Amino acid dipepetide frequency for Marivivens niveibacter

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.538AlaAla: 14.538 ± 0.194	0.941AlaCys: 0.941 ± 0.035	7.339AlaAsp: 7.339 ± 0.104	7.539AlaGlu: 7.539 ± 0.126	4.042AlaPhe: 4.042 ± 0.069	9.322AlaGly: 9.322 ± 0.115	1.971AlaHis: 1.971 ± 0.048	6.582AlaIle: 6.582 ± 0.093	4.355AlaLys: 4.355 ± 0.087	11.299AlaLeu: 11.299 ± 0.133	3.704AlaMet: 3.704 ± 0.072	3.381AlaAsn: 3.381 ± 0.067	4.877AlaPro: 4.877 ± 0.094	4.161AlaGln: 4.161 ± 0.083	6.426AlaArg: 6.426 ± 0.088	5.434AlaSer: 5.434 ± 0.092	6.038AlaThr: 6.038 ± 0.116	8.041AlaVal: 8.041 ± 0.114	1.227AlaTrp: 1.227 ± 0.037	2.508AlaTyr: 2.508 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.044CysAla: 1.044 ± 0.036	0.103CysCys: 0.103 ± 0.011	0.707CysAsp: 0.707 ± 0.029	0.453CysGlu: 0.453 ± 0.021	0.341CysPhe: 0.341 ± 0.017	0.926CysGly: 0.926 ± 0.034	0.267CysHis: 0.267 ± 0.018	0.481CysIle: 0.481 ± 0.024	0.253CysLys: 0.253 ± 0.015	0.728CysLeu: 0.728 ± 0.028	0.19CysMet: 0.19 ± 0.014	0.228CysAsn: 0.228 ± 0.015	0.479CysPro: 0.479 ± 0.026	0.245CysGln: 0.245 ± 0.019	0.506CysArg: 0.506 ± 0.027	0.474CysSer: 0.474 ± 0.027	0.49CysThr: 0.49 ± 0.027	0.65CysVal: 0.65 ± 0.025	0.103CysTrp: 0.103 ± 0.013	0.239CysTyr: 0.239 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.696AspAla: 7.696 ± 0.116	0.589AspCys: 0.589 ± 0.026	4.382AspAsp: 4.382 ± 0.101	3.86AspGlu: 3.86 ± 0.074	2.508AspPhe: 2.508 ± 0.059	5.77AspGly: 5.77 ± 0.094	1.485AspHis: 1.485 ± 0.044	3.819AspIle: 3.819 ± 0.073	2.066AspLys: 2.066 ± 0.048	6.608AspLeu: 6.608 ± 0.093	1.95AspMet: 1.95 ± 0.048	1.663AspAsn: 1.663 ± 0.045	3.435AspPro: 3.435 ± 0.069	2.402AspGln: 2.402 ± 0.052	4.122AspArg: 4.122 ± 0.08	2.393AspSer: 2.393 ± 0.056	3.52AspThr: 3.52 ± 0.087	4.856AspVal: 4.856 ± 0.087	1.156AspTrp: 1.156 ± 0.038	1.774AspTyr: 1.774 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.363GluAla: 6.363 ± 0.114	0.414GluCys: 0.414 ± 0.019	3.167GluAsp: 3.167 ± 0.071	3.356GluGlu: 3.356 ± 0.093	2.209GluPhe: 2.209 ± 0.051	4.022GluGly: 4.022 ± 0.072	1.205GluHis: 1.205 ± 0.036	3.851GluIle: 3.851 ± 0.054	2.58GluLys: 2.58 ± 0.062	5.497GluLeu: 5.497 ± 0.088	1.956GluMet: 1.956 ± 0.045	2.41GluAsn: 2.41 ± 0.055	2.422GluPro: 2.422 ± 0.067	2.325GluGln: 2.325 ± 0.064	3.688GluArg: 3.688 ± 0.08	2.228GluSer: 2.228 ± 0.056	4.208GluThr: 4.208 ± 0.071	3.97GluVal: 3.97 ± 0.077	0.842GluTrp: 0.842 ± 0.03	1.263GluTyr: 1.263 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	4.406PheAla: 4.406 ± 0.067	0.415PheCys: 0.415 ± 0.019	3.237PheAsp: 3.237 ± 0.066	2.343PheGlu: 2.343 ± 0.052	1.501PhePhe: 1.501 ± 0.044	3.854PheGly: 3.854 ± 0.057	0.718PheHis: 0.718 ± 0.032	2.037PheIle: 2.037 ± 0.056	1.182PheLys: 1.182 ± 0.031	3.178PheLeu: 3.178 ± 0.075	0.998PheMet: 0.998 ± 0.03	1.209PheAsn: 1.209 ± 0.043	1.485PhePro: 1.485 ± 0.042	1.071PheGln: 1.071 ± 0.041	1.933PheArg: 1.933 ± 0.05	2.198PheSer: 2.198 ± 0.055	2.195PheThr: 2.195 ± 0.047	2.865PheVal: 2.865 ± 0.058	0.559PheTrp: 0.559 ± 0.027	1.029PheTyr: 1.029 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	8.825GlyAla: 8.825 ± 0.109	0.838GlyCys: 0.838 ± 0.036	5.096GlyAsp: 5.096 ± 0.093	4.525GlyGlu: 4.525 ± 0.074	3.515GlyPhe: 3.515 ± 0.065	6.734GlyGly: 6.734 ± 0.102	1.744GlyHis: 1.744 ± 0.048	4.877GlyIle: 4.877 ± 0.08	3.339GlyLys: 3.339 ± 0.071	7.874GlyLeu: 7.874 ± 0.116	2.601GlyMet: 2.601 ± 0.058	2.406GlyAsn: 2.406 ± 0.084	3.17GlyPro: 3.17 ± 0.055	3.08GlyGln: 3.08 ± 0.06	4.817GlyArg: 4.817 ± 0.082	4.19GlySer: 4.19 ± 0.061	4.612GlyThr: 4.612 ± 0.094	6.297GlyVal: 6.297 ± 0.088	1.252GlyTrp: 1.252 ± 0.036	2.404GlyTyr: 2.404 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.952HisAla: 1.952 ± 0.043	0.237HisCys: 0.237 ± 0.017	1.353HisAsp: 1.353 ± 0.045	0.994HisGlu: 0.994 ± 0.031	0.822HisPhe: 0.822 ± 0.031	1.706HisGly: 1.706 ± 0.049	0.517HisHis: 0.517 ± 0.028	1.055HisIle: 1.055 ± 0.041	0.601HisLys: 0.601 ± 0.026	1.898HisLeu: 1.898 ± 0.047	0.605HisMet: 0.605 ± 0.028	0.578HisAsn: 0.578 ± 0.024	1.256HisPro: 1.256 ± 0.041	0.625HisGln: 0.625 ± 0.026	1.108HisArg: 1.108 ± 0.037	0.996HisSer: 0.996 ± 0.034	0.855HisThr: 0.855 ± 0.033	1.457HisVal: 1.457 ± 0.043	0.32HisTrp: 0.32 ± 0.018	0.569HisTyr: 0.569 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.823IleAla: 7.823 ± 0.097	0.692IleCys: 0.692 ± 0.024	4.44IleAsp: 4.44 ± 0.076	4.14IleGlu: 4.14 ± 0.07	1.976IlePhe: 1.976 ± 0.043	5.252IleGly: 5.252 ± 0.087	1.046IleHis: 1.046 ± 0.034	3.041IleIle: 3.041 ± 0.063	1.986IleLys: 1.986 ± 0.042	5.074IleLeu: 5.074 ± 0.086	1.446IleMet: 1.446 ± 0.042	1.903IleAsn: 1.903 ± 0.05	2.617IlePro: 2.617 ± 0.046	1.595IleGln: 1.595 ± 0.039	3.234IleArg: 3.234 ± 0.059	3.437IleSer: 3.437 ± 0.067	3.5IleThr: 3.5 ± 0.074	4.527IleVal: 4.527 ± 0.075	0.796IleTrp: 0.796 ± 0.03	1.399IleTyr: 1.399 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	3.728LysAla: 3.728 ± 0.079	0.246LysCys: 0.246 ± 0.016	2.068LysAsp: 2.068 ± 0.054	1.859LysGlu: 1.859 ± 0.054	1.256LysPhe: 1.256 ± 0.041	2.875LysGly: 2.875 ± 0.062	0.686LysHis: 0.686 ± 0.03	2.149LysIle: 2.149 ± 0.051	1.507LysLys: 1.507 ± 0.054	3.364LysLeu: 3.364 ± 0.067	1.133LysMet: 1.133 ± 0.039	1.157LysAsn: 1.157 ± 0.04	1.938LysPro: 1.938 ± 0.051	1.179LysGln: 1.179 ± 0.038	2.37LysArg: 2.37 ± 0.06	2.495LysSer: 2.495 ± 0.06	2.31LysThr: 2.31 ± 0.044	2.512LysVal: 2.512 ± 0.057	0.493LysTrp: 0.493 ± 0.023	0.804LysTyr: 0.804 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	10.435LeuAla: 10.435 ± 0.116	0.866LeuCys: 0.866 ± 0.033	5.785LeuAsp: 5.785 ± 0.085	4.862LeuGlu: 4.862 ± 0.091	3.606LeuPhe: 3.606 ± 0.072	7.457LeuGly: 7.457 ± 0.103	1.673LeuHis: 1.673 ± 0.043	5.657LeuIle: 5.657 ± 0.085	3.297LeuLys: 3.297 ± 0.066	7.661LeuLeu: 7.661 ± 0.127	2.72LeuMet: 2.72 ± 0.066	3.217LeuAsn: 3.217 ± 0.059	4.816LeuPro: 4.816 ± 0.084	2.706LeuGln: 2.706 ± 0.05	6.064LeuArg: 6.064 ± 0.094	6.679LeuSer: 6.679 ± 0.094	6.083LeuThr: 6.083 ± 0.098	6.187LeuVal: 6.187 ± 0.09	1.147LeuTrp: 1.147 ± 0.035	1.963LeuTyr: 1.963 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.446MetAla: 3.446 ± 0.065	0.228MetCys: 0.228 ± 0.015	1.765MetAsp: 1.765 ± 0.043	1.379MetGlu: 1.379 ± 0.04	0.972MetPhe: 0.972 ± 0.03	2.445MetGly: 2.445 ± 0.054	0.486MetHis: 0.486 ± 0.024	1.852MetIle: 1.852 ± 0.05	1.237MetLys: 1.237 ± 0.035	2.513MetLeu: 2.513 ± 0.052	0.85MetMet: 0.85 ± 0.03	1.023MetAsn: 1.023 ± 0.036	1.502MetPro: 1.502 ± 0.044	1.053MetGln: 1.053 ± 0.032	1.833MetArg: 1.833 ± 0.05	1.898MetSer: 1.898 ± 0.049	2.373MetThr: 2.373 ± 0.05	2.072MetVal: 2.072 ± 0.048	0.306MetTrp: 0.306 ± 0.017	0.424MetTyr: 0.424 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.844AsnAla: 3.844 ± 0.069	0.318AsnCys: 0.318 ± 0.015	2.183AsnAsp: 2.183 ± 0.065	1.576AsnGlu: 1.576 ± 0.041	1.171AsnPhe: 1.171 ± 0.036	3.16AsnGly: 3.16 ± 0.066	0.62AsnHis: 0.62 ± 0.027	1.869AsnIle: 1.869 ± 0.05	0.908AsnLys: 0.908 ± 0.031	2.962AsnLeu: 2.962 ± 0.059	0.902AsnMet: 0.902 ± 0.031	0.893AsnAsn: 0.893 ± 0.039	2.041AsnPro: 2.041 ± 0.044	0.925AsnGln: 0.925 ± 0.03	1.902AsnArg: 1.902 ± 0.043	1.56AsnSer: 1.56 ± 0.045	1.655AsnThr: 1.655 ± 0.059	2.34AsnVal: 2.34 ± 0.06	0.532AsnTrp: 0.532 ± 0.023	0.836AsnTyr: 0.836 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.849ProAla: 4.849 ± 0.095	0.331ProCys: 0.331 ± 0.02	3.638ProAsp: 3.638 ± 0.066	3.598ProGlu: 3.598 ± 0.067	1.858ProPhe: 1.858 ± 0.044	2.864ProGly: 2.864 ± 0.058	0.953ProHis: 0.953 ± 0.037	2.835ProIle: 2.835 ± 0.059	1.846ProLys: 1.846 ± 0.05	4.056ProLeu: 4.056 ± 0.066	1.296ProMet: 1.296 ± 0.033	1.779ProAsn: 1.779 ± 0.046	1.64ProPro: 1.64 ± 0.049	1.608ProGln: 1.608 ± 0.041	2.244ProArg: 2.244 ± 0.053	2.587ProSer: 2.587 ± 0.055	2.762ProThr: 2.762 ± 0.055	3.932ProVal: 3.932 ± 0.067	0.568ProTrp: 0.568 ± 0.027	1.201ProTyr: 1.201 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.666GlnAla: 3.666 ± 0.066	0.219GlnCys: 0.219 ± 0.017	1.728GlnAsp: 1.728 ± 0.048	1.583GlnGlu: 1.583 ± 0.049	1.335GlnPhe: 1.335 ± 0.038	2.526GlnGly: 2.526 ± 0.051	0.61GlnHis: 0.61 ± 0.027	2.478GlnIle: 2.478 ± 0.055	1.254GlnLys: 1.254 ± 0.039	3.063GlnLeu: 3.063 ± 0.059	1.223GlnMet: 1.223 ± 0.037	1.186GlnAsn: 1.186 ± 0.035	1.426GlnPro: 1.426 ± 0.044	1.13GlnGln: 1.13 ± 0.038	2.031GlnArg: 2.031 ± 0.047	2.353GlnSer: 2.353 ± 0.048	2.186GlnThr: 2.186 ± 0.048	2.397GlnVal: 2.397 ± 0.053	0.404GlnTrp: 0.404 ± 0.017	0.695GlnTyr: 0.695 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.426ArgAla: 6.426 ± 0.085	0.424ArgCys: 0.424 ± 0.021	4.031ArgAsp: 4.031 ± 0.062	3.402ArgGlu: 3.402 ± 0.073	2.356ArgPhe: 2.356 ± 0.055	3.964ArgGly: 3.964 ± 0.074	1.222ArgHis: 1.222 ± 0.034	3.69ArgIle: 3.69 ± 0.07	2.382ArgLys: 2.382 ± 0.055	5.948ArgLeu: 5.948 ± 0.089	1.9ArgMet: 1.9 ± 0.043	1.904ArgAsn: 1.904 ± 0.048	2.715ArgPro: 2.715 ± 0.054	2.151ArgGln: 2.151 ± 0.057	3.864ArgArg: 3.864 ± 0.082	3.13ArgSer: 3.13 ± 0.055	2.773ArgThr: 2.773 ± 0.06	4.167ArgVal: 4.167 ± 0.068	0.778ArgTrp: 0.778 ± 0.03	1.446ArgTyr: 1.446 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.044SerAla: 6.044 ± 0.1	0.462SerCys: 0.462 ± 0.027	3.728SerAsp: 3.728 ± 0.07	2.885SerGlu: 2.885 ± 0.064	2.306SerPhe: 2.306 ± 0.045	5.371SerGly: 5.371 ± 0.084	1.088SerHis: 1.088 ± 0.039	3.194SerIle: 3.194 ± 0.055	1.846SerLys: 1.846 ± 0.055	4.786SerLeu: 4.786 ± 0.076	1.615SerMet: 1.615 ± 0.047	1.821SerAsn: 1.821 ± 0.045	2.446SerPro: 2.446 ± 0.05	1.791SerGln: 1.791 ± 0.045	3.07SerArg: 3.07 ± 0.053	2.756SerSer: 2.756 ± 0.068	2.866SerThr: 2.866 ± 0.062	4.201SerVal: 4.201 ± 0.077	0.625SerTrp: 0.625 ± 0.026	1.421SerTyr: 1.421 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.714ThrAla: 6.714 ± 0.133	0.531ThrCys: 0.531 ± 0.032	3.917ThrAsp: 3.917 ± 0.069	3.286ThrGlu: 3.286 ± 0.066	2.194ThrPhe: 2.194 ± 0.054	5.258ThrGly: 5.258 ± 0.094	1.148ThrHis: 1.148 ± 0.041	3.617ThrIle: 3.617 ± 0.075	1.821ThrLys: 1.821 ± 0.049	5.715ThrLeu: 5.715 ± 0.109	1.349ThrMet: 1.349 ± 0.045	1.799ThrAsn: 1.799 ± 0.059	3.244ThrPro: 3.244 ± 0.062	1.843ThrGln: 1.843 ± 0.048	3.093ThrArg: 3.093 ± 0.056	2.97ThrSer: 2.97 ± 0.065	3.146ThrThr: 3.146 ± 0.078	4.84ThrVal: 4.84 ± 0.1	0.639ThrTrp: 0.639 ± 0.029	1.466ThrTyr: 1.466 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	8.112ValAla: 8.112 ± 0.118	0.678ValCys: 0.678 ± 0.026	4.755ValAsp: 4.755 ± 0.074	4.395ValGlu: 4.395 ± 0.075	2.827ValPhe: 2.827 ± 0.053	5.541ValGly: 5.541 ± 0.081	1.256ValHis: 1.256 ± 0.037	4.831ValIle: 4.831 ± 0.072	2.489ValLys: 2.489 ± 0.056	6.999ValLeu: 6.999 ± 0.09	2.223ValMet: 2.223 ± 0.054	2.371ValAsn: 2.371 ± 0.056	3.26ValPro: 3.26 ± 0.052	2.31ValGln: 2.31 ± 0.047	3.998ValArg: 3.998 ± 0.063	4.412ValSer: 4.412 ± 0.084	4.948ValThr: 4.948 ± 0.128	5.684ValVal: 5.684 ± 0.088	0.955ValTrp: 0.955 ± 0.034	1.637ValTyr: 1.637 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	1.322TrpAla: 1.322 ± 0.037	0.123TrpCys: 0.123 ± 0.009	0.856TrpAsp: 0.856 ± 0.035	0.6TrpGlu: 0.6 ± 0.025	0.563TrpPhe: 0.563 ± 0.025	0.939TrpGly: 0.939 ± 0.037	0.298TrpHis: 0.298 ± 0.019	0.831TrpIle: 0.831 ± 0.031	0.483TrpLys: 0.483 ± 0.024	1.381TrpLeu: 1.381 ± 0.043	0.422TrpMet: 0.422 ± 0.021	0.487TrpAsn: 0.487 ± 0.021	0.632TrpPro: 0.632 ± 0.026	0.461TrpGln: 0.461 ± 0.023	0.871TrpArg: 0.871 ± 0.037	0.742TrpSer: 0.742 ± 0.031	0.781TrpThr: 0.781 ± 0.025	0.976TrpVal: 0.976 ± 0.034	0.188TrpTrp: 0.188 ± 0.014	0.276TrpTyr: 0.276 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.494TyrAla: 2.494 ± 0.052	0.252TyrCys: 0.252 ± 0.015	1.879TyrAsp: 1.879 ± 0.047	1.337TyrGlu: 1.337 ± 0.046	1.057TyrPhe: 1.057 ± 0.033	2.211TyrGly: 2.211 ± 0.056	0.511TyrHis: 0.511 ± 0.024	1.18TyrIle: 1.18 ± 0.038	0.697TyrLys: 0.697 ± 0.031	2.275TyrLeu: 2.275 ± 0.054	0.571TyrMet: 0.571 ± 0.026	0.78TyrAsn: 0.78 ± 0.033	1.044TyrPro: 1.044 ± 0.032	0.833TyrGln: 0.833 ± 0.03	1.501TyrArg: 1.501 ± 0.039	1.393TyrSer: 1.393 ± 0.037	1.286TyrThr: 1.286 ± 0.048	1.707TyrVal: 1.707 ± 0.042	0.343TyrTrp: 0.343 ± 0.017	0.643TyrTyr: 0.643 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2990 proteins (935407 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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