Amino acid dipepetide frequency for Pseudoalteromonas ruthenica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.554AlaAla: 8.554 ± 0.109	0.965AlaCys: 0.965 ± 0.032	5.125AlaAsp: 5.125 ± 0.081	5.37AlaGlu: 5.37 ± 0.075	3.451AlaPhe: 3.451 ± 0.064	5.953AlaGly: 5.953 ± 0.093	2.409AlaHis: 2.409 ± 0.046	5.953AlaIle: 5.953 ± 0.074	5.315AlaLys: 5.315 ± 0.075	11.743AlaLeu: 11.743 ± 0.136	2.785AlaMet: 2.785 ± 0.05	3.866AlaAsn: 3.866 ± 0.066	3.458AlaPro: 3.458 ± 0.058	6.339AlaGln: 6.339 ± 0.092	4.219AlaArg: 4.219 ± 0.065	5.514AlaSer: 5.514 ± 0.076	4.779AlaThr: 4.779 ± 0.08	6.178AlaVal: 6.178 ± 0.083	1.02AlaTrp: 1.02 ± 0.035	2.705AlaTyr: 2.705 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.08CysAla: 1.08 ± 0.035	0.136CysCys: 0.136 ± 0.012	0.587CysAsp: 0.587 ± 0.023	0.648CysGlu: 0.648 ± 0.027	0.406CysPhe: 0.406 ± 0.019	0.823CysGly: 0.823 ± 0.028	0.349CysHis: 0.349 ± 0.016	0.573CysIle: 0.573 ± 0.023	0.403CysLys: 0.403 ± 0.019	0.897CysLeu: 0.897 ± 0.032	0.207CysMet: 0.207 ± 0.014	0.33CysAsn: 0.33 ± 0.019	0.456CysPro: 0.456 ± 0.023	0.557CysGln: 0.557 ± 0.026	0.439CysArg: 0.439 ± 0.02	0.664CysSer: 0.664 ± 0.021	0.454CysThr: 0.454 ± 0.019	0.652CysVal: 0.652 ± 0.024	0.123CysTrp: 0.123 ± 0.01	0.35CysTyr: 0.35 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.235AspAla: 5.235 ± 0.074	0.496AspCys: 0.496 ± 0.022	3.488AspAsp: 3.488 ± 0.056	4.138AspGlu: 4.138 ± 0.069	2.571AspPhe: 2.571 ± 0.049	3.81AspGly: 3.81 ± 0.074	1.069AspHis: 1.069 ± 0.03	4.193AspIle: 4.193 ± 0.06	3.378AspLys: 3.378 ± 0.059	4.776AspLeu: 4.776 ± 0.07	1.474AspMet: 1.474 ± 0.04	2.833AspAsn: 2.833 ± 0.056	1.982AspPro: 1.982 ± 0.045	1.738AspGln: 1.738 ± 0.044	1.831AspArg: 1.831 ± 0.042	3.521AspSer: 3.521 ± 0.061	2.929AspThr: 2.929 ± 0.058	3.961AspVal: 3.961 ± 0.075	0.774AspTrp: 0.774 ± 0.025	2.409AspTyr: 2.409 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.902GluAla: 4.902 ± 0.064	0.431GluCys: 0.431 ± 0.02	2.605GluAsp: 2.605 ± 0.054	3.062GluGlu: 3.062 ± 0.071	2.484GluPhe: 2.484 ± 0.053	3.38GluGly: 3.38 ± 0.062	2.073GluHis: 2.073 ± 0.044	3.131GluIle: 3.131 ± 0.068	3.005GluLys: 3.005 ± 0.061	7.541GluLeu: 7.541 ± 0.096	1.332GluMet: 1.332 ± 0.038	2.179GluAsn: 2.179 ± 0.045	2.183GluPro: 2.183 ± 0.048	6.191GluGln: 6.191 ± 0.098	3.751GluArg: 3.751 ± 0.071	3.075GluSer: 3.075 ± 0.06	2.398GluThr: 2.398 ± 0.05	4.357GluVal: 4.357 ± 0.064	0.503GluTrp: 0.503 ± 0.021	1.758GluTyr: 1.758 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	4.372PheAla: 4.372 ± 0.071	0.511PheCys: 0.511 ± 0.023	2.943PheAsp: 2.943 ± 0.055	2.385PheGlu: 2.385 ± 0.049	1.612PhePhe: 1.612 ± 0.043	2.774PheGly: 2.774 ± 0.059	0.766PheHis: 0.766 ± 0.027	2.676PheIle: 2.676 ± 0.052	1.87PheLys: 1.87 ± 0.042	2.965PheLeu: 2.965 ± 0.063	1.0PheMet: 1.0 ± 0.031	2.138PheAsn: 2.138 ± 0.043	1.194PhePro: 1.194 ± 0.037	1.046PheGln: 1.046 ± 0.031	1.431PheArg: 1.431 ± 0.039	3.25PheSer: 3.25 ± 0.051	2.397PheThr: 2.397 ± 0.045	2.755PheVal: 2.755 ± 0.055	0.512PheTrp: 0.512 ± 0.021	1.484PheTyr: 1.484 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.875GlyAla: 5.875 ± 0.087	0.833GlyCys: 0.833 ± 0.028	3.982GlyAsp: 3.982 ± 0.076	4.698GlyGlu: 4.698 ± 0.065	3.258GlyPhe: 3.258 ± 0.058	4.602GlyGly: 4.602 ± 0.08	1.625GlyHis: 1.625 ± 0.042	3.942GlyIle: 3.942 ± 0.061	3.383GlyLys: 3.383 ± 0.058	6.685GlyLeu: 6.685 ± 0.08	1.755GlyMet: 1.755 ± 0.047	2.402GlyAsn: 2.402 ± 0.051	1.798GlyPro: 1.798 ± 0.044	3.19GlyGln: 3.19 ± 0.06	3.096GlyArg: 3.096 ± 0.055	3.895GlySer: 3.895 ± 0.062	3.246GlyThr: 3.246 ± 0.054	5.137GlyVal: 5.137 ± 0.072	0.877GlyTrp: 0.877 ± 0.028	2.61GlyTyr: 2.61 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.962HisAla: 1.962 ± 0.042	0.404HisCys: 0.404 ± 0.022	1.229HisAsp: 1.229 ± 0.032	1.209HisGlu: 1.209 ± 0.033	1.256HisPhe: 1.256 ± 0.034	1.738HisGly: 1.738 ± 0.042	0.868HisHis: 0.868 ± 0.03	1.607HisIle: 1.607 ± 0.042	1.069HisLys: 1.069 ± 0.034	2.441HisLeu: 2.441 ± 0.051	0.538HisMet: 0.538 ± 0.023	0.976HisAsn: 0.976 ± 0.029	1.22HisPro: 1.22 ± 0.03	1.527HisGln: 1.527 ± 0.038	1.148HisArg: 1.148 ± 0.036	1.799HisSer: 1.799 ± 0.044	1.252HisThr: 1.252 ± 0.029	1.413HisVal: 1.413 ± 0.031	0.447HisTrp: 0.447 ± 0.021	1.152HisTyr: 1.152 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.54IleAla: 6.54 ± 0.087	0.605IleCys: 0.605 ± 0.024	4.271IleAsp: 4.271 ± 0.062	4.218IleGlu: 4.218 ± 0.059	1.925IlePhe: 1.925 ± 0.045	4.072IleGly: 4.072 ± 0.067	1.186IleHis: 1.186 ± 0.031	2.996IleIle: 2.996 ± 0.059	2.93IleLys: 2.93 ± 0.058	4.303IleLeu: 4.303 ± 0.077	1.133IleMet: 1.133 ± 0.034	2.952IleAsn: 2.952 ± 0.044	2.085IlePro: 2.085 ± 0.039	1.73IleGln: 1.73 ± 0.042	2.632IleArg: 2.632 ± 0.052	4.056IleSer: 4.056 ± 0.063	3.427IleThr: 3.427 ± 0.058	3.623IleVal: 3.623 ± 0.062	0.559IleTrp: 0.559 ± 0.022	1.581IleTyr: 1.581 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.879LysAla: 4.879 ± 0.081	0.299LysCys: 0.299 ± 0.019	2.524LysAsp: 2.524 ± 0.051	3.209LysGlu: 3.209 ± 0.068	1.307LysPhe: 1.307 ± 0.035	3.035LysGly: 3.035 ± 0.057	1.33LysHis: 1.33 ± 0.04	2.212LysIle: 2.212 ± 0.047	2.56LysLys: 2.56 ± 0.062	4.951LysLeu: 4.951 ± 0.078	1.097LysMet: 1.097 ± 0.029	1.772LysAsn: 1.772 ± 0.039	2.11LysPro: 2.11 ± 0.046	3.019LysGln: 3.019 ± 0.06	2.918LysArg: 2.918 ± 0.056	2.656LysSer: 2.656 ± 0.047	2.491LysThr: 2.491 ± 0.056	3.697LysVal: 3.697 ± 0.066	0.489LysTrp: 0.489 ± 0.019	1.279LysTyr: 1.279 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	11.453LeuAla: 11.453 ± 0.123	1.204LeuCys: 1.204 ± 0.036	5.945LeuAsp: 5.945 ± 0.088	5.904LeuGlu: 5.904 ± 0.076	4.056LeuPhe: 4.056 ± 0.068	7.048LeuGly: 7.048 ± 0.097	2.362LeuHis: 2.362 ± 0.051	5.624LeuIle: 5.624 ± 0.082	5.044LeuLys: 5.044 ± 0.073	10.717LeuLeu: 10.717 ± 0.15	2.495LeuMet: 2.495 ± 0.043	4.42LeuAsn: 4.42 ± 0.06	4.49LeuPro: 4.49 ± 0.067	4.53LeuGln: 4.53 ± 0.073	4.814LeuArg: 4.814 ± 0.069	8.058LeuSer: 8.058 ± 0.096	5.752LeuThr: 5.752 ± 0.079	7.053LeuVal: 7.053 ± 0.092	1.094LeuTrp: 1.094 ± 0.034	2.983LeuTyr: 2.983 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.609MetAla: 2.609 ± 0.052	0.197MetCys: 0.197 ± 0.014	1.17MetAsp: 1.17 ± 0.033	1.055MetGlu: 1.055 ± 0.033	0.814MetPhe: 0.814 ± 0.03	1.542MetGly: 1.542 ± 0.037	0.582MetHis: 0.582 ± 0.022	1.179MetIle: 1.179 ± 0.035	1.206MetLys: 1.206 ± 0.033	2.627MetLeu: 2.627 ± 0.052	0.648MetMet: 0.648 ± 0.025	0.952MetAsn: 0.952 ± 0.03	1.168MetPro: 1.168 ± 0.033	1.37MetGln: 1.37 ± 0.036	1.331MetArg: 1.331 ± 0.033	1.808MetSer: 1.808 ± 0.042	1.407MetThr: 1.407 ± 0.033	1.647MetVal: 1.647 ± 0.039	0.223MetTrp: 0.223 ± 0.015	0.514MetTyr: 0.514 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.682AsnAla: 3.682 ± 0.059	0.376AsnCys: 0.376 ± 0.018	2.38AsnAsp: 2.38 ± 0.051	2.529AsnGlu: 2.529 ± 0.048	1.44AsnPhe: 1.44 ± 0.032	2.768AsnGly: 2.768 ± 0.054	0.934AsnHis: 0.934 ± 0.029	2.409AsnIle: 2.409 ± 0.049	2.02AsnLys: 2.02 ± 0.038	3.713AsnLeu: 3.713 ± 0.061	0.939AsnMet: 0.939 ± 0.028	1.924AsnAsn: 1.924 ± 0.051	1.946AsnPro: 1.946 ± 0.044	1.986AsnGln: 1.986 ± 0.045	1.82AsnArg: 1.82 ± 0.043	2.37AsnSer: 2.37 ± 0.052	2.385AsnThr: 2.385 ± 0.044	2.527AsnVal: 2.527 ± 0.053	0.57AsnTrp: 0.57 ± 0.026	1.464AsnTyr: 1.464 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.25ProAla: 3.25 ± 0.063	0.34ProCys: 0.34 ± 0.017	2.167ProAsp: 2.167 ± 0.043	2.866ProGlu: 2.866 ± 0.054	1.583ProPhe: 1.583 ± 0.038	2.546ProGly: 2.546 ± 0.057	0.918ProHis: 0.918 ± 0.029	2.125ProIle: 2.125 ± 0.049	1.82ProLys: 1.82 ± 0.039	4.22ProLeu: 4.22 ± 0.065	0.984ProMet: 0.984 ± 0.034	1.433ProAsn: 1.433 ± 0.036	1.169ProPro: 1.169 ± 0.036	2.162ProGln: 2.162 ± 0.049	1.436ProArg: 1.436 ± 0.037	2.674ProSer: 2.674 ± 0.053	1.915ProThr: 1.915 ± 0.043	2.855ProVal: 2.855 ± 0.059	0.566ProTrp: 0.566 ± 0.027	1.356ProTyr: 1.356 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.619GlnAla: 5.619 ± 0.089	0.6GlnCys: 0.6 ± 0.024	2.323GlnAsp: 2.323 ± 0.053	2.519GlnGlu: 2.519 ± 0.058	2.045GlnPhe: 2.045 ± 0.046	4.356GlnGly: 4.356 ± 0.075	1.7GlnHis: 1.7 ± 0.048	2.29GlnIle: 2.29 ± 0.049	2.006GlnLys: 2.006 ± 0.045	6.736GlnLeu: 6.736 ± 0.106	1.111GlnMet: 1.111 ± 0.029	1.504GlnAsn: 1.504 ± 0.039	2.136GlnPro: 2.136 ± 0.048	5.418GlnGln: 5.418 ± 0.125	3.196GlnArg: 3.196 ± 0.058	3.551GlnSer: 3.551 ± 0.07	2.267GlnThr: 2.267 ± 0.04	3.93GlnVal: 3.93 ± 0.063	0.985GlnTrp: 0.985 ± 0.031	1.595GlnTyr: 1.595 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	4.144ArgAla: 4.144 ± 0.056	0.455ArgCys: 0.455 ± 0.02	2.604ArgAsp: 2.604 ± 0.051	2.938ArgGlu: 2.938 ± 0.053	2.44ArgPhe: 2.44 ± 0.041	2.753ArgGly: 2.753 ± 0.05	1.291ArgHis: 1.291 ± 0.034	3.067ArgIle: 3.067 ± 0.055	2.112ArgLys: 2.112 ± 0.056	5.254ArgLeu: 5.254 ± 0.072	1.135ArgMet: 1.135 ± 0.035	1.732ArgAsn: 1.732 ± 0.036	1.681ArgPro: 1.681 ± 0.043	2.654ArgGln: 2.654 ± 0.052	2.47ArgArg: 2.47 ± 0.058	2.769ArgSer: 2.769 ± 0.05	2.168ArgThr: 2.168 ± 0.049	3.325ArgVal: 3.325 ± 0.055	0.646ArgTrp: 0.646 ± 0.022	2.005ArgTyr: 2.005 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.617SerAla: 6.617 ± 0.082	0.607SerCys: 0.607 ± 0.026	3.885SerAsp: 3.885 ± 0.067	4.251SerGlu: 4.251 ± 0.067	2.637SerPhe: 2.637 ± 0.043	4.881SerGly: 4.881 ± 0.081	1.636SerHis: 1.636 ± 0.037	3.387SerIle: 3.387 ± 0.061	2.844SerLys: 2.844 ± 0.048	6.583SerLeu: 6.583 ± 0.092	1.575SerMet: 1.575 ± 0.04	2.394SerAsn: 2.394 ± 0.046	2.257SerPro: 2.257 ± 0.044	3.385SerGln: 3.385 ± 0.058	2.836SerArg: 2.836 ± 0.06	4.177SerSer: 4.177 ± 0.077	3.128SerThr: 3.128 ± 0.048	4.425SerVal: 4.425 ± 0.065	0.76SerTrp: 0.76 ± 0.025	2.149SerTyr: 2.149 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.531ThrAla: 4.531 ± 0.071	0.432ThrCys: 0.432 ± 0.022	2.755ThrAsp: 2.755 ± 0.057	2.858ThrGlu: 2.858 ± 0.055	1.988ThrPhe: 1.988 ± 0.048	3.574ThrGly: 3.574 ± 0.056	1.274ThrHis: 1.274 ± 0.035	2.85ThrIle: 2.85 ± 0.056	2.026ThrLys: 2.026 ± 0.048	6.728ThrLeu: 6.728 ± 0.085	1.056ThrMet: 1.056 ± 0.029	1.849ThrAsn: 1.849 ± 0.04	2.646ThrPro: 2.646 ± 0.055	2.719ThrGln: 2.719 ± 0.049	2.31ThrArg: 2.31 ± 0.044	2.968ThrSer: 2.968 ± 0.056	2.707ThrThr: 2.707 ± 0.051	3.582ThrVal: 3.582 ± 0.066	0.627ThrTrp: 0.627 ± 0.024	1.472ThrTyr: 1.472 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	6.935ValAla: 6.935 ± 0.095	0.734ValCys: 0.734 ± 0.025	4.26ValAsp: 4.26 ± 0.062	4.374ValGlu: 4.374 ± 0.071	2.765ValPhe: 2.765 ± 0.049	4.344ValGly: 4.344 ± 0.066	1.481ValHis: 1.481 ± 0.04	4.418ValIle: 4.418 ± 0.068	3.248ValLys: 3.248 ± 0.064	6.945ValLeu: 6.945 ± 0.084	1.826ValMet: 1.826 ± 0.042	2.973ValAsn: 2.973 ± 0.047	2.512ValPro: 2.512 ± 0.054	2.682ValGln: 2.682 ± 0.046	3.216ValArg: 3.216 ± 0.053	4.783ValSer: 4.783 ± 0.081	3.833ValThr: 3.833 ± 0.06	5.238ValVal: 5.238 ± 0.083	0.695ValTrp: 0.695 ± 0.027	1.992ValTyr: 1.992 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.823TrpAla: 0.823 ± 0.03	0.119TrpCys: 0.119 ± 0.01	0.525TrpAsp: 0.525 ± 0.026	0.399TrpGlu: 0.399 ± 0.022	0.545TrpPhe: 0.545 ± 0.022	0.727TrpGly: 0.727 ± 0.03	0.473TrpHis: 0.473 ± 0.02	0.488TrpIle: 0.488 ± 0.021	0.295TrpLys: 0.295 ± 0.017	1.826TrpLeu: 1.826 ± 0.05	0.301TrpMet: 0.301 ± 0.017	0.337TrpAsn: 0.337 ± 0.017	0.543TrpPro: 0.543 ± 0.022	1.461TrpGln: 1.461 ± 0.042	0.788TrpArg: 0.788 ± 0.025	0.654TrpSer: 0.654 ± 0.022	0.41TrpThr: 0.41 ± 0.018	0.842TrpVal: 0.842 ± 0.027	0.199TrpTrp: 0.199 ± 0.013	0.377TrpTyr: 0.377 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.636TyrAla: 2.636 ± 0.052	0.389TyrCys: 0.389 ± 0.021	1.841TyrAsp: 1.841 ± 0.051	1.712TyrGlu: 1.712 ± 0.044	1.497TyrPhe: 1.497 ± 0.033	2.163TyrGly: 2.163 ± 0.047	0.927TyrHis: 0.927 ± 0.029	1.702TyrIle: 1.702 ± 0.038	1.3TyrLys: 1.3 ± 0.033	3.395TyrLeu: 3.395 ± 0.062	0.661TyrMet: 0.661 ± 0.024	1.214TyrAsn: 1.214 ± 0.037	1.352TyrPro: 1.352 ± 0.033	2.185TyrGln: 2.185 ± 0.043	1.964TyrArg: 1.964 ± 0.047	2.166TyrSer: 2.166 ± 0.05	1.606TyrThr: 1.606 ± 0.04	2.058TyrVal: 2.058 ± 0.046	0.465TyrTrp: 0.465 ± 0.02	1.162TyrTyr: 1.162 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3470 proteins (1147547 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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