Amino acid dipepetide frequency for Acidovorax caeni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.752AlaAla: 18.752 ± 0.192	1.554AlaCys: 1.554 ± 0.037	6.027AlaAsp: 6.027 ± 0.071	6.668AlaGlu: 6.668 ± 0.078	3.986AlaPhe: 3.986 ± 0.056	10.168AlaGly: 10.168 ± 0.113	3.225AlaHis: 3.225 ± 0.056	4.961AlaIle: 4.961 ± 0.072	3.788AlaLys: 3.788 ± 0.073	17.011AlaLeu: 17.011 ± 0.155	3.54AlaMet: 3.54 ± 0.052	2.731AlaAsn: 2.731 ± 0.05	7.259AlaPro: 7.259 ± 0.116	8.43AlaGln: 8.43 ± 0.124	9.751AlaArg: 9.751 ± 0.112	6.619AlaSer: 6.619 ± 0.091	6.434AlaThr: 6.434 ± 0.075	9.182AlaVal: 9.182 ± 0.093	2.245AlaTrp: 2.245 ± 0.052	2.521AlaTyr: 2.521 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.381CysAla: 1.381 ± 0.034	0.123CysCys: 0.123 ± 0.009	0.55CysAsp: 0.55 ± 0.022	0.496CysGlu: 0.496 ± 0.023	0.29CysPhe: 0.29 ± 0.015	1.022CysGly: 1.022 ± 0.028	0.295CysHis: 0.295 ± 0.017	0.402CysIle: 0.402 ± 0.019	0.257CysLys: 0.257 ± 0.016	0.9CysLeu: 0.9 ± 0.031	0.258CysMet: 0.258 ± 0.015	0.244CysAsn: 0.244 ± 0.014	0.562CysPro: 0.562 ± 0.025	0.379CysGln: 0.379 ± 0.02	0.552CysArg: 0.552 ± 0.025	0.519CysSer: 0.519 ± 0.024	0.596CysThr: 0.596 ± 0.029	0.734CysVal: 0.734 ± 0.022	0.135CysTrp: 0.135 ± 0.01	0.218CysTyr: 0.218 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.388AspAla: 7.388 ± 0.081	0.482AspCys: 0.482 ± 0.02	2.561AspAsp: 2.561 ± 0.049	2.832AspGlu: 2.832 ± 0.052	1.93AspPhe: 1.93 ± 0.04	4.37AspGly: 4.37 ± 0.061	1.04AspHis: 1.04 ± 0.036	2.306AspIle: 2.306 ± 0.044	1.717AspLys: 1.717 ± 0.044	5.013AspLeu: 5.013 ± 0.063	1.263AspMet: 1.263 ± 0.034	1.157AspAsn: 1.157 ± 0.03	2.656AspPro: 2.656 ± 0.051	1.596AspGln: 1.596 ± 0.036	2.742AspArg: 2.742 ± 0.046	2.168AspSer: 2.168 ± 0.041	2.493AspThr: 2.493 ± 0.045	3.826AspVal: 3.826 ± 0.057	0.989AspTrp: 0.989 ± 0.029	1.372AspTyr: 1.372 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.949GluAla: 6.949 ± 0.084	0.427GluCys: 0.427 ± 0.019	2.259GluAsp: 2.259 ± 0.044	2.632GluGlu: 2.632 ± 0.059	1.658GluPhe: 1.658 ± 0.046	3.934GluGly: 3.934 ± 0.056	1.369GluHis: 1.369 ± 0.035	2.516GluIle: 2.516 ± 0.051	1.883GluLys: 1.883 ± 0.049	5.596GluLeu: 5.596 ± 0.086	1.212GluMet: 1.212 ± 0.029	1.242GluAsn: 1.242 ± 0.032	2.392GluPro: 2.392 ± 0.05	2.821GluGln: 2.821 ± 0.053	4.811GluArg: 4.811 ± 0.073	2.361GluSer: 2.361 ± 0.054	2.299GluThr: 2.299 ± 0.045	3.909GluVal: 3.909 ± 0.067	0.728GluTrp: 0.728 ± 0.027	1.032GluTyr: 1.032 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.26PheAla: 4.26 ± 0.064	0.377PheCys: 0.377 ± 0.017	2.255PheAsp: 2.255 ± 0.043	1.895PheGlu: 1.895 ± 0.044	1.369PhePhe: 1.369 ± 0.036	3.028PheGly: 3.028 ± 0.051	0.714PheHis: 0.714 ± 0.026	1.439PheIle: 1.439 ± 0.038	1.112PheLys: 1.112 ± 0.035	2.873PheLeu: 2.873 ± 0.057	0.772PheMet: 0.772 ± 0.026	1.014PheAsn: 1.014 ± 0.03	1.409PhePro: 1.409 ± 0.036	1.117PheGln: 1.117 ± 0.026	1.622PheArg: 1.622 ± 0.037	1.923PheSer: 1.923 ± 0.04	1.928PheThr: 1.928 ± 0.039	2.598PheVal: 2.598 ± 0.05	0.509PheTrp: 0.509 ± 0.02	0.842PheTyr: 0.842 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.59GlyAla: 9.59 ± 0.102	0.994GlyCys: 0.994 ± 0.03	3.818GlyAsp: 3.818 ± 0.062	4.211GlyGlu: 4.211 ± 0.067	3.03GlyPhe: 3.03 ± 0.06	6.844GlyGly: 6.844 ± 0.14	1.998GlyHis: 1.998 ± 0.043	3.54GlyIle: 3.54 ± 0.058	3.122GlyLys: 3.122 ± 0.063	9.147GlyLeu: 9.147 ± 0.098	2.324GlyMet: 2.324 ± 0.04	2.061GlyAsn: 2.061 ± 0.046	2.887GlyPro: 2.887 ± 0.049	3.999GlyGln: 3.999 ± 0.065	5.212GlyArg: 5.212 ± 0.072	4.192GlySer: 4.192 ± 0.061	4.395GlyThr: 4.395 ± 0.072	6.588GlyVal: 6.588 ± 0.081	1.52GlyTrp: 1.52 ± 0.039	2.263GlyTyr: 2.263 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	3.282HisAla: 3.282 ± 0.057	0.339HisCys: 0.339 ± 0.018	1.266HisAsp: 1.266 ± 0.035	1.207HisGlu: 1.207 ± 0.03	0.912HisPhe: 0.912 ± 0.03	2.294HisGly: 2.294 ± 0.05	0.706HisHis: 0.706 ± 0.023	1.023HisIle: 1.023 ± 0.028	0.633HisLys: 0.633 ± 0.022	2.435HisLeu: 2.435 ± 0.057	0.57HisMet: 0.57 ± 0.023	0.541HisAsn: 0.541 ± 0.022	1.55HisPro: 1.55 ± 0.037	0.966HisGln: 0.966 ± 0.03	1.462HisArg: 1.462 ± 0.037	1.102HisSer: 1.102 ± 0.029	1.23HisThr: 1.23 ± 0.031	1.558HisVal: 1.558 ± 0.031	0.494HisTrp: 0.494 ± 0.021	0.653HisTyr: 0.653 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.716IleAla: 5.716 ± 0.078	0.335IleCys: 0.335 ± 0.017	2.821IleAsp: 2.821 ± 0.051	2.835IleGlu: 2.835 ± 0.056	1.139IlePhe: 1.139 ± 0.036	3.573IleGly: 3.573 ± 0.064	0.91IleHis: 0.91 ± 0.028	1.389IleIle: 1.389 ± 0.037	1.413IleLys: 1.413 ± 0.039	3.061IleLeu: 3.061 ± 0.054	0.71IleMet: 0.71 ± 0.027	1.315IleAsn: 1.315 ± 0.031	1.875IlePro: 1.875 ± 0.042	1.36IleGln: 1.36 ± 0.034	2.325IleArg: 2.325 ± 0.045	2.025IleSer: 2.025 ± 0.048	2.502IleThr: 2.502 ± 0.045	3.093IleVal: 3.093 ± 0.054	0.38IleTrp: 0.38 ± 0.017	0.888IleTyr: 0.888 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.112LysAla: 4.112 ± 0.075	0.188LysCys: 0.188 ± 0.014	1.609LysAsp: 1.609 ± 0.046	1.624LysGlu: 1.624 ± 0.045	0.846LysPhe: 0.846 ± 0.027	2.356LysGly: 2.356 ± 0.053	0.666LysHis: 0.666 ± 0.023	1.403LysIle: 1.403 ± 0.039	1.499LysLys: 1.499 ± 0.053	3.198LysLeu: 3.198 ± 0.058	0.769LysMet: 0.769 ± 0.026	0.981LysAsn: 0.981 ± 0.034	1.903LysPro: 1.903 ± 0.042	1.241LysGln: 1.241 ± 0.038	2.084LysArg: 2.084 ± 0.049	1.608LysSer: 1.608 ± 0.041	1.842LysThr: 1.842 ± 0.038	2.381LysVal: 2.381 ± 0.058	0.342LysTrp: 0.342 ± 0.017	0.649LysTyr: 0.649 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	16.25LeuAla: 16.25 ± 0.163	1.152LeuCys: 1.152 ± 0.031	5.672LeuAsp: 5.672 ± 0.068	5.279LeuGlu: 5.279 ± 0.066	3.25LeuPhe: 3.25 ± 0.052	8.953LeuGly: 8.953 ± 0.107	2.818LeuHis: 2.818 ± 0.059	3.715LeuIle: 3.715 ± 0.063	3.305LeuLys: 3.305 ± 0.062	12.229LeuLeu: 12.229 ± 0.158	2.32LeuMet: 2.32 ± 0.042	2.456LeuAsn: 2.456 ± 0.039	6.546LeuPro: 6.546 ± 0.08	5.493LeuGln: 5.493 ± 0.075	8.538LeuArg: 8.538 ± 0.101	5.651LeuSer: 5.651 ± 0.077	5.171LeuThr: 5.171 ± 0.079	7.943LeuVal: 7.943 ± 0.095	1.586LeuTrp: 1.586 ± 0.041	2.114LeuTyr: 2.114 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.367MetAla: 3.367 ± 0.057	0.153MetCys: 0.153 ± 0.011	1.154MetAsp: 1.154 ± 0.03	1.126MetGlu: 1.126 ± 0.03	0.667MetPhe: 0.667 ± 0.026	1.916MetGly: 1.916 ± 0.041	0.602MetHis: 0.602 ± 0.02	0.73MetIle: 0.73 ± 0.024	0.883MetLys: 0.883 ± 0.028	2.529MetLeu: 2.529 ± 0.055	0.473MetMet: 0.473 ± 0.02	0.767MetAsn: 0.767 ± 0.022	1.475MetPro: 1.475 ± 0.036	1.222MetGln: 1.222 ± 0.033	1.718MetArg: 1.718 ± 0.035	1.328MetSer: 1.328 ± 0.035	1.36MetThr: 1.36 ± 0.032	1.804MetVal: 1.804 ± 0.044	0.22MetTrp: 0.22 ± 0.012	0.394MetTyr: 0.394 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.321AsnAla: 3.321 ± 0.058	0.213AsnCys: 0.213 ± 0.016	1.257AsnAsp: 1.257 ± 0.032	1.149AsnGlu: 1.149 ± 0.03	0.84AsnPhe: 0.84 ± 0.03	2.053AsnGly: 2.053 ± 0.049	0.555AsnHis: 0.555 ± 0.024	1.031AsnIle: 1.031 ± 0.027	0.77AsnLys: 0.77 ± 0.029	2.534AsnLeu: 2.534 ± 0.047	0.567AsnMet: 0.567 ± 0.024	0.658AsnAsn: 0.658 ± 0.028	1.718AsnPro: 1.718 ± 0.042	0.954AsnGln: 0.954 ± 0.031	1.551AsnArg: 1.551 ± 0.04	1.036AsnSer: 1.036 ± 0.036	1.363AsnThr: 1.363 ± 0.04	1.792AsnVal: 1.792 ± 0.045	0.372AsnTrp: 0.372 ± 0.018	0.603AsnTyr: 0.603 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.401ProAla: 7.401 ± 0.104	0.412ProCys: 0.412 ± 0.018	2.902ProAsp: 2.902 ± 0.045	3.416ProGlu: 3.416 ± 0.063	1.67ProPhe: 1.67 ± 0.037	4.931ProGly: 4.931 ± 0.074	1.255ProHis: 1.255 ± 0.036	1.676ProIle: 1.676 ± 0.038	1.415ProLys: 1.415 ± 0.039	5.814ProLeu: 5.814 ± 0.08	1.255ProMet: 1.255 ± 0.031	1.125ProAsn: 1.125 ± 0.028	3.139ProPro: 3.139 ± 0.068	2.641ProGln: 2.641 ± 0.058	3.203ProArg: 3.203 ± 0.059	2.69ProSer: 2.69 ± 0.043	2.547ProThr: 2.547 ± 0.048	4.159ProVal: 4.159 ± 0.063	0.958ProTrp: 0.958 ± 0.027	1.151ProTyr: 1.151 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	7.83GlnAla: 7.83 ± 0.109	0.398GlnCys: 0.398 ± 0.019	2.06GlnAsp: 2.06 ± 0.04	2.178GlnGlu: 2.178 ± 0.046	1.341GlnPhe: 1.341 ± 0.037	4.056GlnGly: 4.056 ± 0.063	1.216GlnHis: 1.216 ± 0.031	1.751GlnIle: 1.751 ± 0.038	1.219GlnLys: 1.219 ± 0.031	5.004GlnLeu: 5.004 ± 0.07	1.036GlnMet: 1.036 ± 0.029	0.925GlnAsn: 0.925 ± 0.026	2.802GlnPro: 2.802 ± 0.055	2.613GlnGln: 2.613 ± 0.052	4.382GlnArg: 4.382 ± 0.075	2.188GlnSer: 2.188 ± 0.044	2.102GlnThr: 2.102 ± 0.045	3.417GlnVal: 3.417 ± 0.06	0.878GlnTrp: 0.878 ± 0.024	0.84GlnTyr: 0.84 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.539ArgAla: 8.539 ± 0.103	0.665ArgCys: 0.665 ± 0.024	3.343ArgAsp: 3.343 ± 0.051	3.994ArgGlu: 3.994 ± 0.059	2.676ArgPhe: 2.676 ± 0.05	4.546ArgGly: 4.546 ± 0.065	1.893ArgHis: 1.893 ± 0.046	3.309ArgIle: 3.309 ± 0.051	2.145ArgLys: 2.145 ± 0.044	8.189ArgLeu: 8.189 ± 0.089	1.936ArgMet: 1.936 ± 0.04	1.721ArgAsn: 1.721 ± 0.037	3.3ArgPro: 3.3 ± 0.063	3.54ArgGln: 3.54 ± 0.059	4.976ArgArg: 4.976 ± 0.075	3.303ArgSer: 3.303 ± 0.056	3.447ArgThr: 3.447 ± 0.052	4.942ArgVal: 4.942 ± 0.066	1.368ArgTrp: 1.368 ± 0.035	1.891ArgTyr: 1.891 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.45SerAla: 6.45 ± 0.092	0.441SerCys: 0.441 ± 0.022	2.423SerAsp: 2.423 ± 0.05	2.353SerGlu: 2.353 ± 0.043	1.826SerPhe: 1.826 ± 0.036	4.651SerGly: 4.651 ± 0.066	1.126SerHis: 1.126 ± 0.029	2.18SerIle: 2.18 ± 0.043	1.448SerLys: 1.448 ± 0.038	5.268SerLeu: 5.268 ± 0.073	1.22SerMet: 1.22 ± 0.036	1.263SerAsn: 1.263 ± 0.033	2.641SerPro: 2.641 ± 0.047	1.934SerGln: 1.934 ± 0.044	3.035SerArg: 3.035 ± 0.052	2.836SerSer: 2.836 ± 0.049	2.742SerThr: 2.742 ± 0.049	3.784SerVal: 3.784 ± 0.062	0.677SerTrp: 0.677 ± 0.028	1.252SerTyr: 1.252 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.191ThrAla: 6.191 ± 0.077	0.461ThrCys: 0.461 ± 0.023	2.321ThrAsp: 2.321 ± 0.044	2.398ThrGlu: 2.398 ± 0.048	1.633ThrPhe: 1.633 ± 0.034	4.581ThrGly: 4.581 ± 0.078	1.189ThrHis: 1.189 ± 0.033	1.939ThrIle: 1.939 ± 0.037	1.303ThrLys: 1.303 ± 0.038	6.33ThrLeu: 6.33 ± 0.079	1.051ThrMet: 1.051 ± 0.032	1.161ThrAsn: 1.161 ± 0.04	3.669ThrPro: 3.669 ± 0.054	2.354ThrGln: 2.354 ± 0.037	3.198ThrArg: 3.198 ± 0.052	2.45ThrSer: 2.45 ± 0.05	2.69ThrThr: 2.69 ± 0.056	4.073ThrVal: 4.073 ± 0.074	0.727ThrTrp: 0.727 ± 0.026	1.019ThrTyr: 1.019 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.784ValAla: 9.784 ± 0.091	0.736ValCys: 0.736 ± 0.027	3.785ValAsp: 3.785 ± 0.052	3.954ValGlu: 3.954 ± 0.065	2.583ValPhe: 2.583 ± 0.041	5.41ValGly: 5.41 ± 0.078	1.741ValHis: 1.741 ± 0.036	2.923ValIle: 2.923 ± 0.058	2.247ValLys: 2.247 ± 0.053	8.559ValLeu: 8.559 ± 0.097	1.724ValMet: 1.724 ± 0.038	1.99ValAsn: 1.99 ± 0.042	4.046ValPro: 4.046 ± 0.061	3.664ValGln: 3.664 ± 0.053	5.461ValArg: 5.461 ± 0.067	3.631ValSer: 3.631 ± 0.057	3.72ValThr: 3.72 ± 0.071	6.19ValVal: 6.19 ± 0.084	1.026ValTrp: 1.026 ± 0.032	1.512ValTyr: 1.512 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.632TrpAla: 1.632 ± 0.04	0.207TrpCys: 0.207 ± 0.013	0.655TrpAsp: 0.655 ± 0.022	0.6TrpGlu: 0.6 ± 0.02	0.567TrpPhe: 0.567 ± 0.021	1.113TrpGly: 1.113 ± 0.035	0.435TrpHis: 0.435 ± 0.02	0.647TrpIle: 0.647 ± 0.023	0.47TrpLys: 0.47 ± 0.021	2.324TrpLeu: 2.324 ± 0.058	0.477TrpMet: 0.477 ± 0.022	0.401TrpAsn: 0.401 ± 0.016	0.791TrpPro: 0.791 ± 0.032	0.93TrpGln: 0.93 ± 0.03	1.393TrpArg: 1.393 ± 0.041	0.795TrpSer: 0.795 ± 0.024	0.669TrpThr: 0.669 ± 0.026	1.129TrpVal: 1.129 ± 0.029	0.334TrpTrp: 0.334 ± 0.019	0.299TrpTyr: 0.299 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.658TyrAla: 2.658 ± 0.046	0.257TyrCys: 0.257 ± 0.015	1.161TyrAsp: 1.161 ± 0.033	1.182TyrGlu: 1.182 ± 0.036	0.845TyrPhe: 0.845 ± 0.026	1.937TyrGly: 1.937 ± 0.041	0.467TyrHis: 0.467 ± 0.019	0.785TyrIle: 0.785 ± 0.023	0.671TyrLys: 0.671 ± 0.025	2.425TyrLeu: 2.425 ± 0.055	0.409TyrMet: 0.409 ± 0.017	0.584TyrAsn: 0.584 ± 0.021	1.137TyrPro: 1.137 ± 0.03	0.986TyrGln: 0.986 ± 0.028	1.707TyrArg: 1.707 ± 0.04	1.125TyrSer: 1.125 ± 0.03	1.208TyrThr: 1.208 ± 0.034	1.585TyrVal: 1.585 ± 0.034	0.384TyrTrp: 0.384 ± 0.018	0.586TyrTyr: 0.586 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3855 proteins (1245875 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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