 ± 0.785
1.736PheTyr: 1.736 ± 1.159
0.0PheXaa: 0.0 ± 0.0
Gly
1.302GlyAla: 1.302 ± 0.642
1.302GlyCys: 1.302 ± 0.712
0.868GlyAsp: 0.868 ± 0.447
2.17GlyGlu: 2.17 ± 1.1
3.906GlyPhe: 3.906 ± 1.016
1.736GlyGly: 1.736 ± 0.638
0.868GlyHis: 0.868 ± 0.505
6.51GlyIle: 6.51 ± 2.069
2.604GlyLys: 2.604 ± 1.057
2.604GlyLeu: 2.604 ± 1.01
0.868GlyMet: 0.868 ± 0.682
3.906GlyAsn: 3.906 ± 0.848
0.0GlyPro: 0.0 ± 0.0
0.868GlyGln: 0.868 ± 0.572
1.736GlyArg: 1.736 ± 0.836
1.736GlySer: 1.736 ± 0.779
3.472GlyThr: 3.472 ± 1.752
4.774GlyVal: 4.774 ± 1.435
1.302GlyTrp: 1.302 ± 0.696
1.736GlyTyr: 1.736 ± 0.902
0.0GlyXaa: 0.0 ± 0.0
His
1.302HisAla: 1.302 ± 0.729
0.0HisCys: 0.0 ± 0.0
0.868HisAsp: 0.868 ± 0.447
0.868HisGlu: 0.868 ± 0.653
0.868HisPhe: 0.868 ± 0.549
1.302HisGly: 1.302 ± 0.562
1.736HisHis: 1.736 ± 1.506
2.604HisIle: 2.604 ± 0.768
0.434HisLys: 0.434 ± 0.466
4.774HisLeu: 4.774 ± 1.411
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.434HisPro: 0.434 ± 0.341
0.868HisGln: 0.868 ± 0.623
0.434HisArg: 0.434 ± 0.353
2.17HisSer: 2.17 ± 0.996
1.736HisThr: 1.736 ± 1.162
0.868HisVal: 0.868 ± 0.47
0.434HisTrp: 0.434 ± 0.436
0.868HisTyr: 0.868 ± 0.549
0.0HisXaa: 0.0 ± 0.0
Ile
6.076IleAla: 6.076 ± 2.064
0.0IleCys: 0.0 ± 0.0
6.51IleAsp: 6.51 ± 1.622
3.906IleGlu: 3.906 ± 1.607
7.378IlePhe: 7.378 ± 2.319
5.208IleGly: 5.208 ± 1.242
2.17IleHis: 2.17 ± 0.649
5.208IleIle: 5.208 ± 1.76
6.076IleLys: 6.076 ± 1.435
5.208IleLeu: 5.208 ± 2.266
1.736IleMet: 1.736 ± 0.886
5.642IleAsn: 5.642 ± 1.62
1.736IlePro: 1.736 ± 0.736
2.604IleGln: 2.604 ± 0.765
0.868IleArg: 0.868 ± 0.503
6.944IleSer: 6.944 ± 1.678
4.34IleThr: 4.34 ± 1.394
2.17IleVal: 2.17 ± 1.091
0.0IleTrp: 0.0 ± 0.0
3.038IleTyr: 3.038 ± 1.124
0.0IleXaa: 0.0 ± 0.0
Lys
3.472LysAla: 3.472 ± 1.261
0.0LysCys: 0.0 ± 0.0
2.17LysAsp: 2.17 ± 1.244
9.115LysGlu: 9.115 ± 2.527
0.868LysPhe: 0.868 ± 0.476
3.472LysGly: 3.472 ± 1.436
1.736LysHis: 1.736 ± 1.261
5.642LysIle: 5.642 ± 1.689
8.681LysLys: 8.681 ± 2.258
7.812LysLeu: 7.812 ± 1.435
2.604LysMet: 2.604 ± 0.945
4.774LysAsn: 4.774 ± 1.326
3.038LysPro: 3.038 ± 0.917
3.038LysGln: 3.038 ± 0.96
5.208LysArg: 5.208 ± 1.228
4.34LysSer: 4.34 ± 0.909
6.076LysThr: 6.076 ± 1.691
5.642LysVal: 5.642 ± 1.708
0.868LysTrp: 0.868 ± 0.609
2.604LysTyr: 2.604 ± 0.939
0.0LysXaa: 0.0 ± 0.0
Leu
7.378LeuAla: 7.378 ± 1.973
2.17LeuCys: 2.17 ± 1.352
6.944LeuAsp: 6.944 ± 1.133
4.774LeuGlu: 4.774 ± 1.473
8.247LeuPhe: 8.247 ± 2.926
3.472LeuGly: 3.472 ± 0.827
2.604LeuHis: 2.604 ± 1.732
6.944LeuIle: 6.944 ± 1.435
7.812LeuLys: 7.812 ± 1.712
13.455LeuLeu: 13.455 ± 2.392
2.17LeuMet: 2.17 ± 1.005
10.417LeuAsn: 10.417 ± 2.22
2.604LeuPro: 2.604 ± 1.178
7.378LeuGln: 7.378 ± 1.832
3.906LeuArg: 3.906 ± 1.263
7.812LeuSer: 7.812 ± 2.043
6.51LeuThr: 6.51 ± 1.549
5.208LeuVal: 5.208 ± 2.736
0.868LeuTrp: 0.868 ± 0.549
2.604LeuTyr: 2.604 ± 0.768
0.0LeuXaa: 0.0 ± 0.0
Met
1.302MetAla: 1.302 ± 0.716
0.0MetCys: 0.0 ± 0.0
1.736MetAsp: 1.736 ± 0.788
3.038MetGlu: 3.038 ± 1.054
1.736MetPhe: 1.736 ± 1.076
1.302MetGly: 1.302 ± 0.677
0.0MetHis: 0.0 ± 0.0
1.302MetIle: 1.302 ± 0.984
1.736MetLys: 1.736 ± 0.843
2.17MetLeu: 2.17 ± 0.971
1.736MetMet: 1.736 ± 0.801
1.736MetAsn: 1.736 ± 0.713
0.0MetPro: 0.0 ± 0.0
1.736MetGln: 1.736 ± 0.999
0.0MetArg: 0.0 ± 0.0
0.0MetSer: 0.0 ± 0.0
1.302MetThr: 1.302 ± 0.882
1.302MetVal: 1.302 ± 0.658
0.0MetTrp: 0.0 ± 0.0
0.868MetTyr: 0.868 ± 0.623
0.0MetXaa: 0.0 ± 0.0
Asn
2.604AsnAla: 2.604 ± 1.041
0.0AsnCys: 0.0 ± 0.0
2.17AsnAsp: 2.17 ± 0.639
6.51AsnGlu: 6.51 ± 1.656
1.736AsnPhe: 1.736 ± 0.68
1.736AsnGly: 1.736 ± 0.893
1.736AsnHis: 1.736 ± 0.749
3.472AsnIle: 3.472 ± 1.215
6.51AsnLys: 6.51 ± 1.626
4.34AsnLeu: 4.34 ± 1.221
0.434AsnMet: 0.434 ± 0.467
2.17AsnAsn: 2.17 ± 0.797
1.736AsnPro: 1.736 ± 0.879
2.604AsnGln: 2.604 ± 0.982
4.34AsnArg: 4.34 ± 1.376
4.34AsnSer: 4.34 ± 1.473
4.774AsnThr: 4.774 ± 1.841
3.038AsnVal: 3.038 ± 1.202
1.736AsnTrp: 1.736 ± 1.195
3.038AsnTyr: 3.038 ± 1.036
0.0AsnXaa: 0.0 ± 0.0
Pro
1.736ProAla: 1.736 ± 0.594
0.434ProCys: 0.434 ± 0.467
3.472ProAsp: 3.472 ± 0.893
2.604ProGlu: 2.604 ± 1.256
3.472ProPhe: 3.472 ± 1.133
0.0ProGly: 0.0 ± 0.0
0.434ProHis: 0.434 ± 0.417
1.736ProIle: 1.736 ± 0.989
1.302ProLys: 1.302 ± 0.677
3.906ProLeu: 3.906 ± 1.317
0.434ProMet: 0.434 ± 0.421
2.17ProAsn: 2.17 ± 0.907
1.302ProPro: 1.302 ± 0.652
0.0ProGln: 0.0 ± 0.0
0.868ProArg: 0.868 ± 0.521
1.302ProSer: 1.302 ± 0.499
1.302ProThr: 1.302 ± 0.58
2.604ProVal: 2.604 ± 0.999
0.0ProTrp: 0.0 ± 0.0
0.868ProTyr: 0.868 ± 0.447
0.0ProXaa: 0.0 ± 0.0
Gln
3.038GlnAla: 3.038 ± 0.945
0.0GlnCys: 0.0 ± 0.0
1.302GlnAsp: 1.302 ± 0.806
3.038GlnGlu: 3.038 ± 1.095
1.302GlnPhe: 1.302 ± 0.682
2.604GlnGly: 2.604 ± 0.927
0.434GlnHis: 0.434 ± 0.353
2.604GlnIle: 2.604 ± 1.111
2.604GlnLys: 2.604 ± 0.669
5.642GlnLeu: 5.642 ± 1.722
1.736GlnMet: 1.736 ± 0.845
1.302GlnAsn: 1.302 ± 0.729
0.434GlnPro: 0.434 ± 0.341
0.434GlnGln: 0.434 ± 0.341
0.868GlnArg: 0.868 ± 0.447
2.17GlnSer: 2.17 ± 1.156
0.868GlnThr: 0.868 ± 0.438
2.604GlnVal: 2.604 ± 0.548
0.434GlnTrp: 0.434 ± 0.508
3.038GlnTyr: 3.038 ± 1.009
0.0GlnXaa: 0.0 ± 0.0
Arg
1.736ArgAla: 1.736 ± 0.96
0.0ArgCys: 0.0 ± 0.0
2.17ArgAsp: 2.17 ± 0.649
3.038ArgGlu: 3.038 ± 1.196
0.868ArgPhe: 0.868 ± 0.683
2.17ArgGly: 2.17 ± 0.991
1.736ArgHis: 1.736 ± 0.779
5.208ArgIle: 5.208 ± 1.722
3.906ArgLys: 3.906 ± 1.517
3.906ArgLeu: 3.906 ± 1.601
0.868ArgMet: 0.868 ± 0.651
0.868ArgAsn: 0.868 ± 0.447
1.736ArgPro: 1.736 ± 0.642
2.17ArgGln: 2.17 ± 0.596
0.434ArgArg: 0.434 ± 0.508
1.302ArgSer: 1.302 ± 0.462
3.038ArgThr: 3.038 ± 1.328
2.17ArgVal: 2.17 ± 0.902
1.302ArgTrp: 1.302 ± 0.781
2.17ArgTyr: 2.17 ± 0.765
0.0ArgXaa: 0.0 ± 0.0
Ser
2.604SerAla: 2.604 ± 1.252
1.302SerCys: 1.302 ± 0.534
4.774SerAsp: 4.774 ± 1.098
3.472SerGlu: 3.472 ± 0.904
3.038SerPhe: 3.038 ± 0.929
3.038SerGly: 3.038 ± 1.272
3.038SerHis: 3.038 ± 1.072
3.472SerIle: 3.472 ± 0.957
5.208SerLys: 5.208 ± 1.528
3.038SerLeu: 3.038 ± 0.96
0.0SerMet: 0.0 ± 0.0
3.472SerAsn: 3.472 ± 1.291
2.17SerPro: 2.17 ± 0.89
3.038SerGln: 3.038 ± 1.037
1.736SerArg: 1.736 ± 1.033
3.038SerSer: 3.038 ± 1.312
2.17SerThr: 2.17 ± 1.463
2.604SerVal: 2.604 ± 1.016
0.868SerTrp: 0.868 ± 0.648
3.906SerTyr: 3.906 ± 1.038
0.0SerXaa: 0.0 ± 0.0
Thr
3.472ThrAla: 3.472 ± 0.907
0.434ThrCys: 0.434 ± 0.467
3.472ThrAsp: 3.472 ± 1.167
3.472ThrGlu: 3.472 ± 1.207
3.038ThrPhe: 3.038 ± 1.223
3.906ThrGly: 3.906 ± 0.673
1.736ThrHis: 1.736 ± 0.952
2.604ThrIle: 2.604 ± 1.136
5.208ThrLys: 5.208 ± 1.343
7.378ThrLeu: 7.378 ± 1.879
0.868ThrMet: 0.868 ± 0.616
3.472ThrAsn: 3.472 ± 1.27
3.038ThrPro: 3.038 ± 1.214
1.302ThrGln: 1.302 ± 0.918
2.17ThrArg: 2.17 ± 0.784
0.434ThrSer: 0.434 ± 0.341
2.17ThrThr: 2.17 ± 0.662
4.34ThrVal: 4.34 ± 1.805
0.868ThrTrp: 0.868 ± 0.474
2.604ThrTyr: 2.604 ± 0.73
0.0ThrXaa: 0.0 ± 0.0
Val
2.604ValAla: 2.604 ± 1.102
0.434ValCys: 0.434 ± 0.341
2.17ValAsp: 2.17 ± 0.743
3.472ValGlu: 3.472 ± 1.337
1.302ValPhe: 1.302 ± 0.625
2.17ValGly: 2.17 ± 0.851
0.434ValHis: 0.434 ± 0.353
5.208ValIle: 5.208 ± 1.458
4.774ValLys: 4.774 ± 1.707
6.076ValLeu: 6.076 ± 0.867
1.736ValMet: 1.736 ± 0.797
3.906ValAsn: 3.906 ± 1.382
3.472ValPro: 3.472 ± 0.879
1.302ValGln: 1.302 ± 0.499
3.472ValArg: 3.472 ± 1.584
4.774ValSer: 4.774 ± 1.507
4.34ValThr: 4.34 ± 1.039
3.906ValVal: 3.906 ± 0.96
1.302ValTrp: 1.302 ± 0.652
3.038ValTyr: 3.038 ± 1.344
0.0ValXaa: 0.0 ± 0.0
Trp
0.434TrpAla: 0.434 ± 0.353
0.0TrpCys: 0.0 ± 0.0
0.434TrpAsp: 0.434 ± 0.353
1.736TrpGlu: 1.736 ± 0.799
1.302TrpPhe: 1.302 ± 0.785
0.434TrpGly: 0.434 ± 0.341
0.0TrpHis: 0.0 ± 0.0
2.604TrpIle: 2.604 ± 1.537
0.868TrpLys: 0.868 ± 0.657
3.472TrpLeu: 3.472 ± 2.164
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.434TrpArg: 0.434 ± 0.341
1.302TrpSer: 1.302 ± 0.507
0.434TrpThr: 0.434 ± 0.55
0.434TrpVal: 0.434 ± 0.452
0.434TrpTrp: 0.434 ± 0.353
0.434TrpTyr: 0.434 ± 0.341
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.434TyrCys: 0.434 ± 0.353
0.868TyrAsp: 0.868 ± 0.683
2.17TyrGlu: 2.17 ± 1.084
3.472TyrPhe: 3.472 ± 0.977
2.17TyrGly: 2.17 ± 0.903
0.868TyrHis: 0.868 ± 0.565
2.604TyrIle: 2.604 ± 1.275
7.812TyrLys: 7.812 ± 1.595
5.642TyrLeu: 5.642 ± 1.425
0.868TyrMet: 0.868 ± 0.403
1.302TyrAsn: 1.302 ± 0.661
0.868TyrPro: 0.868 ± 0.671
2.604TyrGln: 2.604 ± 1.026
4.34TyrArg: 4.34 ± 1.218
3.038TyrSer: 3.038 ± 1.053
2.17TyrThr: 2.17 ± 1.421
2.17TyrVal: 2.17 ± 1.064
0.0TyrTrp: 0.0 ± 0.0
0.868TyrTyr: 0.868 ± 0.47
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2305 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski