Amino acid dipepetide frequency for Bluetongue virus 10 (isolate USA) (BTV 10)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.029AlaAla: 6.029 ± 1.075
0.773AlaCys: 0.773 ± 0.256
3.865AlaAsp: 3.865 ± 0.53
4.947AlaGlu: 4.947 ± 0.979
2.01AlaPhe: 2.01 ± 0.761
2.628AlaGly: 2.628 ± 0.669
1.082AlaHis: 1.082 ± 0.3
4.792AlaIle: 4.792 ± 1.026
4.019AlaLys: 4.019 ± 0.985
7.42AlaLeu: 7.42 ± 0.999
2.01AlaMet: 2.01 ± 0.736
2.628AlaAsn: 2.628 ± 0.464
3.71AlaPro: 3.71 ± 0.788
2.783AlaGln: 2.783 ± 0.498
4.792AlaArg: 4.792 ± 1.147
2.628AlaSer: 2.628 ± 0.529
5.101AlaThr: 5.101 ± 0.671
5.101AlaVal: 5.101 ± 0.815
0.928AlaTrp: 0.928 ± 0.327
4.019AlaTyr: 4.019 ± 0.514
0.0AlaXaa: 0.0 ± 0.0
Cys
0.464CysAla: 0.464 ± 0.253
0.309CysCys: 0.309 ± 0.241
0.309CysAsp: 0.309 ± 0.267
0.618CysGlu: 0.618 ± 0.291
1.082CysPhe: 1.082 ± 0.369
0.928CysGly: 0.928 ± 0.258
0.155CysHis: 0.155 ± 0.12
0.464CysIle: 0.464 ± 0.221
0.618CysLys: 0.618 ± 0.304
0.773CysLeu: 0.773 ± 0.214
0.155CysMet: 0.155 ± 0.12
0.618CysAsn: 0.618 ± 0.214
0.309CysPro: 0.309 ± 0.203
0.309CysGln: 0.309 ± 0.248
0.309CysArg: 0.309 ± 0.225
0.928CysSer: 0.928 ± 0.531
0.309CysThr: 0.309 ± 0.188
0.773CysVal: 0.773 ± 0.312
0.155CysTrp: 0.155 ± 0.12
1.082CysTyr: 1.082 ± 0.719
0.0CysXaa: 0.0 ± 0.0
Asp
3.71AspAla: 3.71 ± 0.793
0.309AspCys: 0.309 ± 0.165
5.41AspAsp: 5.41 ± 1.392
6.493AspGlu: 6.493 ± 1.625
2.473AspPhe: 2.473 ± 0.557
3.246AspGly: 3.246 ± 0.398
1.237AspHis: 1.237 ± 0.382
4.174AspIle: 4.174 ± 0.791
2.783AspLys: 2.783 ± 0.752
4.792AspLeu: 4.792 ± 0.822
2.01AspMet: 2.01 ± 0.702
0.773AspAsn: 0.773 ± 0.534
3.092AspPro: 3.092 ± 0.468
0.928AspGln: 0.928 ± 0.389
4.174AspArg: 4.174 ± 0.672
2.628AspSer: 2.628 ± 0.594
2.783AspThr: 2.783 ± 1.004
8.038AspVal: 8.038 ± 1.087
0.928AspTrp: 0.928 ± 0.426
2.01AspTyr: 2.01 ± 0.474
0.0AspXaa: 0.0 ± 0.0
Glu
5.874GluAla: 5.874 ± 1.14
0.309GluCys: 0.309 ± 0.16
3.555GluAsp: 3.555 ± 0.751
7.575GluGlu: 7.575 ± 1.544
3.246GluPhe: 3.246 ± 0.754
4.483GluGly: 4.483 ± 1.369
1.237GluHis: 1.237 ± 0.361
5.41GluIle: 5.41 ± 1.102
3.71GluLys: 3.71 ± 0.522
6.183GluLeu: 6.183 ± 0.682
2.473GluMet: 2.473 ± 0.479
1.7GluAsn: 1.7 ± 0.366
3.246GluPro: 3.246 ± 0.772
2.783GluGln: 2.783 ± 0.523
6.647GluArg: 6.647 ± 1.222
4.947GluSer: 4.947 ± 1.386
2.164GluThr: 2.164 ± 0.534
4.328GluVal: 4.328 ± 0.569
0.928GluTrp: 0.928 ± 0.292
2.319GluTyr: 2.319 ± 0.34
0.0GluXaa: 0.0 ± 0.0
Phe
2.473PheAla: 2.473 ± 0.767
0.309PheCys: 0.309 ± 0.203
3.092PheAsp: 3.092 ± 1.104
2.783PheGlu: 2.783 ± 0.432
1.7PhePhe: 1.7 ± 0.473
2.164PheGly: 2.164 ± 0.512
0.928PheHis: 0.928 ± 0.239
3.092PheIle: 3.092 ± 0.658
3.092PheLys: 3.092 ± 0.676
3.401PheLeu: 3.401 ± 1.114
1.082PheMet: 1.082 ± 0.375
1.546PheAsn: 1.546 ± 0.419
1.391PhePro: 1.391 ± 0.366
1.237PheGln: 1.237 ± 0.312
2.783PheArg: 2.783 ± 0.862
2.319PheSer: 2.319 ± 0.449
2.319PheThr: 2.319 ± 0.64
1.391PheVal: 1.391 ± 0.407
0.309PheTrp: 0.309 ± 0.159
2.164PheTyr: 2.164 ± 0.616
0.0PheXaa: 0.0 ± 0.0
Gly
5.565GlyAla: 5.565 ± 0.708
0.464GlyCys: 0.464 ± 0.229
5.874GlyAsp: 5.874 ± 1.053
3.555GlyGlu: 3.555 ± 0.721
2.164GlyPhe: 2.164 ± 0.556
4.792GlyGly: 4.792 ± 1.85
0.928GlyHis: 0.928 ± 0.269
3.401GlyIle: 3.401 ± 0.595
2.783GlyLys: 2.783 ± 0.794
2.628GlyLeu: 2.628 ± 0.414
2.164GlyMet: 2.164 ± 0.774
1.391GlyAsn: 1.391 ± 0.35
2.164GlyPro: 2.164 ± 0.615
2.319GlyGln: 2.319 ± 0.571
4.792GlyArg: 4.792 ± 0.63
3.401GlySer: 3.401 ± 0.699
3.555GlyThr: 3.555 ± 0.908
4.638GlyVal: 4.638 ± 1.289
0.928GlyTrp: 0.928 ± 0.283
2.473GlyTyr: 2.473 ± 0.595
0.0GlyXaa: 0.0 ± 0.0
His
1.082HisAla: 1.082 ± 0.362
0.618HisCys: 0.618 ± 0.214
0.928HisAsp: 0.928 ± 0.324
0.928HisGlu: 0.928 ± 0.39
0.928HisPhe: 0.928 ± 0.648
1.546HisGly: 1.546 ± 0.507
0.309HisHis: 0.309 ± 0.253
1.7HisIle: 1.7 ± 0.442
0.773HisLys: 0.773 ± 0.302
1.855HisLeu: 1.855 ± 0.521
0.928HisMet: 0.928 ± 0.31
1.391HisAsn: 1.391 ± 0.273
1.391HisPro: 1.391 ± 0.391
0.773HisGln: 0.773 ± 0.327
1.391HisArg: 1.391 ± 0.587
1.546HisSer: 1.546 ± 0.32
1.237HisThr: 1.237 ± 0.311
2.01HisVal: 2.01 ± 0.76
0.773HisTrp: 0.773 ± 0.335
0.618HisTyr: 0.618 ± 0.273
0.0HisXaa: 0.0 ± 0.0
Ile
5.874IleAla: 5.874 ± 0.768
1.082IleCys: 1.082 ± 0.782
4.792IleAsp: 4.792 ± 0.683
4.328IleGlu: 4.328 ± 0.969
2.01IlePhe: 2.01 ± 0.427
4.328IleGly: 4.328 ± 0.61
1.546IleHis: 1.546 ± 0.662
3.865IleIle: 3.865 ± 0.715
5.101IleLys: 5.101 ± 0.727
6.029IleLeu: 6.029 ± 0.711
1.546IleMet: 1.546 ± 0.585
3.71IleAsn: 3.71 ± 0.693
3.246IlePro: 3.246 ± 0.659
3.092IleGln: 3.092 ± 0.465
4.174IleArg: 4.174 ± 0.801
4.483IleSer: 4.483 ± 0.419
3.092IleThr: 3.092 ± 0.616
4.019IleVal: 4.019 ± 0.589
0.618IleTrp: 0.618 ± 0.292
2.473IleTyr: 2.473 ± 0.422
0.0IleXaa: 0.0 ± 0.0
Lys
3.555LysAla: 3.555 ± 0.698
0.309LysCys: 0.309 ± 0.157
3.246LysAsp: 3.246 ± 0.842
5.72LysGlu: 5.72 ± 1.919
1.7LysPhe: 1.7 ± 0.467
3.092LysGly: 3.092 ± 0.615
1.546LysHis: 1.546 ± 0.62
5.41LysIle: 5.41 ± 1.033
5.41LysLys: 5.41 ± 1.261
4.328LysLeu: 4.328 ± 0.703
3.555LysMet: 3.555 ± 0.66
2.164LysAsn: 2.164 ± 0.615
0.618LysPro: 0.618 ± 0.307
2.473LysGln: 2.473 ± 0.839
4.019LysArg: 4.019 ± 0.686
2.164LysSer: 2.164 ± 0.787
3.401LysThr: 3.401 ± 0.614
4.174LysVal: 4.174 ± 0.619
0.928LysTrp: 0.928 ± 0.511
2.164LysTyr: 2.164 ± 0.291
0.0LysXaa: 0.0 ± 0.0
Leu
4.328LeuAla: 4.328 ± 0.571
1.391LeuCys: 1.391 ± 0.408
4.947LeuAsp: 4.947 ± 0.855
4.638LeuGlu: 4.638 ± 0.656
3.555LeuPhe: 3.555 ± 0.888
4.328LeuGly: 4.328 ± 0.973
2.473LeuHis: 2.473 ± 0.424
5.41LeuIle: 5.41 ± 0.919
6.183LeuLys: 6.183 ± 0.828
5.256LeuLeu: 5.256 ± 0.682
2.319LeuMet: 2.319 ± 0.513
4.328LeuAsn: 4.328 ± 0.722
4.328LeuPro: 4.328 ± 0.994
3.092LeuGln: 3.092 ± 0.809
7.884LeuArg: 7.884 ± 0.878
6.338LeuSer: 6.338 ± 0.702
4.947LeuThr: 4.947 ± 0.693
4.174LeuVal: 4.174 ± 0.573
0.618LeuTrp: 0.618 ± 0.247
1.855LeuTyr: 1.855 ± 0.772
0.0LeuXaa: 0.0 ± 0.0
Met
3.092MetAla: 3.092 ± 0.368
0.464MetCys: 0.464 ± 0.234
1.7MetAsp: 1.7 ± 0.563
1.391MetGlu: 1.391 ± 0.331
1.391MetPhe: 1.391 ± 0.439
1.391MetGly: 1.391 ± 0.512
1.082MetHis: 1.082 ± 0.268
2.937MetIle: 2.937 ± 0.371
1.7MetLys: 1.7 ± 0.398
4.019MetLeu: 4.019 ± 0.693
1.7MetMet: 1.7 ± 0.522
1.7MetAsn: 1.7 ± 0.411
1.546MetPro: 1.546 ± 0.681
1.237MetGln: 1.237 ± 0.422
3.092MetArg: 3.092 ± 0.749
2.01MetSer: 2.01 ± 0.667
1.546MetThr: 1.546 ± 0.502
2.164MetVal: 2.164 ± 0.454
0.464MetTrp: 0.464 ± 0.229
0.773MetTyr: 0.773 ± 0.252
0.0MetXaa: 0.0 ± 0.0
Asn
2.783AsnAla: 2.783 ± 0.776
0.618AsnCys: 0.618 ± 0.407
2.937AsnAsp: 2.937 ± 0.618
3.865AsnGlu: 3.865 ± 0.791
1.7AsnPhe: 1.7 ± 0.457
2.783AsnGly: 2.783 ± 0.453
0.773AsnHis: 0.773 ± 0.517
2.01AsnIle: 2.01 ± 0.282
0.773AsnLys: 0.773 ± 0.372
3.71AsnLeu: 3.71 ± 0.644
1.237AsnMet: 1.237 ± 0.408
0.464AsnAsn: 0.464 ± 0.235
2.473AsnPro: 2.473 ± 0.484
1.237AsnGln: 1.237 ± 0.401
2.783AsnArg: 2.783 ± 0.559
2.473AsnSer: 2.473 ± 0.915
1.391AsnThr: 1.391 ± 0.309
3.092AsnVal: 3.092 ± 0.725
0.155AsnTrp: 0.155 ± 0.189
0.928AsnTyr: 0.928 ± 0.265
0.0AsnXaa: 0.0 ± 0.0
Pro
2.01ProAla: 2.01 ± 0.419
0.309ProCys: 0.309 ± 0.157
3.092ProAsp: 3.092 ± 0.715
2.628ProGlu: 2.628 ± 0.708
1.082ProPhe: 1.082 ± 0.418
2.937ProGly: 2.937 ± 0.743
1.237ProHis: 1.237 ± 0.392
2.628ProIle: 2.628 ± 0.679
2.319ProLys: 2.319 ± 0.578
3.865ProLeu: 3.865 ± 0.521
1.237ProMet: 1.237 ± 0.527
1.7ProAsn: 1.7 ± 0.405
1.391ProPro: 1.391 ± 0.388
1.546ProGln: 1.546 ± 0.342
2.628ProArg: 2.628 ± 0.492
1.7ProSer: 1.7 ± 0.613
3.092ProThr: 3.092 ± 1.13
1.855ProVal: 1.855 ± 0.557
0.618ProTrp: 0.618 ± 0.188
2.783ProTyr: 2.783 ± 0.623
0.0ProXaa: 0.0 ± 0.0
Gln
1.855GlnAla: 1.855 ± 0.598
0.309GlnCys: 0.309 ± 0.248
1.546GlnAsp: 1.546 ± 0.446
2.01GlnGlu: 2.01 ± 0.763
0.773GlnPhe: 0.773 ± 0.227
2.937GlnGly: 2.937 ± 0.757
0.464GlnHis: 0.464 ± 0.394
4.947GlnIle: 4.947 ± 1.031
2.628GlnLys: 2.628 ± 0.804
3.401GlnLeu: 3.401 ± 0.696
0.928GlnMet: 0.928 ± 0.47
1.546GlnAsn: 1.546 ± 0.531
2.01GlnPro: 2.01 ± 0.446
1.546GlnGln: 1.546 ± 0.584
3.401GlnArg: 3.401 ± 0.749
1.546GlnSer: 1.546 ± 0.369
1.7GlnThr: 1.7 ± 0.506
2.783GlnVal: 2.783 ± 0.823
0.309GlnTrp: 0.309 ± 0.203
1.082GlnTyr: 1.082 ± 0.308
0.0GlnXaa: 0.0 ± 0.0
Arg
5.565ArgAla: 5.565 ± 0.945
0.618ArgCys: 0.618 ± 0.382
5.101ArgAsp: 5.101 ± 0.607
5.101ArgGlu: 5.101 ± 0.865
4.792ArgPhe: 4.792 ± 0.761
3.555ArgGly: 3.555 ± 0.488
1.391ArgHis: 1.391 ± 0.399
5.101ArgIle: 5.101 ± 0.852
3.71ArgLys: 3.71 ± 0.795
5.256ArgLeu: 5.256 ± 0.724
2.473ArgMet: 2.473 ± 0.387
3.71ArgAsn: 3.71 ± 0.632
1.7ArgPro: 1.7 ± 0.55
2.783ArgGln: 2.783 ± 0.506
4.638ArgArg: 4.638 ± 0.493
4.328ArgSer: 4.328 ± 0.708
2.783ArgThr: 2.783 ± 0.67
4.947ArgVal: 4.947 ± 1.025
1.391ArgTrp: 1.391 ± 0.466
2.164ArgTyr: 2.164 ± 0.448
0.0ArgXaa: 0.0 ± 0.0
Ser
4.483SerAla: 4.483 ± 0.752
0.0SerCys: 0.0 ± 0.0
2.164SerAsp: 2.164 ± 0.57
4.792SerGlu: 4.792 ± 0.813
1.855SerPhe: 1.855 ± 0.421
4.019SerGly: 4.019 ± 0.889
1.546SerHis: 1.546 ± 0.503
4.328SerIle: 4.328 ± 0.673
3.246SerLys: 3.246 ± 0.998
5.256SerLeu: 5.256 ± 1.115
1.855SerMet: 1.855 ± 0.237
2.01SerAsn: 2.01 ± 0.464
1.855SerPro: 1.855 ± 0.422
2.473SerGln: 2.473 ± 0.364
2.937SerArg: 2.937 ± 0.792
4.019SerSer: 4.019 ± 0.84
2.783SerThr: 2.783 ± 0.506
3.71SerVal: 3.71 ± 0.531
0.928SerTrp: 0.928 ± 0.4
2.01SerTyr: 2.01 ± 0.442
0.0SerXaa: 0.0 ± 0.0
Thr
3.555ThrAla: 3.555 ± 0.899
0.773ThrCys: 0.773 ± 0.745
2.319ThrAsp: 2.319 ± 0.568
4.174ThrGlu: 4.174 ± 0.839
1.7ThrPhe: 1.7 ± 0.486
3.71ThrGly: 3.71 ± 0.944
1.546ThrHis: 1.546 ± 0.437
3.401ThrIle: 3.401 ± 0.496
4.019ThrLys: 4.019 ± 0.678
5.41ThrLeu: 5.41 ± 1.101
1.391ThrMet: 1.391 ± 0.403
1.7ThrAsn: 1.7 ± 0.411
1.391ThrPro: 1.391 ± 0.596
2.628ThrGln: 2.628 ± 0.563
2.628ThrArg: 2.628 ± 0.498
2.628ThrSer: 2.628 ± 0.564
4.019ThrThr: 4.019 ± 0.695
2.628ThrVal: 2.628 ± 0.69
0.464ThrTrp: 0.464 ± 0.333
2.01ThrTyr: 2.01 ± 0.777
0.0ThrXaa: 0.0 ± 0.0
Val
4.947ValAla: 4.947 ± 0.999
0.773ValCys: 0.773 ± 0.425
3.555ValAsp: 3.555 ± 0.549
4.792ValGlu: 4.792 ± 0.751
3.401ValPhe: 3.401 ± 0.817
4.483ValGly: 4.483 ± 0.644
1.855ValHis: 1.855 ± 0.434
3.092ValIle: 3.092 ± 0.415
3.71ValLys: 3.71 ± 0.406
6.338ValLeu: 6.338 ± 1.81
4.019ValMet: 4.019 ± 0.508
2.164ValAsn: 2.164 ± 0.674
3.555ValPro: 3.555 ± 0.477
3.246ValGln: 3.246 ± 0.591
4.483ValArg: 4.483 ± 0.984
3.401ValSer: 3.401 ± 0.825
2.473ValThr: 2.473 ± 0.89
3.71ValVal: 3.71 ± 0.639
0.773ValTrp: 0.773 ± 0.214
2.783ValTyr: 2.783 ± 0.48
0.0ValXaa: 0.0 ± 0.0
Trp
0.618TrpAla: 0.618 ± 0.278
0.155TrpCys: 0.155 ± 0.12
0.773TrpAsp: 0.773 ± 0.251
0.618TrpGlu: 0.618 ± 0.418
0.928TrpPhe: 0.928 ± 0.262
0.309TrpGly: 0.309 ± 0.188
0.773TrpHis: 0.773 ± 0.329
1.082TrpIle: 1.082 ± 0.349
1.546TrpLys: 1.546 ± 0.32
0.773TrpLeu: 0.773 ± 0.426
0.618TrpMet: 0.618 ± 0.292
0.928TrpAsn: 0.928 ± 0.467
0.0TrpPro: 0.0 ± 0.0
0.464TrpGln: 0.464 ± 0.401
0.618TrpArg: 0.618 ± 0.31
0.773TrpSer: 0.773 ± 0.374
0.309TrpThr: 0.309 ± 0.228
1.082TrpVal: 1.082 ± 0.403
0.155TrpTrp: 0.155 ± 0.125
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.401TyrAla: 3.401 ± 1.06
0.773TyrCys: 0.773 ± 0.577
2.783TyrAsp: 2.783 ± 0.593
2.164TyrGlu: 2.164 ± 0.466
1.082TyrPhe: 1.082 ± 0.228
2.319TyrGly: 2.319 ± 0.392
0.618TyrHis: 0.618 ± 0.291
2.164TyrIle: 2.164 ± 0.367
1.855TyrLys: 1.855 ± 0.367
1.855TyrLeu: 1.855 ± 0.488
1.546TyrMet: 1.546 ± 0.38
2.01TyrAsn: 2.01 ± 0.645
1.237TyrPro: 1.237 ± 0.469
0.773TyrGln: 0.773 ± 0.394
2.937TyrArg: 2.937 ± 0.381
2.01TyrSer: 2.01 ± 0.495
3.092TyrThr: 3.092 ± 0.511
2.937TyrVal: 2.937 ± 1.064
0.155TyrTrp: 0.155 ± 0.133
1.7TyrTyr: 1.7 ± 0.898
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (6470 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski