Amino acid dipepetide frequency for Monascus purpureus (Red mold) (Monascus anka)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.369AlaAla: 8.369 ± 0.058	0.962AlaCys: 0.962 ± 0.018	4.178AlaAsp: 4.178 ± 0.035	5.044AlaGlu: 5.044 ± 0.047	3.057AlaPhe: 3.057 ± 0.028	5.493AlaGly: 5.493 ± 0.044	1.751AlaHis: 1.751 ± 0.021	4.197AlaIle: 4.197 ± 0.038	3.849AlaLys: 3.849 ± 0.039	7.401AlaLeu: 7.401 ± 0.057	1.799AlaMet: 1.799 ± 0.02	2.837AlaAsn: 2.837 ± 0.028	4.403AlaPro: 4.403 ± 0.039	3.128AlaGln: 3.128 ± 0.031	4.976AlaArg: 4.976 ± 0.041	7.28AlaSer: 7.28 ± 0.049	4.864AlaThr: 4.864 ± 0.041	5.434AlaVal: 5.434 ± 0.046	1.019AlaTrp: 1.019 ± 0.018	2.083AlaTyr: 2.083 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.834CysAla: 0.834 ± 0.016	0.211CysCys: 0.211 ± 0.009	0.614CysAsp: 0.614 ± 0.012	0.577CysGlu: 0.577 ± 0.013	0.524CysPhe: 0.524 ± 0.012	0.842CysGly: 0.842 ± 0.015	0.321CysHis: 0.321 ± 0.009	0.665CysIle: 0.665 ± 0.012	0.467CysLys: 0.467 ± 0.011	1.257CysLeu: 1.257 ± 0.021	0.248CysMet: 0.248 ± 0.007	0.4CysAsn: 0.4 ± 0.011	0.631CysPro: 0.631 ± 0.012	0.421CysGln: 0.421 ± 0.011	0.754CysArg: 0.754 ± 0.014	0.897CysSer: 0.897 ± 0.018	0.61CysThr: 0.61 ± 0.012	0.76CysVal: 0.76 ± 0.014	0.183CysTrp: 0.183 ± 0.007	0.335CysTyr: 0.335 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.521AspAla: 4.521 ± 0.037	0.597AspCys: 0.597 ± 0.014	4.187AspAsp: 4.187 ± 0.051	4.535AspGlu: 4.535 ± 0.038	2.191AspPhe: 2.191 ± 0.024	4.029AspGly: 4.029 ± 0.036	1.226AspHis: 1.226 ± 0.018	3.258AspIle: 3.258 ± 0.033	2.29AspLys: 2.29 ± 0.025	5.167AspLeu: 5.167 ± 0.041	1.233AspMet: 1.233 ± 0.017	1.986AspAsn: 1.986 ± 0.023	3.378AspPro: 3.378 ± 0.033	1.853AspGln: 1.853 ± 0.02	3.268AspArg: 3.268 ± 0.036	4.414AspSer: 4.414 ± 0.04	2.915AspThr: 2.915 ± 0.027	3.722AspVal: 3.722 ± 0.033	0.837AspTrp: 0.837 ± 0.015	1.662AspTyr: 1.662 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.135GluAla: 5.135 ± 0.04	0.588GluCys: 0.588 ± 0.014	4.299GluAsp: 4.299 ± 0.036	5.87GluGlu: 5.87 ± 0.07	2.037GluPhe: 2.037 ± 0.024	3.717GluGly: 3.717 ± 0.032	1.432GluHis: 1.432 ± 0.018	3.229GluIle: 3.229 ± 0.029	3.955GluLys: 3.955 ± 0.042	5.312GluLeu: 5.312 ± 0.05	1.421GluMet: 1.421 ± 0.021	2.555GluAsn: 2.555 ± 0.027	2.828GluPro: 2.828 ± 0.043	2.6GluGln: 2.6 ± 0.03	4.272GluArg: 4.272 ± 0.039	4.566GluSer: 4.566 ± 0.039	3.606GluThr: 3.606 ± 0.031	3.473GluVal: 3.473 ± 0.033	0.856GluTrp: 0.856 ± 0.014	1.723GluTyr: 1.723 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	2.899PheAla: 2.899 ± 0.028	0.549PheCys: 0.549 ± 0.012	2.271PheAsp: 2.271 ± 0.025	2.16PheGlu: 2.16 ± 0.023	1.627PhePhe: 1.627 ± 0.023	2.781PheGly: 2.781 ± 0.03	0.915PheHis: 0.915 ± 0.014	1.807PheIle: 1.807 ± 0.022	1.477PheLys: 1.477 ± 0.021	3.645PheLeu: 3.645 ± 0.038	0.757PheMet: 0.757 ± 0.014	1.419PheAsn: 1.419 ± 0.021	2.064PhePro: 2.064 ± 0.025	1.402PheGln: 1.402 ± 0.018	2.093PheArg: 2.093 ± 0.023	3.173PheSer: 3.173 ± 0.03	2.081PheThr: 2.081 ± 0.023	2.395PheVal: 2.395 ± 0.024	0.625PheTrp: 0.625 ± 0.014	1.134PheTyr: 1.134 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	4.828GlyAla: 4.828 ± 0.042	0.822GlyCys: 0.822 ± 0.016	3.609GlyAsp: 3.609 ± 0.032	3.634GlyGlu: 3.634 ± 0.034	2.782GlyPhe: 2.782 ± 0.029	5.224GlyGly: 5.224 ± 0.055	1.664GlyHis: 1.664 ± 0.022	3.655GlyIle: 3.655 ± 0.035	3.468GlyLys: 3.468 ± 0.035	5.999GlyLeu: 5.999 ± 0.039	1.444GlyMet: 1.444 ± 0.018	2.605GlyAsn: 2.605 ± 0.029	3.315GlyPro: 3.315 ± 0.036	2.531GlyGln: 2.531 ± 0.028	4.16GlyArg: 4.16 ± 0.038	5.758GlySer: 5.758 ± 0.046	3.861GlyThr: 3.861 ± 0.039	4.306GlyVal: 4.306 ± 0.037	1.099GlyTrp: 1.099 ± 0.018	2.095GlyTyr: 2.095 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.84HisAla: 1.84 ± 0.023	0.289HisCys: 0.289 ± 0.009	1.293HisAsp: 1.293 ± 0.017	1.343HisGlu: 1.343 ± 0.02	0.912HisPhe: 0.912 ± 0.014	1.736HisGly: 1.736 ± 0.023	0.87HisHis: 0.87 ± 0.02	1.237HisIle: 1.237 ± 0.018	0.882HisLys: 0.882 ± 0.015	2.273HisLeu: 2.273 ± 0.023	0.434HisMet: 0.434 ± 0.01	0.844HisAsn: 0.844 ± 0.016	1.775HisPro: 1.775 ± 0.023	0.921HisGln: 0.921 ± 0.016	1.608HisArg: 1.608 ± 0.021	1.963HisSer: 1.963 ± 0.022	1.253HisThr: 1.253 ± 0.02	1.424HisVal: 1.424 ± 0.018	0.339HisTrp: 0.339 ± 0.008	0.693HisTyr: 0.693 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.058IleAla: 4.058 ± 0.036	0.755IleCys: 0.755 ± 0.013	2.907IleAsp: 2.907 ± 0.026	2.938IleGlu: 2.938 ± 0.032	2.084IlePhe: 2.084 ± 0.025	3.107IleGly: 3.107 ± 0.035	1.259IleHis: 1.259 ± 0.016	2.521IleIle: 2.521 ± 0.03	2.097IleLys: 2.097 ± 0.027	4.831IleLeu: 4.831 ± 0.038	0.982IleMet: 0.982 ± 0.017	1.775IleAsn: 1.775 ± 0.021	3.319IlePro: 3.319 ± 0.031	1.898IleGln: 1.898 ± 0.025	3.027IleArg: 3.027 ± 0.029	4.13IleSer: 4.13 ± 0.032	2.713IleThr: 2.713 ± 0.028	3.245IleVal: 3.245 ± 0.033	0.711IleTrp: 0.711 ± 0.014	1.465IleTyr: 1.465 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.013LysAla: 4.013 ± 0.04	0.464LysCys: 0.464 ± 0.011	2.788LysAsp: 2.788 ± 0.031	3.582LysGlu: 3.582 ± 0.041	1.436LysPhe: 1.436 ± 0.017	2.933LysGly: 2.933 ± 0.032	1.069LysHis: 1.069 ± 0.017	2.335LysIle: 2.335 ± 0.029	3.288LysLys: 3.288 ± 0.049	4.155LysLeu: 4.155 ± 0.034	0.986LysMet: 0.986 ± 0.017	1.817LysAsn: 1.817 ± 0.022	2.726LysPro: 2.726 ± 0.032	1.869LysGln: 1.869 ± 0.024	3.588LysArg: 3.588 ± 0.036	3.481LysSer: 3.481 ± 0.035	2.721LysThr: 2.721 ± 0.029	2.788LysVal: 2.788 ± 0.029	0.645LysTrp: 0.645 ± 0.013	1.432LysTyr: 1.432 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	7.554LeuAla: 7.554 ± 0.054	1.159LeuCys: 1.159 ± 0.017	5.318LeuAsp: 5.318 ± 0.04	5.714LeuGlu: 5.714 ± 0.048	3.391LeuPhe: 3.391 ± 0.034	5.887LeuGly: 5.887 ± 0.047	2.246LeuHis: 2.246 ± 0.029	3.982LeuIle: 3.982 ± 0.035	4.283LeuLys: 4.283 ± 0.035	8.474LeuLeu: 8.474 ± 0.056	1.711LeuMet: 1.711 ± 0.022	3.247LeuAsn: 3.247 ± 0.027	5.612LeuPro: 5.612 ± 0.042	3.927LeuGln: 3.927 ± 0.038	6.181LeuArg: 6.181 ± 0.044	7.874LeuSer: 7.874 ± 0.041	4.744LeuThr: 4.744 ± 0.035	5.479LeuVal: 5.479 ± 0.036	1.142LeuTrp: 1.142 ± 0.02	2.429LeuTyr: 2.429 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.084MetAla: 2.084 ± 0.021	0.218MetCys: 0.218 ± 0.007	1.252MetAsp: 1.252 ± 0.017	1.277MetGlu: 1.277 ± 0.019	0.696MetPhe: 0.696 ± 0.013	1.371MetGly: 1.371 ± 0.019	0.43MetHis: 0.43 ± 0.012	0.921MetIle: 0.921 ± 0.018	0.979MetLys: 0.979 ± 0.015	1.754MetLeu: 1.754 ± 0.019	0.491MetMet: 0.491 ± 0.011	0.782MetAsn: 0.782 ± 0.015	1.149MetPro: 1.149 ± 0.018	0.834MetGln: 0.834 ± 0.017	1.231MetArg: 1.231 ± 0.02	1.757MetSer: 1.757 ± 0.021	1.187MetThr: 1.187 ± 0.018	1.261MetVal: 1.261 ± 0.02	0.227MetTrp: 0.227 ± 0.008	0.494MetTyr: 0.494 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.091AsnAla: 3.091 ± 0.026	0.436AsnCys: 0.436 ± 0.012	2.037AsnAsp: 2.037 ± 0.025	2.136AsnGlu: 2.136 ± 0.025	1.347AsnPhe: 1.347 ± 0.024	2.972AsnGly: 2.972 ± 0.03	0.832AsnHis: 0.832 ± 0.015	2.061AsnIle: 2.061 ± 0.022	1.56AsnLys: 1.56 ± 0.021	3.287AsnLeu: 3.287 ± 0.029	0.777AsnMet: 0.777 ± 0.015	1.566AsnAsn: 1.566 ± 0.024	2.549AsnPro: 2.549 ± 0.028	1.314AsnGln: 1.314 ± 0.021	2.14AsnArg: 2.14 ± 0.02	2.909AsnSer: 2.909 ± 0.03	2.151AsnThr: 2.151 ± 0.024	2.351AsnVal: 2.351 ± 0.026	0.538AsnTrp: 0.538 ± 0.013	1.055AsnTyr: 1.055 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.073ProAla: 5.073 ± 0.049	0.526ProCys: 0.526 ± 0.012	3.293ProAsp: 3.293 ± 0.034	3.962ProGlu: 3.962 ± 0.038	2.154ProPhe: 2.154 ± 0.022	3.981ProGly: 3.981 ± 0.046	1.366ProHis: 1.366 ± 0.019	2.558ProIle: 2.558 ± 0.03	2.604ProLys: 2.604 ± 0.031	4.859ProLeu: 4.859 ± 0.035	1.012ProMet: 1.012 ± 0.017	2.163ProAsn: 2.163 ± 0.027	5.134ProPro: 5.134 ± 0.081	2.378ProGln: 2.378 ± 0.03	3.54ProArg: 3.54 ± 0.038	6.495ProSer: 6.495 ± 0.063	3.696ProThr: 3.696 ± 0.038	3.828ProVal: 3.828 ± 0.033	0.73ProTrp: 0.73 ± 0.012	1.548ProTyr: 1.548 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.187GlnAla: 3.187 ± 0.032	0.399GlnCys: 0.399 ± 0.01	2.02GlnAsp: 2.02 ± 0.024	2.466GlnGlu: 2.466 ± 0.029	1.302GlnPhe: 1.302 ± 0.021	2.34GlnGly: 2.34 ± 0.025	1.031GlnHis: 1.031 ± 0.015	1.93GlnIle: 1.93 ± 0.024	2.067GlnLys: 2.067 ± 0.027	3.532GlnLeu: 3.532 ± 0.032	0.814GlnMet: 0.814 ± 0.016	1.582GlnAsn: 1.582 ± 0.021	2.544GlnPro: 2.544 ± 0.031	2.371GlnGln: 2.371 ± 0.042	2.75GlnArg: 2.75 ± 0.032	3.225GlnSer: 3.225 ± 0.033	2.278GlnThr: 2.278 ± 0.026	2.173GlnVal: 2.173 ± 0.024	0.501GlnTrp: 0.501 ± 0.012	1.13GlnTyr: 1.13 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.691ArgAla: 4.691 ± 0.034	0.695ArgCys: 0.695 ± 0.012	3.487ArgAsp: 3.487 ± 0.035	4.229ArgGlu: 4.229 ± 0.042	2.315ArgPhe: 2.315 ± 0.026	3.817ArgGly: 3.817 ± 0.033	1.653ArgHis: 1.653 ± 0.019	3.134ArgIle: 3.134 ± 0.029	3.705ArgLys: 3.705 ± 0.041	5.835ArgLeu: 5.835 ± 0.045	1.292ArgMet: 1.292 ± 0.017	2.466ArgAsn: 2.466 ± 0.026	3.624ArgPro: 3.624 ± 0.038	2.788ArgGln: 2.788 ± 0.028	5.602ArgArg: 5.602 ± 0.056	5.24ArgSer: 5.24 ± 0.048	3.38ArgThr: 3.38 ± 0.03	3.562ArgVal: 3.562 ± 0.028	0.913ArgTrp: 0.913 ± 0.015	1.731ArgTyr: 1.731 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.689SerAla: 6.689 ± 0.052	0.862SerCys: 0.862 ± 0.019	4.445SerAsp: 4.445 ± 0.041	4.508SerGlu: 4.508 ± 0.039	3.124SerPhe: 3.124 ± 0.026	5.643SerGly: 5.643 ± 0.047	2.082SerHis: 2.082 ± 0.024	4.204SerIle: 4.204 ± 0.034	3.88SerLys: 3.88 ± 0.033	7.776SerLeu: 7.776 ± 0.059	1.664SerMet: 1.664 ± 0.02	3.129SerAsn: 3.129 ± 0.029	5.84SerPro: 5.84 ± 0.06	3.473SerGln: 3.473 ± 0.035	5.537SerArg: 5.537 ± 0.051	9.689SerSer: 9.689 ± 0.107	5.62SerThr: 5.62 ± 0.049	4.944SerVal: 4.944 ± 0.044	1.093SerTrp: 1.093 ± 0.019	2.112SerTyr: 2.112 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.133ThrAla: 5.133 ± 0.042	0.649ThrCys: 0.649 ± 0.012	2.84ThrAsp: 2.84 ± 0.028	3.161ThrGlu: 3.161 ± 0.031	2.131ThrPhe: 2.131 ± 0.025	4.171ThrGly: 4.171 ± 0.036	1.248ThrHis: 1.248 ± 0.019	2.872ThrIle: 2.872 ± 0.031	2.496ThrLys: 2.496 ± 0.027	5.114ThrLeu: 5.114 ± 0.038	1.123ThrMet: 1.123 ± 0.015	1.923ThrAsn: 1.923 ± 0.023	4.159ThrPro: 4.159 ± 0.041	1.943ThrGln: 1.943 ± 0.022	3.125ThrArg: 3.125 ± 0.028	5.282ThrSer: 5.282 ± 0.052	3.977ThrThr: 3.977 ± 0.053	3.867ThrVal: 3.867 ± 0.036	0.769ThrTrp: 0.769 ± 0.013	1.53ThrTyr: 1.53 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.995ValAla: 4.995 ± 0.042	0.811ValCys: 0.811 ± 0.017	3.882ValAsp: 3.882 ± 0.033	3.937ValGlu: 3.937 ± 0.039	2.466ValPhe: 2.466 ± 0.03	3.948ValGly: 3.948 ± 0.035	1.445ValHis: 1.445 ± 0.02	3.054ValIle: 3.054 ± 0.032	2.907ValLys: 2.907 ± 0.031	5.654ValLeu: 5.654 ± 0.041	1.263ValMet: 1.263 ± 0.02	2.316ValAsn: 2.316 ± 0.023	3.724ValPro: 3.724 ± 0.033	2.377ValGln: 2.377 ± 0.025	3.649ValArg: 3.649 ± 0.03	5.032ValSer: 5.032 ± 0.043	3.476ValThr: 3.476 ± 0.033	4.234ValVal: 4.234 ± 0.035	0.832ValTrp: 0.832 ± 0.015	1.747ValTyr: 1.747 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.019TrpAla: 1.019 ± 0.018	0.179TrpCys: 0.179 ± 0.007	0.862TrpAsp: 0.862 ± 0.018	0.843TrpGlu: 0.843 ± 0.016	0.511TrpPhe: 0.511 ± 0.011	0.835TrpGly: 0.835 ± 0.016	0.336TrpHis: 0.336 ± 0.011	0.753TrpIle: 0.753 ± 0.015	0.791TrpLys: 0.791 ± 0.015	1.289TrpLeu: 1.289 ± 0.021	0.349TrpMet: 0.349 ± 0.009	0.625TrpAsn: 0.625 ± 0.013	0.553TrpPro: 0.553 ± 0.012	0.531TrpGln: 0.531 ± 0.012	0.918TrpArg: 0.918 ± 0.018	1.013TrpSer: 1.013 ± 0.018	0.843TrpThr: 0.843 ± 0.016	0.819TrpVal: 0.819 ± 0.015	0.263TrpTrp: 0.263 ± 0.008	0.39TrpTyr: 0.39 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.112TyrAla: 2.112 ± 0.027	0.379TyrCys: 0.379 ± 0.009	1.686TyrAsp: 1.686 ± 0.023	1.557TyrGlu: 1.557 ± 0.021	1.188TyrPhe: 1.188 ± 0.019	2.031TyrGly: 2.031 ± 0.024	0.75TyrHis: 0.75 ± 0.012	1.449TyrIle: 1.449 ± 0.018	1.073TyrLys: 1.073 ± 0.016	2.741TyrLeu: 2.741 ± 0.031	0.593TyrMet: 0.593 ± 0.012	1.074TyrAsn: 1.074 ± 0.017	1.574TyrPro: 1.574 ± 0.022	1.084TyrGln: 1.084 ± 0.018	1.736TyrArg: 1.736 ± 0.019	2.139TyrSer: 2.139 ± 0.026	1.537TyrThr: 1.537 ± 0.021	1.682TyrVal: 1.682 ± 0.023	0.403TyrTrp: 0.403 ± 0.011	0.946TyrTyr: 0.946 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8080 proteins (4068950 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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