Amino acid dipepetide frequency for Fulvimarina manganoxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.915AlaAla: 15.915 ± 0.159	1.002AlaCys: 1.002 ± 0.029	7.116AlaAsp: 7.116 ± 0.072	8.697AlaGlu: 8.697 ± 0.091	4.888AlaPhe: 4.888 ± 0.059	10.632AlaGly: 10.632 ± 0.102	2.111AlaHis: 2.111 ± 0.044	7.351AlaIle: 7.351 ± 0.071	4.361AlaLys: 4.361 ± 0.057	13.085AlaLeu: 13.085 ± 0.12	3.736AlaMet: 3.736 ± 0.054	2.939AlaAsn: 2.939 ± 0.052	5.358AlaPro: 5.358 ± 0.077	3.408AlaGln: 3.408 ± 0.053	8.344AlaArg: 8.344 ± 0.089	7.441AlaSer: 7.441 ± 0.094	5.766AlaThr: 5.766 ± 0.074	8.16AlaVal: 8.16 ± 0.091	1.312AlaTrp: 1.312 ± 0.035	2.626AlaTyr: 2.626 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.878CysAla: 0.878 ± 0.028	0.093CysCys: 0.093 ± 0.008	0.511CysAsp: 0.511 ± 0.02	0.499CysGlu: 0.499 ± 0.022	0.284CysPhe: 0.284 ± 0.014	0.931CysGly: 0.931 ± 0.03	0.228CysHis: 0.228 ± 0.013	0.324CysIle: 0.324 ± 0.015	0.153CysLys: 0.153 ± 0.011	0.871CysLeu: 0.871 ± 0.025	0.129CysMet: 0.129 ± 0.01	0.184CysAsn: 0.184 ± 0.011	0.418CysPro: 0.418 ± 0.02	0.219CysGln: 0.219 ± 0.014	0.638CysArg: 0.638 ± 0.024	0.388CysSer: 0.388 ± 0.018	0.322CysThr: 0.322 ± 0.016	0.522CysVal: 0.522 ± 0.02	0.096CysTrp: 0.096 ± 0.008	0.151CysTyr: 0.151 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.876AspAla: 6.876 ± 0.083	0.509AspCys: 0.509 ± 0.021	3.578AspAsp: 3.578 ± 0.07	4.411AspGlu: 4.411 ± 0.074	2.357AspPhe: 2.357 ± 0.041	5.564AspGly: 5.564 ± 0.083	1.327AspHis: 1.327 ± 0.036	3.238AspIle: 3.238 ± 0.051	1.819AspLys: 1.819 ± 0.046	6.465AspLeu: 6.465 ± 0.08	1.338AspMet: 1.338 ± 0.033	1.298AspAsn: 1.298 ± 0.036	3.605AspPro: 3.605 ± 0.055	1.769AspGln: 1.769 ± 0.04	4.976AspArg: 4.976 ± 0.074	2.065AspSer: 2.065 ± 0.048	2.607AspThr: 2.607 ± 0.056	4.179AspVal: 4.179 ± 0.065	1.017AspTrp: 1.017 ± 0.027	1.515AspTyr: 1.515 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	9.723GluAla: 9.723 ± 0.119	0.35GluCys: 0.35 ± 0.017	3.457GluAsp: 3.457 ± 0.056	3.864GluGlu: 3.864 ± 0.072	1.811GluPhe: 1.811 ± 0.036	5.066GluGly: 5.066 ± 0.071	1.067GluHis: 1.067 ± 0.029	3.906GluIle: 3.906 ± 0.063	2.434GluLys: 2.434 ± 0.048	5.011GluLeu: 5.011 ± 0.064	1.7GluMet: 1.7 ± 0.041	1.69GluAsn: 1.69 ± 0.037	3.183GluPro: 3.183 ± 0.053	1.725GluGln: 1.725 ± 0.036	5.927GluArg: 5.927 ± 0.09	2.753GluSer: 2.753 ± 0.046	4.937GluThr: 4.937 ± 0.066	3.82GluVal: 3.82 ± 0.06	0.75GluTrp: 0.75 ± 0.027	0.923GluTyr: 0.923 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.867PheAla: 4.867 ± 0.063	0.378PheCys: 0.378 ± 0.017	2.848PheAsp: 2.848 ± 0.051	2.505PheGlu: 2.505 ± 0.048	1.48PhePhe: 1.48 ± 0.042	3.83PheGly: 3.83 ± 0.056	0.745PheHis: 0.745 ± 0.022	1.674PheIle: 1.674 ± 0.041	0.981PheLys: 0.981 ± 0.034	3.545PheLeu: 3.545 ± 0.064	0.816PheMet: 0.816 ± 0.028	0.92PheAsn: 0.92 ± 0.029	1.525PhePro: 1.525 ± 0.036	1.04PheGln: 1.04 ± 0.029	2.302PheArg: 2.302 ± 0.043	2.375PheSer: 2.375 ± 0.042	1.884PheThr: 1.884 ± 0.041	3.154PheVal: 3.154 ± 0.053	0.546PheTrp: 0.546 ± 0.026	0.885PheTyr: 0.885 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.35GlyAla: 9.35 ± 0.089	0.811GlyCys: 0.811 ± 0.026	4.856GlyAsp: 4.856 ± 0.073	5.88GlyGlu: 5.88 ± 0.075	3.746GlyPhe: 3.746 ± 0.061	7.305GlyGly: 7.305 ± 0.103	1.861GlyHis: 1.861 ± 0.042	4.445GlyIle: 4.445 ± 0.054	2.906GlyLys: 2.906 ± 0.061	8.967GlyLeu: 8.967 ± 0.096	2.206GlyMet: 2.206 ± 0.042	2.033GlyAsn: 2.033 ± 0.048	3.546GlyPro: 3.546 ± 0.056	2.796GlyGln: 2.796 ± 0.046	6.517GlyArg: 6.517 ± 0.081	4.978GlySer: 4.978 ± 0.069	4.758GlyThr: 4.758 ± 0.08	5.779GlyVal: 5.779 ± 0.073	1.256GlyTrp: 1.256 ± 0.036	2.133GlyTyr: 2.133 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.051HisAla: 2.051 ± 0.044	0.227HisCys: 0.227 ± 0.013	1.149HisAsp: 1.149 ± 0.033	1.081HisGlu: 1.081 ± 0.03	0.787HisPhe: 0.787 ± 0.024	1.855HisGly: 1.855 ± 0.043	0.57HisHis: 0.57 ± 0.026	0.82HisIle: 0.82 ± 0.023	0.456HisLys: 0.456 ± 0.02	1.996HisLeu: 1.996 ± 0.044	0.467HisMet: 0.467 ± 0.016	0.359HisAsn: 0.359 ± 0.017	1.243HisPro: 1.243 ± 0.031	0.564HisGln: 0.564 ± 0.02	1.397HisArg: 1.397 ± 0.032	0.965HisSer: 0.965 ± 0.027	0.679HisThr: 0.679 ± 0.023	1.367HisVal: 1.367 ± 0.034	0.282HisTrp: 0.282 ± 0.012	0.484HisTyr: 0.484 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.831IleAla: 7.831 ± 0.085	0.467IleCys: 0.467 ± 0.019	3.908IleAsp: 3.908 ± 0.056	4.251IleGlu: 4.251 ± 0.063	1.764IlePhe: 1.764 ± 0.042	5.308IleGly: 5.308 ± 0.065	0.923IleHis: 0.923 ± 0.03	2.031IleIle: 2.031 ± 0.045	1.261IleLys: 1.261 ± 0.032	4.804IleLeu: 4.804 ± 0.07	0.945IleMet: 0.945 ± 0.027	1.201IleAsn: 1.201 ± 0.036	2.208IlePro: 2.208 ± 0.044	1.224IleGln: 1.224 ± 0.032	3.321IleArg: 3.321 ± 0.058	2.674IleSer: 2.674 ± 0.046	2.493IleThr: 2.493 ± 0.045	4.713IleVal: 4.713 ± 0.062	0.549IleTrp: 0.549 ± 0.021	1.055IleTyr: 1.055 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.734LysAla: 4.734 ± 0.062	0.137LysCys: 0.137 ± 0.011	1.837LysAsp: 1.837 ± 0.039	1.656LysGlu: 1.656 ± 0.039	0.7LysPhe: 0.7 ± 0.023	2.882LysGly: 2.882 ± 0.055	0.519LysHis: 0.519 ± 0.018	1.614LysIle: 1.614 ± 0.034	1.126LysLys: 1.126 ± 0.038	2.95LysLeu: 2.95 ± 0.05	0.683LysMet: 0.683 ± 0.021	0.779LysAsn: 0.779 ± 0.023	2.052LysPro: 2.052 ± 0.042	0.79LysGln: 0.79 ± 0.024	2.837LysArg: 2.837 ± 0.048	1.866LysSer: 1.866 ± 0.04	2.117LysThr: 2.117 ± 0.038	2.254LysVal: 2.254 ± 0.05	0.315LysTrp: 0.315 ± 0.016	0.473LysTyr: 0.473 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.259LeuAla: 13.259 ± 0.129	0.818LeuCys: 0.818 ± 0.024	6.149LeuAsp: 6.149 ± 0.084	5.125LeuGlu: 5.125 ± 0.064	3.867LeuPhe: 3.867 ± 0.071	7.964LeuGly: 7.964 ± 0.087	1.553LeuHis: 1.553 ± 0.038	4.918LeuIle: 4.918 ± 0.058	3.803LeuLys: 3.803 ± 0.06	8.685LeuLeu: 8.685 ± 0.121	2.183LeuMet: 2.183 ± 0.044	2.337LeuAsn: 2.337 ± 0.039	5.158LeuPro: 5.158 ± 0.078	2.483LeuGln: 2.483 ± 0.045	6.24LeuArg: 6.24 ± 0.08	7.292LeuSer: 7.292 ± 0.082	5.679LeuThr: 5.679 ± 0.074	7.439LeuVal: 7.439 ± 0.078	1.033LeuTrp: 1.033 ± 0.03	1.989LeuTyr: 1.989 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.146MetAla: 3.146 ± 0.047	0.116MetCys: 0.116 ± 0.009	1.184MetAsp: 1.184 ± 0.032	1.18MetGlu: 1.18 ± 0.028	0.636MetPhe: 0.636 ± 0.025	1.766MetGly: 1.766 ± 0.038	0.353MetHis: 0.353 ± 0.018	1.417MetIle: 1.417 ± 0.035	0.986MetLys: 0.986 ± 0.027	2.221MetLeu: 2.221 ± 0.042	0.705MetMet: 0.705 ± 0.023	0.734MetAsn: 0.734 ± 0.026	1.461MetPro: 1.461 ± 0.032	0.746MetGln: 0.746 ± 0.027	2.031MetArg: 2.031 ± 0.039	1.708MetSer: 1.708 ± 0.034	1.949MetThr: 1.949 ± 0.035	1.624MetVal: 1.624 ± 0.036	0.178MetTrp: 0.178 ± 0.011	0.252MetTyr: 0.252 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.171AsnAla: 3.171 ± 0.054	0.196AsnCys: 0.196 ± 0.011	1.523AsnAsp: 1.523 ± 0.037	1.407AsnGlu: 1.407 ± 0.035	0.91AsnPhe: 0.91 ± 0.026	2.419AsnGly: 2.419 ± 0.052	0.44AsnHis: 0.44 ± 0.017	1.19AsnIle: 1.19 ± 0.03	0.582AsnLys: 0.582 ± 0.026	2.342AsnLeu: 2.342 ± 0.043	0.525AsnMet: 0.525 ± 0.019	0.585AsnAsn: 0.585 ± 0.024	1.677AsnPro: 1.677 ± 0.034	0.753AsnGln: 0.753 ± 0.024	1.797AsnArg: 1.797 ± 0.041	1.156AsnSer: 1.156 ± 0.038	1.102AsnThr: 1.102 ± 0.032	1.743AsnVal: 1.743 ± 0.036	0.366AsnTrp: 0.366 ± 0.018	0.606AsnTyr: 0.606 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.91ProAla: 5.91 ± 0.074	0.293ProCys: 0.293 ± 0.013	3.754ProAsp: 3.754 ± 0.055	3.675ProGlu: 3.675 ± 0.057	2.135ProPhe: 2.135 ± 0.04	4.175ProGly: 4.175 ± 0.055	0.967ProHis: 0.967 ± 0.028	2.667ProIle: 2.667 ± 0.047	1.826ProLys: 1.826 ± 0.037	4.555ProLeu: 4.555 ± 0.067	1.127ProMet: 1.127 ± 0.03	1.418ProAsn: 1.418 ± 0.038	2.163ProPro: 2.163 ± 0.047	1.507ProGln: 1.507 ± 0.033	2.801ProArg: 2.801 ± 0.055	3.154ProSer: 3.154 ± 0.054	2.479ProThr: 2.479 ± 0.051	3.892ProVal: 3.892 ± 0.058	0.552ProTrp: 0.552 ± 0.021	1.105ProTyr: 1.105 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.806GlnAla: 3.806 ± 0.055	0.187GlnCys: 0.187 ± 0.012	1.461GlnAsp: 1.461 ± 0.037	1.527GlnGlu: 1.527 ± 0.038	0.911GlnPhe: 0.911 ± 0.025	2.141GlnGly: 2.141 ± 0.042	0.475GlnHis: 0.475 ± 0.017	1.778GlnIle: 1.778 ± 0.043	1.008GlnLys: 1.008 ± 0.027	2.345GlnLeu: 2.345 ± 0.041	0.849GlnMet: 0.849 ± 0.024	0.836GlnAsn: 0.836 ± 0.026	1.578GlnPro: 1.578 ± 0.037	0.896GlnGln: 0.896 ± 0.035	2.277GlnArg: 2.277 ± 0.045	2.0GlnSer: 2.0 ± 0.04	1.945GlnThr: 1.945 ± 0.037	1.836GlnVal: 1.836 ± 0.035	0.336GlnTrp: 0.336 ± 0.017	0.515GlnTyr: 0.515 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	7.583ArgAla: 7.583 ± 0.097	0.512ArgCys: 0.512 ± 0.019	4.063ArgAsp: 4.063 ± 0.057	4.666ArgGlu: 4.666 ± 0.075	3.3ArgPhe: 3.3 ± 0.042	4.772ArgGly: 4.772 ± 0.062	1.664ArgHis: 1.664 ± 0.037	4.062ArgIle: 4.062 ± 0.057	2.259ArgLys: 2.259 ± 0.036	8.383ArgLeu: 8.383 ± 0.089	1.911ArgMet: 1.911 ± 0.038	1.661ArgAsn: 1.661 ± 0.036	3.822ArgPro: 3.822 ± 0.063	2.645ArgGln: 2.645 ± 0.044	6.194ArgArg: 6.194 ± 0.097	4.272ArgSer: 4.272 ± 0.069	3.411ArgThr: 3.411 ± 0.055	4.495ArgVal: 4.495 ± 0.056	0.918ArgTrp: 0.918 ± 0.031	1.677ArgTyr: 1.677 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.89SerAla: 6.89 ± 0.081	0.411SerCys: 0.411 ± 0.022	3.704SerAsp: 3.704 ± 0.067	3.827SerGlu: 3.827 ± 0.057	2.401SerPhe: 2.401 ± 0.047	5.925SerGly: 5.925 ± 0.075	1.031SerHis: 1.031 ± 0.028	3.019SerIle: 3.019 ± 0.05	1.644SerLys: 1.644 ± 0.03	5.697SerLeu: 5.697 ± 0.076	1.376SerMet: 1.376 ± 0.032	1.456SerAsn: 1.456 ± 0.034	2.898SerPro: 2.898 ± 0.045	1.769SerGln: 1.769 ± 0.038	3.886SerArg: 3.886 ± 0.058	3.278SerSer: 3.278 ± 0.069	2.735SerThr: 2.735 ± 0.047	4.188SerVal: 4.188 ± 0.051	0.694SerTrp: 0.694 ± 0.02	1.248SerTyr: 1.248 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.182ThrAla: 6.182 ± 0.08	0.386ThrCys: 0.386 ± 0.018	2.997ThrAsp: 2.997 ± 0.058	