Amino acid dipepetide frequency for Synergistes jonesii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.669AlaAla: 14.669 ± 0.2	1.377AlaCys: 1.377 ± 0.042	5.403AlaAsp: 5.403 ± 0.124	8.174AlaGlu: 8.174 ± 0.132	3.901AlaPhe: 3.901 ± 0.068	8.834AlaGly: 8.834 ± 0.12	1.537AlaHis: 1.537 ± 0.045	5.377AlaIle: 5.377 ± 0.102	5.769AlaLys: 5.769 ± 0.093	11.145AlaLeu: 11.145 ± 0.127	2.928AlaMet: 2.928 ± 0.067	2.483AlaAsn: 2.483 ± 0.056	3.851AlaPro: 3.851 ± 0.08	2.702AlaGln: 2.702 ± 0.071	5.641AlaArg: 5.641 ± 0.091	5.635AlaSer: 5.635 ± 0.098	3.568AlaThr: 3.568 ± 0.074	8.166AlaVal: 8.166 ± 0.098	0.97AlaTrp: 0.97 ± 0.038	2.577AlaTyr: 2.577 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.83CysAla: 1.83 ± 0.047	0.357CysCys: 0.357 ± 0.025	0.893CysAsp: 0.893 ± 0.035	0.939CysGlu: 0.939 ± 0.038	0.627CysPhe: 0.627 ± 0.029	2.038CysGly: 2.038 ± 0.06	0.25CysHis: 0.25 ± 0.017	0.794CysIle: 0.794 ± 0.033	0.546CysLys: 0.546 ± 0.03	1.109CysLeu: 1.109 ± 0.038	0.395CysMet: 0.395 ± 0.024	0.421CysAsn: 0.421 ± 0.026	0.775CysPro: 0.775 ± 0.036	0.229CysGln: 0.229 ± 0.015	1.099CysArg: 1.099 ± 0.038	0.938CysSer: 0.938 ± 0.038	0.734CysThr: 0.734 ± 0.034	1.16CysVal: 1.16 ± 0.037	0.191CysTrp: 0.191 ± 0.016	0.441CysTyr: 0.441 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	5.468AspAla: 5.468 ± 0.078	0.752AspCys: 0.752 ± 0.033	2.742AspAsp: 2.742 ± 0.064	4.239AspGlu: 4.239 ± 0.079	2.497AspPhe: 2.497 ± 0.062	4.841AspGly: 4.841 ± 0.216	0.692AspHis: 0.692 ± 0.033	3.932AspIle: 3.932 ± 0.074	2.772AspLys: 2.772 ± 0.067	3.95AspLeu: 3.95 ± 0.076	1.642AspMet: 1.642 ± 0.047	1.399AspAsn: 1.399 ± 0.044	2.109AspPro: 2.109 ± 0.049	0.781AspGln: 0.781 ± 0.036	2.641AspArg: 2.641 ± 0.064	2.473AspSer: 2.473 ± 0.057	2.088AspThr: 2.088 ± 0.052	3.996AspVal: 3.996 ± 0.08	0.591AspTrp: 0.591 ± 0.031	1.807AspTyr: 1.807 ± 0.046	0.001AspXaa: 0.001 ± 0.001
Glu	7.256GluAla: 7.256 ± 0.098	0.908GluCys: 0.908 ± 0.034	3.148GluAsp: 3.148 ± 0.071	6.452GluGlu: 6.452 ± 0.124	2.261GluPhe: 2.261 ± 0.058	5.184GluGly: 5.184 ± 0.079	1.074GluHis: 1.074 ± 0.035	5.004GluIle: 5.004 ± 0.083	5.65GluLys: 5.65 ± 0.091	6.876GluLeu: 6.876 ± 0.106	2.394GluMet: 2.394 ± 0.061	2.785GluAsn: 2.785 ± 0.063	2.215GluPro: 2.215 ± 0.053	1.621GluGln: 1.621 ± 0.057	5.033GluArg: 5.033 ± 0.099	3.478GluSer: 3.478 ± 0.07	3.095GluThr: 3.095 ± 0.061	3.979GluVal: 3.979 ± 0.081	0.828GluTrp: 0.828 ± 0.034	2.002GluTyr: 2.002 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	4.314PheAla: 4.314 ± 0.084	0.803PheCys: 0.803 ± 0.029	2.338PheAsp: 2.338 ± 0.059	2.357PheGlu: 2.357 ± 0.051	1.991PhePhe: 1.991 ± 0.055	3.592PheGly: 3.592 ± 0.073	0.691PheHis: 0.691 ± 0.031	2.683PheIle: 2.683 ± 0.067	1.693PheLys: 1.693 ± 0.05	3.515PheLeu: 3.515 ± 0.08	1.189PheMet: 1.189 ± 0.035	1.18PheAsn: 1.18 ± 0.044	1.746PhePro: 1.746 ± 0.048	0.83PheGln: 0.83 ± 0.03	2.066PheArg: 2.066 ± 0.054	3.025PheSer: 3.025 ± 0.065	2.08PheThr: 2.08 ± 0.05	2.972PheVal: 2.972 ± 0.058	0.549PheTrp: 0.549 ± 0.029	1.373PheTyr: 1.373 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	9.06GlyAla: 9.06 ± 0.166	1.532GlyCys: 1.532 ± 0.046	4.147GlyAsp: 4.147 ± 0.084	5.729GlyGlu: 5.729 ± 0.094	3.44GlyPhe: 3.44 ± 0.063	7.913GlyGly: 7.913 ± 0.133	1.436GlyHis: 1.436 ± 0.053	5.407GlyIle: 5.407 ± 0.098	4.743GlyLys: 4.743 ± 0.11	7.138GlyLeu: 7.138 ± 0.096	2.572GlyMet: 2.572 ± 0.059	2.297GlyAsn: 2.297 ± 0.048	2.055GlyPro: 2.055 ± 0.057	1.634GlyGln: 1.634 ± 0.05	5.431GlyArg: 5.431 ± 0.086	4.633GlySer: 4.633 ± 0.082	4.046GlyThr: 4.046 ± 0.074	6.755GlyVal: 6.755 ± 0.102	1.041GlyTrp: 1.041 ± 0.047	2.874GlyTyr: 2.874 ± 0.069	0.003GlyXaa: 0.003 ± 0.003
His	1.364HisAla: 1.364 ± 0.042	0.278HisCys: 0.278 ± 0.018	0.772HisAsp: 0.772 ± 0.035	0.938HisGlu: 0.938 ± 0.034	0.711HisPhe: 0.711 ± 0.028	1.399HisGly: 1.399 ± 0.043	0.306HisHis: 0.306 ± 0.021	1.141HisIle: 1.141 ± 0.042	0.749HisLys: 0.749 ± 0.035	1.433HisLeu: 1.433 ± 0.046	0.424HisMet: 0.424 ± 0.024	0.542HisAsn: 0.542 ± 0.028	0.924HisPro: 0.924 ± 0.035	0.349HisGln: 0.349 ± 0.021	0.967HisArg: 0.967 ± 0.037	0.871HisSer: 0.871 ± 0.034	0.808HisThr: 0.808 ± 0.031	1.021HisVal: 1.021 ± 0.046	0.2HisTrp: 0.2 ± 0.017	0.531HisTyr: 0.531 ± 0.027	0.003HisXaa: 0.003 ± 0.002
Ile	6.477IleAla: 6.477 ± 0.1	1.108IleCys: 1.108 ± 0.042	3.458IleAsp: 3.458 ± 0.074	4.224IleGlu: 4.224 ± 0.068	2.745IlePhe: 2.745 ± 0.065	4.934IleGly: 4.934 ± 0.088	0.918IleHis: 0.918 ± 0.036	3.862IleIle: 3.862 ± 0.087	3.554IleLys: 3.554 ± 0.076	5.492IleLeu: 5.492 ± 0.081	1.714IleMet: 1.714 ± 0.055	2.002IleAsn: 2.002 ± 0.053	3.167IlePro: 3.167 ± 0.072	1.337IleGln: 1.337 ± 0.038	3.207IleArg: 3.207 ± 0.063	4.425IleSer: 4.425 ± 0.067	3.128IleThr: 3.128 ± 0.059	4.377IleVal: 4.377 ± 0.084	0.59IleTrp: 0.59 ± 0.027	2.039IleTyr: 2.039 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.009LysAla: 5.009 ± 0.099	0.723LysCys: 0.723 ± 0.032	2.98LysAsp: 2.98 ± 0.088	4.845LysGlu: 4.845 ± 0.089	2.067LysPhe: 2.067 ± 0.051	4.046LysGly: 4.046 ± 0.078	0.811LysHis: 0.811 ± 0.03	4.286LysIle: 4.286 ± 0.079	4.703LysLys: 4.703 ± 0.093	5.058LysLeu: 5.058 ± 0.076	1.977LysMet: 1.977 ± 0.051	2.609LysAsn: 2.609 ± 0.056	1.876LysPro: 1.876 ± 0.048	1.25LysGln: 1.25 ± 0.043	3.407LysArg: 3.407 ± 0.062	3.06LysSer: 3.06 ± 0.069	2.767LysThr: 2.767 ± 0.064	3.212LysVal: 3.212 ± 0.079	0.667LysTrp: 0.667 ± 0.031	2.155LysTyr: 2.155 ± 0.05	0.001LysXaa: 0.001 ± 0.001
Leu	9.717LeuAla: 9.717 ± 0.138	1.791LeuCys: 1.791 ± 0.054	4.588LeuAsp: 4.588 ± 0.072	5.49LeuGlu: 5.49 ± 0.097	4.182LeuPhe: 4.182 ± 0.099	7.208LeuGly: 7.208 ± 0.106	1.537LeuHis: 1.537 ± 0.041	5.319LeuIle: 5.319 ± 0.096	5.241LeuLys: 5.241 ± 0.076	9.261LeuLeu: 9.261 ± 0.159	2.475LeuMet: 2.475 ± 0.064	2.656LeuAsn: 2.656 ± 0.058	4.857LeuPro: 4.857 ± 0.085	1.939LeuGln: 1.939 ± 0.055	5.968LeuArg: 5.968 ± 0.1	7.147LeuSer: 7.147 ± 0.122	4.541LeuThr: 4.541 ± 0.077	5.674LeuVal: 5.674 ± 0.108	1.062LeuTrp: 1.062 ± 0.034	2.7LeuTyr: 2.7 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.856MetAla: 2.856 ± 0.056	0.34MetCys: 0.34 ± 0.019	1.458MetAsp: 1.458 ± 0.045	2.011MetGlu: 2.011 ± 0.052	0.862MetPhe: 0.862 ± 0.04	2.218MetGly: 2.218 ± 0.061	0.419MetHis: 0.419 ± 0.023	1.797MetIle: 1.797 ± 0.046	2.071MetLys: 2.071 ± 0.048	2.822MetLeu: 2.822 ± 0.061	0.779MetMet: 0.779 ± 0.037	1.092MetAsn: 1.092 ± 0.041	1.574MetPro: 1.574 ± 0.044	0.739MetGln: 0.739 ± 0.032	1.902MetArg: 1.902 ± 0.057	1.767MetSer: 1.767 ± 0.046	1.718MetThr: 1.718 ± 0.049	1.591MetVal: 1.591 ± 0.047	0.292MetTrp: 0.292 ± 0.021	0.617MetTyr: 0.617 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.116AsnAla: 3.116 ± 0.072	0.514AsnCys: 0.514 ± 0.027	1.606AsnAsp: 1.606 ± 0.04	1.904AsnGlu: 1.904 ± 0.051	1.36AsnPhe: 1.36 ± 0.045	2.779AsnGly: 2.779 ± 0.066	0.449AsnHis: 0.449 ± 0.025	2.389AsnIle: 2.389 ± 0.052	1.707AsnLys: 1.707 ± 0.044	2.657AsnLeu: 2.657 ± 0.063	0.973AsnMet: 0.973 ± 0.036	1.05AsnAsn: 1.05 ± 0.041	1.719AsnPro: 1.719 ± 0.051	0.663AsnGln: 0.663 ± 0.03	1.586AsnArg: 1.586 ± 0.041	1.67AsnSer: 1.67 ± 0.051	1.29AsnThr: 1.29 ± 0.037	2.408AsnVal: 2.408 ± 0.055	0.376AsnTrp: 0.376 ± 0.024	1.058AsnTyr: 1.058 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.141ProAla: 4.141 ± 0.074	0.593ProCys: 0.593 ± 0.029	2.352ProAsp: 2.352 ± 0.051	3.797ProGlu: 3.797 ± 0.081	1.898ProPhe: 1.898 ± 0.046	3.135ProGly: 3.135 ± 0.065	0.793ProHis: 0.793 ± 0.033	2.208ProIle: 2.208 ± 0.053	2.132ProLys: 2.132 ± 0.059	4.195ProLeu: 4.195 ± 0.072	1.022ProMet: 1.022 ± 0.034	1.175ProAsn: 1.175 ± 0.036	1.522ProPro: 1.522 ± 0.05	1.426ProGln: 1.426 ± 0.04	2.2ProArg: 2.2 ± 0.061	2.405ProSer: 2.405 ± 0.062	1.846ProThr: 1.846 ± 0.049	3.165ProVal: 3.165 ± 0.064	0.565ProTrp: 0.565 ± 0.026	1.346ProTyr: 1.346 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.097GlnAla: 2.097 ± 0.061	0.294GlnCys: 0.294 ± 0.021	0.993GlnAsp: 0.993 ± 0.041	1.558GlnGlu: 1.558 ± 0.045	0.78GlnPhe: 0.78 ± 0.028	1.583GlnGly: 1.583 ± 0.044	0.395GlnHis: 0.395 ± 0.021	1.741GlnIle: 1.741 ± 0.048	1.699GlnLys: 1.699 ± 0.05	2.227GlnLeu: 2.227 ± 0.051	0.735GlnMet: 0.735 ± 0.028	0.97GlnAsn: 0.97 ± 0.036	0.874GlnPro: 0.874 ± 0.036	0.744GlnGln: 0.744 ± 0.036	1.566GlnArg: 1.566 ± 0.049	1.355GlnSer: 1.355 ± 0.045	1.139GlnThr: 1.139 ± 0.036	1.271GlnVal: 1.271 ± 0.038	0.277GlnTrp: 0.277 ± 0.022	0.732GlnTyr: 0.732 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	5.736ArgAla: 5.736 ± 0.089	0.928ArgCys: 0.928 ± 0.036	3.172ArgAsp: 3.172 ± 0.061	4.828ArgGlu: 4.828 ± 0.092	2.315ArgPhe: 2.315 ± 0.053	5.217ArgGly: 5.217 ± 0.089	1.041ArgHis: 1.041 ± 0.035	3.634ArgIle: 3.634 ± 0.07	3.115ArgLys: 3.115 ± 0.059	5.611ArgLeu: 5.611 ± 0.096	1.772ArgMet: 1.772 ± 0.054	1.806ArgAsn: 1.806 ± 0.053	2.205ArgPro: 2.205 ± 0.056	1.529ArgGln: 1.529 ± 0.049	4.576ArgArg: 4.576 ± 0.095	3.197ArgSer: 3.197 ± 0.073	2.454ArgThr: 2.454 ± 0.062	3.955ArgVal: 3.955 ± 0.076	0.696ArgTrp: 0.696 ± 0.033	1.982ArgTyr: 1.982 ± 0.053	0.001ArgXaa: 0.001 ± 0.0
Ser	6.458SerAla: 6.458 ± 0.093	1.009SerCys: 1.009 ± 0.038	2.859SerAsp: 2.859 ± 0.071	3.65SerGlu: 3.65 ± 0.072	2.771SerPhe: 2.771 ± 0.057	5.938SerGly: 5.938 ± 0.099	0.928SerHis: 0.928 ± 0.037	3.339SerIle: 3.339 ± 0.063	2.576SerLys: 2.576 ± 0.061	5.818SerLeu: 5.818 ± 0.109	1.574SerMet: 1.574 ± 0.044	1.477SerAsn: 1.477 ± 0.043	2.65SerPro: 2.65 ± 0.06	1.397SerGln: 1.397 ± 0.044	3.459SerArg: 3.459 ± 0.068	3.566SerSer: 3.566 ± 0.079	2.338SerThr: 2.338 ± 0.05	4.773SerVal: 4.773 ± 0.087	0.77SerTrp: 0.77 ± 0.031	1.942SerTyr: 1.942 ± 0.057	0.001SerXaa: 0.001 ± 0.001
Thr	4.818ThrAla: 4.818 ± 0.076	0.516ThrCys: 0.516 ± 0.023	2.461ThrAsp: 2.461 ± 0.056	2.906ThrGlu: 2.906 ± 0.069	1.837ThrPhe: 1.837 ± 0.049	4.169ThrGly: 4.169 ± 0.073	0.76ThrHis: 0.76 ± 0.028	2.822ThrIle: 2.822 ± 0.062	2.324ThrLys: 2.324 ± 0.067	4.901ThrLeu: 4.901 ± 0.084	1.187ThrMet: 1.187 ± 0.041	1.412ThrAsn: 1.412 ± 0.048	2.656ThrPro: 2.656 ± 0.053	1.169ThrGln: 1.169 ± 0.041	2.205ThrArg: 2.205 ± 0.056	2.396ThrSer: 2.396 ± 0.058	2.304ThrThr: 2.304 ± 0.059	3.503ThrVal: 3.503 ± 0.066	0.464ThrTrp: 0.464 ± 0.023	1.211ThrTyr: 1.211 ± 0.046	0.001ThrXaa: 0.001 ± 0.001
Val	6.591ValAla: 6.591 ± 0.115	1.238ValCys: 1.238 ± 0.039	3.615ValAsp: 3.615 ± 0.081	4.437ValGlu: 4.437 ± 0.082	2.844ValPhe: 2.844 ± 0.062	5.176ValGly: 5.176 ± 0.093	1.011ValHis: 1.011 ± 0.034	4.535ValIle: 4.535 ± 0.095	4.123ValLys: 4.123 ± 0.084	6.226ValLeu: 6.226 ± 0.093	2.07ValMet: 2.07 ± 0.054	2.369ValAsn: 2.369 ± 0.062	3.296ValPro: 3.296 ± 0.066	1.593ValGln: 1.593 ± 0.044	4.024ValArg: 4.024 ± 0.068	4.546ValSer: 4.546 ± 0.093	3.981ValThr: 3.981 ± 0.076	5.525ValVal: 5.525 ± 0.104	0.69ValTrp: 0.69 ± 0.033	2.185ValTyr: 2.185 ± 0.059	0.003ValXaa: 0.003 ± 0.002
Trp	0.873TrpAla: 0.873 ± 0.04	0.185TrpCys: 0.185 ± 0.018	0.576TrpAsp: 0.576 ± 0.025	0.749TrpGlu: 0.749 ± 0.034	0.47TrpPhe: 0.47 ± 0.028	1.029TrpGly: 1.029 ± 0.036	0.226TrpHis: 0.226 ± 0.017	0.604TrpIle: 0.604 ± 0.026	0.701TrpLys: 0.701 ± 0.029	1.141TrpLeu: 1.141 ± 0.04	0.321TrpMet: 0.321 ± 0.02	0.475TrpAsn: 0.475 ± 0.023	0.403TrpPro: 0.403 ± 0.024	0.382TrpGln: 0.382 ± 0.024	0.896TrpArg: 0.896 ± 0.038	0.67TrpSer: 0.67 ± 0.028	0.529TrpThr: 0.529 ± 0.031	0.66TrpVal: 0.66 ± 0.032	0.17TrpTrp: 0.17 ± 0.015	0.328TrpTyr: 0.328 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.854TyrAla: 2.854 ± 0.061	0.523TyrCys: 0.523 ± 0.025	1.851TyrAsp: 1.851 ± 0.058	2.018TyrGlu: 2.018 ± 0.052	1.428TyrPhe: 1.428 ± 0.039	2.651TyrGly: 2.651 ± 0.065	0.459TyrHis: 0.459 ± 0.025	1.884TyrIle: 1.884 ± 0.048	1.642TyrLys: 1.642 ± 0.046	2.776TyrLeu: 2.776 ± 0.067	0.783TyrMet: 0.783 ± 0.032	1.069TyrAsn: 1.069 ± 0.034	1.438TyrPro: 1.438 ± 0.039	0.714TyrGln: 0.714 ± 0.03	1.895TyrArg: 1.895 ± 0.05	2.037TyrSer: 2.037 ± 0.056	1.569TyrThr: 1.569 ± 0.051	1.912TyrVal: 1.912 ± 0.055	0.4TyrTrp: 0.4 ± 0.024	1.034TyrTyr: 1.034 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.004XaaGly: 0.004 ± 0.004	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.003XaaLeu: 0.003 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.003XaaSer: 0.003 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 2481 proteins (784574 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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