Amino acid dipepetide frequency for Thelohanellus kitauei (Myxosporean)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.308AlaAla: 2.308 ± 0.03
0.945AlaCys: 0.945 ± 0.017
2.263AlaAsp: 2.263 ± 0.024
2.603AlaGlu: 2.603 ± 0.033
2.277AlaPhe: 2.277 ± 0.029
1.906AlaGly: 1.906 ± 0.027
1.056AlaHis: 1.056 ± 0.019
3.483AlaIle: 3.483 ± 0.034
2.949AlaLys: 2.949 ± 0.032
4.201AlaLeu: 4.201 ± 0.042
1.069AlaMet: 1.069 ± 0.018
2.245AlaAsn: 2.245 ± 0.024
1.615AlaPro: 1.615 ± 0.026
1.552AlaGln: 1.552 ± 0.024
2.208AlaArg: 2.208 ± 0.027
3.534AlaSer: 3.534 ± 0.034
2.5AlaThr: 2.5 ± 0.032
2.75AlaVal: 2.75 ± 0.026
0.381AlaTrp: 0.381 ± 0.012
1.575AlaTyr: 1.575 ± 0.02
0.0AlaXaa: 0.0 ± 0.0
Cys
0.894CysAla: 0.894 ± 0.017
0.592CysCys: 0.592 ± 0.013
1.268CysAsp: 1.268 ± 0.023
1.266CysGlu: 1.266 ± 0.019
1.198CysPhe: 1.198 ± 0.02
1.18CysGly: 1.18 ± 0.019
0.631CysHis: 0.631 ± 0.014
1.502CysIle: 1.502 ± 0.02
1.427CysLys: 1.427 ± 0.023
2.306CysLeu: 2.306 ± 0.034
0.497CysMet: 0.497 ± 0.012
1.036CysAsn: 1.036 ± 0.019
0.933CysPro: 0.933 ± 0.018
0.957CysGln: 0.957 ± 0.016
1.208CysArg: 1.208 ± 0.025
1.702CysSer: 1.702 ± 0.021
1.017CysThr: 1.017 ± 0.017
1.375CysVal: 1.375 ± 0.02
0.182CysTrp: 0.182 ± 0.007
0.877CysTyr: 0.877 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
2.326AspAla: 2.326 ± 0.029
1.197AspCys: 1.197 ± 0.021
3.607AspAsp: 3.607 ± 0.046
4.369AspGlu: 4.369 ± 0.092
3.135AspPhe: 3.135 ± 0.027
2.516AspGly: 2.516 ± 0.027
1.453AspHis: 1.453 ± 0.026
4.688AspIle: 4.688 ± 0.039
3.352AspLys: 3.352 ± 0.032
4.961AspLeu: 4.961 ± 0.039
1.259AspMet: 1.259 ± 0.017
2.761AspAsn: 2.761 ± 0.029
2.269AspPro: 2.269 ± 0.026
2.046AspGln: 2.046 ± 0.027
2.522AspArg: 2.522 ± 0.027
4.185AspSer: 4.185 ± 0.044
2.749AspThr: 2.749 ± 0.032
3.393AspVal: 3.393 ± 0.034
0.502AspTrp: 0.502 ± 0.013
2.103AspTyr: 2.103 ± 0.024
0.0AspXaa: 0.0 ± 0.0
Glu
2.748GluAla: 2.748 ± 0.032
1.287GluCys: 1.287 ± 0.02
3.265GluAsp: 3.265 ± 0.067
4.263GluGlu: 4.263 ± 0.084
3.1GluPhe: 3.1 ± 0.031
2.25GluGly: 2.25 ± 0.029
1.405GluHis: 1.405 ± 0.029
5.279GluIle: 5.279 ± 0.052
4.683GluLys: 4.683 ± 0.042
5.32GluLeu: 5.32 ± 0.048
1.582GluMet: 1.582 ± 0.024
4.289GluAsn: 4.289 ± 0.038
1.975GluPro: 1.975 ± 0.034
1.924GluGln: 1.924 ± 0.026
2.98GluArg: 2.98 ± 0.032
5.015GluSer: 5.015 ± 0.052
3.617GluThr: 3.617 ± 0.039
3.122GluVal: 3.122 ± 0.051
0.632GluTrp: 0.632 ± 0.011
2.458GluTyr: 2.458 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
2.052PheAla: 2.052 ± 0.028
1.252PheCys: 1.252 ± 0.018
3.258PheAsp: 3.258 ± 0.035
3.471PheGlu: 3.471 ± 0.034
2.331PhePhe: 2.331 ± 0.033
2.728PheGly: 2.728 ± 0.036
1.414PheHis: 1.414 ± 0.021
4.12PheIle: 4.12 ± 0.034
3.665PheLys: 3.665 ± 0.037
5.016PheLeu: 5.016 ± 0.045
1.377PheMet: 1.377 ± 0.021
2.863PheAsn: 2.863 ± 0.033
1.863PhePro: 1.863 ± 0.024
2.006PheGln: 2.006 ± 0.025
2.292PheArg: 2.292 ± 0.026
4.503PheSer: 4.503 ± 0.039
2.81PheThr: 2.81 ± 0.029
3.207PheVal: 3.207 ± 0.026
0.528PheTrp: 0.528 ± 0.012
2.305PheTyr: 2.305 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
1.915GlyAla: 1.915 ± 0.031
0.997GlyCys: 0.997 ± 0.018
2.249GlyAsp: 2.249 ± 0.029
2.203GlyGlu: 2.203 ± 0.026
2.224GlyPhe: 2.224 ± 0.031
2.233GlyGly: 2.233 ± 0.036
1.294GlyHis: 1.294 ± 0.02
3.389GlyIle: 3.389 ± 0.034
2.874GlyLys: 2.874 ± 0.031
3.845GlyLeu: 3.845 ± 0.038
1.127GlyMet: 1.127 ± 0.025
2.278GlyAsn: 2.278 ± 0.027
1.528GlyPro: 1.528 ± 0.024
1.594GlyGln: 1.594 ± 0.024
2.411GlyArg: 2.411 ± 0.029
3.594GlySer: 3.594 ± 0.033
2.316GlyThr: 2.316 ± 0.028
2.629GlyVal: 2.629 ± 0.026
0.509GlyTrp: 0.509 ± 0.011
2.019GlyTyr: 2.019 ± 0.024
0.0GlyXaa: 0.0 ± 0.0
His
1.037HisAla: 1.037 ± 0.017
0.562HisCys: 0.562 ± 0.015
1.332HisAsp: 1.332 ± 0.019
1.508HisGlu: 1.508 ± 0.02
1.538HisPhe: 1.538 ± 0.021
1.15HisGly: 1.15 ± 0.018
0.798HisHis: 0.798 ± 0.019
1.939HisIle: 1.939 ± 0.025
1.611HisLys: 1.611 ± 0.023
2.698HisLeu: 2.698 ± 0.028
0.591HisMet: 0.591 ± 0.014
1.274HisAsn: 1.274 ± 0.018
1.336HisPro: 1.336 ± 0.023
1.078HisGln: 1.078 ± 0.018
1.391HisArg: 1.391 ± 0.022
2.089HisSer: 2.089 ± 0.028
1.293HisThr: 1.293 ± 0.018
1.484HisVal: 1.484 ± 0.022
0.215HisTrp: 0.215 ± 0.012
1.011HisTyr: 1.011 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
3.035IleAla: 3.035 ± 0.031
1.9IleCys: 1.9 ± 0.028
4.843IleAsp: 4.843 ± 0.041
4.789IleGlu: 4.789 ± 0.045
4.518IlePhe: 4.518 ± 0.043
3.153IleGly: 3.153 ± 0.028
2.147IleHis: 2.147 ± 0.026
5.908IleIle: 5.908 ± 0.048
5.697IleLys: 5.697 ± 0.047
7.183IleLeu: 7.183 ± 0.054
1.792IleMet: 1.792 ± 0.022
4.602IleAsn: 4.602 ± 0.037
3.304IlePro: 3.304 ± 0.031
2.988IleGln: 2.988 ± 0.03
3.761IleArg: 3.761 ± 0.031
7.048IleSer: 7.048 ± 0.047
3.989IleThr: 3.989 ± 0.037
4.3IleVal: 4.3 ± 0.033
0.786IleTrp: 0.786 ± 0.016
3.35IleTyr: 3.35 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
2.966LysAla: 2.966 ± 0.034
1.677LysCys: 1.677 ± 0.03
3.462LysAsp: 3.462 ± 0.034
3.952LysGlu: 3.952 ± 0.039
3.633LysPhe: 3.633 ± 0.032
2.495LysGly: 2.495 ± 0.029
1.773LysHis: 1.773 ± 0.024
6.216LysIle: 6.216 ± 0.051
5.512LysLys: 5.512 ± 0.054
6.633LysLeu: 6.633 ± 0.051
1.88LysMet: 1.88 ± 0.028
4.911LysAsn: 4.911 ± 0.048
2.711LysPro: 2.711 ± 0.032
2.244LysGln: 2.244 ± 0.026
3.649LysArg: 3.649 ± 0.035
5.901LysSer: 5.901 ± 0.04
4.271LysThr: 4.271 ± 0.04
3.385LysVal: 3.385 ± 0.033
0.813LysTrp: 0.813 ± 0.018
3.261LysTyr: 3.261 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
4.369LeuAla: 4.369 ± 0.042
2.032LeuCys: 2.032 ± 0.025
4.784LeuAsp: 4.784 ± 0.036
5.415LeuGlu: 5.415 ± 0.049
4.867LeuPhe: 4.867 ± 0.045
3.774LeuGly: 3.774 ± 0.034
2.168LeuHis: 2.168 ± 0.025
6.799LeuIle: 6.799 ± 0.051
7.504LeuLys: 7.504 ± 0.054
8.176LeuLeu: 8.176 ± 0.061
2.336LeuMet: 2.336 ± 0.026
5.635LeuAsn: 5.635 ± 0.051
3.839LeuPro: 3.839 ± 0.034
3.19LeuGln: 3.19 ± 0.027
4.51LeuArg: 4.51 ± 0.036
7.798LeuSer: 7.798 ± 0.054
4.891LeuThr: 4.891 ± 0.037
5.34LeuVal: 5.34 ± 0.041
0.816LeuTrp: 0.816 ± 0.016
3.422LeuTyr: 3.422 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
1.333MetAla: 1.333 ± 0.02
0.5MetCys: 0.5 ± 0.011
1.481MetAsp: 1.481 ± 0.022
1.549MetGlu: 1.549 ± 0.024
1.237MetPhe: 1.237 ± 0.02
1.037MetGly: 1.037 ± 0.02
0.492MetHis: 0.492 ± 0.012
2.052MetIle: 2.052 ± 0.027
1.92MetLys: 1.92 ± 0.024
2.1MetLeu: 2.1 ± 0.029
0.747MetMet: 0.747 ± 0.017
1.679MetAsn: 1.679 ± 0.022
0.913MetPro: 0.913 ± 0.016
0.668MetGln: 0.668 ± 0.016
1.097MetArg: 1.097 ± 0.019
1.991MetSer: 1.991 ± 0.023
1.35MetThr: 1.35 ± 0.018
1.491MetVal: 1.491 ± 0.018
0.231MetTrp: 0.231 ± 0.008
0.855MetTyr: 0.855 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.367AsnAla: 2.367 ± 0.025
1.191AsnCys: 1.191 ± 0.019
3.226AsnAsp: 3.226 ± 0.035
3.715AsnGlu: 3.715 ± 0.049
3.217AsnPhe: 3.217 ± 0.035
2.725AsnGly: 2.725 ± 0.027
1.663AsnHis: 1.663 ± 0.022
5.214AsnIle: 5.214 ± 0.04
3.817AsnLys: 3.817 ± 0.031
5.458AsnLeu: 5.458 ± 0.042
1.449AsnMet: 1.449 ± 0.021
3.189AsnAsn: 3.189 ± 0.038
2.446AsnPro: 2.446 ± 0.031
2.426AsnGln: 2.426 ± 0.031
2.774AsnArg: 2.774 ± 0.028
4.396AsnSer: 4.396 ± 0.036
3.02AsnThr: 3.02 ± 0.03
3.397AsnVal: 3.397 ± 0.035
0.494AsnTrp: 0.494 ± 0.011
2.417AsnTyr: 2.417 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
1.747ProAla: 1.747 ± 0.024
0.793ProCys: 0.793 ± 0.018
2.199ProAsp: 2.199 ± 0.023
2.635ProGlu: 2.635 ± 0.031
2.108ProPhe: 2.108 ± 0.025
1.741ProGly: 1.741 ± 0.028
1.051ProHis: 1.051 ± 0.021
2.974ProIle: 2.974 ± 0.029
2.849ProLys: 2.849 ± 0.029
3.445ProLeu: 3.445 ± 0.032
0.881ProMet: 0.881 ± 0.019
2.361ProAsn: 2.361 ± 0.032
2.17ProPro: 2.17 ± 0.045
1.616ProGln: 1.616 ± 0.029
1.887ProArg: 1.887 ± 0.028
3.378ProSer: 3.378 ± 0.031
2.319ProThr: 2.319 ± 0.03
2.21ProVal: 2.21 ± 0.03
0.405ProTrp: 0.405 ± 0.01
1.542ProTyr: 1.542 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
1.682GlnAla: 1.682 ± 0.025
0.63GlnCys: 0.63 ± 0.013
1.727GlnAsp: 1.727 ± 0.023
2.159GlnGlu: 2.159 ± 0.025
1.729GlnPhe: 1.729 ± 0.021
1.366GlnGly: 1.366 ± 0.02
0.825GlnHis: 0.825 ± 0.016
3.157GlnIle: 3.157 ± 0.034
2.907GlnLys: 2.907 ± 0.03
3.209GlnLeu: 3.209 ± 0.031
1.013GlnMet: 1.013 ± 0.02
2.642GlnAsn: 2.642 ± 0.037
1.582GlnPro: 1.582 ± 0.03
1.435GlnGln: 1.435 ± 0.027
1.881GlnArg: 1.881 ± 0.027
2.785GlnSer: 2.785 ± 0.03
2.359GlnThr: 2.359 ± 0.032
1.796GlnVal: 1.796 ± 0.025
0.288GlnTrp: 0.288 ± 0.009
1.369GlnTyr: 1.369 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
2.078ArgAla: 2.078 ± 0.026
1.169ArgCys: 1.169 ± 0.019
2.399ArgAsp: 2.399 ± 0.027
2.744ArgGlu: 2.744 ± 0.03
2.783ArgPhe: 2.783 ± 0.03
2.124ArgGly: 2.124 ± 0.026
1.337ArgHis: 1.337 ± 0.02
3.859ArgIle: 3.859 ± 0.033
3.656ArgLys: 3.656 ± 0.039
4.487ArgLeu: 4.487 ± 0.041
1.315ArgMet: 1.315 ± 0.023
3.056ArgAsn: 3.056 ± 0.031
1.896ArgPro: 1.896 ± 0.025
1.759ArgGln: 1.759 ± 0.024
3.136ArgArg: 3.136 ± 0.042
3.969ArgSer: 3.969 ± 0.04
2.643ArgThr: 2.643 ± 0.027
2.683ArgVal: 2.683 ± 0.029
0.556ArgTrp: 0.556 ± 0.013
2.067ArgTyr: 2.067 ± 0.025
0.0ArgXaa: 0.0 ± 0.0
Ser
3.521SerAla: 3.521 ± 0.032
1.691SerCys: 1.691 ± 0.023
4.689SerAsp: 4.689 ± 0.043
4.927SerGlu: 4.927 ± 0.043
4.239SerPhe: 4.239 ± 0.043
3.69SerGly: 3.69 ± 0.036
2.147SerHis: 2.147 ± 0.027
6.253SerIle: 6.253 ± 0.042
6.014SerLys: 6.014 ± 0.04
7.487SerLeu: 7.487 ± 0.054
1.984SerMet: 1.984 ± 0.029
4.723SerAsn: 4.723 ± 0.041
3.187SerPro: 3.187 ± 0.033
3.295SerGln: 3.295 ± 0.031
4.262SerArg: 4.262 ± 0.036
7.061SerSer: 7.061 ± 0.067
5.03SerThr: 5.03 ± 0.059
4.514SerVal: 4.514 ± 0.036
0.794SerTrp: 0.794 ± 0.015
2.984SerTyr: 2.984 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
2.475ThrAla: 2.475 ± 0.027
1.204ThrCys: 1.204 ± 0.018
2.992ThrAsp: 2.992 ± 0.031
3.17ThrGlu: 3.17 ± 0.041
2.957ThrPhe: 2.957 ± 0.03
2.559ThrGly: 2.559 ± 0.033
1.409ThrHis: 1.409 ± 0.017
4.227ThrIle: 4.227 ± 0.041
3.696ThrLys: 3.696 ± 0.035
5.128ThrLeu: 5.128 ± 0.043
1.182ThrMet: 1.182 ± 0.018
3.27ThrAsn: 3.27 ± 0.036
2.411ThrPro: 2.411 ± 0.03
2.001ThrGln: 2.001 ± 0.03
2.572ThrArg: 2.572 ± 0.032
4.618ThrSer: 4.618 ± 0.052
3.543ThrThr: 3.543 ± 0.059
3.086ThrVal: 3.086 ± 0.029
0.551ThrTrp: 0.551 ± 0.015
1.973ThrTyr: 1.973 ± 0.024
0.0ThrXaa: 0.0 ± 0.0
Val
2.593ValAla: 2.593 ± 0.029
1.305ValCys: 1.305 ± 0.022
3.609ValAsp: 3.609 ± 0.052
3.653ValGlu: 3.653 ± 0.039
3.052ValPhe: 3.052 ± 0.032
2.4ValGly: 2.4 ± 0.029
1.379ValHis: 1.379 ± 0.02
4.203ValIle: 4.203 ± 0.041
3.949ValLys: 3.949 ± 0.036
5.087ValLeu: 5.087 ± 0.04
1.377ValMet: 1.377 ± 0.02
3.134ValAsn: 3.134 ± 0.033
2.336ValPro: 2.336 ± 0.026
1.822ValGln: 1.822 ± 0.023
2.46ValArg: 2.46 ± 0.026
4.902ValSer: 4.902 ± 0.035
2.908ValThr: 2.908 ± 0.029
3.669ValVal: 3.669 ± 0.04
0.564ValTrp: 0.564 ± 0.013
2.223ValTyr: 2.223 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
0.437TrpAla: 0.437 ± 0.011
0.239TrpCys: 0.239 ± 0.008
0.5TrpAsp: 0.5 ± 0.013
0.502TrpGlu: 0.502 ± 0.014
0.485TrpPhe: 0.485 ± 0.011
0.337TrpGly: 0.337 ± 0.01
0.232TrpHis: 0.232 ± 0.008
0.839TrpIle: 0.839 ± 0.018
0.846TrpLys: 0.846 ± 0.013
0.875TrpLeu: 0.875 ± 0.017
0.287TrpMet: 0.287 ± 0.009
0.57TrpAsn: 0.57 ± 0.012
0.354TrpPro: 0.354 ± 0.01
0.308TrpGln: 0.308 ± 0.01
0.594TrpArg: 0.594 ± 0.012
0.75TrpSer: 0.75 ± 0.015
0.511TrpThr: 0.511 ± 0.012
0.59TrpVal: 0.59 ± 0.013
0.12TrpTrp: 0.12 ± 0.006
0.359TrpTyr: 0.359 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.537TyrAla: 1.537 ± 0.021
0.889TyrCys: 0.889 ± 0.023
2.238TyrAsp: 2.238 ± 0.032
2.3TyrGlu: 2.3 ± 0.027
2.432TyrPhe: 2.432 ± 0.028
1.864TyrGly: 1.864 ± 0.026
1.26TyrHis: 1.26 ± 0.02
2.989TyrIle: 2.989 ± 0.03
2.42TyrLys: 2.42 ± 0.029
4.049TyrLeu: 4.049 ± 0.035
0.977TyrMet: 0.977 ± 0.015
2.083TyrAsn: 2.083 ± 0.026
1.643TyrPro: 1.643 ± 0.026
1.633TyrGln: 1.633 ± 0.022
2.123TyrArg: 2.123 ± 0.026
3.273TyrSer: 3.273 ± 0.033
1.889TyrThr: 1.889 ± 0.024
2.206TyrVal: 2.206 ± 0.029
0.369TyrTrp: 0.369 ± 0.01
1.679TyrTyr: 1.679 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14792 proteins (3533531 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski