Amino acid dipepetide frequency for Ventosimonas gracilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.72AlaAla: 13.72 ± 0.18
1.429AlaCys: 1.429 ± 0.045
5.804AlaAsp: 5.804 ± 0.09
7.115AlaGlu: 7.115 ± 0.125
4.012AlaPhe: 4.012 ± 0.079
8.468AlaGly: 8.468 ± 0.122
2.364AlaHis: 2.364 ± 0.065
5.468AlaIle: 5.468 ± 0.096
4.5AlaLys: 4.5 ± 0.092
15.456AlaLeu: 15.456 ± 0.202
2.544AlaMet: 2.544 ± 0.067
2.855AlaAsn: 2.855 ± 0.069
4.507AlaPro: 4.507 ± 0.08
5.985AlaGln: 5.985 ± 0.097
7.013AlaArg: 7.013 ± 0.117
6.011AlaSer: 6.011 ± 0.096
4.198AlaThr: 4.198 ± 0.079
6.901AlaVal: 6.901 ± 0.108
1.418AlaTrp: 1.418 ± 0.047
2.366AlaTyr: 2.366 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
1.349CysAla: 1.349 ± 0.05
0.177CysCys: 0.177 ± 0.017
0.532CysAsp: 0.532 ± 0.026
0.679CysGlu: 0.679 ± 0.031
0.447CysPhe: 0.447 ± 0.025
1.097CysGly: 1.097 ± 0.036
0.336CysHis: 0.336 ± 0.023
0.643CysIle: 0.643 ± 0.031
0.333CysLys: 0.333 ± 0.022
1.353CysLeu: 1.353 ± 0.048
0.241CysMet: 0.241 ± 0.017
0.311CysAsn: 0.311 ± 0.024
0.582CysPro: 0.582 ± 0.029
0.53CysGln: 0.53 ± 0.027
0.692CysArg: 0.692 ± 0.029
0.595CysSer: 0.595 ± 0.032
0.55CysThr: 0.55 ± 0.028
0.734CysVal: 0.734 ± 0.032
0.146CysTrp: 0.146 ± 0.014
0.312CysTyr: 0.312 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
4.983AspAla: 4.983 ± 0.098
0.671AspCys: 0.671 ± 0.033
2.521AspAsp: 2.521 ± 0.055
3.566AspGlu: 3.566 ± 0.08
2.448AspPhe: 2.448 ± 0.056
4.036AspGly: 4.036 ± 0.088
0.914AspHis: 0.914 ± 0.04
2.738AspIle: 2.738 ± 0.063
2.435AspLys: 2.435 ± 0.059
5.673AspLeu: 5.673 ± 0.092
1.247AspMet: 1.247 ± 0.042
1.811AspAsn: 1.811 ± 0.052
2.21AspPro: 2.21 ± 0.059
1.54AspGln: 1.54 ± 0.048
2.262AspArg: 2.262 ± 0.064
2.886AspSer: 2.886 ± 0.054
2.075AspThr: 2.075 ± 0.059
2.796AspVal: 2.796 ± 0.074
1.071AspTrp: 1.071 ± 0.035
1.795AspTyr: 1.795 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
6.556GluAla: 6.556 ± 0.113
0.426GluCys: 0.426 ± 0.025
2.526GluAsp: 2.526 ± 0.065
2.909GluGlu: 2.909 ± 0.082
1.79GluPhe: 1.79 ± 0.054
3.787GluGly: 3.787 ± 0.069
1.399GluHis: 1.399 ± 0.047
2.905GluIle: 2.905 ± 0.064
2.565GluLys: 2.565 ± 0.067
6.79GluLeu: 6.79 ± 0.095
1.218GluMet: 1.218 ± 0.036
1.913GluAsn: 1.913 ± 0.05
2.505GluPro: 2.505 ± 0.065
4.737GluGln: 4.737 ± 0.106
4.837GluArg: 4.837 ± 0.096
2.587GluSer: 2.587 ± 0.055
2.562GluThr: 2.562 ± 0.067
3.956GluVal: 3.956 ± 0.075
0.628GluTrp: 0.628 ± 0.029
1.197GluTyr: 1.197 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
4.987PheAla: 4.987 ± 0.094
0.565PheCys: 0.565 ± 0.03
2.344PheAsp: 2.344 ± 0.064
2.086PheGlu: 2.086 ± 0.056
1.578PhePhe: 1.578 ± 0.063
3.124PheGly: 3.124 ± 0.069
0.669PheHis: 0.669 ± 0.028
2.172PheIle: 2.172 ± 0.057
1.382PheLys: 1.382 ± 0.051
3.206PheLeu: 3.206 ± 0.083
0.788PheMet: 0.788 ± 0.033
1.53PheAsn: 1.53 ± 0.053
1.431PhePro: 1.431 ± 0.043
1.049PheGln: 1.049 ± 0.038
1.886PheArg: 1.886 ± 0.054
2.737PheSer: 2.737 ± 0.062
1.779PheThr: 1.779 ± 0.045
2.388PheVal: 2.388 ± 0.059
0.598PheTrp: 0.598 ± 0.03
1.151PheTyr: 1.151 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
7.013GlyAla: 7.013 ± 0.11
1.009GlyCys: 1.009 ± 0.038
3.356GlyAsp: 3.356 ± 0.066
5.079GlyGlu: 5.079 ± 0.085
3.549GlyPhe: 3.549 ± 0.06
5.989GlyGly: 5.989 ± 0.107
1.72GlyHis: 1.72 ± 0.052
4.521GlyIle: 4.521 ± 0.104
4.13GlyLys: 4.13 ± 0.081
8.635GlyLeu: 8.635 ± 0.126
2.033GlyMet: 2.033 ± 0.059
2.376GlyAsn: 2.376 ± 0.076
1.692GlyPro: 1.692 ± 0.045
3.872GlyGln: 3.872 ± 0.082
4.77GlyArg: 4.77 ± 0.078
4.642GlySer: 4.642 ± 0.089
3.505GlyThr: 3.505 ± 0.074
4.922GlyVal: 4.922 ± 0.094
1.241GlyTrp: 1.241 ± 0.044
2.242GlyTyr: 2.242 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.112HisAla: 2.112 ± 0.052
0.396HisCys: 0.396 ± 0.025
0.95HisAsp: 0.95 ± 0.042
1.116HisGlu: 1.116 ± 0.04
0.971HisPhe: 0.971 ± 0.041
1.68HisGly: 1.68 ± 0.055
0.627HisHis: 0.627 ± 0.031
1.249HisIle: 1.249 ± 0.042
0.799HisLys: 0.799 ± 0.035
2.858HisLeu: 2.858 ± 0.062
0.488HisMet: 0.488 ± 0.025
0.694HisAsn: 0.694 ± 0.031
1.431HisPro: 1.431 ± 0.048
1.173HisGln: 1.173 ± 0.041
1.198HisArg: 1.198 ± 0.04
1.443HisSer: 1.443 ± 0.047
0.806HisThr: 0.806 ± 0.032
1.025HisVal: 1.025 ± 0.041
0.491HisTrp: 0.491 ± 0.028
0.812HisTyr: 0.812 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.357IleAla: 6.357 ± 0.099
0.61IleCys: 0.61 ± 0.026
3.417IleAsp: 3.417 ± 0.073
3.946IleGlu: 3.946 ± 0.073
1.567IlePhe: 1.567 ± 0.05
4.689IleGly: 4.689 ± 0.093
1.026IleHis: 1.026 ± 0.04
2.398IleIle: 2.398 ± 0.059
2.358IleLys: 2.358 ± 0.058
4.489IleLeu: 4.489 ± 0.082
0.824IleMet: 0.824 ± 0.033
2.017IleAsn: 2.017 ± 0.059
2.254IlePro: 2.254 ± 0.059
1.626IleGln: 1.626 ± 0.049
3.138IleArg: 3.138 ± 0.062
3.414IleSer: 3.414 ± 0.074
2.556IleThr: 2.556 ± 0.066
3.042IleVal: 3.042 ± 0.071
0.59IleTrp: 0.59 ± 0.03
1.243IleTyr: 1.243 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
4.718LysAla: 4.718 ± 0.092
0.224LysCys: 0.224 ± 0.017
2.058LysAsp: 2.058 ± 0.059
1.978LysGlu: 1.978 ± 0.057
0.857LysPhe: 0.857 ± 0.041
2.732LysGly: 2.732 ± 0.071
0.86LysHis: 0.86 ± 0.039
1.997LysIle: 1.997 ± 0.055
1.776LysLys: 1.776 ± 0.055
4.411LysLeu: 4.411 ± 0.07
0.786LysMet: 0.786 ± 0.034
1.557LysAsn: 1.557 ± 0.048
2.316LysPro: 2.316 ± 0.053
2.386LysGln: 2.386 ± 0.065
2.886LysArg: 2.886 ± 0.062
2.314LysSer: 2.314 ± 0.061
2.487LysThr: 2.487 ± 0.054
2.716LysVal: 2.716 ± 0.065
0.399LysTrp: 0.399 ± 0.023
0.761LysTyr: 0.761 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
15.48LeuAla: 15.48 ± 0.218
1.602LeuCys: 1.602 ± 0.052
6.332LeuAsp: 6.332 ± 0.102
6.251LeuGlu: 6.251 ± 0.096
4.397LeuPhe: 4.397 ± 0.091
8.765LeuGly: 8.765 ± 0.143
2.771LeuHis: 2.771 ± 0.063
6.048LeuIle: 6.048 ± 0.102
4.831LeuLys: 4.831 ± 0.081
16.258LeuLeu: 16.258 ± 0.27
2.649LeuMet: 2.649 ± 0.062
3.774LeuAsn: 3.774 ± 0.065
7.023LeuPro: 7.023 ± 0.106
5.295LeuGln: 5.295 ± 0.104
7.513LeuArg: 7.513 ± 0.115
8.012LeuSer: 8.012 ± 0.113
5.188LeuThr: 5.188 ± 0.08
6.784LeuVal: 6.784 ± 0.107
1.566LeuTrp: 1.566 ± 0.049
2.78LeuTyr: 2.78 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.374MetAla: 2.374 ± 0.062
0.163MetCys: 0.163 ± 0.016
1.061MetAsp: 1.061 ± 0.037
1.026MetGlu: 1.026 ± 0.039
0.512MetPhe: 0.512 ± 0.026
1.556MetGly: 1.556 ± 0.053
0.467MetHis: 0.467 ± 0.029
0.901MetIle: 0.901 ± 0.037
0.874MetLys: 0.874 ± 0.032
2.771MetLeu: 2.771 ± 0.078
0.497MetMet: 0.497 ± 0.032
0.82MetAsn: 0.82 ± 0.031
1.38MetPro: 1.38 ± 0.045
1.489MetGln: 1.489 ± 0.044
1.521MetArg: 1.521 ± 0.046
1.488MetSer: 1.488 ± 0.05
1.217MetThr: 1.217 ± 0.042
1.327MetVal: 1.327 ± 0.047
0.146MetTrp: 0.146 ± 0.013
0.37MetTyr: 0.37 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.427AsnAla: 3.427 ± 0.073
0.343AsnCys: 0.343 ± 0.023
1.373AsnAsp: 1.373 ± 0.049
1.534AsnGlu: 1.534 ± 0.04
1.064AsnPhe: 1.064 ± 0.044
2.739AsnGly: 2.739 ± 0.074
0.684AsnHis: 0.684 ± 0.03
1.681AsnIle: 1.681 ± 0.052
1.112AsnLys: 1.112 ± 0.041
3.821AsnLeu: 3.821 ± 0.087
0.589AsnMet: 0.589 ± 0.026
1.198AsnAsn: 1.198 ± 0.051
2.284AsnPro: 2.284 ± 0.057
1.524AsnGln: 1.524 ± 0.045
1.94AsnArg: 1.94 ± 0.055
1.623AsnSer: 1.623 ± 0.051
1.426AsnThr: 1.426 ± 0.043
1.622AsnVal: 1.622 ± 0.05
0.554AsnTrp: 0.554 ± 0.027
0.892AsnTyr: 0.892 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
5.324ProAla: 5.324 ± 0.104
0.519ProCys: 0.519 ± 0.03
2.462ProAsp: 2.462 ± 0.063
2.985ProGlu: 2.985 ± 0.081
1.921ProPhe: 1.921 ± 0.048
3.188ProGly: 3.188 ± 0.06
1.022ProHis: 1.022 ± 0.04
2.278ProIle: 2.278 ± 0.055
2.011ProLys: 2.011 ± 0.054
6.258ProLeu: 6.258 ± 0.112
1.124ProMet: 1.124 ± 0.043
1.483ProAsn: 1.483 ± 0.042
2.423ProPro: 2.423 ± 0.088
2.249ProGln: 2.249 ± 0.056
2.275ProArg: 2.275 ± 0.055
2.632ProSer: 2.632 ± 0.065
1.843ProThr: 1.843 ± 0.048
3.097ProVal: 3.097 ± 0.065
0.77ProTrp: 0.77 ± 0.033
1.177ProTyr: 1.177 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
6.024GlnAla: 6.024 ± 0.104
0.444GlnCys: 0.444 ± 0.028
2.036GlnAsp: 2.036 ± 0.048
2.163GlnGlu: 2.163 ± 0.065
1.512GlnPhe: 1.512 ± 0.043
3.82GlnGly: 3.82 ± 0.069
1.114GlnHis: 1.114 ± 0.036
2.774GlnIle: 2.774 ± 0.06
1.808GlnLys: 1.808 ± 0.055
5.521GlnLeu: 5.521 ± 0.111
1.295GlnMet: 1.295 ± 0.047
1.53GlnAsn: 1.53 ± 0.05
2.259GlnPro: 2.259 ± 0.064
3.632GlnGln: 3.632 ± 0.101
3.615GlnArg: 3.615 ± 0.071
3.159GlnSer: 3.159 ± 0.068
2.442GlnThr: 2.442 ± 0.064
3.475GlnVal: 3.475 ± 0.066
0.741GlnTrp: 0.741 ± 0.033
1.163GlnTyr: 1.163 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
6.306ArgAla: 6.306 ± 0.094
0.687ArgCys: 0.687 ± 0.033
2.93ArgAsp: 2.93 ± 0.067
4.406ArgGlu: 4.406 ± 0.089
2.993ArgPhe: 2.993 ± 0.066
4.071ArgGly: 4.071 ± 0.071
1.53ArgHis: 1.53 ± 0.042
3.484ArgIle: 3.484 ± 0.068
2.427ArgLys: 2.427 ± 0.055
8.852ArgLeu: 8.852 ± 0.147
1.426ArgMet: 1.426 ± 0.042
1.685ArgAsn: 1.685 ± 0.047
2.587ArgPro: 2.587 ± 0.068
3.126ArgGln: 3.126 ± 0.062
4.314ArgArg: 4.314 ± 0.091
3.356ArgSer: 3.356 ± 0.069
2.349ArgThr: 2.349 ± 0.056
3.917ArgVal: 3.917 ± 0.079
0.975ArgTrp: 0.975 ± 0.034
2.058ArgTyr: 2.058 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
6.668SerAla: 6.668 ± 0.102
0.574SerCys: 0.574 ± 0.028
2.496SerAsp: 2.496 ± 0.055
3.401SerGlu: 3.401 ± 0.08
2.284SerPhe: 2.284 ± 0.056
6.175SerGly: 6.175 ± 0.106
1.405SerHis: 1.405 ± 0.046
2.974SerIle: 2.974 ± 0.062
2.089SerLys: 2.089 ± 0.056
7.082SerLeu: 7.082 ± 0.097
1.259SerMet: 1.259 ± 0.046
1.66SerAsn: 1.66 ± 0.052
2.64SerPro: 2.64 ± 0.066
2.491SerGln: 2.491 ± 0.064
3.734SerArg: 3.734 ± 0.065
3.435SerSer: 3.435 ± 0.08
2.677SerThr: 2.677 ± 0.064
3.419SerVal: 3.419 ± 0.077
0.776SerTrp: 0.776 ± 0.036
1.364SerTyr: 1.364 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.028ThrAla: 5.028 ± 0.085
0.496ThrCys: 0.496 ± 0.027
2.377ThrAsp: 2.377 ± 0.058
2.429ThrGlu: 2.429 ± 0.058
1.564ThrPhe: 1.564 ± 0.047
3.442ThrGly: 3.442 ± 0.086
1.16ThrHis: 1.16 ± 0.039
1.839ThrIle: 1.839 ± 0.054
1.056ThrLys: 1.056 ± 0.045
6.435ThrLeu: 6.435 ± 0.101
0.698ThrMet: 0.698 ± 0.039
1.094ThrAsn: 1.094 ± 0.044
2.642ThrPro: 2.642 ± 0.065
1.925ThrGln: 1.925 ± 0.052
2.888ThrArg: 2.888 ± 0.07
2.364ThrSer: 2.364 ± 0.061
2.033ThrThr: 2.033 ± 0.053
3.049ThrVal: 3.049 ± 0.065
0.571ThrTrp: 0.571 ± 0.028
0.926ThrTyr: 0.926 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
6.267ValAla: 6.267 ± 0.104
0.782ValCys: 0.782 ± 0.038
3.23ValAsp: 3.23 ± 0.077
3.611ValGlu: 3.611 ± 0.062
2.399ValPhe: 2.399 ± 0.059
4.091ValGly: 4.091 ± 0.091
1.255ValHis: 1.255 ± 0.038
3.759ValIle: 3.759 ± 0.082
2.562ValLys: 2.562 ± 0.06
7.712ValLeu: 7.712 ± 0.115
1.431ValMet: 1.431 ± 0.046
1.946ValAsn: 1.946 ± 0.049
2.849ValPro: 2.849 ± 0.061
2.82ValGln: 2.82 ± 0.055
3.938ValArg: 3.938 ± 0.074
3.615ValSer: 3.615 ± 0.065
2.889ValThr: 2.889 ± 0.061
4.156ValVal: 4.156 ± 0.093
0.701ValTrp: 0.701 ± 0.033
1.397ValTyr: 1.397 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.013TrpAla: 1.013 ± 0.038
0.177TrpCys: 0.177 ± 0.015
0.614TrpAsp: 0.614 ± 0.031
0.452TrpGlu: 0.452 ± 0.024
0.619TrpPhe: 0.619 ± 0.033
0.817TrpGly: 0.817 ± 0.039
0.413TrpHis: 0.413 ± 0.024
0.587TrpIle: 0.587 ± 0.028
0.43TrpLys: 0.43 ± 0.026
2.439TrpLeu: 2.439 ± 0.06
0.364TrpMet: 0.364 ± 0.021
0.437TrpAsn: 0.437 ± 0.025
0.656TrpPro: 0.656 ± 0.032
1.364TrpGln: 1.364 ± 0.043
1.037TrpArg: 1.037 ± 0.04
0.643TrpSer: 0.643 ± 0.032
0.558TrpThr: 0.558 ± 0.029
0.776TrpVal: 0.776 ± 0.033
0.237TrpTrp: 0.237 ± 0.018
0.389TrpTyr: 0.389 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.427TyrAla: 2.427 ± 0.057
0.348TyrCys: 0.348 ± 0.023
1.262TyrAsp: 1.262 ± 0.042
1.061TyrGlu: 1.061 ± 0.04
0.967TyrPhe: 0.967 ± 0.035
2.029TyrGly: 2.029 ± 0.051
0.583TyrHis: 0.583 ± 0.026
1.147TyrIle: 1.147 ± 0.038
0.739TyrLys: 0.739 ± 0.03
3.296TyrLeu: 3.296 ± 0.076
0.456TyrMet: 0.456 ± 0.027
0.741TyrAsn: 0.741 ± 0.037
1.369TyrPro: 1.369 ± 0.04
1.714TyrGln: 1.714 ± 0.046
2.021TyrArg: 2.021 ± 0.06
1.648TyrSer: 1.648 ± 0.054
0.873TyrThr: 0.873 ± 0.037
1.31TyrVal: 1.31 ± 0.049
0.403TyrTrp: 0.403 ± 0.025
0.698TyrTyr: 0.698 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2412 proteins (755995 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski