Amino acid dipepetide frequency for Human papillomavirus 56

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.914AlaAla: 1.914 ± 1.051
1.914AlaCys: 1.914 ± 0.793
2.553AlaAsp: 2.553 ± 1.244
3.191AlaGlu: 3.191 ± 1.189
2.553AlaPhe: 2.553 ± 1.996
3.191AlaGly: 3.191 ± 1.073
1.914AlaHis: 1.914 ± 1.216
1.276AlaIle: 1.276 ± 0.585
3.829AlaLys: 3.829 ± 1.74
3.191AlaLeu: 3.191 ± 0.804
1.914AlaMet: 1.914 ± 0.79
2.553AlaAsn: 2.553 ± 0.812
3.829AlaPro: 3.829 ± 2.219
1.914AlaGln: 1.914 ± 0.722
3.191AlaArg: 3.191 ± 0.938
1.914AlaSer: 1.914 ± 1.103
7.658AlaThr: 7.658 ± 2.072
5.105AlaVal: 5.105 ± 0.966
0.638AlaTrp: 0.638 ± 0.589
1.914AlaTyr: 1.914 ± 1.408
0.0AlaXaa: 0.0 ± 0.0
Cys
0.638CysAla: 0.638 ± 0.751
1.276CysCys: 1.276 ± 0.92
1.276CysAsp: 1.276 ± 1.621
1.276CysGlu: 1.276 ± 0.92
0.638CysPhe: 0.638 ± 0.589
0.638CysGly: 0.638 ± 0.589
0.0CysHis: 0.0 ± 0.0
1.276CysIle: 1.276 ± 0.938
5.105CysLys: 5.105 ± 0.966
1.914CysLeu: 1.914 ± 1.596
0.638CysMet: 0.638 ± 0.589
0.638CysAsn: 0.638 ± 0.751
2.553CysPro: 2.553 ± 0.704
1.276CysGln: 1.276 ± 0.848
1.914CysArg: 1.914 ± 1.272
1.276CysSer: 1.276 ± 1.178
1.276CysThr: 1.276 ± 0.848
1.914CysVal: 1.914 ± 0.793
1.276CysTrp: 1.276 ± 0.848
1.276CysTyr: 1.276 ± 1.049
0.0CysXaa: 0.0 ± 0.0
Asp
1.914AspAla: 1.914 ± 0.883
1.276AspCys: 1.276 ± 0.585
1.914AspAsp: 1.914 ± 0.76
3.191AspGlu: 3.191 ± 2.2
2.553AspPhe: 2.553 ± 0.605
3.829AspGly: 3.829 ± 0.82
0.638AspHis: 0.638 ± 0.751
3.829AspIle: 3.829 ± 1.692
2.553AspLys: 2.553 ± 0.93
3.191AspLeu: 3.191 ± 2.075
0.638AspMet: 0.638 ± 0.469
3.191AspAsn: 3.191 ± 0.879
4.467AspPro: 4.467 ± 1.521
1.276AspGln: 1.276 ± 0.938
1.276AspArg: 1.276 ± 0.905
5.105AspSer: 5.105 ± 2.079
4.467AspThr: 4.467 ± 1.381
5.743AspVal: 5.743 ± 1.733
0.638AspTrp: 0.638 ± 0.469
1.914AspTyr: 1.914 ± 0.793
0.0AspXaa: 0.0 ± 0.0
Glu
2.553GluAla: 2.553 ± 0.701
0.638GluCys: 0.638 ± 0.751
5.743GluAsp: 5.743 ± 3.3
4.467GluGlu: 4.467 ± 1.258
0.638GluPhe: 0.638 ± 0.589
1.276GluGly: 1.276 ± 0.69
0.638GluHis: 0.638 ± 0.469
3.191GluIle: 3.191 ± 1.601
1.276GluLys: 1.276 ± 0.848
3.829GluLeu: 3.829 ± 1.615
0.638GluMet: 0.638 ± 0.499
1.276GluAsn: 1.276 ± 0.585
3.829GluPro: 3.829 ± 1.466
3.829GluGln: 3.829 ± 1.096
1.914GluArg: 1.914 ± 1.078
7.02GluSer: 7.02 ± 1.84
2.553GluThr: 2.553 ± 0.93
6.382GluVal: 6.382 ± 1.499
0.638GluTrp: 0.638 ± 0.589
1.276GluTyr: 1.276 ± 0.585
0.0GluXaa: 0.0 ± 0.0
Phe
3.829PheAla: 3.829 ± 1.771
0.0PheCys: 0.0 ± 0.0
1.914PheAsp: 1.914 ± 1.183
1.914PheGlu: 1.914 ± 1.051
1.276PhePhe: 1.276 ± 0.998
2.553PheGly: 2.553 ± 0.548
0.638PheHis: 0.638 ± 0.811
0.638PheIle: 0.638 ± 0.499
1.276PheLys: 1.276 ± 0.585
3.191PheLeu: 3.191 ± 0.934
0.638PheMet: 0.638 ± 0.499
2.553PheAsn: 2.553 ± 1.471
1.914PhePro: 1.914 ± 1.105
1.914PheGln: 1.914 ± 0.41
1.914PheArg: 1.914 ± 0.779
1.914PheSer: 1.914 ± 0.779
1.914PheThr: 1.914 ± 1.497
3.191PheVal: 3.191 ± 0.792
0.638PheTrp: 0.638 ± 0.469
2.553PheTyr: 2.553 ± 0.88
0.0PheXaa: 0.0 ± 0.0
Gly
5.105GlyAla: 5.105 ± 1.427
1.914GlyCys: 1.914 ± 0.793
3.829GlyAsp: 3.829 ± 1.058
2.553GlyGlu: 2.553 ± 0.548
1.914GlyPhe: 1.914 ± 0.779
2.553GlyGly: 2.553 ± 1.996
2.553GlyHis: 2.553 ± 1.287
3.191GlyIle: 3.191 ± 1.145
2.553GlyLys: 2.553 ± 1.131
5.105GlyLeu: 5.105 ± 1.783
0.0GlyMet: 0.0 ± 0.0
2.553GlyAsn: 2.553 ± 0.701
1.914GlyPro: 1.914 ± 1.497
1.276GlyGln: 1.276 ± 0.585
3.191GlyArg: 3.191 ± 1.073
7.02GlySer: 7.02 ± 1.967
4.467GlyThr: 4.467 ± 2.712
1.914GlyVal: 1.914 ± 1.051
1.276GlyTrp: 1.276 ± 0.889
0.638GlyTyr: 0.638 ± 0.499
0.0GlyXaa: 0.0 ± 0.0
His
1.276HisAla: 1.276 ± 0.585
0.638HisCys: 0.638 ± 0.811
1.276HisAsp: 1.276 ± 0.69
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
1.914HisGly: 1.914 ± 1.044
0.638HisHis: 0.638 ± 0.811
1.914HisIle: 1.914 ± 1.183
1.276HisLys: 1.276 ± 1.178
3.191HisLeu: 3.191 ± 1.609
0.638HisMet: 0.638 ± 0.589
1.276HisAsn: 1.276 ± 0.938
1.914HisPro: 1.914 ± 0.883
0.0HisGln: 0.0 ± 0.0
1.914HisArg: 1.914 ± 1.051
0.638HisSer: 0.638 ± 0.499
1.276HisThr: 1.276 ± 0.92
2.553HisVal: 2.553 ± 0.704
1.276HisTrp: 1.276 ± 0.585
1.914HisTyr: 1.914 ± 0.722
0.0HisXaa: 0.0 ± 0.0
Ile
2.553IleAla: 2.553 ± 1.172
0.638IleCys: 0.638 ± 0.469
3.191IleAsp: 3.191 ± 1.016
5.105IleGlu: 5.105 ± 1.402
1.914IlePhe: 1.914 ± 1.408
1.914IleGly: 1.914 ± 0.779
1.276IleHis: 1.276 ± 0.8
1.276IleIle: 1.276 ± 1.178
0.638IleLys: 0.638 ± 0.499
1.276IleLeu: 1.276 ± 0.998
0.0IleMet: 0.0 ± 0.0
1.914IleAsn: 1.914 ± 0.883
5.105IlePro: 5.105 ± 1.276
1.914IleGln: 1.914 ± 1.103
0.638IleArg: 0.638 ± 0.811
3.829IleSer: 3.829 ± 0.914
5.105IleThr: 5.105 ± 0.712
4.467IleVal: 4.467 ± 2.015
0.638IleTrp: 0.638 ± 0.589
5.105IleTyr: 5.105 ± 2.521
0.0IleXaa: 0.0 ± 0.0
Lys
3.191LysAla: 3.191 ± 1.034
1.914LysCys: 1.914 ± 1.767
1.276LysAsp: 1.276 ± 0.585
1.914LysGlu: 1.914 ± 1.081
3.191LysPhe: 3.191 ± 1.468
1.914LysGly: 1.914 ± 0.883
0.0LysHis: 0.0 ± 0.0
3.191LysIle: 3.191 ± 0.564
3.829LysLys: 3.829 ± 1.924
1.276LysLeu: 1.276 ± 0.905
1.276LysMet: 1.276 ± 0.603
1.914LysAsn: 1.914 ± 1.767
1.914LysPro: 1.914 ± 0.722
3.191LysGln: 3.191 ± 1.789
5.105LysArg: 5.105 ± 0.966
0.638LysSer: 0.638 ± 0.469
4.467LysThr: 4.467 ± 2.075
5.743LysVal: 5.743 ± 1.764
0.0LysTrp: 0.0 ± 0.0
4.467LysTyr: 4.467 ± 1.647
0.0LysXaa: 0.0 ± 0.0
Leu
3.191LeuAla: 3.191 ± 1.598
3.191LeuCys: 3.191 ± 1.615
5.105LeuAsp: 5.105 ± 1.912
4.467LeuGlu: 4.467 ± 1.78
5.743LeuPhe: 5.743 ± 0.868
5.105LeuGly: 5.105 ± 1.466
3.191LeuHis: 3.191 ± 1.531
3.829LeuIle: 3.829 ± 2.318
3.191LeuLys: 3.191 ± 1.134
3.829LeuLeu: 3.829 ± 1.58
1.276LeuMet: 1.276 ± 0.886
0.0LeuAsn: 0.0 ± 0.0
3.829LeuPro: 3.829 ± 1.444
6.382LeuGln: 6.382 ± 2.776
3.829LeuArg: 3.829 ± 1.265
7.658LeuSer: 7.658 ± 1.043
3.191LeuThr: 3.191 ± 2.047
3.191LeuVal: 3.191 ± 0.776
1.276LeuTrp: 1.276 ± 0.69
2.553LeuTyr: 2.553 ± 1.244
0.0LeuXaa: 0.0 ± 0.0
Met
1.276MetAla: 1.276 ± 0.938
0.0MetCys: 0.0 ± 0.0
0.638MetAsp: 0.638 ± 0.469
1.276MetGlu: 1.276 ± 0.889
0.0MetPhe: 0.0 ± 0.0
1.276MetGly: 1.276 ± 0.886
0.638MetHis: 0.638 ± 0.751
1.276MetIle: 1.276 ± 0.938
0.0MetLys: 0.0 ± 0.0
0.638MetLeu: 0.638 ± 0.469
1.276MetMet: 1.276 ± 0.938
1.276MetAsn: 1.276 ± 0.406
0.0MetPro: 0.0 ± 0.0
2.553MetGln: 2.553 ± 0.701
0.0MetArg: 0.0 ± 0.0
0.638MetSer: 0.638 ± 0.469
0.638MetThr: 0.638 ± 0.469
1.276MetVal: 1.276 ± 0.69
0.638MetTrp: 0.638 ± 0.469
0.638MetTyr: 0.638 ± 0.469
0.0MetXaa: 0.0 ± 0.0
Asn
0.638AsnAla: 0.638 ± 0.469
0.638AsnCys: 0.638 ± 0.589
0.0AsnAsp: 0.0 ± 0.0
2.553AsnGlu: 2.553 ± 1.869
1.276AsnPhe: 1.276 ± 0.905
1.914AsnGly: 1.914 ± 0.883
0.638AsnHis: 0.638 ± 0.589
5.105AsnIle: 5.105 ± 1.097
3.191AsnLys: 3.191 ± 0.934
1.914AsnLeu: 1.914 ± 1.408
1.276AsnMet: 1.276 ± 1.136
6.382AsnAsn: 6.382 ± 2.249
2.553AsnPro: 2.553 ± 0.966
1.914AsnGln: 1.914 ± 0.883
1.914AsnArg: 1.914 ± 0.883
1.276AsnSer: 1.276 ± 0.69
3.191AsnThr: 3.191 ± 0.879
3.191AsnVal: 3.191 ± 0.564
0.0AsnTrp: 0.0 ± 0.0
0.638AsnTyr: 0.638 ± 0.589
0.0AsnXaa: 0.0 ± 0.0
Pro
5.743ProAla: 5.743 ± 1.913
1.276ProCys: 1.276 ± 0.92
5.105ProAsp: 5.105 ± 1.097
1.276ProGlu: 1.276 ± 0.905
1.276ProPhe: 1.276 ± 0.998
2.553ProGly: 2.553 ± 1.381
0.0ProHis: 0.0 ± 0.0
4.467ProIle: 4.467 ± 2.015
1.276ProLys: 1.276 ± 0.585
9.572ProLeu: 9.572 ± 2.319
1.276ProMet: 1.276 ± 0.406
1.914ProAsn: 1.914 ± 0.41
5.743ProPro: 5.743 ± 2.743
3.829ProGln: 3.829 ± 2.088
2.553ProArg: 2.553 ± 1.582
5.743ProSer: 5.743 ± 2.338
5.105ProThr: 5.105 ± 1.48
4.467ProVal: 4.467 ± 1.311
0.0ProTrp: 0.0 ± 0.0
3.191ProTyr: 3.191 ± 0.909
0.0ProXaa: 0.0 ± 0.0
Gln
1.914GlnAla: 1.914 ± 1.47
0.638GlnCys: 0.638 ± 0.751
2.553GlnAsp: 2.553 ± 1.131
3.191GlnGlu: 3.191 ± 1.134
1.914GlnPhe: 1.914 ± 1.105
1.276GlnGly: 1.276 ± 0.406
1.276GlnHis: 1.276 ± 0.92
1.276GlnIle: 1.276 ± 0.69
1.914GlnLys: 1.914 ± 1.183
8.296GlnLeu: 8.296 ± 3.605
0.638GlnMet: 0.638 ± 0.469
0.0GlnAsn: 0.0 ± 0.0
1.914GlnPro: 1.914 ± 0.722
1.914GlnGln: 1.914 ± 1.47
1.914GlnArg: 1.914 ± 0.883
3.191GlnSer: 3.191 ± 1.016
3.829GlnThr: 3.829 ± 1.309
1.914GlnVal: 1.914 ± 0.41
0.638GlnTrp: 0.638 ± 0.499
1.914GlnTyr: 1.914 ± 0.883
0.0GlnXaa: 0.0 ± 0.0
Arg
3.829ArgAla: 3.829 ± 1.173
1.276ArgCys: 1.276 ± 1.621
2.553ArgAsp: 2.553 ± 0.952
4.467ArgGlu: 4.467 ± 1.688
1.914ArgPhe: 1.914 ± 0.913
2.553ArgGly: 2.553 ± 0.701
1.276ArgHis: 1.276 ± 0.938
1.276ArgIle: 1.276 ± 0.998
5.743ArgLys: 5.743 ± 1.816
6.382ArgLeu: 6.382 ± 1.004
0.638ArgMet: 0.638 ± 0.443
0.638ArgAsn: 0.638 ± 0.589
5.743ArgPro: 5.743 ± 1.523
1.276ArgGln: 1.276 ± 1.049
7.02ArgArg: 7.02 ± 3.404
4.467ArgSer: 4.467 ± 1.647
0.638ArgThr: 0.638 ± 0.469
3.191ArgVal: 3.191 ± 1.024
0.0ArgTrp: 0.0 ± 0.0
2.553ArgTyr: 2.553 ± 1.11
0.0ArgXaa: 0.0 ± 0.0
Ser
5.743SerAla: 5.743 ± 1.268
1.276SerCys: 1.276 ± 1.621
0.638SerAsp: 0.638 ± 0.589
3.191SerGlu: 3.191 ± 1.134
3.191SerPhe: 3.191 ± 1.145
7.658SerGly: 7.658 ± 3.793
1.914SerHis: 1.914 ± 1.767
3.829SerIle: 3.829 ± 1.424
4.467SerLys: 4.467 ± 2.094
3.191SerLeu: 3.191 ± 0.776
1.276SerMet: 1.276 ± 0.938
2.553SerAsn: 2.553 ± 0.956
3.829SerPro: 3.829 ± 1.156
0.638SerGln: 0.638 ± 0.499
5.105SerArg: 5.105 ± 1.116
9.572SerSer: 9.572 ± 2.827
14.678SerThr: 14.678 ± 1.36
5.743SerVal: 5.743 ± 0.551
0.0SerTrp: 0.0 ± 0.0
1.276SerTyr: 1.276 ± 0.406
0.0SerXaa: 0.0 ± 0.0
Thr
1.914ThrAla: 1.914 ± 0.722
5.105ThrCys: 5.105 ± 1.408
5.743ThrAsp: 5.743 ± 1.903
4.467ThrGlu: 4.467 ± 0.981
0.638ThrPhe: 0.638 ± 0.499
5.105ThrGly: 5.105 ± 1.992
3.191ThrHis: 3.191 ± 1.845
3.829ThrIle: 3.829 ± 0.82
3.191ThrLys: 3.191 ± 1.615
5.105ThrLeu: 5.105 ± 1.175
0.0ThrMet: 0.0 ± 0.0
3.191ThrAsn: 3.191 ± 1.073
9.572ThrPro: 9.572 ± 1.914
3.191ThrGln: 3.191 ± 0.564
3.829ThrArg: 3.829 ± 1.173
9.572ThrSer: 9.572 ± 1.17
8.296ThrThr: 8.296 ± 3.599
3.191ThrVal: 3.191 ± 0.757
1.914ThrTrp: 1.914 ± 0.779
1.914ThrTyr: 1.914 ± 1.183
0.0ThrXaa: 0.0 ± 0.0
Val
6.382ValAla: 6.382 ± 1.585
3.191ValCys: 3.191 ± 1.618
3.829ValAsp: 3.829 ± 1.018
2.553ValGlu: 2.553 ± 0.701
1.914ValPhe: 1.914 ± 1.408
5.105ValGly: 5.105 ± 2.287
3.829ValHis: 3.829 ± 2.071
1.914ValIle: 1.914 ± 0.779
1.914ValLys: 1.914 ± 0.41
3.191ValLeu: 3.191 ± 1.016
1.276ValMet: 1.276 ± 0.823
2.553ValAsn: 2.553 ± 0.548
3.829ValPro: 3.829 ± 1.389
2.553ValGln: 2.553 ± 1.571
2.553ValArg: 2.553 ± 0.88
5.105ValSer: 5.105 ± 1.413
7.02ValThr: 7.02 ± 1.437
5.743ValVal: 5.743 ± 2.08
2.553ValTrp: 2.553 ± 0.93
5.743ValTyr: 5.743 ± 2.832
0.0ValXaa: 0.0 ± 0.0
Trp
1.276TrpAla: 1.276 ± 0.406
0.0TrpCys: 0.0 ± 0.0
1.276TrpAsp: 1.276 ± 0.585
1.276TrpGlu: 1.276 ± 0.69
1.276TrpPhe: 1.276 ± 0.585
1.276TrpGly: 1.276 ± 0.406
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.638TrpLys: 0.638 ± 0.589
1.276TrpLeu: 1.276 ± 0.585
0.0TrpMet: 0.0 ± 0.0
0.638TrpAsn: 0.638 ± 0.469
1.276TrpPro: 1.276 ± 0.998
0.638TrpGln: 0.638 ± 0.589
1.276TrpArg: 1.276 ± 0.848
0.0TrpSer: 0.0 ± 0.0
2.553TrpThr: 2.553 ± 1.11
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.276TyrAla: 1.276 ± 0.905
1.276TyrCys: 1.276 ± 0.889
3.191TyrAsp: 3.191 ± 1.336
1.276TyrGlu: 1.276 ± 0.406
2.553TyrPhe: 2.553 ± 1.244
1.914TyrGly: 1.914 ± 1.105
1.276TyrHis: 1.276 ± 0.585
1.914TyrIle: 1.914 ± 0.41
2.553TyrLys: 2.553 ± 0.93
4.467TyrLeu: 4.467 ± 2.914
0.0TyrMet: 0.0 ± 0.0
3.829TyrAsn: 3.829 ± 2.126
0.638TyrPro: 0.638 ± 0.469
0.638TyrGln: 0.638 ± 0.469
6.382TyrArg: 6.382 ± 2.091
3.191TyrSer: 3.191 ± 1.371
0.638TyrThr: 0.638 ± 0.589
3.829TyrVal: 3.829 ± 1.058
0.638TyrTrp: 0.638 ± 0.469
4.467TyrTyr: 4.467 ± 1.423
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1568 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski