Amino acid dipepetide frequency for Aerococcus phage vB_AviM_AVP

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.078AlaAla: 0.078 ± 0.044
0.052AlaCys: 0.052 ± 0.034
3.673AlaAsp: 3.673 ± 0.36
3.959AlaGlu: 3.959 ± 0.391
1.693AlaPhe: 1.693 ± 0.202
2.787AlaGly: 2.787 ± 0.452
0.547AlaHis: 0.547 ± 0.124
3.751AlaIle: 3.751 ± 0.315
4.194AlaLys: 4.194 ± 0.382
4.35AlaLeu: 4.35 ± 0.436
1.042AlaMet: 1.042 ± 0.196
3.673AlaAsn: 3.673 ± 0.349
1.485AlaPro: 1.485 ± 0.227
1.407AlaGln: 1.407 ± 0.173
2.292AlaArg: 2.292 ± 0.24
3.386AlaSer: 3.386 ± 0.428
3.594AlaThr: 3.594 ± 0.426
3.048AlaVal: 3.048 ± 0.289
0.625AlaTrp: 0.625 ± 0.142
3.308AlaTyr: 3.308 ± 0.384
0.0AlaXaa: 0.0 ± 0.0
Cys
0.078CysAla: 0.078 ± 0.046
0.026CysCys: 0.026 ± 0.024
0.156CysAsp: 0.156 ± 0.062
0.26CysGlu: 0.26 ± 0.082
0.078CysPhe: 0.078 ± 0.047
0.365CysGly: 0.365 ± 0.134
0.078CysHis: 0.078 ± 0.042
0.156CysIle: 0.156 ± 0.055
0.26CysLys: 0.26 ± 0.08
0.313CysLeu: 0.313 ± 0.125
0.078CysMet: 0.078 ± 0.043
0.156CysAsn: 0.156 ± 0.072
0.208CysPro: 0.208 ± 0.084
0.078CysGln: 0.078 ± 0.046
0.156CysArg: 0.156 ± 0.063
0.208CysSer: 0.208 ± 0.085
0.182CysThr: 0.182 ± 0.076
0.104CysVal: 0.104 ± 0.054
0.026CysTrp: 0.026 ± 0.029
0.13CysTyr: 0.13 ± 0.06
0.0CysXaa: 0.0 ± 0.0
Asp
2.448AspAla: 2.448 ± 0.374
0.208AspCys: 0.208 ± 0.068
4.063AspAsp: 4.063 ± 0.367
5.053AspGlu: 5.053 ± 0.487
3.152AspPhe: 3.152 ± 0.303
4.48AspGly: 4.48 ± 0.597
0.521AspHis: 0.521 ± 0.115
6.277AspIle: 6.277 ± 0.51
6.303AspLys: 6.303 ± 0.452
6.173AspLeu: 6.173 ± 0.585
2.136AspMet: 2.136 ± 0.227
4.584AspAsn: 4.584 ± 0.331
2.006AspPro: 2.006 ± 0.259
1.12AspGln: 1.12 ± 0.143
2.084AspArg: 2.084 ± 0.232
5.991AspSer: 5.991 ± 0.755
5.392AspThr: 5.392 ± 0.425
2.579AspVal: 2.579 ± 0.286
0.781AspTrp: 0.781 ± 0.168
4.793AspTyr: 4.793 ± 0.441
0.0AspXaa: 0.0 ± 0.0
Glu
4.272GluAla: 4.272 ± 0.408
0.287GluCys: 0.287 ± 0.092
7.007GluAsp: 7.007 ± 0.456
10.575GluGlu: 10.575 ± 1.087
3.594GluPhe: 3.594 ± 0.357
4.35GluGly: 4.35 ± 0.312
1.511GluHis: 1.511 ± 0.219
5.209GluIle: 5.209 ± 0.439
5.913GluLys: 5.913 ± 0.566
9.221GluLeu: 9.221 ± 0.7
1.954GluMet: 1.954 ± 0.217
4.402GluAsn: 4.402 ± 0.343
3.048GluPro: 3.048 ± 0.447
3.699GluGln: 3.699 ± 0.372
3.282GluArg: 3.282 ± 0.333
4.741GluSer: 4.741 ± 0.365
4.871GluThr: 4.871 ± 0.418
5.548GluVal: 5.548 ± 0.431
1.12GluTrp: 1.12 ± 0.143
4.741GluTyr: 4.741 ± 0.447
0.0GluXaa: 0.0 ± 0.0
Phe
1.485PheAla: 1.485 ± 0.203
0.13PheCys: 0.13 ± 0.068
2.657PheAsp: 2.657 ± 0.278
2.787PheGlu: 2.787 ± 0.31
1.042PhePhe: 1.042 ± 0.192
1.98PheGly: 1.98 ± 0.23
0.443PheHis: 0.443 ± 0.13
2.553PheIle: 2.553 ± 0.272
3.855PheLys: 3.855 ± 0.324
2.735PheLeu: 2.735 ± 0.251
0.677PheMet: 0.677 ± 0.138
3.49PheAsn: 3.49 ± 0.305
0.964PhePro: 0.964 ± 0.14
0.964PheGln: 0.964 ± 0.176
1.094PheArg: 1.094 ± 0.184
2.969PheSer: 2.969 ± 0.402
2.917PheThr: 2.917 ± 0.244
2.683PheVal: 2.683 ± 0.277
0.313PheTrp: 0.313 ± 0.082
1.563PheTyr: 1.563 ± 0.191
0.0PheXaa: 0.0 ± 0.0
Gly
3.881GlyAla: 3.881 ± 0.566
0.182GlyCys: 0.182 ± 0.069
4.324GlyAsp: 4.324 ± 0.435
5.418GlyGlu: 5.418 ± 0.488
2.37GlyPhe: 2.37 ± 0.338
4.115GlyGly: 4.115 ± 0.643
0.651GlyHis: 0.651 ± 0.154
4.168GlyIle: 4.168 ± 0.395
4.715GlyLys: 4.715 ± 0.384
4.975GlyLeu: 4.975 ± 0.474
1.954GlyMet: 1.954 ± 0.3
4.923GlyAsn: 4.923 ± 0.459
1.12GlyPro: 1.12 ± 0.445
1.98GlyGln: 1.98 ± 0.299
2.318GlyArg: 2.318 ± 0.207
4.61GlySer: 4.61 ± 0.537
4.793GlyThr: 4.793 ± 0.565
3.777GlyVal: 3.777 ± 0.323
0.677GlyTrp: 0.677 ± 0.152
3.178GlyTyr: 3.178 ± 0.337
0.0GlyXaa: 0.0 ± 0.0
His
0.729HisAla: 0.729 ± 0.143
0.078HisCys: 0.078 ± 0.045
0.99HisAsp: 0.99 ± 0.198
0.99HisGlu: 0.99 ± 0.172
0.99HisPhe: 0.99 ± 0.151
0.886HisGly: 0.886 ± 0.159
0.234HisHis: 0.234 ± 0.085
1.302HisIle: 1.302 ± 0.276
1.172HisLys: 1.172 ± 0.205
1.198HisLeu: 1.198 ± 0.154
0.208HisMet: 0.208 ± 0.075
0.886HisAsn: 0.886 ± 0.146
0.365HisPro: 0.365 ± 0.095
0.339HisGln: 0.339 ± 0.085
0.365HisArg: 0.365 ± 0.089
0.938HisSer: 0.938 ± 0.133
0.547HisThr: 0.547 ± 0.124
0.834HisVal: 0.834 ± 0.168
0.156HisTrp: 0.156 ± 0.096
0.781HisTyr: 0.781 ± 0.156
0.0HisXaa: 0.0 ± 0.0
Ile
3.438IleAla: 3.438 ± 0.318
0.313IleCys: 0.313 ± 0.091
5.183IleAsp: 5.183 ± 0.36
6.955IleGlu: 6.955 ± 0.584
1.667IlePhe: 1.667 ± 0.201
3.855IleGly: 3.855 ± 0.477
0.86IleHis: 0.86 ± 0.154
4.897IleIle: 4.897 ± 0.409
5.756IleLys: 5.756 ± 0.454
4.584IleLeu: 4.584 ± 0.364
1.615IleMet: 1.615 ± 0.215
4.845IleAsn: 4.845 ± 0.401
1.849IlePro: 1.849 ± 0.289
2.318IleGln: 2.318 ± 0.218
2.605IleArg: 2.605 ± 0.283
5.131IleSer: 5.131 ± 0.432
4.897IleThr: 4.897 ± 0.34
4.037IleVal: 4.037 ± 0.355
0.26IleTrp: 0.26 ± 0.082
2.995IleTyr: 2.995 ± 0.314
