Amino acid dipepetide frequency for Sphingobium sp. GW456-12-10-14-TSB1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.142AlaAla: 18.142 ± 0.181	1.112AlaCys: 1.112 ± 0.032	8.058AlaAsp: 8.058 ± 0.091	6.704AlaGlu: 6.704 ± 0.079	4.346AlaPhe: 4.346 ± 0.061	10.949AlaGly: 10.949 ± 0.09	2.409AlaHis: 2.409 ± 0.043	7.14AlaIle: 7.14 ± 0.065	4.021AlaLys: 4.021 ± 0.064	14.275AlaLeu: 14.275 ± 0.141	4.228AlaMet: 4.228 ± 0.066	3.121AlaAsn: 3.121 ± 0.05	6.379AlaPro: 6.379 ± 0.086	5.104AlaGln: 5.104 ± 0.071	9.884AlaArg: 9.884 ± 0.103	6.677AlaSer: 6.677 ± 0.078	6.552AlaThr: 6.552 ± 0.077	8.224AlaVal: 8.224 ± 0.087	1.64AlaTrp: 1.64 ± 0.035	2.604AlaTyr: 2.604 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.101CysAla: 1.101 ± 0.032	0.12CysCys: 0.12 ± 0.01	0.523CysAsp: 0.523 ± 0.018	0.391CysGlu: 0.391 ± 0.018	0.287CysPhe: 0.287 ± 0.013	0.885CysGly: 0.885 ± 0.03	0.242CysHis: 0.242 ± 0.016	0.402CysIle: 0.402 ± 0.017	0.171CysLys: 0.171 ± 0.011	0.749CysLeu: 0.749 ± 0.023	0.174CysMet: 0.174 ± 0.012	0.203CysAsn: 0.203 ± 0.012	0.464CysPro: 0.464 ± 0.019	0.235CysGln: 0.235 ± 0.013	0.59CysArg: 0.59 ± 0.022	0.454CysSer: 0.454 ± 0.019	0.426CysThr: 0.426 ± 0.018	0.567CysVal: 0.567 ± 0.021	0.123CysTrp: 0.123 ± 0.009	0.184CysTyr: 0.184 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.906AspAla: 7.906 ± 0.082	0.502AspCys: 0.502 ± 0.02	3.535AspAsp: 3.535 ± 0.057	3.254AspGlu: 3.254 ± 0.055	2.184AspPhe: 2.184 ± 0.043	5.905AspGly: 5.905 ± 0.087	1.558AspHis: 1.558 ± 0.038	3.246AspIle: 3.246 ± 0.047	1.81AspLys: 1.81 ± 0.043	5.955AspLeu: 5.955 ± 0.063	1.665AspMet: 1.665 ± 0.035	1.453AspAsn: 1.453 ± 0.037	3.786AspPro: 3.786 ± 0.052	1.972AspGln: 1.972 ± 0.036	5.061AspArg: 5.061 ± 0.062	2.526AspSer: 2.526 ± 0.056	2.596AspThr: 2.596 ± 0.039	4.023AspVal: 4.023 ± 0.054	1.169AspTrp: 1.169 ± 0.031	1.706AspTyr: 1.706 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.167GluAla: 7.167 ± 0.07	0.307GluCys: 0.307 ± 0.015	2.452GluAsp: 2.452 ± 0.047	2.792GluGlu: 2.792 ± 0.06	1.33GluPhe: 1.33 ± 0.036	4.255GluGly: 4.255 ± 0.054	1.029GluHis: 1.029 ± 0.031	2.834GluIle: 2.834 ± 0.043	1.924GluLys: 1.924 ± 0.047	4.526GluLeu: 4.526 ± 0.052	1.369GluMet: 1.369 ± 0.029	1.289GluAsn: 1.289 ± 0.029	2.306GluPro: 2.306 ± 0.039	2.13GluGln: 2.13 ± 0.04	4.691GluArg: 4.691 ± 0.065	2.182GluSer: 2.182 ± 0.039	2.952GluThr: 2.952 ± 0.05	3.109GluVal: 3.109 ± 0.049	0.685GluTrp: 0.685 ± 0.022	0.909GluTyr: 0.909 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.824PheAla: 4.824 ± 0.058	0.337PheCys: 0.337 ± 0.017	2.665PheAsp: 2.665 ± 0.054	1.836PheGlu: 1.836 ± 0.037	1.21PhePhe: 1.21 ± 0.031	3.484PheGly: 3.484 ± 0.06	0.743PheHis: 0.743 ± 0.022	1.48PheIle: 1.48 ± 0.036	0.864PheLys: 0.864 ± 0.026	3.12PheLeu: 3.12 ± 0.048	0.793PheMet: 0.793 ± 0.022	0.975PheAsn: 0.975 ± 0.03	1.491PhePro: 1.491 ± 0.035	0.905PheGln: 0.905 ± 0.023	2.209PheArg: 2.209 ± 0.041	2.027PheSer: 2.027 ± 0.037	2.002PheThr: 2.002 ± 0.048	2.462PheVal: 2.462 ± 0.048	0.517PheTrp: 0.517 ± 0.022	0.898PheTyr: 0.898 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.784GlyAla: 9.784 ± 0.089	0.839GlyCys: 0.839 ± 0.025	5.079GlyAsp: 5.079 ± 0.061	4.529GlyGlu: 4.529 ± 0.06	3.492GlyPhe: 3.492 ± 0.055	7.726GlyGly: 7.726 ± 0.102	1.952GlyHis: 1.952 ± 0.041	4.418GlyIle: 4.418 ± 0.053	3.362GlyLys: 3.362 ± 0.058	8.73GlyLeu: 8.73 ± 0.087	2.517GlyMet: 2.517 ± 0.048	2.229GlyAsn: 2.229 ± 0.042	3.555GlyPro: 3.555 ± 0.054	3.335GlyGln: 3.335 ± 0.049	6.388GlyArg: 6.388 ± 0.071	4.764GlySer: 4.764 ± 0.061	4.659GlyThr: 4.659 ± 0.062	6.266GlyVal: 6.266 ± 0.071	1.627GlyTrp: 1.627 ± 0.039	2.324GlyTyr: 2.324 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.418HisAla: 2.418 ± 0.051	0.233HisCys: 0.233 ± 0.013	1.334HisAsp: 1.334 ± 0.031	0.968HisGlu: 0.968 ± 0.021	0.853HisPhe: 0.853 ± 0.028	2.092HisGly: 2.092 ± 0.041	0.625HisHis: 0.625 ± 0.021	1.046HisIle: 1.046 ± 0.026	0.485HisLys: 0.485 ± 0.018	1.97HisLeu: 1.97 ± 0.042	0.56HisMet: 0.56 ± 0.02	0.476HisAsn: 0.476 ± 0.019	1.274HisPro: 1.274 ± 0.028	0.59HisGln: 0.59 ± 0.019	1.518HisArg: 1.518 ± 0.039	1.019HisSer: 1.019 ± 0.028	0.645HisThr: 0.645 ± 0.021	1.642HisVal: 1.642 ± 0.032	0.367HisTrp: 0.367 ± 0.017	0.62HisTyr: 0.62 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	8.244IleAla: 8.244 ± 0.089	0.473IleCys: 0.473 ± 0.016	4.117IleAsp: 4.117 ± 0.054	3.314IleGlu: 3.314 ± 0.05	1.787IlePhe: 1.787 ± 0.034	5.095IleGly: 5.095 ± 0.07	0.975IleHis: 0.975 ± 0.027	2.359IleIle: 2.359 ± 0.047	1.256IleLys: 1.256 ± 0.038	4.548IleLeu: 4.548 ± 0.059	1.019IleMet: 1.019 ± 0.03	1.365IleAsn: 1.365 ± 0.034	2.333IlePro: 2.333 ± 0.043	1.192IleGln: 1.192 ± 0.03	3.341IleArg: 3.341 ± 0.05	2.746IleSer: 2.746 ± 0.049	2.547IleThr: 2.547 ± 0.043	4.156IleVal: 4.156 ± 0.055	0.63IleTrp: 0.63 ± 0.023	1.07IleTyr: 1.07 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.303LysAla: 4.303 ± 0.077	0.162LysCys: 0.162 ± 0.011	1.654LysAsp: 1.654 ± 0.043	1.194LysGlu: 1.194 ± 0.027	0.8LysPhe: 0.8 ± 0.026	2.781LysGly: 2.781 ± 0.054	0.471LysHis: 0.471 ± 0.02	1.491LysIle: 1.491 ± 0.032	1.053LysLys: 1.053 ± 0.036	3.079LysLeu: 3.079 ± 0.051	0.791LysMet: 0.791 ± 0.023	0.719LysAsn: 0.719 ± 0.024	2.006LysPro: 2.006 ± 0.047	0.929LysGln: 0.929 ± 0.029	2.17LysArg: 2.17 ± 0.037	1.602LysSer: 1.602 ± 0.033	1.598LysThr: 1.598 ± 0.042	2.124LysVal: 2.124 ± 0.043	0.37LysTrp: 0.37 ± 0.014	0.574LysTyr: 0.574 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.893LeuAla: 13.893 ± 0.136	0.906LeuCys: 0.906 ± 0.026	6.201LeuAsp: 6.201 ± 0.071	4.612LeuGlu: 4.612 ± 0.055	3.811LeuPhe: 3.811 ± 0.059	8.27LeuGly: 8.27 ± 0.085	1.949LeuHis: 1.949 ± 0.037	5.261LeuIle: 5.261 ± 0.067	2.922LeuLys: 2.922 ± 0.052	9.978LeuLeu: 9.978 ± 0.117	2.277LeuMet: 2.277 ± 0.042	2.485LeuAsn: 2.485 ± 0.043	5.703LeuPro: 5.703 ± 0.066	2.478LeuGln: 2.478 ± 0.042	6.967LeuArg: 6.967 ± 0.084	6.298LeuSer: 6.298 ± 0.073	5.581LeuThr: 5.581 ± 0.073	7.073LeuVal: 7.073 ± 0.071	1.307LeuTrp: 1.307 ± 0.033	2.015LeuTyr: 2.015 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.618MetAla: 3.618 ± 0.054	0.155MetCys: 0.155 ± 0.012	1.279MetAsp: 1.279 ± 0.03	1.12MetGlu: 1.12 ± 0.03	0.733MetPhe: 0.733 ± 0.023	2.009MetGly: 2.009 ± 0.04	0.465MetHis: 0.465 ± 0.019	1.471MetIle: 1.471 ± 0.036	0.928MetLys: 0.928 ± 0.025	2.833MetLeu: 2.833 ± 0.054	0.786MetMet: 0.786 ± 0.027	0.714MetAsn: 0.714 ± 0.023	1.572MetPro: 1.572 ± 0.035	0.815MetGln: 0.815 ± 0.023	1.863MetArg: 1.863 ± 0.035	1.507MetSer: 1.507 ± 0.03	1.95MetThr: 1.95 ± 0.035	1.745MetVal: 1.745 ± 0.035	0.229MetTrp: 0.229 ± 0.012	0.245MetTyr: 0.245 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.28AsnAla: 3.28 ± 0.061	0.215AsnCys: 0.215 ± 0.012	1.516AsnAsp: 1.516 ± 0.039	1.04AsnGlu: 1.04 ± 0.029	0.91AsnPhe: 0.91 ± 0.027	2.471AsnGly: 2.471 ± 0.052	0.464AsnHis: 0.464 ± 0.018	1.41AsnIle: 1.41 ± 0.038	0.646AsnLys: 0.646 ± 0.024	2.426AsnLeu: 2.426 ± 0.046	0.609AsnMet: 0.609 ± 0.02	0.684AsnAsn: 0.684 ± 0.024	1.737AsnPro: 1.737 ± 0.035	0.768AsnGln: 0.768 ± 0.026	1.912AsnArg: 1.912 ± 0.03	1.28AsnSer: 1.28 ± 0.03	0.971AsnThr: 0.971 ± 0.031	1.829AsnVal: 1.829 ± 0.043	0.429AsnTrp: 0.429 ± 0.018	0.677AsnTyr: 0.677 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.07ProAla: 7.07 ± 0.077	0.351ProCys: 0.351 ± 0.014	4.129ProAsp: 4.129 ± 0.055	2.916ProGlu: 2.916 ± 0.041	1.92ProPhe: 1.92 ± 0.033	4.635ProGly: 4.635 ± 0.059	1.063ProHis: 1.063 ± 0.027	2.585ProIle: 2.585 ± 0.047	1.519ProLys: 1.519 ± 0.034	5.019ProLeu: 5.019 ± 0.074	1.346ProMet: 1.346 ± 0.033	1.228ProAsn: 1.228 ± 0.034	2.892ProPro: 2.892 ± 0.069	1.76ProGln: 1.76 ± 0.039	3.003ProArg: 3.003 ± 0.054	2.785ProSer: 2.785 ± 0.044	2.686ProThr: 2.686 ± 0.048	4.525ProVal: 4.525 ± 0.061	0.683ProTrp: 0.683 ± 0.022	1.066ProTyr: 1.066 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.509GlnAla: 4.509 ± 0.063	0.259GlnCys: 0.259 ± 0.013	1.668GlnAsp: 1.668 ± 0.037	1.38GlnGlu: 1.38 ± 0.032	1.087GlnPhe: 1.087 ± 0.027	2.706GlnGly: 2.706 ± 0.039	0.653GlnHis: 0.653 ± 0.025	1.935GlnIle: 1.935 ± 0.034	0.963GlnLys: 0.963 ± 0.028	3.105GlnLeu: 3.105 ± 0.053	0.926GlnMet: 0.926 ± 0.025	0.805GlnAsn: 0.805 ± 0.029	1.928GlnPro: 1.928 ± 0.037	1.263GlnGln: 1.263 ± 0.033	2.697GlnArg: 2.697 ± 0.046	1.874GlnSer: 1.874 ± 0.036	1.661GlnThr: 1.661 ± 0.036	2.331GlnVal: 2.331 ± 0.035	0.543GlnTrp: 0.543 ± 0.019	0.638GlnTyr: 0.638 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.818ArgAla: 8.818 ± 0.096	0.55ArgCys: 0.55 ± 0.021	4.5ArgAsp: 4.5 ± 0.058	3.689ArgGlu: 3.689 ± 0.05	2.965ArgPhe: 2.965 ± 0.05	4.978ArgGly: 4.978 ± 0.06	1.797ArgHis: 1.797 ± 0.034	4.292ArgIle: 4.292 ± 0.056	2.163ArgLys: 2.163 ± 0.041	8.429ArgLeu: 8.429 ± 0.083	1.894ArgMet: 1.894 ± 0.035	1.927ArgAsn: 1.927 ± 0.038	3.733ArgPro: 3.733 ± 0.058	2.722ArgGln: 2.722 ± 0.05	5.712ArgArg: 5.712 ± 0.074	3.737ArgSer: 3.737 ± 0.056	3.774ArgThr: 3.774 ± 0.05	4.589ArgVal: 4.589 ± 0.059	1.196ArgTrp: 1.196 ± 0.035	1.983ArgTyr: 1.983 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.723SerAla: 6.723 ± 0.069	0.478SerCys: 0.478 ± 0.022	3.286SerAsp: 3.286 ± 0.054	2.385SerGlu: 2.385 ± 0.042	2.198SerPhe: 2.198 ± 0.044	5.448SerGly: 5.448 ± 0.071	1.038SerHis: 1.038 ± 0.025	2.895SerIle: 2.895 ± 0.048	1.418SerLys: 1.418 ± 0.033	5.213SerLeu: 5.213 ± 0.059	1.222SerMet: 1.222 ± 0.027	1.357SerAsn: 1.357 ± 0.035	2.892SerPro: 2.892 ± 0.042	1.604SerGln: 1.604 ± 0.035	3.626SerArg: 3.626 ± 0.05	2.813SerSer: 2.813 ± 0.047	2.598SerThr: 2.598 ± 0.042	3.7SerVal: 3.7 ± 0.054	0.823SerTrp: 0.823 ± 0.026	1.341SerTyr: 1.341 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.255ThrAla: 6.255 ± 0.068	0.391ThrCys: 0.391 ± 0.018	2.985ThrAsp: 2.985 ± 0.053	2.098ThrGlu: 2.098 ± 0.034	1.712ThrPhe: 1.712 ± 0.034	5.277ThrGly: 5.277 ± 0.068	1.023ThrHis: 1.023 ± 0.027	3.106ThrIle: 3.106 ± 0.055	1.233ThrLys: 1.233 ± 0.033	5.954ThrLeu: 5.954 ± 0.07	1.26ThrMet: 1.26 ± 0.028	1.306ThrAsn: 1.306 ± 0.04	3.512ThrPro: 3.512 ± 0.058	1.594ThrGln: 1.594 ± 0.033	3.449ThrArg: 3.449 ± 0.052	2.683ThrSer: 2.683 ± 0.051	2.538ThrThr: 2.538 ± 0.053	4.013ThrVal: 4.013 ± 0.067	0.586ThrTrp: 0.586 ± 0.022	1.182ThrTyr: 1.182 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.455ValAla: 9.455 ± 0.092	0.511ValCys: 0.511 ± 0.021	4.45ValAsp: 4.45 ± 0.052	4.361ValGlu: 4.361 ± 0.057	1.873ValPhe: 1.873 ± 0.038	5.571ValGly: 5.571 ± 0.08	1.38ValHis: 1.38 ± 0.034	3.581ValIle: 3.581 ± 0.059	2.098ValLys: 2.098 ± 0.038	6.101ValLeu: 6.101 ± 0.072	1.76ValMet: 1.76 ± 0.039	1.918ValAsn: 1.918 ± 0.044	3.827ValPro: 3.827 ± 0.047	2.218ValGln: 2.218 ± 0.035	5.075ValArg: 5.075 ± 0.06	3.966ValSer: 3.966 ± 0.06	4.543ValThr: 4.543 ± 0.08	4.996ValVal: 4.996 ± 0.074	0.801ValTrp: 0.801 ± 0.028	1.315ValTyr: 1.315 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.369TrpAla: 1.369 ± 0.032	0.123TrpCys: 0.123 ± 0.01	0.771TrpAsp: 0.771 ± 0.026	0.561TrpGlu: 0.561 ± 0.022	0.524TrpPhe: 0.524 ± 0.018	0.945TrpGly: 0.945 ± 0.026	0.365TrpHis: 0.365 ± 0.016	0.745TrpIle: 0.745 ± 0.025	0.469TrpLys: 0.469 ± 0.018	1.794TrpLeu: 1.794 ± 0.044	0.376TrpMet: 0.376 ± 0.016	0.436TrpAsn: 0.436 ± 0.019	0.747TrpPro: 0.747 ± 0.023	0.596TrpGln: 0.596 ± 0.019	1.352TrpArg: 1.352 ± 0.029	0.921TrpSer: 0.921 ± 0.027	0.851TrpThr: 0.851 ± 0.031	0.85TrpVal: 0.85 ± 0.023	0.253TrpTrp: 0.253 ± 0.014	0.298TrpTyr: 0.298 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.69TyrAla: 2.69 ± 0.05	0.266TyrCys: 0.266 ± 0.013	1.613TyrAsp: 1.613 ± 0.037	1.097TyrGlu: 1.097 ± 0.03	0.82TyrPhe: 0.82 ± 0.022	2.094TyrGly: 2.094 ± 0.038	0.534TyrHis: 0.534 ± 0.019	0.869TyrIle: 0.869 ± 0.026	0.565TyrLys: 0.565 ± 0.02	2.183TyrLeu: 2.183 ± 0.037	0.463TyrMet: 0.463 ± 0.018	0.584TyrAsn: 0.584 ± 0.022	1.044TyrPro: 1.044 ± 0.029	0.721TyrGln: 0.721 ± 0.025	1.94TyrArg: 1.94 ± 0.04	1.198TyrSer: 1.198 ± 0.031	1.027TyrThr: 1.027 ± 0.028	1.578TyrVal: 1.578 ± 0.034	0.365TyrTrp: 0.365 ± 0.014	0.636TyrTyr: 0.636 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4472 proteins (1434412 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---