2.918ThrGlu: 2.918 ± 0.048	2.095ThrPhe: 2.095 ± 0.042	5.265ThrGly: 5.265 ± 0.068	0.972ThrHis: 0.972 ± 0.03	3.386ThrIle: 3.386 ± 0.051	1.614ThrLys: 1.614 ± 0.034	5.728ThrLeu: 5.728 ± 0.065	1.251ThrMet: 1.251 ± 0.035	1.354ThrAsn: 1.354 ± 0.037	3.138ThrPro: 3.138 ± 0.046	1.355ThrGln: 1.355 ± 0.037	3.311ThrArg: 3.311 ± 0.048	3.031ThrSer: 3.031 ± 0.05	2.843ThrThr: 2.843 ± 0.062	4.366ThrVal: 4.366 ± 0.065	0.576ThrTrp: 0.576 ± 0.023	1.21ThrTyr: 1.21 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.696ValAla: 8.696 ± 0.093	0.629ValCys: 0.629 ± 0.024	4.336ValAsp: 4.336 ± 0.064	5.005ValGlu: 5.005 ± 0.063	2.882ValPhe: 2.882 ± 0.047	5.422ValGly: 5.422 ± 0.063	1.236ValHis: 1.236 ± 0.035	3.671ValIle: 3.671 ± 0.059	2.177ValLys: 2.177 ± 0.044	6.813ValLeu: 6.813 ± 0.067	1.735ValMet: 1.735 ± 0.034	1.809ValAsn: 1.809 ± 0.038	3.464ValPro: 3.464 ± 0.051	1.777ValGln: 1.777 ± 0.037	4.562ValArg: 4.562 ± 0.062	4.712ValSer: 4.712 ± 0.056	4.513ValThr: 4.513 ± 0.057	5.725ValVal: 5.725 ± 0.075	0.867ValTrp: 0.867 ± 0.025	1.43ValTyr: 1.43 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.11TrpAla: 1.11 ± 0.033	0.118TrpCys: 0.118 ± 0.009	0.583TrpAsp: 0.583 ± 0.022	0.53TrpGlu: 0.53 ± 0.022	0.508TrpPhe: 0.508 ± 0.022	0.769TrpGly: 0.769 ± 0.023	0.31TrpHis: 0.31 ± 0.014	0.64TrpIle: 0.64 ± 0.021	0.384TrpLys: 0.384 ± 0.017	1.42TrpLeu: 1.42 ± 0.034	0.334TrpMet: 0.334 ± 0.016	0.384TrpAsn: 0.384 ± 0.016	0.656TrpPro: 0.656 ± 0.025	0.52TrpGln: 0.52 ± 0.018	1.14TrpArg: 1.14 ± 0.031	0.818TrpSer: 0.818 ± 0.025	0.773TrpThr: 0.773 ± 0.026	0.706TrpVal: 0.706 ± 0.02	0.205TrpTrp: 0.205 ± 0.013	0.287TrpTyr: 0.287 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.266TyrAla: 2.266 ± 0.046	0.198TyrCys: 0.198 ± 0.012	1.499TyrAsp: 1.499 ± 0.037	1.391TyrGlu: 1.391 ± 0.033	0.838TyrPhe: 0.838 ± 0.025	2.139TyrGly: 2.139 ± 0.035	0.446TyrHis: 0.446 ± 0.019	0.78TyrIle: 0.78 ± 0.022	0.541TyrLys: 0.541 ± 0.024	2.091TyrLeu: 2.091 ± 0.039	0.375TyrMet: 0.375 ± 0.016	0.515TyrAsn: 0.515 ± 0.021	1.004TyrPro: 1.004 ± 0.027	0.725TyrGln: 0.725 ± 0.022	1.774TyrArg: 1.774 ± 0.038	1.152TyrSer: 1.152 ± 0.032	0.986TyrThr: 0.986 ± 0.033	1.495TyrVal: 1.495 ± 0.034	0.347TyrTrp: 0.347 ± 0.016	0.561TyrTyr: 0.561 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4454 proteins (1381884 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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