Amino acid dipepetide frequency for Snodgrassella alvi wkB2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.804AlaAla: 9.804 ± 0.216
1.115AlaCys: 1.115 ± 0.042
5.2AlaAsp: 5.2 ± 0.108
5.49AlaGlu: 5.49 ± 0.123
3.139AlaPhe: 3.139 ± 0.064
6.922AlaGly: 6.922 ± 0.144
1.814AlaHis: 1.814 ± 0.05
5.752AlaIle: 5.752 ± 0.101
4.151AlaLys: 4.151 ± 0.088
9.598AlaLeu: 9.598 ± 0.153
2.28AlaMet: 2.28 ± 0.068
3.48AlaAsn: 3.48 ± 0.081
2.843AlaPro: 2.843 ± 0.067
4.908AlaGln: 4.908 ± 0.133
4.509AlaArg: 4.509 ± 0.094
4.955AlaSer: 4.955 ± 0.141
4.034AlaThr: 4.034 ± 0.079
6.395AlaVal: 6.395 ± 0.122
0.973AlaTrp: 0.973 ± 0.041
2.624AlaTyr: 2.624 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.961CysAla: 0.961 ± 0.044
0.207CysCys: 0.207 ± 0.018
0.514CysAsp: 0.514 ± 0.028
0.545CysGlu: 0.545 ± 0.033
0.496CysPhe: 0.496 ± 0.027
1.019CysGly: 1.019 ± 0.041
0.332CysHis: 0.332 ± 0.022
0.764CysIle: 0.764 ± 0.036
0.388CysLys: 0.388 ± 0.025
1.167CysLeu: 1.167 ± 0.05
0.265CysMet: 0.265 ± 0.022
0.456CysAsn: 0.456 ± 0.031
0.443CysPro: 0.443 ± 0.029
0.485CysGln: 0.485 ± 0.028
0.551CysArg: 0.551 ± 0.03
0.668CysSer: 0.668 ± 0.032
0.574CysThr: 0.574 ± 0.029
0.676CysVal: 0.676 ± 0.036
0.168CysTrp: 0.168 ± 0.015
0.38CysTyr: 0.38 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.368AspAla: 4.368 ± 0.152
0.488AspCys: 0.488 ± 0.027
2.719AspAsp: 2.719 ± 0.103
3.355AspGlu: 3.355 ± 0.084
2.305AspPhe: 2.305 ± 0.068
3.416AspGly: 3.416 ± 0.095
0.878AspHis: 0.878 ± 0.035
4.365AspIle: 4.365 ± 0.116
3.139AspLys: 3.139 ± 0.08
4.745AspLeu: 4.745 ± 0.09
1.46AspMet: 1.46 ± 0.046
2.833AspAsn: 2.833 ± 0.09
1.719AspPro: 1.719 ± 0.057
1.647AspGln: 1.647 ± 0.055
2.053AspArg: 2.053 ± 0.066
3.229AspSer: 3.229 ± 0.086
2.775AspThr: 2.775 ± 0.074
3.234AspVal: 3.234 ± 0.085
0.794AspTrp: 0.794 ± 0.032
2.174AspTyr: 2.174 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
4.7GluAla: 4.7 ± 0.103
0.463GluCys: 0.463 ± 0.028
2.344GluAsp: 2.344 ± 0.065
2.987GluGlu: 2.987 ± 0.075
2.027GluPhe: 2.027 ± 0.063
2.632GluGly: 2.632 ± 0.075
1.469GluHis: 1.469 ± 0.048
3.955GluIle: 3.955 ± 0.079
3.391GluLys: 3.391 ± 0.091
5.659GluLeu: 5.659 ± 0.108
1.314GluMet: 1.314 ± 0.04
2.99GluAsn: 2.99 ± 0.07
1.768GluPro: 1.768 ± 0.048
3.617GluGln: 3.617 ± 0.098
2.77GluArg: 2.77 ± 0.067
2.758GluSer: 2.758 ± 0.073
2.742GluThr: 2.742 ± 0.074
3.267GluVal: 3.267 ± 0.08
0.708GluTrp: 0.708 ± 0.034
