Amino acid dipepetide frequency for Crenothrix polyspora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.524AlaAla: 8.524 ± 0.127	1.064AlaCys: 1.064 ± 0.031	4.944AlaAsp: 4.944 ± 0.071	5.319AlaGlu: 5.319 ± 0.09	3.427AlaPhe: 3.427 ± 0.063	6.456AlaGly: 6.456 ± 0.093	2.028AlaHis: 2.028 ± 0.047	6.298AlaIle: 6.298 ± 0.075	5.049AlaLys: 5.049 ± 0.077	10.555AlaLeu: 10.555 ± 0.126	2.346AlaMet: 2.346 ± 0.045	3.779AlaAsn: 3.779 ± 0.063	3.048AlaPro: 3.048 ± 0.058	3.835AlaGln: 3.835 ± 0.065	3.679AlaArg: 3.679 ± 0.067	5.312AlaSer: 5.312 ± 0.077	5.146AlaThr: 5.146 ± 0.089	6.364AlaVal: 6.364 ± 0.083	1.136AlaTrp: 1.136 ± 0.032	2.64AlaTyr: 2.64 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.937CysAla: 0.937 ± 0.026	0.176CysCys: 0.176 ± 0.013	0.549CysAsp: 0.549 ± 0.026	0.501CysGlu: 0.501 ± 0.02	0.501CysPhe: 0.501 ± 0.023	0.903CysGly: 0.903 ± 0.033	0.383CysHis: 0.383 ± 0.022	0.604CysIle: 0.604 ± 0.024	0.486CysLys: 0.486 ± 0.025	1.189CysLeu: 1.189 ± 0.032	0.217CysMet: 0.217 ± 0.013	0.459CysAsn: 0.459 ± 0.022	0.53CysPro: 0.53 ± 0.021	0.482CysGln: 0.482 ± 0.019	0.525CysArg: 0.525 ± 0.022	0.724CysSer: 0.724 ± 0.029	0.649CysThr: 0.649 ± 0.032	0.849CysVal: 0.849 ± 0.03	0.131CysTrp: 0.131 ± 0.01	0.387CysTyr: 0.387 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.676AspAla: 4.676 ± 0.07	0.618AspCys: 0.618 ± 0.023	3.065AspAsp: 3.065 ± 0.064	2.943AspGlu: 2.943 ± 0.053	2.647AspPhe: 2.647 ± 0.053	3.789AspGly: 3.789 ± 0.096	1.091AspHis: 1.091 ± 0.033	4.085AspIle: 4.085 ± 0.063	3.273AspLys: 3.273 ± 0.054	4.994AspLeu: 4.994 ± 0.077	1.346AspMet: 1.346 ± 0.034	2.738AspAsn: 2.738 ± 0.051	2.072AspPro: 2.072 ± 0.047	1.779AspGln: 1.779 ± 0.045	2.272AspArg: 2.272 ± 0.048	3.293AspSer: 3.293 ± 0.061	3.222AspThr: 3.222 ± 0.081	3.761AspVal: 3.761 ± 0.071	0.876AspTrp: 0.876 ± 0.027	2.016AspTyr: 2.016 ± 0.046	0.002AspXaa: 0.002 ± 0.001
Glu	4.676GluAla: 4.676 ± 0.076	0.47GluCys: 0.47 ± 0.024	2.351GluAsp: 2.351 ± 0.048	2.543GluGlu: 2.543 ± 0.057	2.032GluPhe: 2.032 ± 0.046	2.774GluGly: 2.774 ± 0.055	1.327GluHis: 1.327 ± 0.037	3.637GluIle: 3.637 ± 0.06	3.404GluLys: 3.404 ± 0.068	5.694GluLeu: 5.694 ± 0.082	1.285GluMet: 1.285 ± 0.038	2.374GluAsn: 2.374 ± 0.049	1.8GluPro: 1.8 ± 0.043	3.164GluGln: 3.164 ± 0.059	2.89GluArg: 2.89 ± 0.068	2.723GluSer: 2.723 ± 0.048	2.924GluThr: 2.924 ± 0.055	3.149GluVal: 3.149 ± 0.065	0.63GluTrp: 0.63 ± 0.026	1.519GluTyr: 1.519 ± 0.038	0.001GluXaa: 0.001 ± 0.001
Phe	3.322PheAla: 3.322 ± 0.053	0.522PheCys: 0.522 ± 0.024	2.634PheAsp: 2.634 ± 0.051	2.021PheGlu: 2.021 ± 0.044	1.957PhePhe: 1.957 ± 0.047	2.861PheGly: 2.861 ± 0.058	0.9PheHis: 0.9 ± 0.031	2.77PheIle: 2.77 ± 0.046	2.212PheLys: 2.212 ± 0.046	3.765PheLeu: 3.765 ± 0.062	1.07PheMet: 1.07 ± 0.034	2.121PheAsn: 2.121 ± 0.042	1.469PhePro: 1.469 ± 0.039	1.302PheGln: 1.302 ± 0.035	1.605PheArg: 1.605 ± 0.041	3.222PheSer: 3.222 ± 0.053	2.419PheThr: 2.419 ± 0.048	2.68PheVal: 2.68 ± 0.049	0.598PheTrp: 0.598 ± 0.022	1.455PheTyr: 1.455 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.285GlyAla: 5.285 ± 0.101	0.982GlyCys: 0.982 ± 0.033	3.626GlyAsp: 3.626 ± 0.11	3.307GlyGlu: 3.307 ± 0.058	3.268GlyPhe: 3.268 ± 0.057	5.037GlyGly: 5.037 ± 0.104	1.544GlyHis: 1.544 ± 0.04	4.829GlyIle: 4.829 ± 0.077	4.309GlyLys: 4.309 ± 0.065	7.07GlyLeu: 7.07 ± 0.092	1.802GlyMet: 1.802 ± 0.044	3.079GlyAsn: 3.079 ± 0.083	1.32GlyPro: 1.32 ± 0.035	2.767GlyGln: 2.767 ± 0.052	3.04GlyArg: 3.04 ± 0.058	4.115GlySer: 4.115 ± 0.078	3.667GlyThr: 3.667 ± 0.087	5.018GlyVal: 5.018 ± 0.075	0.992GlyTrp: 0.992 ± 0.033	2.519GlyTyr: 2.519 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.097HisAla: 2.097 ± 0.045	0.332HisCys: 0.332 ± 0.02	1.292HisAsp: 1.292 ± 0.037	1.14HisGlu: 1.14 ± 0.032	1.188HisPhe: 1.188 ± 0.029	1.639HisGly: 1.639 ± 0.037	0.747HisHis: 0.747 ± 0.031	1.688HisIle: 1.688 ± 0.045	1.195HisLys: 1.195 ± 0.035	2.324HisLeu: 2.324 ± 0.053	0.482HisMet: 0.482 ± 0.022	1.166HisAsn: 1.166 ± 0.035	1.276HisPro: 1.276 ± 0.037	0.992HisGln: 0.992 ± 0.03	1.023HisArg: 1.023 ± 0.032	1.465HisSer: 1.465 ± 0.04	1.342HisThr: 1.342 ± 0.037	1.408HisVal: 1.408 ± 0.038	0.418HisTrp: 0.418 ± 0.02	1.033HisTyr: 1.033 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.638IleAla: 6.638 ± 0.079	0.642IleCys: 0.642 ± 0.025	4.225IleAsp: 4.225 ± 0.07	3.898IleGlu: 3.898 ± 0.073	2.382IlePhe: 2.382 ± 0.06	4.472IleGly: 4.472 ± 0.071	1.405IleHis: 1.405 ± 0.038	4.293IleIle: 4.293 ± 0.074	4.029IleLys: 4.029 ± 0.068	5.582IleLeu: 5.582 ± 0.09	1.388IleMet: 1.388 ± 0.037	3.638IleAsn: 3.638 ± 0.064	2.91IlePro: 2.91 ± 0.058	2.23IleGln: 2.23 ± 0.046	2.876IleArg: 2.876 ± 0.049	4.402IleSer: 4.402 ± 0.057	4.239IleThr: 4.239 ± 0.072	4.167IleVal: 4.167 ± 0.072	0.633IleTrp: 0.633 ± 0.022	1.853IleTyr: 1.853 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.969LysAla: 4.969 ± 0.063	0.393LysCys: 0.393 ± 0.018	2.857LysAsp: 2.857 ± 0.053	2.589LysGlu: 2.589 ± 0.061	1.67LysPhe: 1.67 ± 0.034	3.168LysGly: 3.168 ± 0.056	1.451LysHis: 1.451 ± 0.043	4.037LysIle: 4.037 ± 0.069	3.508LysLys: 3.508 ± 0.068	5.561LysLeu: 5.561 ± 0.075	1.453LysMet: 1.453 ± 0.044	2.98LysAsn: 2.98 ± 0.063	2.781LysPro: 2.781 ± 0.059	2.871LysGln: 2.871 ± 0.057	2.53LysArg: 2.53 ± 0.053	3.175LysSer: 3.175 ± 0.058	3.81LysThr: 3.81 ± 0.062	3.214LysVal: 3.214 ± 0.063	0.509LysTrp: 0.509 ± 0.02	1.356LysTyr: 1.356 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	10.573LeuAla: 10.573 ± 0.118	1.193LeuCys: 1.193 ± 0.035	5.555LeuAsp: 5.555 ± 0.07	5.246LeuGlu: 5.246 ± 0.081	4.155LeuPhe: 4.155 ± 0.077	6.763LeuGly: 6.763 ± 0.091	2.454LeuHis: 2.454 ± 0.058	6.561LeuIle: 6.561 ± 0.094	5.844LeuLys: 5.844 ± 0.084	11.459LeuLeu: 11.459 ± 0.147	2.522LeuMet: 2.522 ± 0.048	4.753LeuAsn: 4.753 ± 0.068	5.124LeuPro: 5.124 ± 0.072	4.341LeuGln: 4.341 ± 0.076	4.779LeuArg: 4.779 ± 0.07	7.639LeuSer: 7.639 ± 0.083	6.323LeuThr: 6.323 ± 0.08	6.452LeuVal: 6.452 ± 0.072	1.219LeuTrp: 1.219 ± 0.036	2.869LeuTyr: 2.869 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.554MetAla: 2.554 ± 0.054	0.173MetCys: 0.173 ± 0.013	1.133MetAsp: 1.133 ± 0.032	1.053MetGlu: 1.053 ± 0.031	0.685MetPhe: 0.685 ± 0.026	1.63MetGly: 1.63 ± 0.039	0.536MetHis: 0.536 ± 0.022	1.371MetIle: 1.371 ± 0.036	1.319MetLys: 1.319 ± 0.035	2.536MetLeu: 2.536 ± 0.047	0.62MetMet: 0.62 ± 0.024	1.064MetAsn: 1.064 ± 0.03	1.302MetPro: 1.302 ± 0.033	1.136MetGln: 1.136 ± 0.034	1.163MetArg: 1.163 ± 0.033	1.596MetSer: 1.596 ± 0.033	1.581MetThr: 1.581 ± 0.038	1.516MetVal: 1.516 ± 0.034	0.174MetTrp: 0.174 ± 0.014	0.488MetTyr: 0.488 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	4.137AsnAla: 4.137 ± 0.069	0.486AsnCys: 0.486 ± 0.022	2.458AsnAsp: 2.458 ± 0.075	1.975AsnGlu: 1.975 ± 0.044	1.694AsnPhe: 1.694 ± 0.037	3.244AsnGly: 3.244 ± 0.087	1.07AsnHis: 1.07 ± 0.034	2.935AsnIle: 2.935 ± 0.057	2.486AsnLys: 2.486 ± 0.055	4.223AsnLeu: 4.223 ± 0.07	0.948AsnMet: 0.948 ± 0.028	2.438AsnAsn: 2.438 ± 0.069	2.479AsnPro: 2.479 ± 0.052	1.98AsnGln: 1.98 ± 0.051	2.081AsnArg: 2.081 ± 0.039	2.779AsnSer: 2.779 ± 0.059	3.106AsnThr: 3.106 ± 0.069	2.726AsnVal: 2.726 ± 0.058	0.71AsnTrp: 0.71 ± 0.028	1.527AsnTyr: 1.527 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	3.624ProAla: 3.624 ± 0.057	0.428ProCys: 0.428 ± 0.02	2.747ProAsp: 2.747 ± 0.048	2.809ProGlu: 2.809 ± 0.057	1.706ProPhe: 1.706 ± 0.046	2.49ProGly: 2.49 ± 0.044	0.938ProHis: 0.938 ± 0.033	2.622ProIle: 2.622 ± 0.055	2.163ProLys: 2.163 ± 0.051	4.269ProLeu: 4.269 ± 0.065	0.987ProMet: 0.987 ± 0.031	1.651ProAsn: 1.651 ± 0.036	1.619ProPro: 1.619 ± 0.055	1.569ProGln: 1.569 ± 0.038	1.461ProArg: 1.461 ± 0.04	2.494ProSer: 2.494 ± 0.051	2.398ProThr: 2.398 ± 0.055	3.537ProVal: 3.537 ± 0.065	0.517ProTrp: 0.517 ± 0.022	1.295ProTyr: 1.295 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.379GlnAla: 4.379 ± 0.08	0.456GlnCys: 0.456 ± 0.019	1.991GlnAsp: 1.991 ± 0.042	2.021GlnGlu: 2.021 ± 0.052	1.686GlnPhe: 1.686 ± 0.039	2.715GlnGly: 2.715 ± 0.049	1.532GlnHis: 1.532 ± 0.041	2.629GlnIle: 2.629 ± 0.046	2.275GlnLys: 2.275 ± 0.046	4.969GlnLeu: 4.969 ± 0.088	0.992GlnMet: 0.992 ± 0.028	1.698GlnAsn: 1.698 ± 0.043	1.822GlnPro: 1.822 ± 0.044	3.223GlnGln: 3.223 ± 0.086	2.459GlnArg: 2.459 ± 0.052	2.427GlnSer: 2.427 ± 0.048	2.343GlnThr: 2.343 ± 0.049	2.701GlnVal: 2.701 ± 0.046	0.681GlnTrp: 0.681 ± 0.027	1.284GlnTyr: 1.284 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.357ArgAla: 3.357 ± 0.058	0.514ArgCys: 0.514 ± 0.022	2.399ArgAsp: 2.399 ± 0.05	2.407ArgGlu: 2.407 ± 0.052	2.153ArgPhe: 2.153 ± 0.048	2.5ArgGly: 2.5 ± 0.052	1.252ArgHis: 1.252 ± 0.031	3.118ArgIle: 3.118 ± 0.055	2.232ArgLys: 2.232 ± 0.047	5.368ArgLeu: 5.368 ± 0.082	1.154ArgMet: 1.154 ± 0.031	1.827ArgAsn: 1.827 ± 0.04	1.69ArgPro: 1.69 ± 0.046	2.252ArgGln: 2.252 ± 0.054	2.209ArgArg: 2.209 ± 0.055	2.536ArgSer: 2.536 ± 0.055	2.183ArgThr: 2.183 ± 0.04	3.091ArgVal: 3.091 ± 0.051	0.72ArgTrp: 0.72 ± 0.029	1.995ArgTyr: 1.995 ± 0.05	0.001ArgXaa: 0.001 ± 0.001
Ser	5.857SerAla: 5.857 ± 0.077	0.767SerCys: 0.767 ± 0.036	3.219SerAsp: 3.219 ± 0.058	2.955SerGlu: 2.955 ± 0.051	2.658SerPhe: 2.658 ± 0.05	4.952SerGly: 4.952 ± 0.075	1.536SerHis: 1.536 ± 0.039	3.981SerIle: 3.981 ± 0.06	3.124SerLys: 3.124 ± 0.05	6.583SerLeu: 6.583 ± 0.083	1.325SerMet: 1.325 ± 0.038	2.741SerAsn: 2.741 ± 0.062	2.538SerPro: 2.538 ± 0.05	2.53SerGln: 2.53 ± 0.047	2.527SerArg: 2.527 ± 0.048	4.027SerSer: 4.027 ± 0.073	3.549SerThr: 3.549 ± 0.069	4.741SerVal: 4.741 ± 0.07	0.825SerTrp: 0.825 ± 0.031	1.972SerTyr: 1.972 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.594ThrAla: 5.594 ± 0.1	0.563ThrCys: 0.563 ± 0.024	3.283ThrAsp: 3.283 ± 0.061	3.113ThrGlu: 3.113 ± 0.052	1.95ThrPhe: 1.95 ± 0.042	4.772ThrGly: 4.772 ± 0.102	1.524ThrHis: 1.524 ± 0.04	3.379ThrIle: 3.379 ± 0.066	2.418ThrLys: 2.418 ± 0.05	7.152ThrLeu: 7.152 ± 0.096	1.044ThrMet: 1.044 ± 0.03	2.163ThrAsn: 2.163 ± 0.052	3.156ThrPro: 3.156 ± 0.062	2.764ThrGln: 2.764 ± 0.052	2.443ThrArg: 2.443 ± 0.046	3.158ThrSer: 3.158 ± 0.058	3.33ThrThr: 3.33 ± 0.077	4.627ThrVal: 4.627 ± 0.08	0.676ThrTrp: 0.676 ± 0.025	1.575ThrTyr: 1.575 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	6.113ValAla: 6.113 ± 0.082	0.851ValCys: 0.851 ± 0.032	3.868ValAsp: 3.868 ± 0.062	3.534ValGlu: 3.534 ± 0.061	3.104ValPhe: 3.104 ± 0.052	4.384ValGly: 4.384 ± 0.075	1.366ValHis: 1.366 ± 0.035	4.801ValIle: 4.801 ± 0.075	3.491ValLys: 3.491 ± 0.067	7.331ValLeu: 7.331 ± 0.095	1.748ValMet: 1.748 ± 0.042	2.989ValAsn: 2.989 ± 0.061	2.476ValPro: 2.476 ± 0.045	2.287ValGln: 2.287 ± 0.044	2.899ValArg: 2.899 ± 0.055	4.552ValSer: 4.552 ± 0.071	4.101ValThr: 4.101 ± 0.086	4.88ValVal: 4.88 ± 0.079	0.816ValTrp: 0.816 ± 0.03	1.991ValTyr: 1.991 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.924TrpAla: 0.924 ± 0.032	0.148TrpCys: 0.148 ± 0.013	0.668TrpAsp: 0.668 ± 0.029	0.54TrpGlu: 0.54 ± 0.02	0.512TrpPhe: 0.512 ± 0.024	0.769TrpGly: 0.769 ± 0.028	0.414TrpHis: 0.414 ± 0.018	0.675TrpIle: 0.675 ± 0.028	0.573TrpLys: 0.573 ± 0.027	1.854TrpLeu: 1.854 ± 0.048	0.308TrpMet: 0.308 ± 0.016	0.489TrpAsn: 0.489 ± 0.023	0.522TrpPro: 0.522 ± 0.021	1.001TrpGln: 1.001 ± 0.033	0.779TrpArg: 0.779 ± 0.03	0.728TrpSer: 0.728 ± 0.029	0.577TrpThr: 0.577 ± 0.022	0.866TrpVal: 0.866 ± 0.031	0.195TrpTrp: 0.195 ± 0.013	0.413TrpTyr: 0.413 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.711TyrAla: 2.711 ± 0.049	0.403TyrCys: 0.403 ± 0.02	1.695TyrAsp: 1.695 ± 0.042	1.455TyrGlu: 1.455 ± 0.038	1.531TyrPhe: 1.531 ± 0.041	2.258TyrGly: 2.258 ± 0.052	0.75TyrHis: 0.75 ± 0.028	1.592TyrIle: 1.592 ± 0.044	1.493TyrLys: 1.493 ± 0.034	3.341TyrLeu: 3.341 ± 0.062	0.591TyrMet: 0.591 ± 0.022	1.336TyrAsn: 1.336 ± 0.034	1.387TyrPro: 1.387 ± 0.036	1.779TyrGln: 1.779 ± 0.04	1.721TyrArg: 1.721 ± 0.043	2.041TyrSer: 2.041 ± 0.044	1.772TyrThr: 1.772 ± 0.044	1.836TyrVal: 1.836 ± 0.041	0.499TyrTrp: 0.499 ± 0.021	1.099TyrTyr: 1.099 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3943 proteins (1122853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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