0.0IleXaa: 0.0 ± 0.0
Lys
4.793LysAla: 4.793 ± 0.284
0.208LysCys: 0.208 ± 0.09
5.913LysAsp: 5.913 ± 0.398
9.247LysGlu: 9.247 ± 0.698
2.474LysPhe: 2.474 ± 0.295
5.626LysGly: 5.626 ± 0.711
1.407LysHis: 1.407 ± 0.222
3.673LysIle: 3.673 ± 0.298
4.688LysLys: 4.688 ± 0.476
6.85LysLeu: 6.85 ± 0.458
1.615LysMet: 1.615 ± 0.203
3.516LysAsn: 3.516 ± 0.278
2.839LysPro: 2.839 ± 0.276
3.178LysGln: 3.178 ± 0.403
2.969LysArg: 2.969 ± 0.289
4.194LysSer: 4.194 ± 0.344
3.49LysThr: 3.49 ± 0.3
6.303LysVal: 6.303 ± 0.472
0.625LysTrp: 0.625 ± 0.182
4.168LysTyr: 4.168 ± 0.41
0.0LysXaa: 0.0 ± 0.0
Leu
3.933LeuAla: 3.933 ± 0.35
0.208LeuCys: 0.208 ± 0.071
7.163LeuAsp: 7.163 ± 0.491
8.361LeuGlu: 8.361 ± 0.744
3.23LeuPhe: 3.23 ± 0.309
5.053LeuGly: 5.053 ± 0.458
1.354LeuHis: 1.354 ± 0.205
4.636LeuIle: 4.636 ± 0.425
5.262LeuLys: 5.262 ± 0.405
6.382LeuLeu: 6.382 ± 0.631
1.98LeuMet: 1.98 ± 0.238
6.46LeuAsn: 6.46 ± 0.506
2.761LeuPro: 2.761 ± 0.282
2.527LeuGln: 2.527 ± 0.326
2.761LeuArg: 2.761 ± 0.3
5.809LeuSer: 5.809 ± 0.509
5.574LeuThr: 5.574 ± 0.32
4.688LeuVal: 4.688 ± 0.301
0.469LeuTrp: 0.469 ± 0.119
4.298LeuTyr: 4.298 ± 0.417
0.0LeuXaa: 0.0 ± 0.0
Met
1.875MetAla: 1.875 ± 0.275
0.026MetCys: 0.026 ± 0.024
1.459MetAsp: 1.459 ± 0.199
1.823MetGlu: 1.823 ± 0.237
1.016MetPhe: 1.016 ± 0.148
1.797MetGly: 1.797 ± 0.253
0.13MetHis: 0.13 ± 0.067
1.25MetIle: 1.25 ± 0.174
1.771MetLys: 1.771 ± 0.227
1.745MetLeu: 1.745 ± 0.183
0.417MetMet: 0.417 ± 0.109
1.459MetAsn: 1.459 ± 0.205
0.443MetPro: 0.443 ± 0.089
0.521MetGln: 0.521 ± 0.125
0.964MetArg: 0.964 ± 0.14
1.667MetSer: 1.667 ± 0.236
1.38MetThr: 1.38 ± 0.209
1.328MetVal: 1.328 ± 0.167
0.208MetTrp: 0.208 ± 0.062
1.25MetTyr: 1.25 ± 0.254
0.0MetXaa: 0.0 ± 0.0
Asn
3.36AsnAla: 3.36 ± 0.317
0.208AsnCys: 0.208 ± 0.072
3.673AsnAsp: 3.673 ± 0.327
5.053AsnGlu: 5.053 ± 0.387
2.422AsnPhe: 2.422 ± 0.267
4.61AsnGly: 4.61 ± 0.396
1.042AsnHis: 1.042 ± 0.186
4.558AsnIle: 4.558 ± 0.343
5.626AsnLys: 5.626 ± 0.454
5.913AsnLeu: 5.913 ± 0.451
1.511AsnMet: 1.511 ± 0.182
5.392AsnAsn: 5.392 ± 0.385
2.553AsnPro: 2.553 ± 0.297
2.084AsnGln: 2.084 ± 0.214
2.865AsnArg: 2.865 ± 0.262
3.907AsnSer: 3.907 ± 0.276
4.48AsnThr: 4.48 ± 0.299
3.959AsnVal: 3.959 ± 0.345
0.469AsnTrp: 0.469 ± 0.124
3.308AsnTyr: 3.308 ± 0.311
0.0AsnXaa: 0.0 ± 0.0
Pro
0.86ProAla: 0.86 ± 0.167
0.078ProCys: 0.078 ± 0.043
1.771ProAsp: 1.771 ± 0.238
2.084ProGlu: 2.084 ± 0.258
1.094ProPhe: 1.094 ± 0.171
1.302ProGly: 1.302 ± 0.363
0.443ProHis: 0.443 ± 0.106
2.266ProIle: 2.266 ± 0.255
2.657ProLys: 2.657 ± 0.278
2.37ProLeu: 2.37 ± 0.268
0.677ProMet: 0.677 ± 0.131
2.318ProAsn: 2.318 ± 0.228
0.599ProPro: 0.599 ± 0.137
1.459ProGln: 1.459 ± 0.302
0.964ProArg: 0.964 ± 0.197
2.344ProSer: 2.344 ± 0.304
2.136ProThr: 2.136 ± 0.226
2.24ProVal: 2.24 ± 0.302
0.234ProTrp: 0.234 ± 0.085
2.032ProTyr: 2.032 ± 0.247
0.0ProXaa: 0.0 ± 0.0
Gln
2.501GlnAla: 2.501 ± 0.375
0.0GlnCys: 0.0 ± 0.0
2.058GlnAsp: 2.058 ± 0.219
3.36GlnGlu: 3.36 ± 0.363
1.198GlnPhe: 1.198 ± 0.202
3.152GlnGly: 3.152 ± 0.92
0.391GlnHis: 0.391 ± 0.096
1.615GlnIle: 1.615 ± 0.22
1.667GlnLys: 1.667 ± 0.262
2.709GlnLeu: 2.709 ± 0.36
0.677GlnMet: 0.677 ± 0.15
1.745GlnAsn: 1.745 ± 0.261
0.938GlnPro: 0.938 ± 0.27
1.094GlnGln: 1.094 ± 0.249
1.641GlnArg: 1.641 ± 0.231
1.693GlnSer: 1.693 ± 0.22
1.38GlnThr: 1.38 ± 0.19
2.318GlnVal: 2.318 ± 0.284
0.156GlnTrp: 0.156 ± 0.067
1.589GlnTyr: 1.589 ± 0.253
0.0GlnXaa: 0.0 ± 0.0
Arg
1.954ArgAla: 1.954 ± 0.264
0.104ArgCys: 0.104 ± 0.054
2.761ArgAsp: 2.761 ± 0.243
3.256ArgGlu: 3.256 ± 0.285
1.302ArgPhe: 1.302 ± 0.157
2.657ArgGly: 2.657 ± 0.33
0.339ArgHis: 0.339 ± 0.079
2.943ArgIle: 2.943 ± 0.308
2.891ArgLys: 2.891 ± 0.295
2.631ArgLeu: 2.631 ± 0.28
0.729ArgMet: 0.729 ± 0.158
2.11ArgAsn: 2.11 ± 0.239
1.12ArgPro: 1.12 ± 0.166
1.38ArgGln: 1.38 ± 0.188
1.302ArgArg: 1.302 ± 0.246
1.745ArgSer: 1.745 ± 0.219
2.396ArgThr: 2.396 ± 0.266
2.474ArgVal: 2.474 ± 0.324
0.469ArgTrp: 0.469 ± 0.102
1.589ArgTyr: 1.589 ± 0.209
0.0ArgXaa: 0.0 ± 0.0
Ser
3.308SerAla: 3.308 ± 0.45
0.052SerCys: 0.052 ± 0.035
4.741SerAsp: 4.741 ± 0.459
4.949SerGlu: 4.949 ± 0.409
2.943SerPhe: 2.943 ± 0.335
4.298SerGly: 4.298 ± 0.494
0.834SerHis: 0.834 ± 0.154
4.819SerIle: 4.819 ± 0.377
5.73SerLys: 5.73 ± 0.393
5.157SerLeu: 5.157 ± 0.348
1.198SerMet: 1.198 ± 0.181
4.35SerAsn: 4.35 ± 0.456
1.589SerPro: 1.589 ± 0.185
2.084SerGln: 2.084 ± 0.242
2.37SerArg: 2.37 ± 0.27
5.131SerSer: 5.131 ± 0.519
4.923SerThr: 4.923 ± 0.894
4.063SerVal: 4.063 ± 0.38
0.729SerTrp: 0.729 ± 0.198
3.308SerTyr: 3.308 ± 0.339
0.0SerXaa: 0.0 ± 0.0
Thr
3.516ThrAla: 3.516 ± 0.297
0.26ThrCys: 0.26 ± 0.091
4.584ThrAsp: 4.584 ± 0.418
4.089ThrGlu: 4.089 ± 0.356
2.735ThrPhe: 2.735 ± 0.279
4.636ThrGly: 4.636 ± 0.564
1.537ThrHis: 1.537 ± 0.238
5.183ThrIle: 5.183 ± 0.371
4.975ThrLys: 4.975 ± 0.408
5.678ThrLeu: 5.678 ± 0.376
1.354ThrMet: 1.354 ± 0.167
4.063ThrAsn: 4.063 ± 0.474
2.709ThrPro: 2.709 ± 0.256
2.084ThrGln: 2.084 ± 0.256
2.162ThrArg: 2.162 ± 0.287
3.725ThrSer: 3.725 ± 0.405
4.011ThrThr: 4.011 ± 0.492
4.741ThrVal: 4.741 ± 0.493
0.547ThrTrp: 0.547 ± 0.132
3.178ThrTyr: 3.178 ± 0.349
0.0ThrXaa: 0.0 ± 0.0
Val
3.126ValAla: 3.126 ± 0.265
0.417ValCys: 0.417 ± 0.115
4.61ValAsp: 4.61 ± 0.321
6.225ValGlu: 6.225 ± 0.524
2.136ValPhe: 2.136 ± 0.234
4.272ValGly: 4.272 ± 0.331
0.755ValHis: 0.755 ± 0.134
4.063ValIle: 4.063 ± 0.352
5.209ValLys: 5.209 ± 0.402
4.48ValLeu: 4.48 ± 0.414
1.511ValMet: 1.511 ± 0.223
3.985ValAsn: 3.985 ± 0.337
2.006ValPro: 2.006 ± 0.235
2.058ValGln: 2.058 ± 0.238
1.927ValArg: 1.927 ± 0.199
4.141ValSer: 4.141 ± 0.357
4.089ValThr: 4.089 ± 0.402
4.089ValVal: 4.089 ± 0.36
0.469ValTrp: 0.469 ± 0.119
3.152ValTyr: 3.152 ± 0.317
0.0ValXaa: 0.0 ± 0.0
Trp
0.339TrpAla: 0.339 ± 0.106
0.026TrpCys: 0.026 ± 0.025
0.469TrpAsp: 0.469 ± 0.11
0.938TrpGlu: 0.938 ± 0.18
0.208TrpPhe: 0.208 ± 0.081
0.625TrpGly: 0.625 ± 0.121
0.182TrpHis: 0.182 ± 0.085
0.651TrpIle: 0.651 ± 0.146
0.703TrpLys: 0.703 ± 0.168
0.834TrpLeu: 0.834 ± 0.172
0.104TrpMet: 0.104 ± 0.051
0.547TrpAsn: 0.547 ± 0.133
0.0TrpPro: 0.0 ± 0.0
0.313TrpGln: 0.313 ± 0.077
0.365TrpArg: 0.365 ± 0.09
0.677TrpSer: 0.677 ± 0.136
0.729TrpThr: 0.729 ± 0.275
0.547TrpVal: 0.547 ± 0.099
0.182TrpTrp: 0.182 ± 0.068
0.625TrpTyr: 0.625 ± 0.127
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.969TyrAla: 2.969 ± 0.359
0.234TyrCys: 0.234 ± 0.102
2.891TyrAsp: 2.891 ± 0.381
3.959TyrGlu: 3.959 ± 0.361
1.954TyrPhe: 1.954 ± 0.258
3.282TyrGly: 3.282 ± 0.324
0.729TyrHis: 0.729 ± 0.14
4.089TyrIle: 4.089 ± 0.528
4.454TyrLys: 4.454 ± 0.387
4.61TyrLeu: 4.61 ± 0.394
1.068TyrMet: 1.068 ± 0.197
4.089TyrAsn: 4.089 ± 0.367
1.328TyrPro: 1.328 ± 0.183
1.198TyrGln: 1.198 ± 0.187
1.667TyrArg: 1.667 ± 0.199
3.568TyrSer: 3.568 ± 0.325
3.985TyrThr: 3.985 ± 0.486
3.36TyrVal: 3.36 ± 0.313
0.547TyrTrp: 0.547 ± 0.128
2.709TyrTyr: 2.709 ± 0.276
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 165 proteins (38393 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski