Amino acid dipepetide frequency for Acetohalobium arabaticum (strain ATCC 49924 / DSM 5501 / Z-7288)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.743AlaAla: 5.743 ± 0.113
0.563AlaCys: 0.563 ± 0.032
4.516AlaAsp: 4.516 ± 0.086
6.507AlaGlu: 6.507 ± 0.121
2.157AlaPhe: 2.157 ± 0.066
5.802AlaGly: 5.802 ± 0.116
0.947AlaHis: 0.947 ± 0.042
4.872AlaIle: 4.872 ± 0.083
4.63AlaLys: 4.63 ± 0.088
6.344AlaLeu: 6.344 ± 0.108
1.536AlaMet: 1.536 ± 0.051
2.558AlaAsn: 2.558 ± 0.059
1.859AlaPro: 1.859 ± 0.055
2.409AlaGln: 2.409 ± 0.056
2.653AlaArg: 2.653 ± 0.064
3.283AlaSer: 3.283 ± 0.073
3.236AlaThr: 3.236 ± 0.08
5.904AlaVal: 5.904 ± 0.111
0.41AlaTrp: 0.41 ± 0.024
1.948AlaTyr: 1.948 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.434CysAla: 0.434 ± 0.023
0.137CysCys: 0.137 ± 0.018
0.478CysAsp: 0.478 ± 0.029
0.563CysGlu: 0.563 ± 0.032
0.299CysPhe: 0.299 ± 0.02
0.978CysGly: 0.978 ± 0.046
0.169CysHis: 0.169 ± 0.017
0.609CysIle: 0.609 ± 0.029
0.486CysLys: 0.486 ± 0.03
0.735CysLeu: 0.735 ± 0.035
0.178CysMet: 0.178 ± 0.017
0.432CysAsn: 0.432 ± 0.025
0.488CysPro: 0.488 ± 0.034
0.33CysGln: 0.33 ± 0.021
0.38CysArg: 0.38 ± 0.026
0.653CysSer: 0.653 ± 0.033
0.395CysThr: 0.395 ± 0.02
0.458CysVal: 0.458 ± 0.034
0.07CysTrp: 0.07 ± 0.01
0.27CysTyr: 0.27 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
2.963AspAla: 2.963 ± 0.072
0.572AspCys: 0.572 ± 0.031
3.35AspAsp: 3.35 ± 0.079
5.52AspGlu: 5.52 ± 0.108
2.612AspPhe: 2.612 ± 0.065
3.598AspGly: 3.598 ± 0.084
0.914AspHis: 0.914 ± 0.035
5.274AspIle: 5.274 ± 0.097
5.071AspLys: 5.071 ± 0.085
7.025AspLeu: 7.025 ± 0.108
1.291AspMet: 1.291 ± 0.049
3.251AspAsn: 3.251 ± 0.084
1.859AspPro: 1.859 ± 0.059
2.208AspGln: 2.208 ± 0.06
2.901AspArg: 2.901 ± 0.072
3.342AspSer: 3.342 ± 0.074
2.486AspThr: 2.486 ± 0.061
3.649AspVal: 3.649 ± 0.073
0.606AspTrp: 0.606 ± 0.035
3.012AspTyr: 3.012 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
6.622GluAla: 6.622 ± 0.125
0.584GluCys: 0.584 ± 0.03
5.62GluAsp: 5.62 ± 0.097
11.043GluGlu: 11.043 ± 0.181
3.062GluPhe: 3.062 ± 0.056
4.832GluGly: 4.832 ± 0.096
1.167GluHis: 1.167 ± 0.037
8.252GluIle: 8.252 ± 0.124
5.776GluLys: 5.776 ± 0.106
10.002GluLeu: 10.002 ± 0.181
2.396GluMet: 2.396 ± 0.062
3.514GluAsn: 3.514 ± 0.078
2.156GluPro: 2.156 ± 0.062
2.5GluGln: 2.5 ± 0.068
3.482GluArg: 3.482 ± 0.091
3.734GluSer: 3.734 ± 0.073
3.876GluThr: 3.876 ± 0.076
7.999GluVal: 7.999 ± 0.12
0.53GluTrp: 0.53 ± 0.028
3.103GluTyr: 3.103 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
2.343PheAla: 2.343 ± 0.055
0.395PheCys: 0.395 ± 0.023
2.376PheAsp: 2.376 ± 0.058
2.56PheGlu: 2.56 ± 0.059
1.537PhePhe: 1.537 ± 0.051
2.963PheGly: 2.963 ± 0.08
0.539PheHis: 0.539 ± 0.029
3.063PheIle: 3.063 ± 0.081
2.776PheLys: 2.776 ± 0.066
3.346PheLeu: 3.346 ± 0.077
0.892PheMet: 0.892 ± 0.034
2.046PheAsn: 2.046 ± 0.056
1.183PhePro: 1.183 ± 0.042
1.03PheGln: 1.03 ± 0.043
1.216PheArg: 1.216 ± 0.047
2.58PheSer: 2.58 ± 0.068
2.049PheThr: 2.049 ± 0.062
2.196PheVal: 2.196 ± 0.06
0.346PheTrp: 0.346 ± 0.023
1.264PheTyr: 1.264 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
4.949GlyAla: 4.949 ± 0.111
0.826GlyCys: 0.826 ± 0.041
3.77GlyAsp: 3.77 ± 0.073
5.027GlyGlu: 5.027 ± 0.098
2.889GlyPhe: 2.889 ± 0.075
5.072GlyGly: 5.072 ± 0.115
1.166GlyHis: 1.166 ± 0.045
6.42GlyIle: 6.42 ± 0.111
4.367GlyLys: 4.367 ± 0.077
7.215GlyLeu: 7.215 ± 0.111
1.797GlyMet: 1.797 ± 0.053
2.713GlyAsn: 2.713 ± 0.071
1.834GlyPro: 1.834 ± 0.063
2.245GlyGln: 2.245 ± 0.069
2.971GlyArg: 2.971 ± 0.074
3.966GlySer: 3.966 ± 0.08
3.733GlyThr: 3.733 ± 0.087
5.382GlyVal: 5.382 ± 0.097
0.599GlyTrp: 0.599 ± 0.036
2.817GlyTyr: 2.817 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
0.816HisAla: 0.816 ± 0.036
0.191HisCys: 0.191 ± 0.015
0.762HisAsp: 0.762 ± 0.034
0.856HisGlu: 0.856 ± 0.036
0.594HisPhe: 0.594 ± 0.027
1.155HisGly: 1.155 ± 0.044
0.327HisHis: 0.327 ± 0.024
1.106HisIle: 1.106 ± 0.038
0.957HisLys: 0.957 ± 0.039
1.45HisLeu: 1.45 ± 0.051
0.25HisMet: 0.25 ± 0.021
0.751HisAsn: 0.751 ± 0.03
0.809HisPro: 0.809 ± 0.036
0.784HisGln: 0.784 ± 0.036
0.674HisArg: 0.674 ± 0.026
0.879HisSer: 0.879 ± 0.031
0.715HisThr: 0.715 ± 0.034
0.766HisVal: 0.766 ± 0.033
0.149HisTrp: 0.149 ± 0.015
0.57HisTyr: 0.57 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.593IleAla: 5.593 ± 0.095
0.693IleCys: 0.693 ± 0.033
5.705IleAsp: 5.705 ± 0.086
7.171IleGlu: 7.171 ± 0.099
3.05IlePhe: 3.05 ± 0.088
5.928IleGly: 5.928 ± 0.104
1.074IleHis: 1.074 ± 0.039
7.313IleIle: 7.313 ± 0.139
6.564IleLys: 6.564 ± 0.119
7.663IleLeu: 7.663 ± 0.127
1.787IleMet: 1.787 ± 0.056
4.414IleAsn: 4.414 ± 0.084
3.188IlePro: 3.188 ± 0.075
2.223IleGln: 2.223 ± 0.058
2.831IleArg: 2.831 ± 0.062
5.054IleSer: 5.054 ± 0.111
4.755IleThr: 4.755 ± 0.083
5.234IleVal: 5.234 ± 0.093
0.488IleTrp: 0.488 ± 0.031
2.403IleTyr: 2.403 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.448LysAla: 4.448 ± 0.082
0.411LysCys: 0.411 ± 0.027
4.238LysAsp: 4.238 ± 0.073
8.509LysGlu: 8.509 ± 0.137
2.392LysPhe: 2.392 ± 0.055
3.689LysGly: 3.689 ± 0.075
0.876LysHis: 0.876 ± 0.036
5.551LysIle: 5.551 ± 0.083
5.516LysLys: 5.516 ± 0.131
7.616LysLeu: 7.616 ± 0.129
1.591LysMet: 1.591 ± 0.046
3.126LysAsn: 3.126 ± 0.074
2.129LysPro: 2.129 ± 0.06
2.945LysGln: 2.945 ± 0.077
3.081LysArg: 3.081 ± 0.068
3.463LysSer: 3.463 ± 0.063
3.127LysThr: 3.127 ± 0.065
5.409LysVal: 5.409 ± 0.1
0.445LysTrp: 0.445 ± 0.03
2.474LysTyr: 2.474 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
8.037LeuAla: 8.037 ± 0.123
0.7LeuCys: 0.7 ± 0.035
6.58LeuAsp: 6.58 ± 0.118
8.913LeuGlu: 8.913 ± 0.141
3.447LeuPhe: 3.447 ± 0.084
7.366LeuGly: 7.366 ± 0.124
1.411LeuHis: 1.411 ± 0.044
8.179LeuIle: 8.179 ± 0.15
7.099LeuLys: 7.099 ± 0.13
9.408LeuLeu: 9.408 ± 0.169
2.115LeuMet: 2.115 ± 0.057
4.966LeuAsn: 4.966 ± 0.105
3.73LeuPro: 3.73 ± 0.083
3.596LeuGln: 3.596 ± 0.072
3.568LeuArg: 3.568 ± 0.083
6.197LeuSer: 6.197 ± 0.095
5.664LeuThr: 5.664 ± 0.092
6.978LeuVal: 6.978 ± 0.112
0.562LeuTrp: 0.562 ± 0.024
2.544LeuTyr: 2.544 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
1.807MetAla: 1.807 ± 0.055
0.129MetCys: 0.129 ± 0.016
1.284MetAsp: 1.284 ± 0.048
2.076MetGlu: 2.076 ± 0.057
0.616MetPhe: 0.616 ± 0.031
1.611MetGly: 1.611 ± 0.05
0.297MetHis: 0.297 ± 0.019
1.82MetIle: 1.82 ± 0.059
1.797MetLys: 1.797 ± 0.045
2.146MetLeu: 2.146 ± 0.061
0.594MetMet: 0.594 ± 0.03
1.048MetAsn: 1.048 ± 0.038
0.813MetPro: 0.813 ± 0.035
0.704MetGln: 0.704 ± 0.034
0.823MetArg: 0.823 ± 0.033
1.443MetSer: 1.443 ± 0.049
1.27MetThr: 1.27 ± 0.043
1.601MetVal: 1.601 ± 0.045
0.134MetTrp: 0.134 ± 0.014
0.474MetTyr: 0.474 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.149AsnAla: 2.149 ± 0.045
0.486AsnCys: 0.486 ± 0.024
2.287AsnAsp: 2.287 ± 0.063
3.204AsnGlu: 3.204 ± 0.071
1.981AsnPhe: 1.981 ± 0.059
2.558AsnGly: 2.558 ± 0.083
0.725AsnHis: 0.725 ± 0.032
3.935AsnIle: 3.935 ± 0.081
3.593AsnLys: 3.593 ± 0.093
5.684AsnLeu: 5.684 ± 0.104
0.998AsnMet: 0.998 ± 0.039
2.752AsnAsn: 2.752 ± 0.069
2.113AsnPro: 2.113 ± 0.054
2.494AsnGln: 2.494 ± 0.061
2.261AsnArg: 2.261 ± 0.058
2.767AsnSer: 2.767 ± 0.067
1.914AsnThr: 1.914 ± 0.06
2.4AsnVal: 2.4 ± 0.063
0.496AsnTrp: 0.496 ± 0.029
2.068AsnTyr: 2.068 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.171ProAla: 2.171 ± 0.06
0.289ProCys: 0.289 ± 0.021
2.193ProAsp: 2.193 ± 0.059
3.635ProGlu: 3.635 ± 0.087
1.266ProPhe: 1.266 ± 0.042
2.459ProGly: 2.459 ± 0.064
0.597ProHis: 0.597 ± 0.027
2.386ProIle: 2.386 ± 0.057
1.942ProLys: 1.942 ± 0.054
3.106ProLeu: 3.106 ± 0.077
0.63ProMet: 0.63 ± 0.029
1.422ProAsn: 1.422 ± 0.044
0.998ProPro: 0.998 ± 0.044
1.322ProGln: 1.322 ± 0.04
1.034ProArg: 1.034 ± 0.034
1.439ProSer: 1.439 ± 0.045
1.851ProThr: 1.851 ± 0.052
2.83ProVal: 2.83 ± 0.068
0.25ProTrp: 0.25 ± 0.02
1.148ProTyr: 1.148 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.737GlnAla: 2.737 ± 0.066
0.215GlnCys: 0.215 ± 0.018
1.977GlnAsp: 1.977 ± 0.052
3.717GlnGlu: 3.717 ± 0.086
1.069GlnPhe: 1.069 ± 0.04
2.318GlnGly: 2.318 ± 0.057
0.491GlnHis: 0.491 ± 0.026
2.702GlnIle: 2.702 ± 0.061
2.835GlnLys: 2.835 ± 0.07
3.538GlnLeu: 3.538 ± 0.078
0.84GlnMet: 0.84 ± 0.039
1.743GlnAsn: 1.743 ± 0.056
1.148GlnPro: 1.148 ± 0.046
2.45GlnGln: 2.45 ± 0.064
1.583GlnArg: 1.583 ± 0.053
1.53GlnSer: 1.53 ± 0.047
1.719GlnThr: 1.719 ± 0.05
2.649GlnVal: 2.649 ± 0.062
0.195GlnTrp: 0.195 ± 0.016
0.849GlnTyr: 0.849 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.277ArgAla: 2.277 ± 0.061
0.321ArgCys: 0.321 ± 0.022
2.265ArgAsp: 2.265 ± 0.067
3.444ArgGlu: 3.444 ± 0.076
1.486ArgPhe: 1.486 ± 0.05
2.514ArgGly: 2.514 ± 0.069
0.587ArgHis: 0.587 ± 0.03
3.713ArgIle: 3.713 ± 0.078
2.872ArgLys: 2.872 ± 0.068
4.526ArgLeu: 4.526 ± 0.086
1.005ArgMet: 1.005 ± 0.037
1.763ArgAsn: 1.763 ± 0.053
1.257ArgPro: 1.257 ± 0.041
1.495ArgGln: 1.495 ± 0.054
2.056ArgArg: 2.056 ± 0.066
1.975ArgSer: 1.975 ± 0.053
1.741ArgThr: 1.741 ± 0.05
2.949ArgVal: 2.949 ± 0.074
0.314ArgTrp: 0.314 ± 0.024
1.455ArgTyr: 1.455 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
3.382SerAla: 3.382 ± 0.072
0.546SerCys: 0.546 ± 0.032
3.32SerAsp: 3.32 ± 0.077
4.011SerGlu: 4.011 ± 0.074
2.43SerPhe: 2.43 ± 0.066
4.253SerGly: 4.253 ± 0.079
0.833SerHis: 0.833 ± 0.034
4.519SerIle: 4.519 ± 0.093
3.801SerLys: 3.801 ± 0.086
5.786SerLeu: 5.786 ± 0.102
1.169SerMet: 1.169 ± 0.044
2.688SerAsn: 2.688 ± 0.077
1.681SerPro: 1.681 ± 0.046
2.304SerGln: 2.304 ± 0.062
2.385SerArg: 2.385 ± 0.063
3.421SerSer: 3.421 ± 0.084
2.837SerThr: 2.837 ± 0.063
3.275SerVal: 3.275 ± 0.069
0.508SerTrp: 0.508 ± 0.027
1.847SerTyr: 1.847 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.184ThrAla: 4.184 ± 0.082
0.411ThrCys: 0.411 ± 0.027
3.421ThrAsp: 3.421 ± 0.086
4.461ThrGlu: 4.461 ± 0.093
1.632ThrPhe: 1.632 ± 0.051
4.523ThrGly: 4.523 ± 0.085
0.715ThrHis: 0.715 ± 0.031
3.726ThrIle: 3.726 ± 0.075
3.184ThrLys: 3.184 ± 0.072
4.54ThrLeu: 4.54 ± 0.083
0.988ThrMet: 0.988 ± 0.032
2.109ThrAsn: 2.109 ± 0.057
1.95ThrPro: 1.95 ± 0.051
1.153ThrGln: 1.153 ± 0.04
1.704ThrArg: 1.704 ± 0.048
2.75ThrSer: 2.75 ± 0.07
2.854ThrThr: 2.854 ± 0.062
3.996ThrVal: 3.996 ± 0.072
0.274ThrTrp: 0.274 ± 0.025
1.502ThrTyr: 1.502 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
5.109ValAla: 5.109 ± 0.096
0.62ValCys: 0.62 ± 0.035
4.897ValAsp: 4.897 ± 0.08
6.301ValGlu: 6.301 ± 0.12
2.308ValPhe: 2.308 ± 0.06
5.371ValGly: 5.371 ± 0.093
0.977ValHis: 0.977 ± 0.041
6.575ValIle: 6.575 ± 0.093
5.159ValLys: 5.159 ± 0.085
6.365ValLeu: 6.365 ± 0.098
1.682ValMet: 1.682 ± 0.04
3.342ValAsn: 3.342 ± 0.067
2.342ValPro: 2.342 ± 0.07
1.829ValGln: 1.829 ± 0.054
2.538ValArg: 2.538 ± 0.057
4.048ValSer: 4.048 ± 0.081
3.965ValThr: 3.965 ± 0.077
5.809ValVal: 5.809 ± 0.108
0.417ValTrp: 0.417 ± 0.024
1.846ValTyr: 1.846 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.452TrpAla: 0.452 ± 0.026
0.061TrpCys: 0.061 ± 0.01
0.387TrpAsp: 0.387 ± 0.025
0.461TrpGlu: 0.461 ± 0.028
0.306TrpPhe: 0.306 ± 0.027
0.512TrpGly: 0.512 ± 0.03
0.127TrpHis: 0.127 ± 0.013
0.559TrpIle: 0.559 ± 0.032
0.495TrpLys: 0.495 ± 0.026
0.755TrpLeu: 0.755 ± 0.037
0.178TrpMet: 0.178 ± 0.013
0.371TrpAsn: 0.371 ± 0.022
0.237TrpPro: 0.237 ± 0.018
0.464TrpGln: 0.464 ± 0.027
0.3TrpArg: 0.3 ± 0.021
0.404TrpSer: 0.404 ± 0.021
0.331TrpThr: 0.331 ± 0.028
0.4TrpVal: 0.4 ± 0.024
0.091TrpTrp: 0.091 ± 0.012
0.283TrpTyr: 0.283 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.661TyrAla: 1.661 ± 0.05
0.391TyrCys: 0.391 ± 0.027
2.078TyrAsp: 2.078 ± 0.06
2.272TyrGlu: 2.272 ± 0.063
1.566TyrPhe: 1.566 ± 0.054
2.255TyrGly: 2.255 ± 0.062
0.623TyrHis: 0.623 ± 0.032
2.558TyrIle: 2.558 ± 0.063
2.115TyrLys: 2.115 ± 0.064
3.81TyrLeu: 3.81 ± 0.088
0.569TyrMet: 0.569 ± 0.031
1.857TyrAsn: 1.857 ± 0.063
1.194TyrPro: 1.194 ± 0.037
1.822TyrGln: 1.822 ± 0.05
1.576TyrArg: 1.576 ± 0.053
2.068TyrSer: 2.068 ± 0.059
1.559TyrThr: 1.559 ± 0.051
1.614TyrVal: 1.614 ± 0.047
0.29TyrTrp: 0.29 ± 0.022
1.314TyrTyr: 1.314 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2276 proteins (703237 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski