Amino acid dipepetide frequency for Chitinophaga terrae Kim and Jung 2007

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.269AlaAla: 8.269 ± 0.092	0.766AlaCys: 0.766 ± 0.023	4.449AlaAsp: 4.449 ± 0.046	4.199AlaGlu: 4.199 ± 0.055	3.539AlaPhe: 3.539 ± 0.048	6.422AlaGly: 6.422 ± 0.073	1.242AlaHis: 1.242 ± 0.025	5.416AlaIle: 5.416 ± 0.059	4.24AlaLys: 4.24 ± 0.055	7.441AlaLeu: 7.441 ± 0.07	1.925AlaMet: 1.925 ± 0.036	3.897AlaAsn: 3.897 ± 0.05	3.023AlaPro: 3.023 ± 0.049	2.976AlaGln: 2.976 ± 0.035	3.253AlaArg: 3.253 ± 0.043	4.678AlaSer: 4.678 ± 0.06	4.762AlaThr: 4.762 ± 0.053	5.437AlaVal: 5.437 ± 0.063	0.989AlaTrp: 0.989 ± 0.022	3.178AlaTyr: 3.178 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.472CysAla: 0.472 ± 0.016	0.148CysCys: 0.148 ± 0.008	0.361CysAsp: 0.361 ± 0.017	0.391CysGlu: 0.391 ± 0.014	0.439CysPhe: 0.439 ± 0.016	0.625CysGly: 0.625 ± 0.02	0.181CysHis: 0.181 ± 0.011	0.596CysIle: 0.596 ± 0.019	0.474CysLys: 0.474 ± 0.017	0.818CysLeu: 0.818 ± 0.023	0.198CysMet: 0.198 ± 0.011	0.431CysAsn: 0.431 ± 0.014	0.313CysPro: 0.313 ± 0.012	0.237CysGln: 0.237 ± 0.011	0.403CysArg: 0.403 ± 0.014	0.533CysSer: 0.533 ± 0.018	0.475CysThr: 0.475 ± 0.018	0.44CysVal: 0.44 ± 0.015	0.112CysTrp: 0.112 ± 0.007	0.358CysTyr: 0.358 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.052AspAla: 4.052 ± 0.046	0.352AspCys: 0.352 ± 0.017	2.339AspAsp: 2.339 ± 0.041	3.028AspGlu: 3.028 ± 0.047	2.682AspPhe: 2.682 ± 0.039	3.724AspGly: 3.724 ± 0.051	1.001AspHis: 1.001 ± 0.023	3.826AspIle: 3.826 ± 0.045	3.65AspLys: 3.65 ± 0.04	4.731AspLeu: 4.731 ± 0.05	1.12AspMet: 1.12 ± 0.025	2.774AspAsn: 2.774 ± 0.04	2.407AspPro: 2.407 ± 0.041	1.861AspGln: 1.861 ± 0.032	2.182AspArg: 2.182 ± 0.039	2.962AspSer: 2.962 ± 0.05	2.687AspThr: 2.687 ± 0.047	3.205AspVal: 3.205 ± 0.041	0.808AspTrp: 0.808 ± 0.02	2.427AspTyr: 2.427 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	4.452GluAla: 4.452 ± 0.052	0.336GluCys: 0.336 ± 0.013	2.593GluAsp: 2.593 ± 0.04	3.825GluGlu: 3.825 ± 0.07	2.095GluPhe: 2.095 ± 0.032	3.425GluGly: 3.425 ± 0.044	1.101GluHis: 1.101 ± 0.026	4.097GluIle: 4.097 ± 0.054	4.698GluLys: 4.698 ± 0.055	5.498GluLeu: 5.498 ± 0.055	1.533GluMet: 1.533 ± 0.031	2.945GluAsn: 2.945 ± 0.039	1.637GluPro: 1.637 ± 0.034	2.573GluGln: 2.573 ± 0.042	2.565GluArg: 2.565 ± 0.042	2.589GluSer: 2.589 ± 0.038	2.766GluThr: 2.766 ± 0.043	3.709GluVal: 3.709 ± 0.046	0.723GluTrp: 0.723 ± 0.02	2.026GluTyr: 2.026 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.231PheAla: 3.231 ± 0.046	0.447PheCys: 0.447 ± 0.014	2.71PheAsp: 2.71 ± 0.037	2.408PheGlu: 2.408 ± 0.039	2.382PhePhe: 2.382 ± 0.04	3.077PheGly: 3.077 ± 0.041	0.878PheHis: 0.878 ± 0.021	3.099PheIle: 3.099 ± 0.045	2.636PheLys: 2.636 ± 0.039	4.269PheLeu: 4.269 ± 0.053	1.138PheMet: 1.138 ± 0.024	2.815PheAsn: 2.815 ± 0.035	1.945PhePro: 1.945 ± 0.032	1.467PheGln: 1.467 ± 0.025	2.288PheArg: 2.288 ± 0.03	3.444PheSer: 3.444 ± 0.048	3.101PheThr: 3.101 ± 0.045	2.741PheVal: 2.741 ± 0.041	0.55PheTrp: 0.55 ± 0.02	1.975PheTyr: 1.975 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.195GlyAla: 5.195 ± 0.062	0.628GlyCys: 0.628 ± 0.025	3.4GlyAsp: 3.4 ± 0.046	3.389GlyGlu: 3.389 ± 0.041	3.419GlyPhe: 3.419 ± 0.042	5.044GlyGly: 5.044 ± 0.07	1.25GlyHis: 1.25 ± 0.024	5.248GlyIle: 5.248 ± 0.05	5.23GlyLys: 5.23 ± 0.054	6.235GlyLeu: 6.235 ± 0.059	1.835GlyMet: 1.835 ± 0.032	4.076GlyAsn: 4.076 ± 0.054	1.844GlyPro: 1.844 ± 0.041	2.447GlyGln: 2.447 ± 0.038	2.901GlyArg: 2.901 ± 0.041	4.315GlySer: 4.315 ± 0.054	4.175GlyThr: 4.175 ± 0.053	4.627GlyVal: 4.627 ± 0.059	1.118GlyTrp: 1.118 ± 0.027	3.391GlyTyr: 3.391 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.23HisAla: 1.23 ± 0.024	0.195HisCys: 0.195 ± 0.009	0.835HisAsp: 0.835 ± 0.021	0.933HisGlu: 0.933 ± 0.025	1.11HisPhe: 1.11 ± 0.024	1.166HisGly: 1.166 ± 0.027	0.529HisHis: 0.529 ± 0.019	1.368HisIle: 1.368 ± 0.028	0.975HisLys: 0.975 ± 0.023	1.934HisLeu: 1.934 ± 0.03	0.375HisMet: 0.375 ± 0.014	0.944HisAsn: 0.944 ± 0.024	1.155HisPro: 1.155 ± 0.024	0.813HisGln: 0.813 ± 0.02	0.849HisArg: 0.849 ± 0.023	1.082HisSer: 1.082 ± 0.024	1.091HisThr: 1.091 ± 0.023	0.927HisVal: 0.927 ± 0.026	0.3HisTrp: 0.3 ± 0.013	0.899HisTyr: 0.899 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.666IleAla: 5.666 ± 0.067	0.658IleCys: 0.658 ± 0.022	3.642IleAsp: 3.642 ± 0.04	3.422IleGlu: 3.422 ± 0.046	2.86IlePhe: 2.86 ± 0.042	4.613IleGly: 4.613 ± 0.056	1.27IleHis: 1.27 ± 0.026	4.332IleIle: 4.332 ± 0.061	3.897IleLys: 3.897 ± 0.049	5.748IleLeu: 5.748 ± 0.065	1.367IleMet: 1.367 ± 0.025	3.683IleAsn: 3.683 ± 0.048	3.262IlePro: 3.262 ± 0.043	2.377IleGln: 2.377 ± 0.039	3.529IleArg: 3.529 ± 0.045	4.799IleSer: 4.799 ± 0.057	4.394IleThr: 4.394 ± 0.052	4.027IleVal: 4.027 ± 0.05	0.723IleTrp: 0.723 ± 0.02	2.579IleTyr: 2.579 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	5.154LysAla: 5.154 ± 0.06	0.322LysCys: 0.322 ± 0.012	4.03LysAsp: 4.03 ± 0.049	4.587LysGlu: 4.587 ± 0.06	2.157LysPhe: 2.157 ± 0.037	4.551LysGly: 4.551 ± 0.049	1.174LysHis: 1.174 ± 0.024	4.115LysIle: 4.115 ± 0.048	4.729LysLys: 4.729 ± 0.073	5.534LysLeu: 5.534 ± 0.06	1.78LysMet: 1.78 ± 0.032	3.37LysAsn: 3.37 ± 0.046	2.692LysPro: 2.692 ± 0.034	2.858LysGln: 2.858 ± 0.041	2.755LysArg: 2.755 ± 0.039	3.338LysSer: 3.338 ± 0.042	3.599LysThr: 3.599 ± 0.051	4.281LysVal: 4.281 ± 0.049	0.847LysTrp: 0.847 ± 0.023	2.612LysTyr: 2.612 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	7.357LeuAla: 7.357 ± 0.071	0.873LeuCys: 0.873 ± 0.022	4.657LeuAsp: 4.657 ± 0.049	5.185LeuGlu: 5.185 ± 0.062	4.579LeuPhe: 4.579 ± 0.059	5.912LeuGly: 5.912 ± 0.061	1.89LeuHis: 1.89 ± 0.031	5.596LeuIle: 5.596 ± 0.068	6.567LeuLys: 6.567 ± 0.062	10.44LeuLeu: 10.44 ± 0.109	2.199LeuMet: 2.199 ± 0.036	4.918LeuAsn: 4.918 ± 0.059	4.69LeuPro: 4.69 ± 0.055	4.534LeuGln: 4.534 ± 0.057	4.173LeuArg: 4.173 ± 0.045	6.67LeuSer: 6.67 ± 0.064	5.45LeuThr: 5.45 ± 0.057	5.883LeuVal: 5.883 ± 0.065	0.963LeuTrp: 0.963 ± 0.023	3.468LeuTyr: 3.468 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.911MetAla: 1.911 ± 0.034	0.136MetCys: 0.136 ± 0.008	1.211MetAsp: 1.211 ± 0.025	1.521MetGlu: 1.521 ± 0.027	0.828MetPhe: 0.828 ± 0.021	1.54MetGly: 1.54 ± 0.03	0.451MetHis: 0.451 ± 0.014	1.459MetIle: 1.459 ± 0.03	2.033MetLys: 2.033 ± 0.032	2.331MetLeu: 2.331 ± 0.037	0.597MetMet: 0.597 ± 0.018	1.323MetAsn: 1.323 ± 0.027	1.148MetPro: 1.148 ± 0.024	1.164MetGln: 1.164 ± 0.023	1.048MetArg: 1.048 ± 0.023	1.34MetSer: 1.34 ± 0.029	1.112MetThr: 1.112 ± 0.027	1.438MetVal: 1.438 ± 0.026	0.22MetTrp: 0.22 ± 0.01	0.722MetTyr: 0.722 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	4.084AsnAla: 4.084 ± 0.052	0.381AsnCys: 0.381 ± 0.018	2.7AsnAsp: 2.7 ± 0.039	2.817AsnGlu: 2.817 ± 0.042	2.4AsnPhe: 2.4 ± 0.036	4.177AsnGly: 4.177 ± 0.053	0.826AsnHis: 0.826 ± 0.02	3.948AsnIle: 3.948 ± 0.053	3.436AsnLys: 3.436 ± 0.047	4.44AsnLeu: 4.44 ± 0.05	1.21AsnMet: 1.21 ± 0.027	3.287AsnAsn: 3.287 ± 0.054	2.654AsnPro: 2.654 ± 0.042	1.924AsnGln: 1.924 ± 0.038	2.52AsnArg: 2.52 ± 0.043	3.143AsnSer: 3.143 ± 0.046	3.351AsnThr: 3.351 ± 0.051	3.12AsnVal: 3.12 ± 0.045	0.803AsnTrp: 0.803 ± 0.02	2.439AsnTyr: 2.439 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	4.372ProAla: 4.372 ± 0.054	0.224ProCys: 0.224 ± 0.011	2.883ProAsp: 2.883 ± 0.039	2.93ProGlu: 2.93 ± 0.041	2.02ProPhe: 2.02 ± 0.033	3.609ProGly: 3.609 ± 0.044	0.731ProHis: 0.731 ± 0.02	2.151ProIle: 2.151 ± 0.036	2.062ProLys: 2.062 ± 0.036	3.741ProLeu: 3.741 ± 0.044	0.859ProMet: 0.859 ± 0.019	1.912ProAsn: 1.912 ± 0.037	1.386ProPro: 1.386 ± 0.031	1.482ProGln: 1.482 ± 0.033	1.356ProArg: 1.356 ± 0.026	2.399ProSer: 2.399 ± 0.035	2.037ProThr: 2.037 ± 0.034	3.86ProVal: 3.86 ± 0.049	0.5ProTrp: 0.5 ± 0.017	1.689ProTyr: 1.689 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.996GlnAla: 2.996 ± 0.042	0.238GlnCys: 0.238 ± 0.012	1.725GlnAsp: 1.725 ± 0.027	2.31GlnGlu: 2.31 ± 0.034	1.817GlnPhe: 1.817 ± 0.031	2.237GlnGly: 2.237 ± 0.042	1.011GlnHis: 1.011 ± 0.021	2.236GlnIle: 2.236 ± 0.038	2.269GlnLys: 2.269 ± 0.036	4.738GlnLeu: 4.738 ± 0.054	0.917GlnMet: 0.917 ± 0.022	1.721GlnAsn: 1.721 ± 0.035	1.929GlnPro: 1.929 ± 0.034	2.906GlnGln: 2.906 ± 0.05	1.934GlnArg: 1.934 ± 0.034	2.169GlnSer: 2.169 ± 0.032	2.069GlnThr: 2.069 ± 0.032	2.84GlnVal: 2.84 ± 0.037	0.553GlnTrp: 0.553 ± 0.016	1.755GlnTyr: 1.755 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.702ArgAla: 2.702 ± 0.044	0.284ArgCys: 0.284 ± 0.012	2.018ArgAsp: 2.018 ± 0.029	2.7ArgGlu: 2.7 ± 0.043	2.336ArgPhe: 2.336 ± 0.033	2.341ArgGly: 2.341 ± 0.039	0.85ArgHis: 0.85 ± 0.022	3.325ArgIle: 3.325 ± 0.037	3.321ArgLys: 3.321 ± 0.043	4.496ArgLeu: 4.496 ± 0.048	1.239ArgMet: 1.239 ± 0.023	2.627ArgAsn: 2.627 ± 0.036	1.61ArgPro: 1.61 ± 0.028	2.052ArgGln: 2.052 ± 0.033	2.019ArgArg: 2.019 ± 0.036	2.591ArgSer: 2.591 ± 0.037	2.306ArgThr: 2.306 ± 0.032	2.535ArgVal: 2.535 ± 0.036	0.653ArgTrp: 0.653 ± 0.019	2.224ArgTyr: 2.224 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.859SerAla: 4.859 ± 0.054	0.567SerCys: 0.567 ± 0.016	2.853SerAsp: 2.853 ± 0.038	2.772SerGlu: 2.772 ± 0.037	3.394SerPhe: 3.394 ± 0.039	4.755SerGly: 4.755 ± 0.059	1.065SerHis: 1.065 ± 0.024	4.138SerIle: 4.138 ± 0.055	3.412SerLys: 3.412 ± 0.043	6.278SerLeu: 6.278 ± 0.065	1.351SerMet: 1.351 ± 0.027	3.077SerAsn: 3.077 ± 0.048	2.518SerPro: 2.518 ± 0.033	2.127SerGln: 2.127 ± 0.033	2.821SerArg: 2.821 ± 0.038	3.797SerSer: 3.797 ± 0.054	3.347SerThr: 3.347 ± 0.044	4.005SerVal: 4.005 ± 0.049	0.853SerTrp: 0.853 ± 0.02	2.764SerTyr: 2.764 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.124ThrAla: 5.124 ± 0.059	0.392ThrCys: 0.392 ± 0.016	3.255ThrAsp: 3.255 ± 0.043	2.744ThrGlu: 2.744 ± 0.035	2.68ThrPhe: 2.68 ± 0.043	5.104ThrGly: 5.104 ± 0.056	0.969ThrHis: 0.969 ± 0.024	4.009ThrIle: 4.009 ± 0.052	2.823ThrLys: 2.823 ± 0.043	5.581ThrLeu: 5.581 ± 0.062	1.083ThrMet: 1.083 ± 0.02	2.754ThrAsn: 2.754 ± 0.048	2.959ThrPro: 2.959 ± 0.04	1.831ThrGln: 1.831 ± 0.031	2.413ThrArg: 2.413 ± 0.038	3.343ThrSer: 3.343 ± 0.042	3.561ThrThr: 3.561 ± 0.053	4.171ThrVal: 4.171 ± 0.06	0.762ThrTrp: 0.762 ± 0.026	2.356ThrTyr: 2.356 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	5.144ValAla: 5.144 ± 0.06	0.565ValCys: 0.565 ± 0.018	3.179ValAsp: 3.179 ± 0.046	3.122ValGlu: 3.122 ± 0.046	2.969ValPhe: 2.969 ± 0.044	3.743ValGly: 3.743 ± 0.051	1.159ValHis: 1.159 ± 0.023	4.642ValIle: 4.642 ± 0.057	4.535ValLys: 4.535 ± 0.05	6.268ValLeu: 6.268 ± 0.063	1.593ValMet: 1.593 ± 0.03	3.75ValAsn: 3.75 ± 0.046	2.817ValPro: 2.817 ± 0.04	2.316ValGln: 2.316 ± 0.037	2.553ValArg: 2.553 ± 0.034	4.209ValSer: 4.209 ± 0.047	4.312ValThr: 4.312 ± 0.063	4.38ValVal: 4.38 ± 0.056	0.72ValTrp: 0.72 ± 0.019	2.662ValTyr: 2.662 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.84TrpAla: 0.84 ± 0.023	0.117TrpCys: 0.117 ± 0.007	0.661TrpAsp: 0.661 ± 0.022	0.758TrpGlu: 0.758 ± 0.019	0.597TrpPhe: 0.597 ± 0.016	0.889TrpGly: 0.889 ± 0.022	0.276TrpHis: 0.276 ± 0.011	0.79TrpIle: 0.79 ± 0.022	0.962TrpLys: 0.962 ± 0.024	1.364TrpLeu: 1.364 ± 0.028	0.378TrpMet: 0.378 ± 0.014	0.761TrpAsn: 0.761 ± 0.023	0.406TrpPro: 0.406 ± 0.015	0.675TrpGln: 0.675 ± 0.016	0.588TrpArg: 0.588 ± 0.016	0.727TrpSer: 0.727 ± 0.02	0.688TrpThr: 0.688 ± 0.022	0.759TrpVal: 0.759 ± 0.02	0.235TrpTrp: 0.235 ± 0.01	0.55TrpTyr: 0.55 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.991TyrAla: 2.991 ± 0.042	0.374TyrCys: 0.374 ± 0.013	2.317TyrAsp: 2.317 ± 0.042	2.145TyrGlu: 2.145 ± 0.036	2.298TyrPhe: 2.298 ± 0.036	2.812TyrGly: 2.812 ± 0.039	0.857TyrHis: 0.857 ± 0.02	2.458TyrIle: 2.458 ± 0.036	2.536TyrLys: 2.536 ± 0.034	4.12TyrLeu: 4.12 ± 0.054	0.837TyrMet: 0.837 ± 0.021	2.594TyrAsn: 2.594 ± 0.041	1.808TyrPro: 1.808 ± 0.031	1.751TyrGln: 1.751 ± 0.033	2.08TyrArg: 2.08 ± 0.031	2.624TyrSer: 2.624 ± 0.036	2.631TyrThr: 2.631 ± 0.048	2.253TyrVal: 2.253 ± 0.035	0.588TyrTrp: 0.588 ± 0.016	2.092TyrTyr: 2.092 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5564 proteins (1984624 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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