Amino acid dipepetide frequency for Oesophagostomum dentatum (Nodular worm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.662AlaAla: 6.662 ± 0.044	1.358AlaCys: 1.358 ± 0.019	3.65AlaAsp: 3.65 ± 0.025	4.901AlaGlu: 4.901 ± 0.038	2.948AlaPhe: 2.948 ± 0.024	4.087AlaGly: 4.087 ± 0.031	1.611AlaHis: 1.611 ± 0.017	3.977AlaIle: 3.977 ± 0.024	4.28AlaLys: 4.28 ± 0.031	6.753AlaLeu: 6.753 ± 0.042	1.946AlaMet: 1.946 ± 0.019	2.814AlaAsn: 2.814 ± 0.023	3.5AlaPro: 3.5 ± 0.035	2.714AlaGln: 2.714 ± 0.025	3.964AlaArg: 3.964 ± 0.035	5.221AlaSer: 5.221 ± 0.034	4.016AlaThr: 4.016 ± 0.03	5.301AlaVal: 5.301 ± 0.031	0.705AlaTrp: 0.705 ± 0.012	2.035AlaTyr: 2.035 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.47CysAla: 1.47 ± 0.02	0.633CysCys: 0.633 ± 0.015	1.209CysAsp: 1.209 ± 0.019	1.298CysGlu: 1.298 ± 0.018	1.003CysPhe: 1.003 ± 0.015	1.508CysGly: 1.508 ± 0.019	0.52CysHis: 0.52 ± 0.01	1.23CysIle: 1.23 ± 0.021	1.128CysLys: 1.128 ± 0.02	1.88CysLeu: 1.88 ± 0.018	0.554CysMet: 0.554 ± 0.01	0.872CysAsn: 0.872 ± 0.013	1.323CysPro: 1.323 ± 0.022	0.795CysGln: 0.795 ± 0.015	1.307CysArg: 1.307 ± 0.02	1.895CysSer: 1.895 ± 0.024	1.186CysThr: 1.186 ± 0.018	1.448CysVal: 1.448 ± 0.02	0.246CysTrp: 0.246 ± 0.007	0.71CysTyr: 0.71 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.715AspAla: 3.715 ± 0.03	1.108AspCys: 1.108 ± 0.02	3.588AspAsp: 3.588 ± 0.03	4.369AspGlu: 4.369 ± 0.033	2.35AspPhe: 2.35 ± 0.023	3.519AspGly: 3.519 ± 0.034	1.162AspHis: 1.162 ± 0.016	3.01AspIle: 3.01 ± 0.026	2.753AspLys: 2.753 ± 0.023	4.669AspLeu: 4.669 ± 0.03	1.338AspMet: 1.338 ± 0.017	1.94AspAsn: 1.94 ± 0.018	2.566AspPro: 2.566 ± 0.024	1.775AspGln: 1.775 ± 0.019	2.967AspArg: 2.967 ± 0.026	3.699AspSer: 3.699 ± 0.03	2.524AspThr: 2.524 ± 0.021	3.844AspVal: 3.844 ± 0.029	0.69AspTrp: 0.69 ± 0.011	1.843AspTyr: 1.843 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	4.693GluAla: 4.693 ± 0.034	1.278GluCys: 1.278 ± 0.019	3.814GluAsp: 3.814 ± 0.032	6.144GluGlu: 6.144 ± 0.056	2.382GluPhe: 2.382 ± 0.026	3.268GluGly: 3.268 ± 0.026	1.563GluHis: 1.563 ± 0.016	3.502GluIle: 3.502 ± 0.025	5.018GluLys: 5.018 ± 0.042	5.722GluLeu: 5.722 ± 0.036	1.926GluMet: 1.926 ± 0.023	3.03GluAsn: 3.03 ± 0.025	2.564GluPro: 2.564 ± 0.028	2.847GluGln: 2.847 ± 0.025	4.127GluArg: 4.127 ± 0.032	3.985GluSer: 3.985 ± 0.037	3.333GluThr: 3.333 ± 0.025	4.014GluVal: 4.014 ± 0.027	0.821GluTrp: 0.821 ± 0.014	1.917GluTyr: 1.917 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.108PheAla: 3.108 ± 0.03	1.097PheCys: 1.097 ± 0.016	2.434PheAsp: 2.434 ± 0.02	2.425PheGlu: 2.425 ± 0.024	2.179PhePhe: 2.179 ± 0.022	2.737PheGly: 2.737 ± 0.025	1.086PheHis: 1.086 ± 0.014	2.445PheIle: 2.445 ± 0.024	1.913PheLys: 1.913 ± 0.018	4.137PheLeu: 4.137 ± 0.03	1.114PheMet: 1.114 ± 0.015	1.683PheAsn: 1.683 ± 0.015	1.932PhePro: 1.932 ± 0.02	1.465PheGln: 1.465 ± 0.017	2.344PheArg: 2.344 ± 0.022	3.303PheSer: 3.303 ± 0.027	2.338PheThr: 2.338 ± 0.02	3.045PheVal: 3.045 ± 0.025	0.552PheTrp: 0.552 ± 0.009	1.555PheTyr: 1.555 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	3.89GlyAla: 3.89 ± 0.031	1.34GlyCys: 1.34 ± 0.019	3.016GlyAsp: 3.016 ± 0.026	3.574GlyGlu: 3.574 ± 0.029	2.57GlyPhe: 2.57 ± 0.022	4.282GlyGly: 4.282 ± 0.054	1.361GlyHis: 1.361 ± 0.018	3.209GlyIle: 3.209 ± 0.027	3.572GlyLys: 3.572 ± 0.031	4.594GlyLeu: 4.594 ± 0.041	1.634GlyMet: 1.634 ± 0.023	2.409GlyAsn: 2.409 ± 0.022	2.885GlyPro: 2.885 ± 0.058	2.145GlyGln: 2.145 ± 0.025	3.463GlyArg: 3.463 ± 0.032	4.316GlySer: 4.316 ± 0.032	3.297GlyThr: 3.297 ± 0.028	3.893GlyVal: 3.893 ± 0.027	0.742GlyTrp: 0.742 ± 0.013	2.138GlyTyr: 2.138 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.498HisAla: 1.498 ± 0.018	0.617HisCys: 0.617 ± 0.011	1.132HisAsp: 1.132 ± 0.017	1.348HisGlu: 1.348 ± 0.018	1.135HisPhe: 1.135 ± 0.013	1.408HisGly: 1.408 ± 0.018	0.727HisHis: 0.727 ± 0.015	1.337HisIle: 1.337 ± 0.014	1.146HisLys: 1.146 ± 0.012	2.276HisLeu: 2.276 ± 0.021	0.646HisMet: 0.646 ± 0.01	0.927HisAsn: 0.927 ± 0.013	1.322HisPro: 1.322 ± 0.017	0.834HisGln: 0.834 ± 0.012	1.499HisArg: 1.499 ± 0.017	1.785HisSer: 1.785 ± 0.017	1.188HisThr: 1.188 ± 0.015	1.527HisVal: 1.527 ± 0.018	0.313HisTrp: 0.313 ± 0.008	0.866HisTyr: 0.866 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.217IleAla: 4.217 ± 0.033	1.341IleCys: 1.341 ± 0.017	3.088IleAsp: 3.088 ± 0.026	3.378IleGlu: 3.378 ± 0.025	2.464IlePhe: 2.464 ± 0.022	3.15IleGly: 3.15 ± 0.03	1.301IleHis: 1.301 ± 0.015	2.93IleIle: 2.93 ± 0.024	2.665IleLys: 2.665 ± 0.024	4.919IleLeu: 4.919 ± 0.033	1.33IleMet: 1.33 ± 0.017	2.151IleAsn: 2.151 ± 0.023	2.863IlePro: 2.863 ± 0.023	1.885IleGln: 1.885 ± 0.017	3.264IleArg: 3.264 ± 0.028	4.212IleSer: 4.212 ± 0.026	3.107IleThr: 3.107 ± 0.026	3.759IleVal: 3.759 ± 0.032	0.644IleTrp: 0.644 ± 0.011	1.801IleTyr: 1.801 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.992LysAla: 3.992 ± 0.036	1.284LysCys: 1.284 ± 0.022	3.085LysAsp: 3.085 ± 0.027	4.469LysGlu: 4.469 ± 0.036	2.201LysPhe: 2.201 ± 0.023	2.938LysGly: 2.938 ± 0.029	1.34LysHis: 1.34 ± 0.017	3.193LysIle: 3.193 ± 0.028	4.675LysLys: 4.675 ± 0.042	5.085LysLeu: 5.085 ± 0.035	1.714LysMet: 1.714 ± 0.018	2.551LysAsn: 2.551 ± 0.021	2.671LysPro: 2.671 ± 0.031	2.259LysGln: 2.259 ± 0.023	3.722LysArg: 3.722 ± 0.03	3.804LysSer: 3.804 ± 0.031	3.149LysThr: 3.149 ± 0.023	3.588LysVal: 3.588 ± 0.025	0.726LysTrp: 0.726 ± 0.012	1.917LysTyr: 1.917 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	6.702LeuAla: 6.702 ± 0.037	2.085LeuCys: 2.085 ± 0.022	4.729LeuAsp: 4.729 ± 0.03	5.54LeuGlu: 5.54 ± 0.041	4.089LeuPhe: 4.089 ± 0.03	4.553LeuGly: 4.553 ± 0.033	2.248LeuHis: 2.248 ± 0.02	4.819LeuIle: 4.819 ± 0.033	5.253LeuLys: 5.253 ± 0.033	9.273LeuLeu: 9.273 ± 0.056	2.316LeuMet: 2.316 ± 0.02	3.72LeuAsn: 3.72 ± 0.031	4.771LeuPro: 4.771 ± 0.036	3.621LeuGln: 3.621 ± 0.03	5.75LeuArg: 5.75 ± 0.036	7.042LeuSer: 7.042 ± 0.044	4.895LeuThr: 4.895 ± 0.031	5.633LeuVal: 5.633 ± 0.035	1.025LeuTrp: 1.025 ± 0.014	2.756LeuTyr: 2.756 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	1.964MetAla: 1.964 ± 0.02	0.548MetCys: 0.548 ± 0.009	1.474MetAsp: 1.474 ± 0.017	1.802MetGlu: 1.802 ± 0.02	1.132MetPhe: 1.132 ± 0.015	1.453MetGly: 1.453 ± 0.02	0.61MetHis: 0.61 ± 0.01	1.379MetIle: 1.379 ± 0.017	1.687MetLys: 1.687 ± 0.018	2.505MetLeu: 2.505 ± 0.022	0.813MetMet: 0.813 ± 0.014	1.174MetAsn: 1.174 ± 0.015	1.289MetPro: 1.289 ± 0.018	1.045MetGln: 1.045 ± 0.015	1.651MetArg: 1.651 ± 0.017	1.948MetSer: 1.948 ± 0.019	1.501MetThr: 1.501 ± 0.018	1.653MetVal: 1.653 ± 0.017	0.328MetTrp: 0.328 ± 0.008	0.773MetTyr: 0.773 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.042AsnAla: 3.042 ± 0.024	0.924AsnCys: 0.924 ± 0.016	2.153AsnAsp: 2.153 ± 0.022	2.72AsnGlu: 2.72 ± 0.025	1.791AsnPhe: 1.791 ± 0.019	2.911AsnGly: 2.911 ± 0.027	0.852AsnHis: 0.852 ± 0.015	2.397AsnIle: 2.397 ± 0.024	2.121AsnLys: 2.121 ± 0.023	3.497AsnLeu: 3.497 ± 0.028	1.107AsnMet: 1.107 ± 0.014	1.752AsnAsn: 1.752 ± 0.021	2.1AsnPro: 2.1 ± 0.023	1.386AsnGln: 1.386 ± 0.017	2.261AsnArg: 2.261 ± 0.022	2.987AsnSer: 2.987 ± 0.024	2.142AsnThr: 2.142 ± 0.021	2.897AsnVal: 2.897 ± 0.024	0.474AsnTrp: 0.474 ± 0.008	1.448AsnTyr: 1.448 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	3.602ProAla: 3.602 ± 0.033	0.884ProCys: 0.884 ± 0.015	2.516ProAsp: 2.516 ± 0.022	3.295ProGlu: 3.295 ± 0.031	2.008ProPhe: 2.008 ± 0.023	3.564ProGly: 3.564 ± 0.091	1.171ProHis: 1.171 ± 0.014	2.448ProIle: 2.448 ± 0.022	2.699ProLys: 2.699 ± 0.027	4.184ProLeu: 4.184 ± 0.032	1.142ProMet: 1.142 ± 0.016	1.954ProAsn: 1.954 ± 0.02	4.115ProPro: 4.115 ± 0.06	1.994ProGln: 1.994 ± 0.023	2.713ProArg: 2.713 ± 0.023	4.246ProSer: 4.246 ± 0.033	3.034ProThr: 3.034 ± 0.031	3.378ProVal: 3.378 ± 0.025	0.509ProTrp: 0.509 ± 0.011	1.58ProTyr: 1.58 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	2.505GlnAla: 2.505 ± 0.023	0.915GlnCys: 0.915 ± 0.019	1.498GlnAsp: 1.498 ± 0.016	2.288GlnGlu: 2.288 ± 0.024	1.611GlnPhe: 1.611 ± 0.017	1.824GlnGly: 1.824 ± 0.021	0.93GlnHis: 0.93 ± 0.014	2.103GlnIle: 2.103 ± 0.019	2.401GlnLys: 2.401 ± 0.022	3.977GlnLeu: 3.977 ± 0.029	1.245GlnMet: 1.245 ± 0.016	1.604GlnAsn: 1.604 ± 0.019	1.979GlnPro: 1.979 ± 0.024	2.121GlnGln: 2.121 ± 0.027	2.466GlnArg: 2.466 ± 0.023	2.432GlnSer: 2.432 ± 0.023	1.898GlnThr: 1.898 ± 0.018	2.293GlnVal: 2.293 ± 0.02	0.495GlnTrp: 0.495 ± 0.009	1.278GlnTyr: 1.278 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	3.826ArgAla: 3.826 ± 0.028	1.265ArgCys: 1.265 ± 0.021	2.979ArgAsp: 2.979 ± 0.026	3.818ArgGlu: 3.818 ± 0.032	2.504ArgPhe: 2.504 ± 0.021	3.05ArgGly: 3.05 ± 0.031	1.472ArgHis: 1.472 ± 0.02	3.377ArgIle: 3.377 ± 0.027	4.033ArgLys: 4.033 ± 0.031	5.589ArgLeu: 5.589 ± 0.037	1.689ArgMet: 1.689 ± 0.015	2.631ArgAsn: 2.631 ± 0.022	2.773ArgPro: 2.773 ± 0.026	2.374ArgGln: 2.374 ± 0.023	4.788ArgArg: 4.788 ± 0.04	4.39ArgSer: 4.39 ± 0.035	3.152ArgThr: 3.152 ± 0.025	3.526ArgVal: 3.526 ± 0.027	0.699ArgTrp: 0.699 ± 0.011	1.921ArgTyr: 1.921 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	5.468SerAla: 5.468 ± 0.033	1.608SerCys: 1.608 ± 0.021	3.992SerAsp: 3.992 ± 0.03	4.525SerGlu: 4.525 ± 0.032	3.229SerPhe: 3.229 ± 0.028	4.475SerGly: 4.475 ± 0.031	1.648SerHis: 1.648 ± 0.018	3.875SerIle: 3.875 ± 0.028	3.988SerLys: 3.988 ± 0.029	6.743SerLeu: 6.743 ± 0.041	1.895SerMet: 1.895 ± 0.019	2.882SerAsn: 2.882 ± 0.023	3.874SerPro: 3.874 ± 0.038	2.644SerGln: 2.644 ± 0.025	4.337SerArg: 4.337 ± 0.032	7.362SerSer: 7.362 ± 0.056	4.753SerThr: 4.753 ± 0.042	4.799SerVal: 4.799 ± 0.031	0.839SerTrp: 0.839 ± 0.014	2.203SerTyr: 2.203 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	4.345ThrAla: 4.345 ± 0.033	1.233ThrCys: 1.233 ± 0.019	2.785ThrAsp: 2.785 ± 0.025	3.231ThrGlu: 3.231 ± 0.026	2.332ThrPhe: 2.332 ± 0.02	3.229ThrGly: 3.229 ± 0.032	1.186ThrHis: 1.186 ± 0.015	3.105ThrIle: 3.105 ± 0.028	2.962ThrLys: 2.962 ± 0.027	4.843ThrLeu: 4.843 ± 0.031	1.389ThrMet: 1.389 ± 0.016	2.191ThrAsn: 2.191 ± 0.02	3.148ThrPro: 3.148 ± 0.034	1.882ThrGln: 1.882 ± 0.022	2.791ThrArg: 2.791 ± 0.023	4.515ThrSer: 4.515 ± 0.037	3.932ThrThr: 3.932 ± 0.045	4.201ThrVal: 4.201 ± 0.031	0.603ThrTrp: 0.603 ± 0.011	1.671ThrTyr: 1.671 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.87ValAla: 4.87 ± 0.031	1.606ValCys: 1.606 ± 0.019	3.821ValAsp: 3.821 ± 0.028	4.284ValGlu: 4.284 ± 0.03	3.0ValPhe: 3.0 ± 0.023	3.55ValGly: 3.55 ± 0.028	1.651ValHis: 1.651 ± 0.017	3.699ValIle: 3.699 ± 0.027	3.585ValLys: 3.585 ± 0.032	6.161ValLeu: 6.161 ± 0.035	1.691ValMet: 1.691 ± 0.018	2.674ValAsn: 2.674 ± 0.022	3.394ValPro: 3.394 ± 0.03	2.479ValGln: 2.479 ± 0.019	3.712ValArg: 3.712 ± 0.027	4.849ValSer: 4.849 ± 0.032	3.713ValThr: 3.713 ± 0.031	4.939ValVal: 4.939 ± 0.034	0.72ValTrp: 0.72 ± 0.011	2.069ValTyr: 2.069 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.75TrpAla: 0.75 ± 0.012	0.226TrpCys: 0.226 ± 0.007	0.626TrpAsp: 0.626 ± 0.012	0.642TrpGlu: 0.642 ± 0.011	0.474TrpPhe: 0.474 ± 0.01	0.578TrpGly: 0.578 ± 0.012	0.27TrpHis: 0.27 ± 0.008	0.737TrpIle: 0.737 ± 0.012	0.813TrpLys: 0.813 ± 0.013	1.124TrpLeu: 1.124 ± 0.016	0.397TrpMet: 0.397 ± 0.009	0.614TrpAsn: 0.614 ± 0.011	0.485TrpPro: 0.485 ± 0.011	0.454TrpGln: 0.454 ± 0.009	0.768TrpArg: 0.768 ± 0.011	0.865TrpSer: 0.865 ± 0.012	0.732TrpThr: 0.732 ± 0.011	0.644TrpVal: 0.644 ± 0.009	0.214TrpTrp: 0.214 ± 0.006	0.373TrpTyr: 0.373 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.126TyrAla: 2.126 ± 0.017	0.866TyrCys: 0.866 ± 0.013	1.845TyrAsp: 1.845 ± 0.021	1.894TyrGlu: 1.894 ± 0.02	1.493TyrPhe: 1.493 ± 0.016	2.245TyrGly: 2.245 ± 0.026	0.821TyrHis: 0.821 ± 0.014	1.698TyrIle: 1.698 ± 0.019	1.673TyrLys: 1.673 ± 0.016	2.887TyrLeu: 2.887 ± 0.026	0.841TyrMet: 0.841 ± 0.013	1.387TyrAsn: 1.387 ± 0.018	1.48TyrPro: 1.48 ± 0.021	1.143TyrGln: 1.143 ± 0.014	1.96TyrArg: 1.96 ± 0.02	2.286TyrSer: 2.286 ± 0.02	1.684TyrThr: 1.684 ± 0.022	2.087TyrVal: 2.087 ± 0.021	0.439TyrTrp: 0.439 ± 0.009	1.306TyrTyr: 1.306 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 25133 proteins (5464594 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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