Amino acid dipepetide frequency for Melbournevirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.287AlaAla: 3.287 ± 0.269
1.262AlaCys: 1.262 ± 0.107
2.116AlaAsp: 2.116 ± 0.157
4.159AlaGlu: 4.159 ± 0.203
3.178AlaPhe: 3.178 ± 0.198
2.47AlaGly: 2.47 ± 0.155
0.835AlaHis: 0.835 ± 0.069
2.452AlaIle: 2.452 ± 0.177
4.613AlaLys: 4.613 ± 0.28
5.276AlaLeu: 5.276 ± 0.262
1.299AlaMet: 1.299 ± 0.128
1.798AlaAsn: 1.798 ± 0.134
1.853AlaPro: 1.853 ± 0.144
1.671AlaGln: 1.671 ± 0.111
2.733AlaArg: 2.733 ± 0.179
4.413AlaSer: 4.413 ± 0.246
2.806AlaThr: 2.806 ± 0.259
3.233AlaVal: 3.233 ± 0.194
0.554AlaTrp: 0.554 ± 0.064
1.435AlaTyr: 1.435 ± 0.123
0.0AlaXaa: 0.0 ± 0.0
Cys
1.171CysAla: 1.171 ± 0.115
0.772CysCys: 0.772 ± 0.095
1.199CysAsp: 1.199 ± 0.11
2.134CysGlu: 2.134 ± 0.19
1.653CysPhe: 1.653 ± 0.129
2.107CysGly: 2.107 ± 0.17
0.445CysHis: 0.445 ± 0.063
0.981CysIle: 0.981 ± 0.087
1.898CysLys: 1.898 ± 0.159
2.379CysLeu: 2.379 ± 0.154
0.427CysMet: 0.427 ± 0.059
0.672CysAsn: 0.672 ± 0.082
1.507CysPro: 1.507 ± 0.141
0.754CysGln: 0.754 ± 0.079
1.335CysArg: 1.335 ± 0.11
2.425CysSer: 2.425 ± 0.178
0.954CysThr: 0.954 ± 0.108
1.489CysVal: 1.489 ± 0.11
0.272CysTrp: 0.272 ± 0.053
0.745CysTyr: 0.745 ± 0.079
0.0CysXaa: 0.0 ± 0.0
Asp
2.697AspAla: 2.697 ± 0.172
1.371AspCys: 1.371 ± 0.142
2.089AspAsp: 2.089 ± 0.131
3.723AspGlu: 3.723 ± 0.197
2.969AspPhe: 2.969 ± 0.16
3.923AspGly: 3.923 ± 0.194
0.581AspHis: 0.581 ± 0.082
3.75AspIle: 3.75 ± 0.187
2.969AspLys: 2.969 ± 0.157
3.433AspLeu: 3.433 ± 0.191
1.09AspMet: 1.09 ± 0.098
1.517AspAsn: 1.517 ± 0.107
1.843AspPro: 1.843 ± 0.13
0.981AspGln: 0.981 ± 0.104
2.297AspArg: 2.297 ± 0.127
3.106AspSer: 3.106 ± 0.169
1.88AspThr: 1.88 ± 0.146
3.66AspVal: 3.66 ± 0.197
0.781AspTrp: 0.781 ± 0.08
1.344AspTyr: 1.344 ± 0.106
0.0AspXaa: 0.0 ± 0.0
Glu
4.477GluAla: 4.477 ± 0.216
1.553GluCys: 1.553 ± 0.155
3.95GluAsp: 3.95 ± 0.233
9.926GluGlu: 9.926 ± 0.561
4.777GluPhe: 4.777 ± 0.246
5.076GluGly: 5.076 ± 0.233
1.798GluHis: 1.798 ± 0.139
4.568GluIle: 4.568 ± 0.187
10.425GluLys: 10.425 ± 0.419
6.883GluLeu: 6.883 ± 0.257
2.216GluMet: 2.216 ± 0.173
4.232GluAsn: 4.232 ± 0.235
2.007GluPro: 2.007 ± 0.164
3.097GluGln: 3.097 ± 0.182
6.193GluArg: 6.193 ± 0.235
4.141GluSer: 4.141 ± 0.232
5.194GluThr: 5.194 ± 0.208
4.168GluVal: 4.168 ± 0.215
1.199GluTrp: 1.199 ± 0.101
2.724GluTyr: 2.724 ± 0.18
0.0GluXaa: 0.0 ± 0.0
Phe
3.478PheAla: 3.478 ± 0.201
2.161PheCys: 2.161 ± 0.179
3.078PheAsp: 3.078 ± 0.186
4.876PheGlu: 4.876 ± 0.266
3.251PhePhe: 3.251 ± 0.185
3.959PheGly: 3.959 ± 0.206
1.017PheHis: 1.017 ± 0.091
2.125PheIle: 2.125 ± 0.116
2.361PheLys: 2.361 ± 0.151
6.838PheLeu: 6.838 ± 0.288
1.108PheMet: 1.108 ± 0.101
1.044PheAsn: 1.044 ± 0.084
2.525PhePro: 2.525 ± 0.153
1.371PheGln: 1.371 ± 0.114
3.142PheArg: 3.142 ± 0.184
5.594PheSer: 5.594 ± 0.252
1.78PheThr: 1.78 ± 0.119
5.004PheVal: 5.004 ± 0.23
1.408PheTrp: 1.408 ± 0.141
1.753PheTyr: 1.753 ± 0.154
0.0PheXaa: 0.0 ± 0.0
Gly
3.342GlyAla: 3.342 ± 0.203
1.526GlyCys: 1.526 ± 0.159
2.615GlyAsp: 2.615 ± 0.143
5.739GlyGlu: 5.739 ± 0.263
2.824GlyPhe: 2.824 ± 0.168
3.424GlyGly: 3.424 ± 0.222
1.19GlyHis: 1.19 ± 0.102
3.787GlyIle: 3.787 ± 0.18
6.665GlyLys: 6.665 ± 0.258
4.45GlyLeu: 4.45 ± 0.212
1.308GlyMet: 1.308 ± 0.112
2.752GlyAsn: 2.752 ± 0.184
1.744GlyPro: 1.744 ± 0.127
1.98GlyGln: 1.98 ± 0.149
3.932GlyArg: 3.932 ± 0.19
4.223GlySer: 4.223 ± 0.204
3.832GlyThr: 3.832 ± 0.218
4.186GlyVal: 4.186 ± 0.226
0.944GlyTrp: 0.944 ± 0.097
2.307GlyTyr: 2.307 ± 0.165
0.0GlyXaa: 0.0 ± 0.0
His
0.763HisAla: 0.763 ± 0.091
0.509HisCys: 0.509 ± 0.065
0.581HisAsp: 0.581 ± 0.088
1.362HisGlu: 1.362 ± 0.103
1.135HisPhe: 1.135 ± 0.1
1.517HisGly: 1.517 ± 0.149
0.3HisHis: 0.3 ± 0.053
1.28HisIle: 1.28 ± 0.112
1.853HisLys: 1.853 ± 0.164
1.843HisLeu: 1.843 ± 0.124
0.345HisMet: 0.345 ± 0.065
0.69HisAsn: 0.69 ± 0.071
0.881HisPro: 0.881 ± 0.102
0.581HisGln: 0.581 ± 0.073
0.881HisArg: 0.881 ± 0.085
1.462HisSer: 1.462 ± 0.115
0.618HisThr: 0.618 ± 0.073
0.972HisVal: 0.972 ± 0.089
0.263HisTrp: 0.263 ± 0.056
0.563HisTyr: 0.563 ± 0.073
0.0HisXaa: 0.0 ± 0.0
Ile
2.534IleAla: 2.534 ± 0.17
1.235IleCys: 1.235 ± 0.091
2.125IleAsp: 2.125 ± 0.137
3.269IleGlu: 3.269 ± 0.185
3.187IlePhe: 3.187 ± 0.161
2.824IleGly: 2.824 ± 0.198
1.044IleHis: 1.044 ± 0.108
2.216IleIle: 2.216 ± 0.158
2.77IleLys: 2.77 ± 0.179
5.231IleLeu: 5.231 ± 0.204
0.69IleMet: 0.69 ± 0.072
1.062IleAsn: 1.062 ± 0.098
2.833IlePro: 2.833 ± 0.151
1.971IleGln: 1.971 ± 0.151
2.452IleArg: 2.452 ± 0.126
5.539IleSer: 5.539 ± 0.199
2.007IleThr: 2.007 ± 0.171
3.36IleVal: 3.36 ± 0.184
0.781IleTrp: 0.781 ± 0.09
1.208IleTyr: 1.208 ± 0.101
0.0IleXaa: 0.0 ± 0.0
Lys
4.159LysAla: 4.159 ± 0.266
1.398LysCys: 1.398 ± 0.129
4.186LysAsp: 4.186 ± 0.183
8.79LysGlu: 8.79 ± 0.359
4.304LysPhe: 4.304 ± 0.2
5.258LysGly: 5.258 ± 0.231
1.898LysHis: 1.898 ± 0.148
4.649LysIle: 4.649 ± 0.202
11.115LysLys: 11.115 ± 0.699
5.93LysLeu: 5.93 ± 0.251
1.789LysMet: 1.789 ± 0.147
4.804LysAsn: 4.804 ± 0.224
2.216LysPro: 2.216 ± 0.171
2.715LysGln: 2.715 ± 0.157
5.884LysArg: 5.884 ± 0.252
4.277LysSer: 4.277 ± 0.239
5.104LysThr: 5.104 ± 0.191
4.55LysVal: 4.55 ± 0.219
0.908LysTrp: 0.908 ± 0.091
3.06LysTyr: 3.06 ± 0.173
0.0LysXaa: 0.0 ± 0.0
Leu
4.55LeuAla: 4.55 ± 0.218
2.915LeuCys: 2.915 ± 0.194
4.304LeuAsp: 4.304 ± 0.226
8.364LeuGlu: 8.364 ± 0.332
5.294LeuPhe: 5.294 ± 0.239
5.222LeuGly: 5.222 ± 0.239
1.553LeuHis: 1.553 ± 0.139
2.861LeuIle: 2.861 ± 0.197
5.467LeuLys: 5.467 ± 0.262
9.008LeuLeu: 9.008 ± 0.319
1.58LeuMet: 1.58 ± 0.121
2.697LeuAsn: 2.697 ± 0.173
4.477LeuPro: 4.477 ± 0.223
3.505LeuGln: 3.505 ± 0.248
5.076LeuArg: 5.076 ± 0.232
8.663LeuSer: 8.663 ± 0.368
3.242LeuThr: 3.242 ± 0.169
5.966LeuVal: 5.966 ± 0.249
1.789LeuTrp: 1.789 ± 0.142
2.452LeuTyr: 2.452 ± 0.141
0.0LeuXaa: 0.0 ± 0.0
Met
1.29MetAla: 1.29 ± 0.121
0.599MetCys: 0.599 ± 0.07
1.19MetAsp: 1.19 ± 0.114
2.27MetGlu: 2.27 ± 0.152
1.044MetPhe: 1.044 ± 0.097
1.181MetGly: 1.181 ± 0.118
0.345MetHis: 0.345 ± 0.062
0.499MetIle: 0.499 ± 0.07
1.398MetLys: 1.398 ± 0.124
1.462MetLeu: 1.462 ± 0.1
0.49MetMet: 0.49 ± 0.07
0.944MetAsn: 0.944 ± 0.09
0.599MetPro: 0.599 ± 0.078
0.772MetGln: 0.772 ± 0.079
0.981MetArg: 0.981 ± 0.103
2.025MetSer: 2.025 ± 0.15
1.162MetThr: 1.162 ± 0.127
1.099MetVal: 1.099 ± 0.1
0.318MetTrp: 0.318 ± 0.053
0.554MetTyr: 0.554 ± 0.075
0.0MetXaa: 0.0 ± 0.0
Asn
1.989AsnAla: 1.989 ± 0.159
0.763AsnCys: 0.763 ± 0.085
1.344AsnAsp: 1.344 ± 0.108
2.198AsnGlu: 2.198 ± 0.147
2.661AsnPhe: 2.661 ± 0.147
3.042AsnGly: 3.042 ± 0.211
0.436AsnHis: 0.436 ± 0.065
3.106AsnIle: 3.106 ± 0.19
3.197AsnLys: 3.197 ± 0.194
3.26AsnLeu: 3.26 ± 0.16
0.799AsnMet: 0.799 ± 0.084
1.589AsnAsn: 1.589 ± 0.135
2.116AsnPro: 2.116 ± 0.161
0.835AsnGln: 0.835 ± 0.081
1.616AsnArg: 1.616 ± 0.137
3.142AsnSer: 3.142 ± 0.18
2.052AsnThr: 2.052 ± 0.211
2.488AsnVal: 2.488 ± 0.166
0.527AsnTrp: 0.527 ± 0.061
1.162AsnTyr: 1.162 ± 0.092
0.0AsnXaa: 0.0 ± 0.0
Pro
1.344ProAla: 1.344 ± 0.112
0.763ProCys: 0.763 ± 0.079
1.971ProAsp: 1.971 ± 0.144
4.195ProGlu: 4.195 ± 0.206
2.179ProPhe: 2.179 ± 0.171
2.361ProGly: 2.361 ± 0.162
0.808ProHis: 0.808 ± 0.098
1.671ProIle: 1.671 ± 0.125
3.705ProLys: 3.705 ± 0.257
3.587ProLeu: 3.587 ± 0.203
0.69ProMet: 0.69 ± 0.07
1.689ProAsn: 1.689 ± 0.119
1.853ProPro: 1.853 ± 0.173
1.571ProGln: 1.571 ± 0.131
2.061ProArg: 2.061 ± 0.163
3.424ProSer: 3.424 ± 0.431
2.17ProThr: 2.17 ± 0.161
2.016ProVal: 2.016 ± 0.145
0.599ProTrp: 0.599 ± 0.08
1.326ProTyr: 1.326 ± 0.141
0.0ProXaa: 0.0 ± 0.0
Gln
1.48GlnAla: 1.48 ± 0.156
0.536GlnCys: 0.536 ± 0.089
1.253GlnAsp: 1.253 ± 0.107
3.542GlnGlu: 3.542 ± 0.187
0.99GlnPhe: 0.99 ± 0.079
2.179GlnGly: 2.179 ± 0.155
0.754GlnHis: 0.754 ± 0.073
1.471GlnIle: 1.471 ± 0.111
4.35GlnLys: 4.35 ± 0.214
2.198GlnLeu: 2.198 ± 0.128
0.881GlnMet: 0.881 ± 0.103
1.834GlnAsn: 1.834 ± 0.138
0.817GlnPro: 0.817 ± 0.118
1.58GlnGln: 1.58 ± 0.176
2.624GlnArg: 2.624 ± 0.178
1.698GlnSer: 1.698 ± 0.145
2.125GlnThr: 2.125 ± 0.162
1.816GlnVal: 1.816 ± 0.173
0.463GlnTrp: 0.463 ± 0.073
0.817GlnTyr: 0.817 ± 0.079
0.0GlnXaa: 0.0 ± 0.0
Arg
2.597ArgAla: 2.597 ± 0.175
1.117ArgCys: 1.117 ± 0.094
2.942ArgAsp: 2.942 ± 0.161
6.139ArgGlu: 6.139 ± 0.259
2.688ArgPhe: 2.688 ± 0.177
3.46ArgGly: 3.46 ± 0.177
1.217ArgHis: 1.217 ± 0.12
3.015ArgIle: 3.015 ± 0.173
6.157ArgLys: 6.157 ± 0.25
4.595ArgLeu: 4.595 ± 0.249
1.326ArgMet: 1.326 ± 0.103
2.752ArgAsn: 2.752 ± 0.143
1.571ArgPro: 1.571 ± 0.141
1.961ArgGln: 1.961 ± 0.137
3.115ArgArg: 3.115 ± 0.193
3.106ArgSer: 3.106 ± 0.183
3.006ArgThr: 3.006 ± 0.195
3.76ArgVal: 3.76 ± 0.2
0.772ArgTrp: 0.772 ± 0.078
1.88ArgTyr: 1.88 ± 0.133
0.0ArgXaa: 0.0 ± 0.0
Ser
3.968SerAla: 3.968 ± 0.195
2.361SerCys: 2.361 ± 0.171
3.187SerAsp: 3.187 ± 0.162
5.576SerGlu: 5.576 ± 0.214
5.558SerPhe: 5.558 ± 0.243
5.512SerGly: 5.512 ± 0.26
1.453SerHis: 1.453 ± 0.149
2.997SerIle: 2.997 ± 0.159
5.93SerLys: 5.93 ± 0.259
7.628SerLeu: 7.628 ± 0.308
1.235SerMet: 1.235 ± 0.096
2.488SerAsn: 2.488 ± 0.166
3.85SerPro: 3.85 ± 0.396
2.879SerGln: 2.879 ± 0.162
3.968SerArg: 3.968 ± 0.195
7.11SerSer: 7.11 ± 0.305
3.287SerThr: 3.287 ± 0.192
5.203SerVal: 5.203 ± 0.232
1.398SerTrp: 1.398 ± 0.112
2.134SerTyr: 2.134 ± 0.167
0.0SerXaa: 0.0 ± 0.0
Thr
2.47ThrAla: 2.47 ± 0.174
1.271ThrCys: 1.271 ± 0.107
1.898ThrAsp: 1.898 ± 0.137
3.805ThrGlu: 3.805 ± 0.198
2.824ThrPhe: 2.824 ± 0.161
2.997ThrGly: 2.997 ± 0.211
0.854ThrHis: 0.854 ± 0.094
2.161ThrIle: 2.161 ± 0.131
4.504ThrLys: 4.504 ± 0.207
4.568ThrLeu: 4.568 ± 0.298
1.008ThrMet: 1.008 ± 0.092
2.125ThrAsn: 2.125 ± 0.213
2.633ThrPro: 2.633 ± 0.199
1.825ThrGln: 1.825 ± 0.148
2.888ThrArg: 2.888 ± 0.166
3.387ThrSer: 3.387 ± 0.212
3.142ThrThr: 3.142 ± 0.202
2.842ThrVal: 2.842 ± 0.156
0.654ThrTrp: 0.654 ± 0.076
1.398ThrTyr: 1.398 ± 0.124
0.0ThrXaa: 0.0 ± 0.0
Val
3.569ValAla: 3.569 ± 0.225
1.816ValCys: 1.816 ± 0.148
3.296ValAsp: 3.296 ± 0.156
4.867ValGlu: 4.867 ± 0.281
4.332ValPhe: 4.332 ± 0.195
3.224ValGly: 3.224 ± 0.182
1.153ValHis: 1.153 ± 0.105
2.434ValIle: 2.434 ± 0.16
4.195ValLys: 4.195 ± 0.213
6.475ValLeu: 6.475 ± 0.228
1.053ValMet: 1.053 ± 0.097
1.771ValAsn: 1.771 ± 0.116
3.197ValPro: 3.197 ± 0.184
2.025ValGln: 2.025 ± 0.136
3.251ValArg: 3.251 ± 0.183
5.948ValSer: 5.948 ± 0.225
2.561ValThr: 2.561 ± 0.159
4.976ValVal: 4.976 ± 0.235
1.181ValTrp: 1.181 ± 0.111
2.043ValTyr: 2.043 ± 0.141
0.0ValXaa: 0.0 ± 0.0
Trp
0.59TrpAla: 0.59 ± 0.064
0.618TrpCys: 0.618 ± 0.084
0.808TrpAsp: 0.808 ± 0.088
1.135TrpGlu: 1.135 ± 0.099
1.398TrpPhe: 1.398 ± 0.125
0.627TrpGly: 0.627 ± 0.098
0.218TrpHis: 0.218 ± 0.045
0.745TrpIle: 0.745 ± 0.098
1.48TrpLys: 1.48 ± 0.125
1.398TrpLeu: 1.398 ± 0.133
0.309TrpMet: 0.309 ± 0.052
0.681TrpAsn: 0.681 ± 0.081
0.254TrpPro: 0.254 ± 0.044
0.327TrpGln: 0.327 ± 0.054
1.026TrpArg: 1.026 ± 0.11
1.535TrpSer: 1.535 ± 0.118
0.826TrpThr: 0.826 ± 0.088
0.863TrpVal: 0.863 ± 0.084
0.3TrpTrp: 0.3 ± 0.056
0.554TrpTyr: 0.554 ± 0.072
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.689TyrAla: 1.689 ± 0.118
0.772TyrCys: 0.772 ± 0.081
1.871TyrAsp: 1.871 ± 0.149
2.534TyrGlu: 2.534 ± 0.139
1.625TyrPhe: 1.625 ± 0.107
2.406TyrGly: 2.406 ± 0.145
0.499TyrHis: 0.499 ± 0.067
1.571TyrIle: 1.571 ± 0.139
1.943TyrLys: 1.943 ± 0.135
2.543TyrLeu: 2.543 ± 0.142
0.572TyrMet: 0.572 ± 0.072
1.181TyrAsn: 1.181 ± 0.093
1.208TyrPro: 1.208 ± 0.112
1.008TyrGln: 1.008 ± 0.094
1.716TyrArg: 1.716 ± 0.134
2.506TyrSer: 2.506 ± 0.168
1.507TyrThr: 1.507 ± 0.123
1.725TyrVal: 1.725 ± 0.136
0.581TyrTrp: 0.581 ± 0.069
0.663TyrTyr: 0.663 ± 0.075
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 448 proteins (110121 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski