Amino acid dipepetide frequency for Trichuris trichiura (Whipworm) (Trichocephalus trichiurus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.21AlaAla: 6.21 ± 0.072	1.544AlaCys: 1.544 ± 0.023	3.894AlaAsp: 3.894 ± 0.034	4.698AlaGlu: 4.698 ± 0.045	3.061AlaPhe: 3.061 ± 0.032	4.075AlaGly: 4.075 ± 0.041	1.452AlaHis: 1.452 ± 0.021	3.876AlaIle: 3.876 ± 0.036	4.127AlaLys: 4.127 ± 0.037	6.949AlaLeu: 6.949 ± 0.054	1.853AlaMet: 1.853 ± 0.022	2.947AlaAsn: 2.947 ± 0.028	2.851AlaPro: 2.851 ± 0.04	2.599AlaGln: 2.599 ± 0.032	3.54AlaArg: 3.54 ± 0.037	5.455AlaSer: 5.455 ± 0.044	3.855AlaThr: 3.855 ± 0.03	5.325AlaVal: 5.325 ± 0.045	0.792AlaTrp: 0.792 ± 0.017	2.119AlaTyr: 2.119 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	1.499CysAla: 1.499 ± 0.021	0.743CysCys: 0.743 ± 0.019	1.338CysAsp: 1.338 ± 0.031	1.339CysGlu: 1.339 ± 0.032	1.181CysPhe: 1.181 ± 0.019	1.51CysGly: 1.51 ± 0.026	0.659CysHis: 0.659 ± 0.016	1.289CysIle: 1.289 ± 0.024	1.298CysLys: 1.298 ± 0.027	2.456CysLeu: 2.456 ± 0.032	0.511CysMet: 0.511 ± 0.013	1.03CysAsn: 1.03 ± 0.02	1.345CysPro: 1.345 ± 0.035	1.028CysGln: 1.028 ± 0.022	1.533CysArg: 1.533 ± 0.024	2.205CysSer: 2.205 ± 0.029	1.284CysThr: 1.284 ± 0.022	1.56CysVal: 1.56 ± 0.022	0.312CysTrp: 0.312 ± 0.01	0.753CysTyr: 0.753 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.49AspAla: 3.49 ± 0.031	1.297AspCys: 1.297 ± 0.027	3.312AspAsp: 3.312 ± 0.064	3.996AspGlu: 3.996 ± 0.042	2.399AspPhe: 2.399 ± 0.029	3.479AspGly: 3.479 ± 0.04	1.191AspHis: 1.191 ± 0.018	2.815AspIle: 2.815 ± 0.026	2.644AspLys: 2.644 ± 0.037	4.846AspLeu: 4.846 ± 0.038	1.252AspMet: 1.252 ± 0.017	2.043AspAsn: 2.043 ± 0.028	2.309AspPro: 2.309 ± 0.027	1.946AspGln: 1.946 ± 0.021	2.9AspArg: 2.9 ± 0.031	4.023AspSer: 4.023 ± 0.036	2.253AspThr: 2.253 ± 0.025	3.891AspVal: 3.891 ± 0.034	0.713AspTrp: 0.713 ± 0.015	1.781AspTyr: 1.781 ± 0.021	0.001AspXaa: 0.001 ± 0.0
Glu	4.628GluAla: 4.628 ± 0.05	1.326GluCys: 1.326 ± 0.027	3.278GluAsp: 3.278 ± 0.038	5.534GluGlu: 5.534 ± 0.066	2.285GluPhe: 2.285 ± 0.028	3.072GluGly: 3.072 ± 0.038	1.42GluHis: 1.42 ± 0.019	3.343GluIle: 3.343 ± 0.032	4.643GluLys: 4.643 ± 0.043	6.089GluLeu: 6.089 ± 0.051	1.828GluMet: 1.828 ± 0.02	3.142GluAsn: 3.142 ± 0.036	2.471GluPro: 2.471 ± 0.032	2.922GluGln: 2.922 ± 0.031	3.842GluArg: 3.842 ± 0.038	4.23GluSer: 4.23 ± 0.034	3.32GluThr: 3.32 ± 0.033	4.108GluVal: 4.108 ± 0.04	0.743GluTrp: 0.743 ± 0.015	1.838GluTyr: 1.838 ± 0.021	0.001GluXaa: 0.001 ± 0.0
Phe	3.084PheAla: 3.084 ± 0.031	1.267PheCys: 1.267 ± 0.021	2.541PheAsp: 2.541 ± 0.023	2.511PheGlu: 2.511 ± 0.028	2.1PhePhe: 2.1 ± 0.025	2.826PheGly: 2.826 ± 0.029	1.086PheHis: 1.086 ± 0.015	2.254PheIle: 2.254 ± 0.024	2.051PheLys: 2.051 ± 0.026	4.257PheLeu: 4.257 ± 0.04	0.944PheMet: 0.944 ± 0.017	1.853PheAsn: 1.853 ± 0.024	1.906PhePro: 1.906 ± 0.024	1.57PheGln: 1.57 ± 0.021	2.386PheArg: 2.386 ± 0.03	3.528PheSer: 3.528 ± 0.03	2.268PheThr: 2.268 ± 0.026	3.183PheVal: 3.183 ± 0.032	0.587PheTrp: 0.587 ± 0.013	1.559PheTyr: 1.559 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	3.667GlyAla: 3.667 ± 0.046	1.316GlyCys: 1.316 ± 0.025	2.978GlyAsp: 2.978 ± 0.033	3.397GlyGlu: 3.397 ± 0.039	2.559GlyPhe: 2.559 ± 0.028	3.844GlyGly: 3.844 ± 0.052	1.465GlyHis: 1.465 ± 0.024	3.344GlyIle: 3.344 ± 0.035	3.663GlyLys: 3.663 ± 0.039	4.862GlyLeu: 4.862 ± 0.047	1.464GlyMet: 1.464 ± 0.023	2.554GlyAsn: 2.554 ± 0.03	2.272GlyPro: 2.272 ± 0.044	2.302GlyGln: 2.302 ± 0.029	3.586GlyArg: 3.586 ± 0.028	4.709GlySer: 4.709 ± 0.044	3.159GlyThr: 3.159 ± 0.031	3.678GlyVal: 3.678 ± 0.031	0.745GlyTrp: 0.745 ± 0.016	2.097GlyTyr: 2.097 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.462HisAla: 1.462 ± 0.019	0.78HisCys: 0.78 ± 0.016	1.022HisAsp: 1.022 ± 0.018	1.242HisGlu: 1.242 ± 0.019	1.245HisPhe: 1.245 ± 0.017	1.476HisGly: 1.476 ± 0.02	0.669HisHis: 0.669 ± 0.018	1.149HisIle: 1.149 ± 0.017	1.011HisLys: 1.011 ± 0.016	2.44HisLeu: 2.44 ± 0.026	0.553HisMet: 0.553 ± 0.014	0.818HisAsn: 0.818 ± 0.015	1.271HisPro: 1.271 ± 0.018	0.869HisGln: 0.869 ± 0.016	1.452HisArg: 1.452 ± 0.019	1.833HisSer: 1.833 ± 0.025	1.009HisThr: 1.009 ± 0.016	1.611HisVal: 1.611 ± 0.02	0.348HisTrp: 0.348 ± 0.009	0.862HisTyr: 0.862 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.043IleAla: 4.043 ± 0.036	1.373IleCys: 1.373 ± 0.021	3.074IleAsp: 3.074 ± 0.027	3.269IleGlu: 3.269 ± 0.037	2.3IlePhe: 2.3 ± 0.027	3.222IleGly: 3.222 ± 0.033	1.178IleHis: 1.178 ± 0.015	2.655IleIle: 2.655 ± 0.031	2.456IleLys: 2.456 ± 0.03	4.779IleLeu: 4.779 ± 0.043	1.181IleMet: 1.181 ± 0.019	2.119IleAsn: 2.119 ± 0.025	2.542IlePro: 2.542 ± 0.029	1.826IleGln: 1.826 ± 0.025	3.122IleArg: 3.122 ± 0.034	4.095IleSer: 4.095 ± 0.032	2.672IleThr: 2.672 ± 0.027	3.843IleVal: 3.843 ± 0.036	0.594IleTrp: 0.594 ± 0.012	1.625IleTyr: 1.625 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.076LysAla: 4.076 ± 0.039	1.344LysCys: 1.344 ± 0.025	2.769LysAsp: 2.769 ± 0.042	4.204LysGlu: 4.204 ± 0.044	2.067LysPhe: 2.067 ± 0.025	2.926LysGly: 2.926 ± 0.041	1.303LysHis: 1.303 ± 0.019	2.844LysIle: 2.844 ± 0.034	3.962LysLys: 3.962 ± 0.081	5.474LysLeu: 5.474 ± 0.04	1.49LysMet: 1.49 ± 0.02	2.397LysAsn: 2.397 ± 0.025	2.606LysPro: 2.606 ± 0.032	2.473LysGln: 2.473 ± 0.027	3.897LysArg: 3.897 ± 0.041	3.905LysSer: 3.905 ± 0.035	2.915LysThr: 2.915 ± 0.033	3.7LysVal: 3.7 ± 0.033	0.679LysTrp: 0.679 ± 0.014	1.721LysTyr: 1.721 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	6.909LeuAla: 6.909 ± 0.05	2.426LeuCys: 2.426 ± 0.031	4.666LeuAsp: 4.666 ± 0.037	5.835LeuGlu: 5.835 ± 0.059	4.318LeuPhe: 4.318 ± 0.04	4.656LeuGly: 4.656 ± 0.037	2.353LeuHis: 2.353 ± 0.027	4.955LeuIle: 4.955 ± 0.043	5.81LeuLys: 5.81 ± 0.043	10.634LeuLeu: 10.634 ± 0.076	2.29LeuMet: 2.29 ± 0.027	4.318LeuAsn: 4.318 ± 0.038	5.262LeuPro: 5.262 ± 0.041	4.163LeuGln: 4.163 ± 0.039	6.088LeuArg: 6.088 ± 0.045	7.79LeuSer: 7.79 ± 0.052	5.202LeuThr: 5.202 ± 0.035	5.902LeuVal: 5.902 ± 0.038	1.13LeuTrp: 1.13 ± 0.02	2.9LeuTyr: 2.9 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	1.921MetAla: 1.921 ± 0.023	0.47MetCys: 0.47 ± 0.011	1.356MetAsp: 1.356 ± 0.018	1.681MetGlu: 1.681 ± 0.022	1.011MetPhe: 1.011 ± 0.017	1.208MetGly: 1.208 ± 0.019	0.574MetHis: 0.574 ± 0.011	1.256MetIle: 1.256 ± 0.018	1.488MetLys: 1.488 ± 0.021	2.442MetLeu: 2.442 ± 0.028	0.631MetMet: 0.631 ± 0.014	1.128MetAsn: 1.128 ± 0.016	1.23MetPro: 1.23 ± 0.02	1.08MetGln: 1.08 ± 0.017	1.356MetArg: 1.356 ± 0.02	1.789MetSer: 1.789 ± 0.022	1.335MetThr: 1.335 ± 0.017	1.613MetVal: 1.613 ± 0.021	0.23MetTrp: 0.23 ± 0.008	0.676MetTyr: 0.676 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.264AsnAla: 3.264 ± 0.031	1.144AsnCys: 1.144 ± 0.022	2.398AsnAsp: 2.398 ± 0.03	2.847AsnGlu: 2.847 ± 0.029	1.955AsnPhe: 1.955 ± 0.024	3.167AsnGly: 3.167 ± 0.035	0.858AsnHis: 0.858 ± 0.015	2.164AsnIle: 2.164 ± 0.022	1.977AsnLys: 1.977 ± 0.025	3.894AsnLeu: 3.894 ± 0.031	1.028AsnMet: 1.028 ± 0.015	1.76AsnAsn: 1.76 ± 0.022	1.98AsnPro: 1.98 ± 0.027	1.436AsnGln: 1.436 ± 0.021	2.447AsnArg: 2.447 ± 0.026	3.173AsnSer: 3.173 ± 0.034	1.785AsnThr: 1.785 ± 0.023	3.265AsnVal: 3.265 ± 0.031	0.543AsnTrp: 0.543 ± 0.012	1.43AsnTyr: 1.43 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	3.202ProAla: 3.202 ± 0.048	1.023ProCys: 1.023 ± 0.024	2.425ProAsp: 2.425 ± 0.026	3.047ProGlu: 3.047 ± 0.03	2.152ProPhe: 2.152 ± 0.026	2.866ProGly: 2.866 ± 0.085	0.919ProHis: 0.919 ± 0.015	2.226ProIle: 2.226 ± 0.024	2.501ProLys: 2.501 ± 0.029	4.344ProLeu: 4.344 ± 0.035	1.036ProMet: 1.036 ± 0.018	1.94ProAsn: 1.94 ± 0.027	3.079ProPro: 3.079 ± 0.052	1.572ProGln: 1.572 ± 0.023	2.182ProArg: 2.182 ± 0.024	4.165ProSer: 4.165 ± 0.04	2.778ProThr: 2.778 ± 0.03	3.411ProVal: 3.411 ± 0.034	0.569ProTrp: 0.569 ± 0.012	1.552ProTyr: 1.552 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	2.747GlnAla: 2.747 ± 0.033	1.065GlnCys: 1.065 ± 0.023	1.507GlnAsp: 1.507 ± 0.021	2.415GlnGlu: 2.415 ± 0.027	1.643GlnPhe: 1.643 ± 0.022	1.823GlnGly: 1.823 ± 0.022	0.946GlnHis: 0.946 ± 0.017	1.965GlnIle: 1.965 ± 0.025	2.298GlnLys: 2.298 ± 0.023	4.452GlnLeu: 4.452 ± 0.044	1.129GlnMet: 1.129 ± 0.014	1.623GlnAsn: 1.623 ± 0.021	1.946GlnPro: 1.946 ± 0.026	2.359GlnGln: 2.359 ± 0.042	2.621GlnArg: 2.621 ± 0.025	2.914GlnSer: 2.914 ± 0.031	2.011GlnThr: 2.011 ± 0.023	2.47GlnVal: 2.47 ± 0.028	0.582GlnTrp: 0.582 ± 0.011	1.187GlnTyr: 1.187 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	3.416ArgAla: 3.416 ± 0.032	1.559ArgCys: 1.559 ± 0.029	2.668ArgAsp: 2.668 ± 0.029	3.389ArgGlu: 3.389 ± 0.031	2.652ArgPhe: 2.652 ± 0.026	2.814ArgGly: 2.814 ± 0.034	1.573ArgHis: 1.573 ± 0.02	3.189ArgIle: 3.189 ± 0.03	3.796ArgLys: 3.796 ± 0.04	6.3ArgLeu: 6.3 ± 0.045	1.547ArgMet: 1.547 ± 0.02	2.59ArgAsn: 2.59 ± 0.025	2.536ArgPro: 2.536 ± 0.026	2.689ArgGln: 2.689 ± 0.029	4.611ArgArg: 4.611 ± 0.041	4.471ArgSer: 4.471 ± 0.043	2.948ArgThr: 2.948 ± 0.028	3.334ArgVal: 3.334 ± 0.034	0.831ArgTrp: 0.831 ± 0.015	1.963ArgTyr: 1.963 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	5.6SerAla: 5.6 ± 0.044	1.956SerCys: 1.956 ± 0.03	4.218SerAsp: 4.218 ± 0.033	4.567SerGlu: 4.567 ± 0.038	3.497SerPhe: 3.497 ± 0.035	4.82SerGly: 4.82 ± 0.047	1.672SerHis: 1.672 ± 0.023	3.961SerIle: 3.961 ± 0.032	4.132SerLys: 4.132 ± 0.037	7.537SerLeu: 7.537 ± 0.052	1.823SerMet: 1.823 ± 0.022	3.321SerAsn: 3.321 ± 0.031	3.737SerPro: 3.737 ± 0.047	2.76SerGln: 2.76 ± 0.032	4.298SerArg: 4.298 ± 0.034	8.325SerSer: 8.325 ± 0.092	4.424SerThr: 4.424 ± 0.035	5.437SerVal: 5.437 ± 0.043	0.938SerTrp: 0.938 ± 0.015	2.313SerTyr: 2.313 ± 0.025	0.001SerXaa: 0.001 ± 0.0
Thr	4.064ThrAla: 4.064 ± 0.034	1.35ThrCys: 1.35 ± 0.026	2.798ThrAsp: 2.798 ± 0.028	3.228ThrGlu: 3.228 ± 0.03	2.382ThrPhe: 2.382 ± 0.026	3.333ThrGly: 3.333 ± 0.031	0.984ThrHis: 0.984 ± 0.016	2.912ThrIle: 2.912 ± 0.032	2.671ThrLys: 2.671 ± 0.032	5.126ThrLeu: 5.126 ± 0.038	1.253ThrMet: 1.253 ± 0.018	2.072ThrAsn: 2.072 ± 0.023	2.481ThrPro: 2.481 ± 0.032	1.582ThrGln: 1.582 ± 0.025	2.399ThrArg: 2.399 ± 0.024	4.276ThrSer: 4.276 ± 0.038	3.097ThrThr: 3.097 ± 0.043	4.149ThrVal: 4.149 ± 0.036	0.589ThrTrp: 0.589 ± 0.014	1.552ThrTyr: 1.552 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.089ValAla: 5.089 ± 0.038	1.704ValCys: 1.704 ± 0.026	3.955ValAsp: 3.955 ± 0.031	4.345ValGlu: 4.345 ± 0.041	2.789ValPhe: 2.789 ± 0.029	3.897ValGly: 3.897 ± 0.033	1.705ValHis: 1.705 ± 0.023	3.613ValIle: 3.613 ± 0.028	3.824ValLys: 3.824 ± 0.032	6.293ValLeu: 6.293 ± 0.049	1.562ValMet: 1.562 ± 0.021	2.953ValAsn: 2.953 ± 0.029	3.198ValPro: 3.198 ± 0.03	2.717ValGln: 2.717 ± 0.029	3.845ValArg: 3.845 ± 0.038	5.156ValSer: 5.156 ± 0.038	3.821ValThr: 3.821 ± 0.03	4.938ValVal: 4.938 ± 0.044	0.763ValTrp: 0.763 ± 0.013	2.047ValTyr: 2.047 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	0.671TrpAla: 0.671 ± 0.014	0.285TrpCys: 0.285 ± 0.009	0.614TrpAsp: 0.614 ± 0.015	0.636TrpGlu: 0.636 ± 0.014	0.574TrpPhe: 0.574 ± 0.013	0.504TrpGly: 0.504 ± 0.013	0.33TrpHis: 0.33 ± 0.01	0.686TrpIle: 0.686 ± 0.015	0.853TrpLys: 0.853 ± 0.013	1.363TrpLeu: 1.363 ± 0.021	0.346TrpMet: 0.346 ± 0.01	0.644TrpAsn: 0.644 ± 0.013	0.531TrpPro: 0.531 ± 0.011	0.604TrpGln: 0.604 ± 0.015	0.786TrpArg: 0.786 ± 0.015	0.961TrpSer: 0.961 ± 0.02	0.682TrpThr: 0.682 ± 0.015	0.645TrpVal: 0.645 ± 0.012	0.195TrpTrp: 0.195 ± 0.007	0.425TrpTyr: 0.425 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.18TyrAla: 2.18 ± 0.023	0.899TyrCys: 0.899 ± 0.016	1.771TyrAsp: 1.771 ± 0.021	1.88TyrGlu: 1.88 ± 0.026	1.591TyrPhe: 1.591 ± 0.023	2.144TyrGly: 2.144 ± 0.026	0.787TyrHis: 0.787 ± 0.015	1.472TyrIle: 1.472 ± 0.02	1.548TyrLys: 1.548 ± 0.022	3.07TyrLeu: 3.07 ± 0.027	0.752TyrMet: 0.752 ± 0.015	1.261TyrAsn: 1.261 ± 0.02	1.437TyrPro: 1.437 ± 0.021	1.207TyrGln: 1.207 ± 0.019	1.987TyrArg: 1.987 ± 0.026	2.332TyrSer: 2.332 ± 0.025	1.481TyrThr: 1.481 ± 0.02	2.148TyrVal: 2.148 ± 0.025	0.452TyrTrp: 0.452 ± 0.012	1.219TyrTyr: 1.219 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.016XaaXaa: 0.016 ± 0.008

Statistics based on 9625 proteins (4182167 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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