Amino acid dipepetide frequency for Fusobacterium necrophorum subsp. funduliforme B35

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.611AlaAla: 4.611 ± 0.151	0.741AlaCys: 0.741 ± 0.035	2.606AlaAsp: 2.606 ± 0.074	4.306AlaGlu: 4.306 ± 0.099	3.11AlaPhe: 3.11 ± 0.08	4.721AlaGly: 4.721 ± 0.135	0.968AlaHis: 0.968 ± 0.039	5.273AlaIle: 5.273 ± 0.125	5.619AlaLys: 5.619 ± 0.116	6.497AlaLeu: 6.497 ± 0.123	1.913AlaMet: 1.913 ± 0.068	2.505AlaAsn: 2.505 ± 0.08	1.522AlaPro: 1.522 ± 0.06	1.624AlaGln: 1.624 ± 0.05	2.268AlaArg: 2.268 ± 0.064	3.616AlaSer: 3.616 ± 0.088	2.743AlaThr: 2.743 ± 0.075	4.443AlaVal: 4.443 ± 0.106	0.503AlaTrp: 0.503 ± 0.029	2.306AlaTyr: 2.306 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.41CysAla: 0.41 ± 0.028	0.138CysCys: 0.138 ± 0.014	0.422CysAsp: 0.422 ± 0.03	0.56CysGlu: 0.56 ± 0.034	0.583CysPhe: 0.583 ± 0.032	0.873CysGly: 0.873 ± 0.041	0.256CysHis: 0.256 ± 0.022	0.908CysIle: 0.908 ± 0.046	0.578CysLys: 0.578 ± 0.035	0.925CysLeu: 0.925 ± 0.04	0.273CysMet: 0.273 ± 0.021	0.387CysAsn: 0.387 ± 0.026	0.441CysPro: 0.441 ± 0.031	0.348CysGln: 0.348 ± 0.025	0.395CysArg: 0.395 ± 0.025	0.717CysSer: 0.717 ± 0.037	0.392CysThr: 0.392 ± 0.027	0.527CysVal: 0.527 ± 0.033	0.054CysTrp: 0.054 ± 0.009	0.395CysTyr: 0.395 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	2.418AspAla: 2.418 ± 0.076	0.522AspCys: 0.522 ± 0.033	1.578AspAsp: 1.578 ± 0.056	3.221AspGlu: 3.221 ± 0.094	2.835AspPhe: 2.835 ± 0.075	2.956AspGly: 2.956 ± 0.099	0.59AspHis: 0.59 ± 0.032	4.611AspIle: 4.611 ± 0.088	3.597AspLys: 3.597 ± 0.101	4.586AspLeu: 4.586 ± 0.088	1.413AspMet: 1.413 ± 0.045	1.73AspAsn: 1.73 ± 0.066	1.31AspPro: 1.31 ± 0.055	0.844AspGln: 0.844 ± 0.038	1.943AspArg: 1.943 ± 0.064	2.856AspSer: 2.856 ± 0.083	2.23AspThr: 2.23 ± 0.065	2.808AspVal: 2.808 ± 0.071	0.443AspTrp: 0.443 ± 0.027	2.44AspTyr: 2.44 ± 0.084	0.0AspXaa: 0.0 ± 0.0
Glu	5.346GluAla: 5.346 ± 0.124	0.478GluCys: 0.478 ± 0.028	4.073GluAsp: 4.073 ± 0.106	10.776GluGlu: 10.776 ± 0.224	3.103GluPhe: 3.103 ± 0.076	4.673GluGly: 4.673 ± 0.097	1.4GluHis: 1.4 ± 0.046	7.881GluIle: 7.881 ± 0.136	10.443GluLys: 10.443 ± 0.18	6.819GluLeu: 6.819 ± 0.122	2.414GluMet: 2.414 ± 0.053	5.226GluAsn: 5.226 ± 0.133	1.191GluPro: 1.191 ± 0.05	2.492GluGln: 2.492 ± 0.061	3.906GluArg: 3.906 ± 0.136	3.397GluSer: 3.397 ± 0.088	3.514GluThr: 3.514 ± 0.094	5.413GluVal: 5.413 ± 0.102	0.59GluTrp: 0.59 ± 0.033	3.499GluTyr: 3.499 ± 0.078	0.0GluXaa: 0.0 ± 0.0
Phe	2.759PheAla: 2.759 ± 0.067	0.552PheCys: 0.552 ± 0.028	2.232PheAsp: 2.232 ± 0.067	3.091PheGlu: 3.091 ± 0.075	2.932PhePhe: 2.932 ± 0.099	3.391PheGly: 3.391 ± 0.091	1.176PheHis: 1.176 ± 0.046	3.641PheIle: 3.641 ± 0.104	2.398PheLys: 2.398 ± 0.071	5.981PheLeu: 5.981 ± 0.152	1.291PheMet: 1.291 ± 0.05	1.502PheAsn: 1.502 ± 0.044	1.641PhePro: 1.641 ± 0.05	2.3PheGln: 2.3 ± 0.076	1.832PheArg: 1.832 ± 0.055	4.235PheSer: 4.235 ± 0.1	2.143PheThr: 2.143 ± 0.065	2.97PheVal: 2.97 ± 0.078	0.471PheTrp: 0.471 ± 0.027	2.138PheTyr: 2.138 ± 0.069	0.0PheXaa: 0.0 ± 0.0
Gly	4.61GlyAla: 4.61 ± 0.133	0.654GlyCys: 0.654 ± 0.038	3.018GlyAsp: 3.018 ± 0.081	5.206GlyGlu: 5.206 ± 0.115	3.037GlyPhe: 3.037 ± 0.085	4.678GlyGly: 4.678 ± 0.118	1.03GlyHis: 1.03 ± 0.04	6.776GlyIle: 6.776 ± 0.137	6.9GlyLys: 6.9 ± 0.109	5.449GlyLeu: 5.449 ± 0.094	2.062GlyMet: 2.062 ± 0.065	3.451GlyAsn: 3.451 ± 0.1	1.137GlyPro: 1.137 ± 0.052	1.568GlyGln: 1.568 ± 0.049	2.811GlyArg: 2.811 ± 0.071	3.872GlySer: 3.872 ± 0.101	3.372GlyThr: 3.372 ± 0.094	4.783GlyVal: 4.783 ± 0.11	0.433GlyTrp: 0.433 ± 0.027	2.776GlyTyr: 2.776 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	0.916HisAla: 0.916 ± 0.041	0.208HisCys: 0.208 ± 0.019	0.733HisAsp: 0.733 ± 0.035	1.084HisGlu: 1.084 ± 0.046	1.111HisPhe: 1.111 ± 0.043	1.235HisGly: 1.235 ± 0.053	0.508HisHis: 0.508 ± 0.038	1.544HisIle: 1.544 ± 0.055	1.154HisLys: 1.154 ± 0.045	1.841HisLeu: 1.841 ± 0.056	0.362HisMet: 0.362 ± 0.027	0.76HisAsn: 0.76 ± 0.034	0.792HisPro: 0.792 ± 0.037	0.638HisGln: 0.638 ± 0.031	0.806HisArg: 0.806 ± 0.045	1.271HisSer: 1.271 ± 0.048	0.825HisThr: 0.825 ± 0.039	0.844HisVal: 0.844 ± 0.039	0.168HisTrp: 0.168 ± 0.017	0.803HisTyr: 0.803 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.964IleAla: 5.964 ± 0.127	0.91IleCys: 0.91 ± 0.04	3.741IleAsp: 3.741 ± 0.086	6.083IleGlu: 6.083 ± 0.11	4.478IlePhe: 4.478 ± 0.117	5.808IleGly: 5.808 ± 0.128	1.656IleHis: 1.656 ± 0.056	5.848IleIle: 5.848 ± 0.132	5.418IleLys: 5.418 ± 0.096	9.848IleLeu: 9.848 ± 0.161	1.81IleMet: 1.81 ± 0.057	2.979IleAsn: 2.979 ± 0.084	3.375IlePro: 3.375 ± 0.079	3.57IleGln: 3.57 ± 0.085	3.381IleArg: 3.381 ± 0.066	6.186IleSer: 6.186 ± 0.12	3.895IleThr: 3.895 ± 0.082	5.395IleVal: 5.395 ± 0.099	0.578IleTrp: 0.578 ± 0.034	3.184IleTyr: 3.184 ± 0.078	0.0IleXaa: 0.0 ± 0.0
Lys	5.195LysAla: 5.195 ± 0.124	0.514LysCys: 0.514 ± 0.027	4.337LysAsp: 4.337 ± 0.119	9.876LysGlu: 9.876 ± 0.167	2.806LysPhe: 2.806 ± 0.066	4.802LysGly: 4.802 ± 0.109	1.346LysHis: 1.346 ± 0.042	8.224LysIle: 8.224 ± 0.119	9.764LysLys: 9.764 ± 0.149	6.916LysLeu: 6.916 ± 0.116	2.838LysMet: 2.838 ± 0.07	5.268LysAsn: 5.268 ± 0.108	1.603LysPro: 1.603 ± 0.053	2.975LysGln: 2.975 ± 0.07	3.595LysArg: 3.595 ± 0.09	3.951LysSer: 3.951 ± 0.09	4.203LysThr: 4.203 ± 0.071	5.473LysVal: 5.473 ± 0.112	0.694LysTrp: 0.694 ± 0.033	3.859LysTyr: 3.859 ± 0.091	0.0LysXaa: 0.0 ± 0.0
Leu	6.216LeuAla: 6.216 ± 0.101	1.083LeuCys: 1.083 ± 0.045	4.622LeuAsp: 4.622 ± 0.088	9.6LeuGlu: 9.6 ± 0.179	4.873LeuPhe: 4.873 ± 0.129	7.24LeuGly: 7.24 ± 0.126	1.768LeuHis: 1.768 ± 0.057	6.121LeuIle: 6.121 ± 0.121	7.872LeuLys: 7.872 ± 0.121	9.783LeuLeu: 9.783 ± 0.186	2.156LeuMet: 2.156 ± 0.069	3.979LeuAsn: 3.979 ± 0.093	3.237LeuPro: 3.237 ± 0.065	3.911LeuGln: 3.911 ± 0.082	3.843LeuArg: 3.843 ± 0.099	7.356LeuSer: 7.356 ± 0.127	4.302LeuThr: 4.302 ± 0.084	5.37LeuVal: 5.37 ± 0.113	0.765LeuTrp: 0.765 ± 0.032	3.451LeuTyr: 3.451 ± 0.087	0.0LeuXaa: 0.0 ± 0.0
Met	1.797MetAla: 1.797 ± 0.057	0.165MetCys: 0.165 ± 0.016	1.305MetAsp: 1.305 ± 0.039	2.578MetGlu: 2.578 ± 0.077	0.908MetPhe: 0.908 ± 0.042	1.894MetGly: 1.894 ± 0.053	0.283MetHis: 0.283 ± 0.021	2.356MetIle: 2.356 ± 0.064	3.279MetLys: 3.279 ± 0.083	2.46MetLeu: 2.46 ± 0.067	0.779MetMet: 0.779 ± 0.036	1.333MetAsn: 1.333 ± 0.048	0.773MetPro: 0.773 ± 0.037	0.76MetGln: 0.76 ± 0.036	1.043MetArg: 1.043 ± 0.04	1.475MetSer: 1.475 ± 0.05	1.41MetThr: 1.41 ± 0.056	1.475MetVal: 1.475 ± 0.048	0.133MetTrp: 0.133 ± 0.015	0.833MetTyr: 0.833 ± 0.039	0.0MetXaa: 0.0 ± 0.0
Asn	2.51AsnAla: 2.51 ± 0.076	0.443AsnCys: 0.443 ± 0.032	1.527AsnAsp: 1.527 ± 0.053	2.605AsnGlu: 2.605 ± 0.063	2.465AsnPhe: 2.465 ± 0.061	2.948AsnGly: 2.948 ± 0.099	0.905AsnHis: 0.905 ± 0.042	4.743AsnIle: 4.743 ± 0.106	3.403AsnLys: 3.403 ± 0.108	4.703AsnLeu: 4.703 ± 0.084	1.321AsnMet: 1.321 ± 0.049	1.841AsnAsn: 1.841 ± 0.071	2.16AsnPro: 2.16 ± 0.066	1.633AsnGln: 1.633 ± 0.059	2.118AsnArg: 2.118 ± 0.058	2.803AsnSer: 2.803 ± 0.095	2.365AsnThr: 2.365 ± 0.077	2.649AsnVal: 2.649 ± 0.087	0.371AsnTrp: 0.371 ± 0.025	2.198AsnTyr: 2.198 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	1.584ProAla: 1.584 ± 0.058	0.306ProCys: 0.306 ± 0.023	1.175ProAsp: 1.175 ± 0.046	2.627ProGlu: 2.627 ± 0.077	1.6ProPhe: 1.6 ± 0.055	1.77ProGly: 1.77 ± 0.057	0.524ProHis: 0.524 ± 0.034	2.435ProIle: 2.435 ± 0.07	2.589ProLys: 2.589 ± 0.061	2.572ProLeu: 2.572 ± 0.077	0.776ProMet: 0.776 ± 0.034	1.5ProAsn: 1.5 ± 0.056	0.537ProPro: 0.537 ± 0.032	0.77ProGln: 0.77 ± 0.035	0.905ProArg: 0.905 ± 0.041	1.656ProSer: 1.656 ± 0.053	1.291ProThr: 1.291 ± 0.046	2.022ProVal: 2.022 ± 0.067	0.232ProTrp: 0.232 ± 0.019	1.267ProTyr: 1.267 ± 0.051	0.0ProXaa: 0.0 ± 0.0
Gln	2.086GlnAla: 2.086 ± 0.06	0.249GlnCys: 0.249 ± 0.022	1.603GlnAsp: 1.603 ± 0.059	3.986GlnGlu: 3.986 ± 0.104	1.291GlnPhe: 1.291 ± 0.046	2.325GlnGly: 2.325 ± 0.064	0.484GlnHis: 0.484 ± 0.029	2.491GlnIle: 2.491 ± 0.061	3.745GlnLys: 3.745 ± 0.08	2.686GlnLeu: 2.686 ± 0.059	0.765GlnMet: 0.765 ± 0.033	1.783GlnAsn: 1.783 ± 0.057	0.497GlnPro: 0.497 ± 0.028	1.038GlnGln: 1.038 ± 0.046	1.381GlnArg: 1.381 ± 0.05	1.616GlnSer: 1.616 ± 0.046	1.214GlnThr: 1.214 ± 0.039	1.898GlnVal: 1.898 ± 0.056	0.27GlnTrp: 0.27 ± 0.022	1.518GlnTyr: 1.518 ± 0.05	0.0GlnXaa: 0.0 ± 0.0
Arg	2.349ArgAla: 2.349 ± 0.069	0.33ArgCys: 0.33 ± 0.022	1.986ArgAsp: 1.986 ± 0.063	4.47ArgGlu: 4.47 ± 0.125	1.694ArgPhe: 1.694 ± 0.054	2.552ArgGly: 2.552 ± 0.065	0.589ArgHis: 0.589 ± 0.03	3.475ArgIle: 3.475 ± 0.082	4.303ArgLys: 4.303 ± 0.093	3.433ArgLeu: 3.433 ± 0.084	1.254ArgMet: 1.254 ± 0.043	2.249ArgAsn: 2.249 ± 0.07	0.881ArgPro: 0.881 ± 0.041	1.213ArgGln: 1.213 ± 0.044	1.838ArgArg: 1.838 ± 0.059	1.8ArgSer: 1.8 ± 0.057	1.529ArgThr: 1.529 ± 0.046	2.656ArgVal: 2.656 ± 0.065	0.263ArgTrp: 0.263 ± 0.024	1.743ArgTyr: 1.743 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	3.281SerAla: 3.281 ± 0.09	0.675SerCys: 0.675 ± 0.037	2.384SerAsp: 2.384 ± 0.066	3.894SerGlu: 3.894 ± 0.086	3.889SerPhe: 3.889 ± 0.09	4.302SerGly: 4.302 ± 0.104	1.256SerHis: 1.256 ± 0.046	5.38SerIle: 5.38 ± 0.11	4.826SerLys: 4.826 ± 0.107	7.124SerLeu: 7.124 ± 0.127	1.802SerMet: 1.802 ± 0.059	2.494SerAsn: 2.494 ± 0.079	1.779SerPro: 1.779 ± 0.053	1.91SerGln: 1.91 ± 0.064	2.164SerArg: 2.164 ± 0.066	4.403SerSer: 4.403 ± 0.122	2.825SerThr: 2.825 ± 0.087	3.657SerVal: 3.657 ± 0.097	0.505SerTrp: 0.505 ± 0.027	3.022SerTyr: 3.022 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	3.046ThrAla: 3.046 ± 0.083	0.429ThrCys: 0.429 ± 0.029	2.057ThrAsp: 2.057 ± 0.064	3.605ThrGlu: 3.605 ± 0.089	2.019ThrPhe: 2.019 ± 0.055	3.784ThrGly: 3.784 ± 0.098	0.77ThrHis: 0.77 ± 0.036	3.568ThrIle: 3.568 ± 0.081	3.772ThrLys: 3.772 ± 0.086	4.706ThrLeu: 4.706 ± 0.086	1.148ThrMet: 1.148 ± 0.038	1.897ThrAsn: 1.897 ± 0.067	1.697ThrPro: 1.697 ± 0.062	1.237ThrGln: 1.237 ± 0.051	1.729ThrArg: 1.729 ± 0.055	2.735ThrSer: 2.735 ± 0.073	2.281ThrThr: 2.281 ± 0.073	3.214ThrVal: 3.214 ± 0.078	0.43ThrTrp: 0.43 ± 0.026	1.494ThrTyr: 1.494 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	4.122ValAla: 4.122 ± 0.088	0.641ValCys: 0.641 ± 0.035	3.075ValAsp: 3.075 ± 0.081	5.23ValGlu: 5.23 ± 0.11	3.106ValPhe: 3.106 ± 0.071	4.391ValGly: 4.391 ± 0.101	0.989ValHis: 0.989 ± 0.042	5.053ValIle: 5.053 ± 0.086	4.976ValLys: 4.976 ± 0.098	6.311ValLeu: 6.311 ± 0.124	1.53ValMet: 1.53 ± 0.051	2.756ValAsn: 2.756 ± 0.095	1.921ValPro: 1.921 ± 0.062	1.797ValGln: 1.797 ± 0.053	2.264ValArg: 2.264 ± 0.065	4.346ValSer: 4.346 ± 0.091	2.918ValThr: 2.918 ± 0.078	4.116ValVal: 4.116 ± 0.095	0.448ValTrp: 0.448 ± 0.03	2.31ValTyr: 2.31 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.397TrpAla: 0.397 ± 0.029	0.065TrpCys: 0.065 ± 0.011	0.379TrpAsp: 0.379 ± 0.025	0.735TrpGlu: 0.735 ± 0.037	0.302TrpPhe: 0.302 ± 0.025	0.533TrpGly: 0.533 ± 0.03	0.124TrpHis: 0.124 ± 0.015	0.77TrpIle: 0.77 ± 0.038	1.052TrpLys: 1.052 ± 0.041	0.625TrpLeu: 0.625 ± 0.036	0.232TrpMet: 0.232 ± 0.019	0.503TrpAsn: 0.503 ± 0.031	0.113TrpPro: 0.113 ± 0.014	0.237TrpGln: 0.237 ± 0.018	0.303TrpArg: 0.303 ± 0.023	0.375TrpSer: 0.375 ± 0.022	0.359TrpThr: 0.359 ± 0.027	0.359TrpVal: 0.359 ± 0.024	0.076TrpTrp: 0.076 ± 0.01	0.263TrpTyr: 0.263 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.281TyrAla: 2.281 ± 0.067	0.479TyrCys: 0.479 ± 0.029	2.076TyrAsp: 2.076 ± 0.06	3.102TyrGlu: 3.102 ± 0.078	2.537TyrPhe: 2.537 ± 0.074	2.748TyrGly: 2.748 ± 0.077	0.986TyrHis: 0.986 ± 0.041	3.008TyrIle: 3.008 ± 0.07	2.552TyrLys: 2.552 ± 0.067	4.279TyrLeu: 4.279 ± 0.096	0.9TyrMet: 0.9 ± 0.038	1.568TyrAsn: 1.568 ± 0.063	1.53TyrPro: 1.53 ± 0.05	2.06TyrGln: 2.06 ± 0.073	2.083TyrArg: 2.083 ± 0.061	2.905TyrSer: 2.905 ± 0.078	1.806TyrThr: 1.806 ± 0.057	2.225TyrVal: 2.225 ± 0.059	0.373TyrTrp: 0.373 ± 0.025	1.949TyrTyr: 1.949 ± 0.072	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1906 proteins (629983 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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