Amino acid dipepetide frequency for Williamsia sp. D3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.616AlaAla: 17.616 ± 0.145	0.92AlaCys: 0.92 ± 0.026	8.443AlaAsp: 8.443 ± 0.079	7.287AlaGlu: 7.287 ± 0.078	3.362AlaPhe: 3.362 ± 0.054	11.455AlaGly: 11.455 ± 0.098	2.437AlaHis: 2.437 ± 0.042	5.626AlaIle: 5.626 ± 0.064	2.936AlaLys: 2.936 ± 0.054	12.158AlaLeu: 12.158 ± 0.098	2.874AlaMet: 2.874 ± 0.04	2.359AlaAsn: 2.359 ± 0.04	5.67AlaPro: 5.67 ± 0.078	3.963AlaGln: 3.963 ± 0.046	7.717AlaArg: 7.717 ± 0.09	6.043AlaSer: 6.043 ± 0.063	7.225AlaThr: 7.225 ± 0.071	11.113AlaVal: 11.113 ± 0.111	1.483AlaTrp: 1.483 ± 0.031	2.138AlaTyr: 2.138 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.004CysAla: 1.004 ± 0.026	0.105CysCys: 0.105 ± 0.009	0.482CysAsp: 0.482 ± 0.021	0.406CysGlu: 0.406 ± 0.017	0.216CysPhe: 0.216 ± 0.013	0.89CysGly: 0.89 ± 0.026	0.177CysHis: 0.177 ± 0.013	0.287CysIle: 0.287 ± 0.015	0.117CysLys: 0.117 ± 0.008	0.643CysLeu: 0.643 ± 0.021	0.132CysMet: 0.132 ± 0.009	0.168CysAsn: 0.168 ± 0.012	0.45CysPro: 0.45 ± 0.02	0.182CysGln: 0.182 ± 0.012	0.53CysArg: 0.53 ± 0.02	0.518CysSer: 0.518 ± 0.016	0.464CysThr: 0.464 ± 0.019	0.651CysVal: 0.651 ± 0.022	0.119CysTrp: 0.119 ± 0.009	0.149CysTyr: 0.149 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.222AspAla: 7.222 ± 0.078	0.431AspCys: 0.431 ± 0.018	4.601AspAsp: 4.601 ± 0.063	4.28AspGlu: 4.28 ± 0.05	1.872AspPhe: 1.872 ± 0.036	5.793AspGly: 5.793 ± 0.067	1.673AspHis: 1.673 ± 0.035	2.741AspIle: 2.741 ± 0.045	1.532AspLys: 1.532 ± 0.037	6.509AspLeu: 6.509 ± 0.067	1.117AspMet: 1.117 ± 0.028	1.507AspAsn: 1.507 ± 0.03	4.505AspPro: 4.505 ± 0.057	2.055AspGln: 2.055 ± 0.041	4.648AspArg: 4.648 ± 0.059	3.446AspSer: 3.446 ± 0.049	3.45AspThr: 3.45 ± 0.05	5.434AspVal: 5.434 ± 0.066	0.886AspTrp: 0.886 ± 0.025	1.39AspTyr: 1.39 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.808GluAla: 5.808 ± 0.066	0.341GluCys: 0.341 ± 0.017	2.527GluAsp: 2.527 ± 0.049	2.544GluGlu: 2.544 ± 0.046	1.887GluPhe: 1.887 ± 0.036	3.528GluGly: 3.528 ± 0.056	1.557GluHis: 1.557 ± 0.032	2.715GluIle: 2.715 ± 0.044	1.513GluLys: 1.513 ± 0.036	6.453GluLeu: 6.453 ± 0.078	1.204GluMet: 1.204 ± 0.025	1.341GluAsn: 1.341 ± 0.028	3.086GluPro: 3.086 ± 0.048	2.428GluGln: 2.428 ± 0.042	4.302GluArg: 4.302 ± 0.06	3.302GluSer: 3.302 ± 0.048	2.801GluThr: 2.801 ± 0.04	4.666GluVal: 4.666 ± 0.064	0.793GluTrp: 0.793 ± 0.023	1.141GluTyr: 1.141 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.899PheAla: 3.899 ± 0.049	0.296PheCys: 0.296 ± 0.014	2.497PheAsp: 2.497 ± 0.045	1.63PheGlu: 1.63 ± 0.034	0.958PhePhe: 0.958 ± 0.028	3.478PheGly: 3.478 ± 0.05	0.618PheHis: 0.618 ± 0.02	1.223PheIle: 1.223 ± 0.028	0.576PheLys: 0.576 ± 0.019	2.414PheLeu: 2.414 ± 0.046	0.511PheMet: 0.511 ± 0.019	0.717PheAsn: 0.717 ± 0.022	1.355PhePro: 1.355 ± 0.035	0.634PheGln: 0.634 ± 0.021	1.692PheArg: 1.692 ± 0.035	1.811PheSer: 1.811 ± 0.038	2.015PheThr: 2.015 ± 0.031	2.652PheVal: 2.652 ± 0.05	0.408PheTrp: 0.408 ± 0.018	0.665PheTyr: 0.665 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.544GlyAla: 9.544 ± 0.097	0.779GlyCys: 0.779 ± 0.024	5.26GlyAsp: 5.26 ± 0.062	4.649GlyGlu: 4.649 ± 0.065	3.068GlyPhe: 3.068 ± 0.041	7.713GlyGly: 7.713 ± 0.087	2.049GlyHis: 2.049 ± 0.042	4.238GlyIle: 4.238 ± 0.049	2.569GlyLys: 2.569 ± 0.043	8.507GlyLeu: 8.507 ± 0.076	2.048GlyMet: 2.048 ± 0.041	1.956GlyAsn: 1.956 ± 0.04	4.433GlyPro: 4.433 ± 0.062	2.897GlyGln: 2.897 ± 0.045	6.309GlyArg: 6.309 ± 0.071	5.702GlySer: 5.702 ± 0.061	5.392GlyThr: 5.392 ± 0.064	7.432GlyVal: 7.432 ± 0.077	1.558GlyTrp: 1.558 ± 0.034	2.254GlyTyr: 2.254 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.179HisAla: 2.179 ± 0.04	0.209HisCys: 0.209 ± 0.014	1.367HisAsp: 1.367 ± 0.031	1.073HisGlu: 1.073 ± 0.027	0.657HisPhe: 0.657 ± 0.021	1.965HisGly: 1.965 ± 0.041	0.759HisHis: 0.759 ± 0.024	0.87HisIle: 0.87 ± 0.021	0.419HisLys: 0.419 ± 0.017	2.212HisLeu: 2.212 ± 0.042	0.425HisMet: 0.425 ± 0.017	0.476HisAsn: 0.476 ± 0.017	1.616HisPro: 1.616 ± 0.034	0.711HisGln: 0.711 ± 0.021	1.802HisArg: 1.802 ± 0.033	1.198HisSer: 1.198 ± 0.027	1.216HisThr: 1.216 ± 0.034	1.64HisVal: 1.64 ± 0.029	0.344HisTrp: 0.344 ± 0.016	0.501HisTyr: 0.501 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.718IleAla: 6.718 ± 0.073	0.423IleCys: 0.423 ± 0.018	3.867IleAsp: 3.867 ± 0.055	2.916IleGlu: 2.916 ± 0.052	1.157IlePhe: 1.157 ± 0.03	4.81IleGly: 4.81 ± 0.061	0.804IleHis: 0.804 ± 0.025	1.857IleIle: 1.857 ± 0.043	0.966IleLys: 0.966 ± 0.028	3.433IleLeu: 3.433 ± 0.054	0.664IleMet: 0.664 ± 0.022	1.3IleAsn: 1.3 ± 0.035	2.472IlePro: 2.472 ± 0.04	0.879IleGln: 0.879 ± 0.027	2.807IleArg: 2.807 ± 0.042	2.699IleSer: 2.699 ± 0.046	3.147IleThr: 3.147 ± 0.048	3.944IleVal: 3.944 ± 0.054	0.493IleTrp: 0.493 ± 0.017	0.852IleTyr: 0.852 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.886LysAla: 2.886 ± 0.055	0.127LysCys: 0.127 ± 0.01	1.222LysAsp: 1.222 ± 0.033	1.05LysGlu: 1.05 ± 0.028	0.654LysPhe: 0.654 ± 0.02	1.691LysGly: 1.691 ± 0.042	0.514LysHis: 0.514 ± 0.017	1.225LysIle: 1.225 ± 0.035	0.852LysLys: 0.852 ± 0.036	2.232LysLeu: 2.232 ± 0.047	0.541LysMet: 0.541 ± 0.021	0.62LysAsn: 0.62 ± 0.023	1.408LysPro: 1.408 ± 0.035	0.793LysGln: 0.793 ± 0.025	1.635LysArg: 1.635 ± 0.038	1.499LysSer: 1.499 ± 0.033	1.57LysThr: 1.57 ± 0.041	2.203LysVal: 2.203 ± 0.037	0.315LysTrp: 0.315 ± 0.017	0.591LysTyr: 0.591 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.824LeuAla: 12.824 ± 0.105	0.789LeuCys: 0.789 ± 0.024	6.619LeuAsp: 6.619 ± 0.076	4.537LeuGlu: 4.537 ± 0.061	2.692LeuPhe: 2.692 ± 0.054	8.643LeuGly: 8.643 ± 0.07	1.919LeuHis: 1.919 ± 0.036	4.607LeuIle: 4.607 ± 0.065	1.952LeuLys: 1.952 ± 0.039	9.29LeuLeu: 9.29 ± 0.098	1.888LeuMet: 1.888 ± 0.041	1.959LeuAsn: 1.959 ± 0.037	5.263LeuPro: 5.263 ± 0.054	2.554LeuGln: 2.554 ± 0.047	6.933LeuArg: 6.933 ± 0.074	5.891LeuSer: 5.891 ± 0.074	6.433LeuThr: 6.433 ± 0.065	8.382LeuVal: 8.382 ± 0.095	1.182LeuTrp: 1.182 ± 0.029	1.632LeuTyr: 1.632 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.559MetAla: 2.559 ± 0.043	0.178MetCys: 0.178 ± 0.012	0.998MetAsp: 0.998 ± 0.024	0.739MetGlu: 0.739 ± 0.022	0.679MetPhe: 0.679 ± 0.021	1.556MetGly: 1.556 ± 0.033	0.41MetHis: 0.41 ± 0.018	1.066MetIle: 1.066 ± 0.029	0.55MetLys: 0.55 ± 0.02	2.056MetLeu: 2.056 ± 0.036	0.445MetMet: 0.445 ± 0.018	0.593MetAsn: 0.593 ± 0.02	1.218MetPro: 1.218 ± 0.033	0.59MetGln: 0.59 ± 0.02	1.469MetArg: 1.469 ± 0.033	1.817MetSer: 1.817 ± 0.037	1.954MetThr: 1.954 ± 0.038	1.8MetVal: 1.8 ± 0.035	0.26MetTrp: 0.26 ± 0.014	0.395MetTyr: 0.395 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.563AsnAla: 2.563 ± 0.044	0.189AsnCys: 0.189 ± 0.01	1.261AsnAsp: 1.261 ± 0.03	1.096AsnGlu: 1.096 ± 0.029	0.652AsnPhe: 0.652 ± 0.021	2.125AsnGly: 2.125 ± 0.035	0.471AsnHis: 0.471 ± 0.015	1.07AsnIle: 1.07 ± 0.028	0.613AsnLys: 0.613 ± 0.022	2.104AsnLeu: 2.104 ± 0.042	0.45AsnMet: 0.45 ± 0.015	0.685AsnAsn: 0.685 ± 0.023	1.767AsnPro: 1.767 ± 0.042	0.691AsnGln: 0.691 ± 0.023	1.59AsnArg: 1.59 ± 0.032	1.336AsnSer: 1.336 ± 0.027	1.475AsnThr: 1.475 ± 0.031	1.799AsnVal: 1.799 ± 0.033	0.394AsnTrp: 0.394 ± 0.017	0.533AsnTyr: 0.533 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.83ProAla: 6.83 ± 0.071	0.248ProCys: 0.248 ± 0.014	4.352ProAsp: 4.352 ± 0.06	3.574ProGlu: 3.574 ± 0.049	1.538ProPhe: 1.538 ± 0.028	5.436ProGly: 5.436 ± 0.07	1.163ProHis: 1.163 ± 0.029	2.308ProIle: 2.308 ± 0.043	1.284ProLys: 1.284 ± 0.026	4.558ProLeu: 4.558 ± 0.056	1.159ProMet: 1.159 ± 0.029	1.229ProAsn: 1.229 ± 0.03	3.024ProPro: 3.024 ± 0.07	1.709ProGln: 1.709 ± 0.038	3.224ProArg: 3.224 ± 0.049	3.313ProSer: 3.313 ± 0.048	3.606ProThr: 3.606 ± 0.049	4.858ProVal: 4.858 ± 0.063	0.814ProTrp: 0.814 ± 0.023	1.084ProTyr: 1.084 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.446GlnAla: 3.446 ± 0.05	0.232GlnCys: 0.232 ± 0.014	1.225GlnAsp: 1.225 ± 0.032	1.199GlnGlu: 1.199 ± 0.03	0.956GlnPhe: 0.956 ± 0.025	2.125GlnGly: 2.125 ± 0.039	0.675GlnHis: 0.675 ± 0.02	1.743GlnIle: 1.743 ± 0.038	0.678GlnLys: 0.678 ± 0.022	3.482GlnLeu: 3.482 ± 0.05	0.789GlnMet: 0.789 ± 0.025	0.766GlnAsn: 0.766 ± 0.022	1.724GlnPro: 1.724 ± 0.037	1.444GlnGln: 1.444 ± 0.036	2.482GlnArg: 2.482 ± 0.04	1.776GlnSer: 1.776 ± 0.035	1.726GlnThr: 1.726 ± 0.034	2.701GlnVal: 2.701 ± 0.041	0.61GlnTrp: 0.61 ± 0.02	0.657GlnTyr: 0.657 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.54ArgAla: 7.54 ± 0.076	0.507ArgCys: 0.507 ± 0.019	4.234ArgAsp: 4.234 ± 0.058	3.972ArgGlu: 3.972 ± 0.059	2.25ArgPhe: 2.25 ± 0.037	5.008ArgGly: 5.008 ± 0.055	1.629ArgHis: 1.629 ± 0.033	3.343ArgIle: 3.343 ± 0.052	1.783ArgLys: 1.783 ± 0.039	6.696ArgLeu: 6.696 ± 0.076	1.786ArgMet: 1.786 ± 0.035	1.607ArgAsn: 1.607 ± 0.031	3.673ArgPro: 3.673 ± 0.05	2.222ArgGln: 2.222 ± 0.041	6.045ArgArg: 6.045 ± 0.07	4.405ArgSer: 4.405 ± 0.056	4.413ArgThr: 4.413 ± 0.053	5.408ArgVal: 5.408 ± 0.07	1.333ArgTrp: 1.333 ± 0.031	1.644ArgTyr: 1.644 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	7.458SerAla: 7.458 ± 0.08	0.406SerCys: 0.406 ± 0.019	3.839SerAsp: 3.839 ± 0.05	3.129SerGlu: 3.129 ± 0.045	1.702SerPhe: 1.702 ± 0.036	6.166SerGly: 6.166 ± 0.076	1.071SerHis: 1.071 ± 0.028	2.702SerIle: 2.702 ± 0.041	1.391SerLys: 1.391 ± 0.036	5.113SerLeu: 5.113 ± 0.066	1.54SerMet: 1.54 ± 0.033	1.325SerAsn: 1.325 ± 0.03	3.341SerPro: 3.341 ± 0.048	1.588SerGln: 1.588 ± 0.033	3.884SerArg: 3.884 ± 0.052	3.791SerSer: 3.791 ± 0.052	3.919SerThr: 3.919 ± 0.055	5.22SerVal: 5.22 ± 0.058	0.956SerTrp: 0.956 ± 0.026	1.199SerTyr: 1.199 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	7.799ThrAla: 7.799 ± 0.067	0.429ThrCys: 0.429 ± 0.017	4.264ThrAsp: 4.264 ± 0.062	3.511ThrGlu: 3.511 ± 0.052	1.821ThrPhe: 1.821 ± 0.039	5.835ThrGly: 5.835 ± 0.061	1.242ThrHis: 1.242 ± 0.029	2.852ThrIle: 2.852 ± 0.049	1.421ThrLys: 1.421 ± 0.034	5.563ThrLeu: 5.563 ± 0.059	1.318ThrMet: 1.318 ± 0.026	1.297ThrAsn: 1.297 ± 0.033	3.858ThrPro: 3.858 ± 0.055	1.552ThrGln: 1.552 ± 0.033	3.671ThrArg: 3.671 ± 0.05	3.798ThrSer: 3.798 ± 0.058	4.347ThrThr: 4.347 ± 0.066	6.011ThrVal: 6.011 ± 0.068	0.93ThrTrp: 0.93 ± 0.029	1.27ThrTyr: 1.27 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.249ValAla: 11.249 ± 0.099	0.729ValCys: 0.729 ± 0.022	5.971ValAsp: 5.971 ± 0.074	4.624ValGlu: 4.624 ± 0.06	2.618ValPhe: 2.618 ± 0.046	7.164ValGly: 7.164 ± 0.074	1.791ValHis: 1.791 ± 0.035	4.33ValIle: 4.33 ± 0.057	1.724ValLys: 1.724 ± 0.037	8.864ValLeu: 8.864 ± 0.091	1.778ValMet: 1.778 ± 0.039	2.034ValAsn: 2.034 ± 0.039	4.547ValPro: 4.547 ± 0.055	2.274ValGln: 2.274 ± 0.043	5.803ValArg: 5.803 ± 0.065	5.131ValSer: 5.131 ± 0.061	5.514ValThr: 5.514 ± 0.064	8.878ValVal: 8.878 ± 0.101	1.072ValTrp: 1.072 ± 0.029	1.503ValTyr: 1.503 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.506TrpAla: 1.506 ± 0.03	0.151TrpCys: 0.151 ± 0.009	0.798TrpAsp: 0.798 ± 0.028	0.644TrpGlu: 0.644 ± 0.021	0.552TrpPhe: 0.552 ± 0.019	0.992TrpGly: 0.992 ± 0.029	0.324TrpHis: 0.324 ± 0.015	0.714TrpIle: 0.714 ± 0.023	0.37TrpLys: 0.37 ± 0.017	1.56TrpLeu: 1.56 ± 0.037	0.368TrpMet: 0.368 ± 0.015	0.43TrpAsn: 0.43 ± 0.017	0.754TrpPro: 0.754 ± 0.019	0.593TrpGln: 0.593 ± 0.02	1.167TrpArg: 1.167 ± 0.029	0.99TrpSer: 0.99 ± 0.027	0.956TrpThr: 0.956 ± 0.027	1.144TrpVal: 1.144 ± 0.03	0.36TrpTrp: 0.36 ± 0.017	0.3TrpTyr: 0.3 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.178TyrAla: 2.178 ± 0.037	0.202TyrCys: 0.202 ± 0.011	1.269TyrAsp: 1.269 ± 0.032	1.078TyrGlu: 1.078 ± 0.029	0.755TyrPhe: 0.755 ± 0.022	1.981TyrGly: 1.981 ± 0.039	0.354TyrHis: 0.354 ± 0.017	0.691TyrIle: 0.691 ± 0.022	0.379TyrLys: 0.379 ± 0.016	2.14TyrLeu: 2.14 ± 0.036	0.296TyrMet: 0.296 ± 0.013	0.498TyrAsn: 0.498 ± 0.02	1.146TyrPro: 1.146 ± 0.03	0.676TyrGln: 0.676 ± 0.021	1.79TyrArg: 1.79 ± 0.037	1.274TyrSer: 1.274 ± 0.033	1.167TyrThr: 1.167 ± 0.03	1.662TyrVal: 1.662 ± 0.037	0.361TyrTrp: 0.361 ± 0.017	0.462TyrTyr: 0.462 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4926 proteins (1498476 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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