1.826GluTyr: 1.826 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.539PheAla: 3.539 ± 0.088
0.601PheCys: 0.601 ± 0.032
2.267PheAsp: 2.267 ± 0.058
1.827PheGlu: 1.827 ± 0.06
1.757PhePhe: 1.757 ± 0.068
3.034PheGly: 3.034 ± 0.08
0.787PheHis: 0.787 ± 0.032
2.954PheIle: 2.954 ± 0.086
1.84PheLys: 1.84 ± 0.064
3.506PheLeu: 3.506 ± 0.087
0.967PheMet: 0.967 ± 0.041
2.198PheAsn: 2.198 ± 0.063
1.339PhePro: 1.339 ± 0.041
1.41PheGln: 1.41 ± 0.047
1.596PheArg: 1.596 ± 0.05
2.915PheSer: 2.915 ± 0.068
2.434PheThr: 2.434 ± 0.071
2.332PheVal: 2.332 ± 0.059
0.548PheTrp: 0.548 ± 0.03
1.449PheTyr: 1.449 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
5.108GlyAla: 5.108 ± 0.101
0.905GlyCys: 0.905 ± 0.041
3.341GlyAsp: 3.341 ± 0.116
3.488GlyGlu: 3.488 ± 0.077
2.997GlyPhe: 2.997 ± 0.081
4.978GlyGly: 4.978 ± 0.151
1.598GlyHis: 1.598 ± 0.056
4.932GlyIle: 4.932 ± 0.095
4.394GlyLys: 4.394 ± 0.091
6.929GlyLeu: 6.929 ± 0.12
2.055GlyMet: 2.055 ± 0.064
3.36GlyAsn: 3.36 ± 0.163
1.237GlyPro: 1.237 ± 0.048
2.889GlyGln: 2.889 ± 0.072
3.387GlyArg: 3.387 ± 0.083
4.135GlySer: 4.135 ± 0.117
3.447GlyThr: 3.447 ± 0.092
4.616GlyVal: 4.616 ± 0.093
1.052GlyTrp: 1.052 ± 0.05
2.462GlyTyr: 2.462 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.81HisAla: 1.81 ± 0.054
0.281HisCys: 0.281 ± 0.022
1.095HisAsp: 1.095 ± 0.043
1.14HisGlu: 1.14 ± 0.046
1.027HisPhe: 1.027 ± 0.037
1.778HisGly: 1.778 ± 0.075
0.693HisHis: 0.693 ± 0.036
1.676HisIle: 1.676 ± 0.051
1.026HisLys: 1.026 ± 0.042
2.25HisLeu: 2.25 ± 0.06
0.545HisMet: 0.545 ± 0.033
1.204HisAsn: 1.204 ± 0.038
1.239HisPro: 1.239 ± 0.048
1.276HisGln: 1.276 ± 0.047
1.004HisArg: 1.004 ± 0.038
1.363HisSer: 1.363 ± 0.045
1.462HisThr: 1.462 ± 0.049
1.157HisVal: 1.157 ± 0.052
0.378HisTrp: 0.378 ± 0.023
1.026HisTyr: 1.026 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
6.358IleAla: 6.358 ± 0.104
0.837IleCys: 0.837 ± 0.039
4.112IleAsp: 4.112 ± 0.089
3.941IleGlu: 3.941 ± 0.081
2.575IlePhe: 2.575 ± 0.077
4.945IleGly: 4.945 ± 0.109
1.554IleHis: 1.554 ± 0.056
4.932IleIle: 4.932 ± 0.116
3.706IleLys: 3.706 ± 0.098
6.472IleLeu: 6.472 ± 0.129
1.508IleMet: 1.508 ± 0.055
3.974IleAsn: 3.974 ± 0.098
2.909IlePro: 2.909 ± 0.065
2.796IleGln: 2.796 ± 0.07
3.213IleArg: 3.213 ± 0.067
4.58IleSer: 4.58 ± 0.098
4.319IleThr: 4.319 ± 0.141
4.119IleVal: 4.119 ± 0.074
0.78IleTrp: 0.78 ± 0.036
2.157IleTyr: 2.157 ± 0.065
0.0IleXaa: 0.0 ± 0.0
Lys
4.321LysAla: 4.321 ± 0.098
0.348LysCys: 0.348 ± 0.021
2.557LysAsp: 2.557 ± 0.087
2.693LysGlu: 2.693 ± 0.074
1.601LysPhe: 1.601 ± 0.059
2.869LysGly: 2.869 ± 0.088
1.2LysHis: 1.2 ± 0.049
3.882LysIle: 3.882 ± 0.096
3.203LysLys: 3.203 ± 0.088
5.228LysLeu: 5.228 ± 0.103
1.433LysMet: 1.433 ± 0.054
3.007LysAsn: 3.007 ± 0.083
2.375LysPro: 2.375 ± 0.074
3.056LysGln: 3.056 ± 0.071
2.433LysArg: 2.433 ± 0.066
2.801LysSer: 2.801 ± 0.077
3.017LysThr: 3.017 ± 0.064
3.148LysVal: 3.148 ± 0.074
0.59LysTrp: 0.59 ± 0.033
1.624LysTyr: 1.624 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
10.12LeuAla: 10.12 ± 0.143
1.262LeuCys: 1.262 ± 0.048
5.017LeuAsp: 5.017 ± 0.088
4.544LeuGlu: 4.544 ± 0.097
4.185LeuPhe: 4.185 ± 0.101
6.487LeuGly: 6.487 ± 0.122
2.324LeuHis: 2.324 ± 0.067
7.079LeuIle: 7.079 ± 0.129
5.112LeuLys: 5.112 ± 0.09
11.178LeuLeu: 11.178 ± 0.217
2.515LeuMet: 2.515 ± 0.055
5.571LeuAsn: 5.571 ± 0.114
5.611LeuPro: 5.611 ± 0.133
5.344LeuGln: 5.344 ± 0.12
4.696LeuArg: 4.696 ± 0.095
7.523LeuSer: 7.523 ± 0.241
5.84LeuThr: 5.84 ± 0.108
5.975LeuVal: 5.975 ± 0.124
1.288LeuTrp: 1.288 ± 0.053
3.026LeuTyr: 3.026 ± 0.088
0.0LeuXaa: 0.0 ± 0.0
Met
2.443MetAla: 2.443 ± 0.067
0.213MetCys: 0.213 ± 0.018
1.171MetAsp: 1.171 ± 0.046
0.996MetGlu: 0.996 ± 0.04
0.774MetPhe: 0.774 ± 0.04
1.614MetGly: 1.614 ± 0.058
0.632MetHis: 0.632 ± 0.033
1.445MetIle: 1.445 ± 0.046
1.285MetLys: 1.285 ± 0.051
2.739MetLeu: 2.739 ± 0.071
0.718MetMet: 0.718 ± 0.035
1.247MetAsn: 1.247 ± 0.044
1.227MetPro: 1.227 ± 0.047
1.511MetGln: 1.511 ± 0.059
1.226MetArg: 1.226 ± 0.046
1.702MetSer: 1.702 ± 0.053
1.27MetThr: 1.27 ± 0.043
1.682MetVal: 1.682 ± 0.051
0.216MetTrp: 0.216 ± 0.018
0.617MetTyr: 0.617 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.803AsnAla: 3.803 ± 0.117
0.501AsnCys: 0.501 ± 0.029
2.59AsnAsp: 2.59 ± 0.156
2.407AsnGlu: 2.407 ± 0.069
1.613AsnPhe: 1.613 ± 0.065
3.649AsnGly: 3.649 ± 0.145
1.237AsnHis: 1.237 ± 0.042
3.834AsnIle: 3.834 ± 0.106
2.785AsnLys: 2.785 ± 0.093
4.833AsnLeu: 4.833 ± 0.129
1.138AsnMet: 1.138 ± 0.038
2.941AsnAsn: 2.941 ± 0.134
2.27AsnPro: 2.27 ± 0.059
2.623AsnGln: 2.623 ± 0.075
2.275AsnArg: 2.275 ± 0.063
3.17AsnSer: 3.17 ± 0.14
2.914AsnThr: 2.914 ± 0.103
2.673AsnVal: 2.673 ± 0.102
0.722AsnTrp: 0.722 ± 0.032
1.647AsnTyr: 1.647 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
3.947ProAla: 3.947 ± 0.091
0.347ProCys: 0.347 ± 0.022
2.699ProAsp: 2.699 ± 0.068
3.214ProGlu: 3.214 ± 0.086
1.708ProPhe: 1.708 ± 0.066
2.171ProGly: 2.171 ± 0.065
0.895ProHis: 0.895 ± 0.041
2.124ProIle: 2.124 ± 0.058
1.844ProLys: 1.844 ± 0.062
4.106ProLeu: 4.106 ± 0.098
0.773ProMet: 0.773 ± 0.035
1.542ProAsn: 1.542 ± 0.047
1.42ProPro: 1.42 ± 0.058
2.108ProGln: 2.108 ± 0.063
1.489ProArg: 1.489 ± 0.042
1.899ProSer: 1.899 ± 0.057
1.83ProThr: 1.83 ± 0.054
3.695ProVal: 3.695 ± 0.08
0.486ProTrp: 0.486 ± 0.028
1.322ProTyr: 1.322 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
4.777GlnAla: 4.777 ± 0.105
0.479GlnCys: 0.479 ± 0.036
1.916GlnAsp: 1.916 ± 0.057
2.463GlnGlu: 2.463 ± 0.065
1.729GlnPhe: 1.729 ± 0.052
2.722GlnGly: 2.722 ± 0.079
1.489GlnHis: 1.489 ± 0.05
3.42GlnIle: 3.42 ± 0.081
2.712GlnLys: 2.712 ± 0.067
5.919GlnLeu: 5.919 ± 0.121
1.222GlnMet: 1.222 ± 0.037
2.676GlnAsn: 2.676 ± 0.074
2.309GlnPro: 2.309 ± 0.07
4.49GlnGln: 4.49 ± 0.131
2.564GlnArg: 2.564 ± 0.076
2.758GlnSer: 2.758 ± 0.063
2.922GlnThr: 2.922 ± 0.064
2.752GlnVal: 2.752 ± 0.07
0.909GlnTrp: 0.909 ± 0.053
1.735GlnTyr: 1.735 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
3.598ArgAla: 3.598 ± 0.074
0.463ArgCys: 0.463 ± 0.029
2.232ArgAsp: 2.232 ± 0.062
2.673ArgGlu: 2.673 ± 0.08
2.227ArgPhe: 2.227 ± 0.053
2.526ArgGly: 2.526 ± 0.066
1.305ArgHis: 1.305 ± 0.044
3.498ArgIle: 3.498 ± 0.077
2.358ArgLys: 2.358 ± 0.057
5.451ArgLeu: 5.451 ± 0.131
1.305ArgMet: 1.305 ± 0.041
2.111ArgAsn: 2.111 ± 0.056
1.742ArgPro: 1.742 ± 0.047
3.04ArgGln: 3.04 ± 0.08
2.669ArgArg: 2.669 ± 0.079
2.42ArgSer: 2.42 ± 0.068
2.28ArgThr: 2.28 ± 0.063
2.705ArgVal: 2.705 ± 0.064
0.614ArgTrp: 0.614 ± 0.033
2.05ArgTyr: 2.05 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
5.567SerAla: 5.567 ± 0.134
0.66SerCys: 0.66 ± 0.036
3.122SerAsp: 3.122 ± 0.093
3.141SerGlu: 3.141 ± 0.076
2.426SerPhe: 2.426 ± 0.06
5.092SerGly: 5.092 ± 0.118
1.352SerHis: 1.352 ± 0.051
4.06SerIle: 4.06 ± 0.094
2.977SerLys: 2.977 ± 0.069
6.457SerLeu: 6.457 ± 0.182
1.541SerMet: 1.541 ± 0.047
2.752SerAsn: 2.752 ± 0.098
2.036SerPro: 2.036 ± 0.049
2.492SerGln: 2.492 ± 0.06
2.879SerArg: 2.879 ± 0.061
4.011SerSer: 4.011 ± 0.225
3.39SerThr: 3.39 ± 0.267
4.177SerVal: 4.177 ± 0.083
0.833SerTrp: 0.833 ± 0.035
1.948SerTyr: 1.948 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
5.336ThrAla: 5.336 ± 0.114
0.493ThrCys: 0.493 ± 0.027
3.234ThrAsp: 3.234 ± 0.088
3.134ThrGlu: 3.134 ± 0.068
1.865ThrPhe: 1.865 ± 0.056
4.42ThrGly: 4.42 ± 0.13
1.247ThrHis: 1.247 ± 0.044
3.555ThrIle: 3.555 ± 0.076
1.962ThrLys: 1.962 ± 0.065
5.954ThrLeu: 5.954 ± 0.092
1.101ThrMet: 1.101 ± 0.045
2.326ThrAsn: 2.326 ± 0.155
2.761ThrPro: 2.761 ± 0.065
2.403ThrGln: 2.403 ± 0.064
2.443ThrArg: 2.443 ± 0.069
3.152ThrSer: 3.152 ± 0.141
2.952ThrThr: 2.952 ± 0.093
3.876ThrVal: 3.876 ± 0.085
0.538ThrTrp: 0.538 ± 0.029
1.365ThrTyr: 1.365 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
5.88ValAla: 5.88 ± 0.128
0.809ValCys: 0.809 ± 0.04
3.178ValAsp: 3.178 ± 0.077
3.17ValGlu: 3.17 ± 0.082
2.604ValPhe: 2.604 ± 0.067
3.873ValGly: 3.873 ± 0.09
1.337ValHis: 1.337 ± 0.047
4.657ValIle: 4.657 ± 0.086
3.193ValLys: 3.193 ± 0.08
6.933ValLeu: 6.933 ± 0.116
1.659ValMet: 1.659 ± 0.062
3.118ValAsn: 3.118 ± 0.108
2.466ValPro: 2.466 ± 0.071
2.518ValGln: 2.518 ± 0.061
2.972ValArg: 2.972 ± 0.087
4.243ValSer: 4.243 ± 0.105
3.654ValThr: 3.654 ± 0.076
4.393ValVal: 4.393 ± 0.095
0.834ValTrp: 0.834 ± 0.035
1.934ValTyr: 1.934 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.852TrpAla: 0.852 ± 0.035
0.186TrpCys: 0.186 ± 0.018
0.554TrpAsp: 0.554 ± 0.034
0.505TrpGlu: 0.505 ± 0.029
0.673TrpPhe: 0.673 ± 0.034
0.725TrpGly: 0.725 ± 0.034
0.463TrpHis: 0.463 ± 0.029
0.773TrpIle: 0.773 ± 0.034
0.527TrpLys: 0.527 ± 0.035
2.04TrpLeu: 2.04 ± 0.07
0.288TrpMet: 0.288 ± 0.022
0.504TrpAsn: 0.504 ± 0.037
0.501TrpPro: 0.501 ± 0.031
1.265TrpGln: 1.265 ± 0.049
0.757TrpArg: 0.757 ± 0.041
0.663TrpSer: 0.663 ± 0.03
0.476TrpThr: 0.476 ± 0.024
0.801TrpVal: 0.801 ± 0.034
0.227TrpTrp: 0.227 ± 0.02
0.397TrpTyr: 0.397 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.696TyrAla: 2.696 ± 0.078
0.401TyrCys: 0.401 ± 0.026
1.836TyrAsp: 1.836 ± 0.08
1.675TyrGlu: 1.675 ± 0.076
1.573TyrPhe: 1.573 ± 0.051
2.436TyrGly: 2.436 ± 0.085
0.823TyrHis: 0.823 ± 0.038
2.129TyrIle: 2.129 ± 0.071
1.393TyrLys: 1.393 ± 0.054
3.531TyrLeu: 3.531 ± 0.085
0.642TyrMet: 0.642 ± 0.032
1.334TyrAsn: 1.334 ± 0.054
1.401TyrPro: 1.401 ± 0.057
2.089TyrGln: 2.089 ± 0.065
1.784TyrArg: 1.784 ± 0.057
1.968TyrSer: 1.968 ± 0.057
1.786TyrThr: 1.786 ± 0.054
1.751TyrVal: 1.751 ± 0.049
0.517TyrTrp: 0.517 ± 0.026
1.354TyrTyr: 1.354 ± 0.082
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2295 proteins (695041 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski