Amino acid dipepetide frequency for Maribacter polysiphoniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.214AlaAla: 4.214 ± 0.069	0.532AlaCys: 0.532 ± 0.019	3.516AlaAsp: 3.516 ± 0.056	3.903AlaGlu: 3.903 ± 0.059	3.203AlaPhe: 3.203 ± 0.05	4.146AlaGly: 4.146 ± 0.06	1.239AlaHis: 1.239 ± 0.032	5.403AlaIle: 5.403 ± 0.069	4.605AlaLys: 4.605 ± 0.064	6.568AlaLeu: 6.568 ± 0.08	1.797AlaMet: 1.797 ± 0.037	3.413AlaAsn: 3.413 ± 0.044	2.042AlaPro: 2.042 ± 0.05	2.414AlaGln: 2.414 ± 0.04	2.019AlaArg: 2.019 ± 0.035	4.039AlaSer: 4.039 ± 0.052	3.672AlaThr: 3.672 ± 0.068	4.065AlaVal: 4.065 ± 0.054	0.709AlaTrp: 0.709 ± 0.026	2.659AlaTyr: 2.659 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.474CysAla: 0.474 ± 0.02	0.107CysCys: 0.107 ± 0.009	0.419CysAsp: 0.419 ± 0.02	0.441CysGlu: 0.441 ± 0.02	0.385CysPhe: 0.385 ± 0.017	0.617CysGly: 0.617 ± 0.023	0.195CysHis: 0.195 ± 0.015	0.541CysIle: 0.541 ± 0.018	0.474CysLys: 0.474 ± 0.018	0.626CysLeu: 0.626 ± 0.023	0.174CysMet: 0.174 ± 0.012	0.404CysAsn: 0.404 ± 0.021	0.337CysPro: 0.337 ± 0.019	0.192CysGln: 0.192 ± 0.011	0.232CysArg: 0.232 ± 0.013	0.541CysSer: 0.541 ± 0.023	0.466CysThr: 0.466 ± 0.029	0.387CysVal: 0.387 ± 0.018	0.07CysTrp: 0.07 ± 0.007	0.31CysTyr: 0.31 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.89AspAla: 3.89 ± 0.057	0.408AspCys: 0.408 ± 0.018	3.263AspAsp: 3.263 ± 0.062	3.577AspGlu: 3.577 ± 0.053	3.778AspPhe: 3.778 ± 0.052	4.498AspGly: 4.498 ± 0.084	1.119AspHis: 1.119 ± 0.024	4.585AspIle: 4.585 ± 0.055	4.085AspLys: 4.085 ± 0.057	5.423AspLeu: 5.423 ± 0.068	1.303AspMet: 1.303 ± 0.033	3.21AspAsn: 3.21 ± 0.055	2.054AspPro: 2.054 ± 0.044	1.695AspGln: 1.695 ± 0.036	2.161AspArg: 2.161 ± 0.04	3.306AspSer: 3.306 ± 0.049	2.99AspThr: 2.99 ± 0.048	3.655AspVal: 3.655 ± 0.05	0.899AspTrp: 0.899 ± 0.023	3.017AspTyr: 3.017 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.266GluAla: 4.266 ± 0.066	0.341GluCys: 0.341 ± 0.018	3.609GluAsp: 3.609 ± 0.053	4.748GluGlu: 4.748 ± 0.07	2.758GluPhe: 2.758 ± 0.044	4.195GluGly: 4.195 ± 0.054	1.241GluHis: 1.241 ± 0.029	5.144GluIle: 5.144 ± 0.061	5.568GluLys: 5.568 ± 0.078	6.2GluLeu: 6.2 ± 0.066	1.673GluMet: 1.673 ± 0.034	4.352GluAsn: 4.352 ± 0.057	1.735GluPro: 1.735 ± 0.032	2.248GluGln: 2.248 ± 0.045	2.696GluArg: 2.696 ± 0.044	3.368GluSer: 3.368 ± 0.049	3.521GluThr: 3.521 ± 0.046	4.373GluVal: 4.373 ± 0.056	0.664GluTrp: 0.664 ± 0.024	2.402GluTyr: 2.402 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	2.861PheAla: 2.861 ± 0.047	0.417PheCys: 0.417 ± 0.02	3.294PheAsp: 3.294 ± 0.05	3.286PheGlu: 3.286 ± 0.051	2.586PhePhe: 2.586 ± 0.05	3.636PheGly: 3.636 ± 0.054	0.849PheHis: 0.849 ± 0.023	3.621PheIle: 3.621 ± 0.056	3.545PheLys: 3.545 ± 0.049	4.736PheLeu: 4.736 ± 0.06	1.213PheMet: 1.213 ± 0.03	3.042PheAsn: 3.042 ± 0.05	1.789PhePro: 1.789 ± 0.039	1.493PheGln: 1.493 ± 0.029	1.645PheArg: 1.645 ± 0.033	3.677PheSer: 3.677 ± 0.061	2.977PheThr: 2.977 ± 0.048	2.982PheVal: 2.982 ± 0.05	0.617PheTrp: 0.617 ± 0.021	2.121PheTyr: 2.121 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.355GlyAla: 4.355 ± 0.054	0.662GlyCys: 0.662 ± 0.038	3.792GlyAsp: 3.792 ± 0.057	3.982GlyGlu: 3.982 ± 0.047	3.833GlyPhe: 3.833 ± 0.048	4.801GlyGly: 4.801 ± 0.088	1.344GlyHis: 1.344 ± 0.034	5.816GlyIle: 5.816 ± 0.066	5.294GlyLys: 5.294 ± 0.075	6.427GlyLeu: 6.427 ± 0.08	1.817GlyMet: 1.817 ± 0.039	3.916GlyAsn: 3.916 ± 0.066	1.638GlyPro: 1.638 ± 0.04	2.149GlyGln: 2.149 ± 0.04	2.299GlyArg: 2.299 ± 0.042	4.264GlySer: 4.264 ± 0.064	4.281GlyThr: 4.281 ± 0.071	4.63GlyVal: 4.63 ± 0.059	0.888GlyTrp: 0.888 ± 0.027	3.067GlyTyr: 3.067 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.057HisAla: 1.057 ± 0.029	0.189HisCys: 0.189 ± 0.012	0.926HisAsp: 0.926 ± 0.023	1.031HisGlu: 1.031 ± 0.024	1.097HisPhe: 1.097 ± 0.028	1.274HisGly: 1.274 ± 0.037	0.528HisHis: 0.528 ± 0.022	1.464HisIle: 1.464 ± 0.036	1.298HisLys: 1.298 ± 0.029	1.868HisLeu: 1.868 ± 0.039	0.453HisMet: 0.453 ± 0.017	0.933HisAsn: 0.933 ± 0.025	0.978HisPro: 0.978 ± 0.031	0.74HisGln: 0.74 ± 0.023	0.731HisArg: 0.731 ± 0.02	1.128HisSer: 1.128 ± 0.03	1.047HisThr: 1.047 ± 0.025	1.013HisVal: 1.013 ± 0.025	0.285HisTrp: 0.285 ± 0.014	0.849HisTyr: 0.849 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.577IleAla: 5.577 ± 0.063	0.561IleCys: 0.561 ± 0.018	4.875IleAsp: 4.875 ± 0.06	4.98IleGlu: 4.98 ± 0.062	3.353IlePhe: 3.353 ± 0.054	5.391IleGly: 5.391 ± 0.062	1.368IleHis: 1.368 ± 0.03	5.332IleIle: 5.332 ± 0.072	5.292IleLys: 5.292 ± 0.065	6.861IleLeu: 6.861 ± 0.079	1.557IleMet: 1.557 ± 0.034	4.106IleAsn: 4.106 ± 0.058	3.35IlePro: 3.35 ± 0.051	2.391IleGln: 2.391 ± 0.041	2.724IleArg: 2.724 ± 0.044	5.301IleSer: 5.301 ± 0.064	4.674IleThr: 4.674 ± 0.081	4.665IleVal: 4.665 ± 0.06	0.749IleTrp: 0.749 ± 0.021	2.64IleTyr: 2.64 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.948LysAla: 4.948 ± 0.067	0.314LysCys: 0.314 ± 0.017	4.571LysAsp: 4.571 ± 0.06	6.118LysGlu: 6.118 ± 0.071	2.634LysPhe: 2.634 ± 0.05	4.957LysGly: 4.957 ± 0.059	1.324LysHis: 1.324 ± 0.031	5.593LysIle: 5.593 ± 0.059	6.496LysLys: 6.496 ± 0.083	6.032LysLeu: 6.032 ± 0.08	1.926LysMet: 1.926 ± 0.04	4.664LysAsn: 4.664 ± 0.068	2.395LysPro: 2.395 ± 0.044	2.319LysGln: 2.319 ± 0.047	2.882LysArg: 2.882 ± 0.047	4.411LysSer: 4.411 ± 0.064	4.466LysThr: 4.466 ± 0.06	4.652LysVal: 4.652 ± 0.065	0.834LysTrp: 0.834 ± 0.021	2.855LysTyr: 2.855 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	6.009LeuAla: 6.009 ± 0.086	0.705LeuCys: 0.705 ± 0.024	5.524LeuAsp: 5.524 ± 0.06	6.13LeuGlu: 6.13 ± 0.076	4.862LeuPhe: 4.862 ± 0.066	6.404LeuGly: 6.404 ± 0.076	1.671LeuHis: 1.671 ± 0.04	6.441LeuIle: 6.441 ± 0.074	7.388LeuLys: 7.388 ± 0.085	8.965LeuLeu: 8.965 ± 0.117	2.252LeuMet: 2.252 ± 0.041	5.262LeuAsn: 5.262 ± 0.065	3.731LeuPro: 3.731 ± 0.054	3.12LeuGln: 3.12 ± 0.054	3.466LeuArg: 3.466 ± 0.051	6.457LeuSer: 6.457 ± 0.076	5.1LeuThr: 5.1 ± 0.061	5.671LeuVal: 5.671 ± 0.067	1.001LeuTrp: 1.001 ± 0.027	3.319LeuTyr: 3.319 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.973MetAla: 1.973 ± 0.037	0.143MetCys: 0.143 ± 0.009	1.545MetAsp: 1.545 ± 0.036	1.7MetGlu: 1.7 ± 0.035	0.919MetPhe: 0.919 ± 0.024	1.925MetGly: 1.925 ± 0.037	0.456MetHis: 0.456 ± 0.019	1.494MetIle: 1.494 ± 0.029	2.123MetLys: 2.123 ± 0.037	1.998MetLeu: 1.998 ± 0.036	0.63MetMet: 0.63 ± 0.025	1.294MetAsn: 1.294 ± 0.027	0.948MetPro: 0.948 ± 0.023	0.854MetGln: 0.854 ± 0.024	0.899MetArg: 0.899 ± 0.026	1.27MetSer: 1.27 ± 0.027	1.209MetThr: 1.209 ± 0.027	1.862MetVal: 1.862 ± 0.042	0.188MetTrp: 0.188 ± 0.011	0.726MetTyr: 0.726 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.692AsnAla: 3.692 ± 0.052	0.438AsnCys: 0.438 ± 0.021	3.325AsnAsp: 3.325 ± 0.052	3.55AsnGlu: 3.55 ± 0.048	2.622AsnPhe: 2.622 ± 0.046	4.297AsnGly: 4.297 ± 0.068	1.135AsnHis: 1.135 ± 0.03	4.332AsnIle: 4.332 ± 0.06	3.768AsnLys: 3.768 ± 0.054	5.016AsnLeu: 5.016 ± 0.065	1.303AsnMet: 1.303 ± 0.031	3.364AsnAsn: 3.364 ± 0.062	2.804AsnPro: 2.804 ± 0.044	1.941AsnGln: 1.941 ± 0.044	2.234AsnArg: 2.234 ± 0.043	3.489AsnSer: 3.489 ± 0.055	3.633AsnThr: 3.633 ± 0.058	3.243AsnVal: 3.243 ± 0.045	0.75AsnTrp: 0.75 ± 0.022	2.54AsnTyr: 2.54 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	1.889ProAla: 1.889 ± 0.041	0.205ProCys: 0.205 ± 0.011	2.393ProAsp: 2.393 ± 0.045	3.038ProGlu: 3.038 ± 0.045	1.952ProPhe: 1.952 ± 0.035	2.163ProGly: 2.163 ± 0.044	0.634ProHis: 0.634 ± 0.022	2.863ProIle: 2.863 ± 0.047	2.809ProLys: 2.809 ± 0.05	3.273ProLeu: 3.273 ± 0.049	0.906ProMet: 0.906 ± 0.025	2.216ProAsn: 2.216 ± 0.041	0.988ProPro: 0.988 ± 0.026	1.154ProGln: 1.154 ± 0.03	0.977ProArg: 0.977 ± 0.021	2.286ProSer: 2.286 ± 0.049	2.132ProThr: 2.132 ± 0.049	2.322ProVal: 2.322 ± 0.04	0.423ProTrp: 0.423 ± 0.017	1.525ProTyr: 1.525 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	1.904GlnAla: 1.904 ± 0.036	0.191GlnCys: 0.191 ± 0.012	1.704GlnAsp: 1.704 ± 0.032	2.348GlnGlu: 2.348 ± 0.044	1.566GlnPhe: 1.566 ± 0.032	2.034GlnGly: 2.034 ± 0.036	0.62GlnHis: 0.62 ± 0.02	2.467GlnIle: 2.467 ± 0.044	2.677GlnLys: 2.677 ± 0.053	3.336GlnLeu: 3.336 ± 0.049	0.913GlnMet: 0.913 ± 0.026	1.958GlnAsn: 1.958 ± 0.04	1.093GlnPro: 1.093 ± 0.028	1.249GlnGln: 1.249 ± 0.03	1.339GlnArg: 1.339 ± 0.033	1.843GlnSer: 1.843 ± 0.037	1.733GlnThr: 1.733 ± 0.035	2.002GlnVal: 2.002 ± 0.044	0.432GlnTrp: 0.432 ± 0.018	1.3GlnTyr: 1.3 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.057ArgAla: 2.057 ± 0.04	0.221ArgCys: 0.221 ± 0.013	1.87ArgAsp: 1.87 ± 0.038	2.267ArgGlu: 2.267 ± 0.038	1.994ArgPhe: 1.994 ± 0.033	2.078ArgGly: 2.078 ± 0.043	0.646ArgHis: 0.646 ± 0.018	3.076ArgIle: 3.076 ± 0.044	2.955ArgLys: 2.955 ± 0.052	3.497ArgLeu: 3.497 ± 0.051	0.991ArgMet: 0.991 ± 0.024	2.237ArgAsn: 2.237 ± 0.04	1.274ArgPro: 1.274 ± 0.031	1.125ArgGln: 1.125 ± 0.03	1.376ArgArg: 1.376 ± 0.033	1.983ArgSer: 1.983 ± 0.038	2.079ArgThr: 2.079 ± 0.034	2.111ArgVal: 2.111 ± 0.037	0.454ArgTrp: 0.454 ± 0.018	1.642ArgTyr: 1.642 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	3.771SerAla: 3.771 ± 0.05	0.619SerCys: 0.619 ± 0.022	3.588SerAsp: 3.588 ± 0.053	3.838SerGlu: 3.838 ± 0.053	3.498SerPhe: 3.498 ± 0.053	4.758SerGly: 4.758 ± 0.064	1.135SerHis: 1.135 ± 0.029	4.919SerIle: 4.919 ± 0.065	4.612SerLys: 4.612 ± 0.061	5.879SerLeu: 5.879 ± 0.084	1.446SerMet: 1.446 ± 0.033	3.52SerAsn: 3.52 ± 0.055	2.221SerPro: 2.221 ± 0.036	2.002SerGln: 2.002 ± 0.037	2.183SerArg: 2.183 ± 0.042	4.105SerSer: 4.105 ± 0.063	3.435SerThr: 3.435 ± 0.057	3.811SerVal: 3.811 ± 0.053	0.75SerTrp: 0.75 ± 0.023	2.75SerTyr: 2.75 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.714ThrAla: 3.714 ± 0.063	0.367ThrCys: 0.367 ± 0.022	3.525ThrAsp: 3.525 ± 0.065	3.311ThrGlu: 3.311 ± 0.04	2.997ThrPhe: 2.997 ± 0.063	4.169ThrGly: 4.169 ± 0.063	1.074ThrHis: 1.074 ± 0.029	4.745ThrIle: 4.745 ± 0.076	3.697ThrLys: 3.697 ± 0.052	5.402ThrLeu: 5.402 ± 0.061	1.188ThrMet: 1.188 ± 0.03	3.132ThrAsn: 3.132 ± 0.063	2.496ThrPro: 2.496 ± 0.054	1.81ThrGln: 1.81 ± 0.033	1.708ThrArg: 1.708 ± 0.033	3.696ThrSer: 3.696 ± 0.054	3.523ThrThr: 3.523 ± 0.066	3.848ThrVal: 3.848 ± 0.064	0.633ThrTrp: 0.633 ± 0.022	2.517ThrTyr: 2.517 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.204ValAla: 4.204 ± 0.057	0.522ValCys: 0.522 ± 0.018	3.88ValAsp: 3.88 ± 0.05	3.73ValGlu: 3.73 ± 0.047	3.38ValPhe: 3.38 ± 0.052	4.162ValGly: 4.162 ± 0.059	1.158ValHis: 1.158 ± 0.025	4.567ValIle: 4.567 ± 0.055	4.052ValLys: 4.052 ± 0.057	6.436ValLeu: 6.436 ± 0.068	1.425ValMet: 1.425 ± 0.031	3.306ValAsn: 3.306 ± 0.04	2.356ValPro: 2.356 ± 0.039	1.934ValGln: 1.934 ± 0.038	2.156ValArg: 2.156 ± 0.038	4.326ValSer: 4.326 ± 0.059	3.527ValThr: 3.527 ± 0.075	4.453ValVal: 4.453 ± 0.061	0.673ValTrp: 0.673 ± 0.021	2.474ValTyr: 2.474 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.728TrpAla: 0.728 ± 0.022	0.107TrpCys: 0.107 ± 0.009	0.763TrpAsp: 0.763 ± 0.026	0.774TrpGlu: 0.774 ± 0.024	0.597TrpPhe: 0.597 ± 0.021	0.806TrpGly: 0.806 ± 0.025	0.278TrpHis: 0.278 ± 0.014	0.791TrpIle: 0.791 ± 0.024	0.883TrpLys: 0.883 ± 0.028	1.041TrpLeu: 1.041 ± 0.026	0.347TrpMet: 0.347 ± 0.016	0.733TrpAsn: 0.733 ± 0.024	0.341TrpPro: 0.341 ± 0.017	0.437TrpGln: 0.437 ± 0.018	0.436TrpArg: 0.436 ± 0.016	0.726TrpSer: 0.726 ± 0.023	0.58TrpThr: 0.58 ± 0.021	0.704TrpVal: 0.704 ± 0.023	0.177TrpTrp: 0.177 ± 0.011	0.47TrpTyr: 0.47 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.575TyrAla: 2.575 ± 0.045	0.343TyrCys: 0.343 ± 0.016	2.532TyrAsp: 2.532 ± 0.046	2.352TyrGlu: 2.352 ± 0.038	2.372TyrPhe: 2.372 ± 0.046	2.944TyrGly: 2.944 ± 0.049	0.875TyrHis: 0.875 ± 0.024	2.55TyrIle: 2.55 ± 0.042	2.769TyrLys: 2.769 ± 0.043	3.896TyrLeu: 3.896 ± 0.058	0.843TyrMet: 0.843 ± 0.025	2.416TyrAsn: 2.416 ± 0.034	1.578TyrPro: 1.578 ± 0.031	1.439TyrGln: 1.439 ± 0.03	1.771TyrArg: 1.771 ± 0.035	2.626TyrSer: 2.626 ± 0.05	2.507TyrThr: 2.507 ± 0.064	2.273TyrVal: 2.273 ± 0.04	0.522TyrTrp: 0.522 ± 0.017	1.858TyrTyr: 1.858 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4431 proteins (1523809 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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