Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) (RV-C)

Taxonomy: Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes; Reovirales; Reoviridae; Sedoreovirinae; Rotavirus; Rotavirus C

Average proteome isoelectric point is 6.41

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 11 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    

Protein with the lowest isoelectric point:
>sp|Q91E95|RDRP_ROTHC RNA-directed RNA polymerase OS=Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) OX=31567 PE=3 SV=1
MM1 pKa = 7.33VCTTLYY7 pKa = 8.78TVCAILFILFIYY19 pKa = 10.33ILLFRR24 pKa = 11.84KK25 pKa = 8.46MFHH28 pKa = 7.25LITDD32 pKa = 4.02TLIVILILSNCVEE45 pKa = 4.35WSQGQMFTDD54 pKa = 4.69DD55 pKa = 3.54IYY57 pKa = 11.55YY58 pKa = 10.17NGNVEE63 pKa = 4.41TIINSTDD70 pKa = 3.34PFNVEE75 pKa = 3.85SLCIYY80 pKa = 9.73FPNAVVGSQGPGKK93 pKa = 10.4SDD95 pKa = 2.77GHH97 pKa = 8.08LNDD100 pKa = 3.7GNYY103 pKa = 10.46AQTIATLFEE112 pKa = 4.43TKK114 pKa = 10.21GFPKK118 pKa = 10.58GSIILKK124 pKa = 9.46TYY126 pKa = 7.58TQTSDD131 pKa = 4.08FINSVEE137 pKa = 4.26MTCSYY142 pKa = 10.97NIVIIPDD149 pKa = 3.7SPNDD153 pKa = 3.66SEE155 pKa = 5.39SIEE158 pKa = 4.82QIAEE162 pKa = 3.94WILNVWRR169 pKa = 11.84CDD171 pKa = 3.57DD172 pKa = 4.06MNLEE176 pKa = 4.3IYY178 pKa = 9.64TYY180 pKa = 9.6EE181 pKa = 3.99QIGINNLWAAFGSDD195 pKa = 4.29CDD197 pKa = 4.41ISVCPLDD204 pKa = 3.68TTSNGIGCSPASTEE218 pKa = 4.12TYY220 pKa = 10.02EE221 pKa = 4.47VVSNDD226 pKa = 3.22TQLALINVVDD236 pKa = 4.1NVRR239 pKa = 11.84HH240 pKa = 6.38RR241 pKa = 11.84IQMNTAQCKK250 pKa = 9.81LKK252 pKa = 10.97NCIKK256 pKa = 10.93GEE258 pKa = 3.91ARR260 pKa = 11.84LNTALIRR267 pKa = 11.84ISTSSSFDD275 pKa = 3.34NSLSPLNNGQTTRR288 pKa = 11.84SFKK291 pKa = 10.82INAKK295 pKa = 9.15KK296 pKa = 9.06WWTIFYY302 pKa = 9.29TIIDD306 pKa = 4.45YY307 pKa = 11.08INTIVQAMTPRR318 pKa = 11.84HH319 pKa = 5.18RR320 pKa = 11.84AIYY323 pKa = 9.33PEE325 pKa = 3.79GWMLRR330 pKa = 11.84YY331 pKa = 9.45AA332 pKa = 4.23

Molecular weight:
37.47 kDa
Isoelectric point according different methods:






Protein with the highest isoelectric point:
>sp|Q91E96|VP2_ROTHC Inner capsid protein VP2 OS=Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) OX=31567 PE=3 SV=1
MM1 pKa = 7.11AQSIVVDD8 pKa = 3.94GDD10 pKa = 3.44YY11 pKa = 11.3DD12 pKa = 3.97ALASRR17 pKa = 11.84YY18 pKa = 10.17LKK20 pKa = 10.37FVYY23 pKa = 10.25DD24 pKa = 4.32FEE26 pKa = 4.73NVTYY30 pKa = 10.35QNNYY34 pKa = 9.06FATDD38 pKa = 3.29KK39 pKa = 10.54FKK41 pKa = 11.23KK42 pKa = 10.42DD43 pKa = 2.7IEE45 pKa = 4.37QYY47 pKa = 10.67LKK49 pKa = 10.71SIHH52 pKa = 7.03DD53 pKa = 3.97GEE55 pKa = 5.93KK56 pKa = 8.92ITQSKK61 pKa = 9.92IDD63 pKa = 3.87EE64 pKa = 4.38KK65 pKa = 11.34EE66 pKa = 3.93KK67 pKa = 10.74ILLDD71 pKa = 3.42RR72 pKa = 11.84VPAEE76 pKa = 4.13EE77 pKa = 4.14RR78 pKa = 11.84CLISKK83 pKa = 9.67LVFAYY88 pKa = 9.75GKK90 pKa = 9.95HH91 pKa = 5.52GNVEE95 pKa = 4.13NKK97 pKa = 9.43LVKK100 pKa = 10.85YY101 pKa = 9.66GVKK104 pKa = 10.21DD105 pKa = 3.86ALSHH109 pKa = 7.09APQKK113 pKa = 10.15DD114 pKa = 3.2AKK116 pKa = 9.9PYY118 pKa = 8.58EE119 pKa = 4.17NNIITSEE126 pKa = 3.85IFKK129 pKa = 10.54EE130 pKa = 3.99KK131 pKa = 10.8SEE133 pKa = 4.07YY134 pKa = 9.44TDD136 pKa = 3.28IYY138 pKa = 9.73MDD140 pKa = 4.0PSINTSCQSNCQAMMFTISEE160 pKa = 4.2MKK162 pKa = 10.56LNNIKK167 pKa = 10.44NAARR171 pKa = 11.84LEE173 pKa = 4.0KK174 pKa = 10.67LFTIIAATINKK185 pKa = 9.71YY186 pKa = 10.66GMPRR190 pKa = 11.84HH191 pKa = 4.69NTRR194 pKa = 11.84YY195 pKa = 8.54RR196 pKa = 11.84YY197 pKa = 8.92EE198 pKa = 3.9WEE200 pKa = 3.94TMKK203 pKa = 10.97NKK205 pKa = 9.83PYY207 pKa = 10.77HH208 pKa = 5.31LAAWINSSIEE218 pKa = 3.9MIACVVDD225 pKa = 2.54HH226 pKa = 6.41HH227 pKa = 6.96TYY229 pKa = 9.82MIARR233 pKa = 11.84EE234 pKa = 4.43LIVKK238 pKa = 9.94SFTNRR243 pKa = 11.84TSLAKK248 pKa = 10.32LVSSPMTVLTAMLPIRR264 pKa = 11.84GTFITTEE271 pKa = 3.96NLEE274 pKa = 4.19LEE276 pKa = 4.45YY277 pKa = 11.13SNKK280 pKa = 10.12SINYY284 pKa = 8.98LISKK288 pKa = 9.53EE289 pKa = 3.97MAEE292 pKa = 5.71DD293 pKa = 4.13FMQAIKK299 pKa = 9.93QLRR302 pKa = 11.84DD303 pKa = 3.07EE304 pKa = 4.36GLEE307 pKa = 4.12YY308 pKa = 10.56IPDD311 pKa = 3.87YY312 pKa = 9.78YY313 pKa = 10.88EE314 pKa = 4.07KK315 pKa = 10.09WFKK318 pKa = 11.34SPDD321 pKa = 3.54PLTFPNIALIYY332 pKa = 10.09SFSFHH337 pKa = 6.17VGYY340 pKa = 10.48RR341 pKa = 11.84KK342 pKa = 9.09QALSDD347 pKa = 3.44AVYY350 pKa = 10.62DD351 pKa = 4.08QITVTYY357 pKa = 9.29SDD359 pKa = 3.67NVNMEE364 pKa = 3.9MYY366 pKa = 10.18KK367 pKa = 10.24EE368 pKa = 3.87YY369 pKa = 10.86SEE371 pKa = 5.63RR372 pKa = 11.84IEE374 pKa = 4.64NEE376 pKa = 3.1IFTILKK382 pKa = 10.31DD383 pKa = 4.28KK384 pKa = 10.58IIHH387 pKa = 5.46EE388 pKa = 4.44DD389 pKa = 3.24KK390 pKa = 10.86RR391 pKa = 11.84LEE393 pKa = 4.08EE394 pKa = 4.38YY395 pKa = 10.32EE396 pKa = 4.46LSALLSMSSASNGILRR412 pKa = 11.84EE413 pKa = 4.16INFGGQKK420 pKa = 9.72VRR422 pKa = 11.84STKK425 pKa = 10.96KK426 pKa = 9.83NMHH429 pKa = 6.66VIDD432 pKa = 5.48DD433 pKa = 4.54IYY435 pKa = 10.49HH436 pKa = 6.33KK437 pKa = 10.54KK438 pKa = 8.56YY439 pKa = 7.24TTDD442 pKa = 3.2IPPVDD447 pKa = 3.97ARR449 pKa = 11.84NPIPLGRR456 pKa = 11.84RR457 pKa = 11.84DD458 pKa = 3.43VPGRR462 pKa = 11.84RR463 pKa = 11.84TRR465 pKa = 11.84AIFILPYY472 pKa = 9.96QYY474 pKa = 10.79FIAQHH479 pKa = 5.69SFAEE483 pKa = 4.12IMLNYY488 pKa = 10.12AKK490 pKa = 10.44RR491 pKa = 11.84EE492 pKa = 3.84RR493 pKa = 11.84EE494 pKa = 3.69YY495 pKa = 11.49SEE497 pKa = 5.63FYY499 pKa = 10.85SQANQVLSYY508 pKa = 11.54GDD510 pKa = 3.22VTRR513 pKa = 11.84YY514 pKa = 10.16LDD516 pKa = 3.99SNSILCFTDD525 pKa = 3.64VSQWDD530 pKa = 3.74ASQHH534 pKa = 4.09NTKK537 pKa = 10.07VLRR540 pKa = 11.84RR541 pKa = 11.84SIIRR545 pKa = 11.84AMKK548 pKa = 10.01RR549 pKa = 11.84LKK551 pKa = 10.53QLTHH555 pKa = 6.97NINIHH560 pKa = 5.39KK561 pKa = 10.19AINIYY566 pKa = 9.94IQSQEE571 pKa = 4.01NLEE574 pKa = 4.01NSYY577 pKa = 11.5VLIDD581 pKa = 4.13KK582 pKa = 10.65KK583 pKa = 10.76AIQYY587 pKa = 8.39GATASGEE594 pKa = 4.15KK595 pKa = 7.52QTKK598 pKa = 9.23IMNSIANKK606 pKa = 10.46ALIQTVLGKK615 pKa = 11.04LMTDD619 pKa = 3.18YY620 pKa = 11.04TFDD623 pKa = 3.17VKK625 pKa = 10.38MIRR628 pKa = 11.84VDD630 pKa = 3.5GDD632 pKa = 3.41DD633 pKa = 3.45NYY635 pKa = 11.59AIVRR639 pKa = 11.84FPIAITEE646 pKa = 4.16KK647 pKa = 10.46LLSEE651 pKa = 4.6FTSKK655 pKa = 10.44LRR657 pKa = 11.84SYY659 pKa = 10.12YY660 pKa = 10.58SEE662 pKa = 3.99MNVKK666 pKa = 9.88VKK668 pKa = 10.67ALASLTGCEE677 pKa = 3.38IAKK680 pKa = 10.08RR681 pKa = 11.84YY682 pKa = 8.51VAGGMLFFRR691 pKa = 11.84AGVNILHH698 pKa = 6.39HH699 pKa = 6.33EE700 pKa = 4.14KK701 pKa = 10.58RR702 pKa = 11.84NQDD705 pKa = 2.94SAYY708 pKa = 11.06DD709 pKa = 3.75MAATLYY715 pKa = 11.24ANYY718 pKa = 9.6IVNALRR724 pKa = 11.84GLTMSRR730 pKa = 11.84TFILTKK736 pKa = 9.36ICQMTSIKK744 pKa = 9.37ITGTLRR750 pKa = 11.84LFPMKK755 pKa = 10.44SILALNSAFKK765 pKa = 11.19VFDD768 pKa = 3.56EE769 pKa = 4.01VDD771 pKa = 3.45YY772 pKa = 11.26VINYY776 pKa = 7.54PISNLFIQLQRR787 pKa = 11.84KK788 pKa = 8.93LSSIKK793 pKa = 10.48AKK795 pKa = 10.72SKK797 pKa = 10.22IADD800 pKa = 4.2NIAKK804 pKa = 10.1SPQFKK809 pKa = 10.72SYY811 pKa = 11.54VEE813 pKa = 4.31LLNKK817 pKa = 10.34SLTTDD822 pKa = 3.35EE823 pKa = 4.61NPIVSDD829 pKa = 4.71GIRR832 pKa = 11.84LTEE835 pKa = 3.83KK836 pKa = 10.91AKK838 pKa = 10.75LNSYY842 pKa = 10.86APIALEE848 pKa = 3.65KK849 pKa = 10.79RR850 pKa = 11.84RR851 pKa = 11.84DD852 pKa = 3.54QFSIMVSFLQNPTTFKK868 pKa = 11.02SEE870 pKa = 4.21TVVTINDD877 pKa = 3.21VLYY880 pKa = 10.23FISGFIKK887 pKa = 9.86IDD889 pKa = 3.36SSTVLPKK896 pKa = 10.75EE897 pKa = 4.55EE898 pKa = 4.46NNTMPLLPAIIKK910 pKa = 8.17RR911 pKa = 11.84TLSYY915 pKa = 10.75FGLRR919 pKa = 11.84THH921 pKa = 7.59DD922 pKa = 3.77YY923 pKa = 10.17DD924 pKa = 3.94IKK926 pKa = 10.91GSSSTVSKK934 pKa = 10.41IIKK937 pKa = 9.37QYY939 pKa = 10.99SVYY942 pKa = 10.25TPGIEE947 pKa = 3.87EE948 pKa = 4.76LYY950 pKa = 10.55EE951 pKa = 4.01IVNKK955 pKa = 10.66SVDD958 pKa = 3.57TIRR961 pKa = 11.84GYY963 pKa = 10.03FASFNVPKK971 pKa = 10.55ADD973 pKa = 2.96VDD975 pKa = 4.32TYY977 pKa = 11.27ISTQMYY983 pKa = 8.78KK984 pKa = 10.03HH985 pKa = 6.74DD986 pKa = 4.07RR987 pKa = 11.84FKK989 pKa = 10.84ILQAYY994 pKa = 8.83IYY996 pKa = 10.59NLLSVNYY1003 pKa = 10.43GMYY1006 pKa = 10.44QLVDD1010 pKa = 4.04LNSARR1015 pKa = 11.84FFDD1018 pKa = 4.73HH1019 pKa = 7.35VIHH1022 pKa = 6.49TPMAKK1027 pKa = 9.17TPTAVFMIDD1036 pKa = 2.87LALRR1040 pKa = 11.84LKK1042 pKa = 10.38IINHH1046 pKa = 6.7CIEE1049 pKa = 4.21KK1050 pKa = 10.99GEE1052 pKa = 4.39IITVSVHH1059 pKa = 6.42ANKK1062 pKa = 9.54TDD1064 pKa = 3.68YY1065 pKa = 11.32LKK1067 pKa = 10.7LWRR1070 pKa = 11.84MLWNVKK1076 pKa = 7.82TMNSPYY1082 pKa = 10.41SKK1084 pKa = 11.05NSMFDD1089 pKa = 3.17EE1090 pKa = 4.64

Molecular weight:
125.8 kDa
Isoelectric point according different methods:






Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

11

0

11

5608

150

1090

509.8

58.59

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.314 ± 0.369

1.409 ± 0.457

5.617 ± 0.35

5.599 ± 0.514

4.297 ± 0.221

3.852 ± 0.416

1.819 ± 0.215

8.827 ± 0.326

6.758 ± 0.636

8.06 ± 0.383

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

3.156 ± 0.191

7.614 ± 0.446

2.889 ± 0.288

3.406 ± 0.372

4.494 ± 0.191

8.006 ± 0.571

6.758 ± 0.45

5.76 ± 0.287

1.088 ± 0.208

5.278 ± 0.485

Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski