Amino acid dipepetide frequency for Wenzhou picorna-like virus 12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.029AlaAla: 5.029 ± 0.335
1.257AlaCys: 1.257 ± 0.642
2.934AlaAsp: 2.934 ± 0.772
2.096AlaGlu: 2.096 ± 1.107
3.772AlaPhe: 3.772 ± 0.474
4.61AlaGly: 4.61 ± 1.275
1.676AlaHis: 1.676 ± 0.856
2.515AlaIle: 2.515 ± 0.893
4.191AlaLys: 4.191 ± 0.037
10.897AlaLeu: 10.897 ± 2.661
0.838AlaMet: 0.838 ± 0.428
2.515AlaAsn: 2.515 ± 0.168
5.448AlaPro: 5.448 ± 0.847
2.096AlaGln: 2.096 ± 0.382
3.353AlaArg: 3.353 ± 0.986
7.125AlaSer: 7.125 ± 2.894
3.772AlaThr: 3.772 ± 2.429
7.544AlaVal: 7.544 ± 1.675
2.934AlaTrp: 2.934 ± 0.679
1.676AlaTyr: 1.676 ± 0.13
0.0AlaXaa: 0.0 ± 0.0
Cys
1.676CysAla: 1.676 ± 0.856
1.257CysCys: 1.257 ± 0.642
1.676CysAsp: 1.676 ± 0.856
2.096CysGlu: 2.096 ± 1.07
1.676CysPhe: 1.676 ± 0.13
0.838CysGly: 0.838 ± 0.428
0.838CysHis: 0.838 ± 0.428
0.0CysIle: 0.0 ± 0.0
0.419CysLys: 0.419 ± 0.214
2.934CysLeu: 2.934 ± 0.772
0.838CysMet: 0.838 ± 0.428
0.0CysAsn: 0.0 ± 0.0
2.096CysPro: 2.096 ± 1.07
1.676CysGln: 1.676 ± 0.13
2.515CysArg: 2.515 ± 1.284
1.257CysSer: 1.257 ± 0.084
0.838CysThr: 0.838 ± 0.428
0.838CysVal: 0.838 ± 0.298
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.353AspAla: 3.353 ± 0.26
1.676AspCys: 1.676 ± 0.856
5.868AspAsp: 5.868 ± 1.544
5.868AspGlu: 5.868 ± 0.093
2.934AspPhe: 2.934 ± 0.046
3.353AspGly: 3.353 ± 1.191
1.257AspHis: 1.257 ± 0.81
4.191AspIle: 4.191 ± 0.688
2.096AspLys: 2.096 ± 1.07
3.772AspLeu: 3.772 ± 1.2
2.515AspMet: 2.515 ± 0.558
1.257AspAsn: 1.257 ± 0.81
3.772AspPro: 3.772 ± 0.977
0.0AspGln: 0.0 ± 0.0
2.096AspArg: 2.096 ± 0.344
2.934AspSer: 2.934 ± 0.772
2.515AspThr: 2.515 ± 0.168
7.125AspVal: 7.125 ± 0.717
1.257AspTrp: 1.257 ± 0.642
2.934AspTyr: 2.934 ± 0.772
0.0AspXaa: 0.0 ± 0.0
Glu
4.191GluAla: 4.191 ± 1.414
2.096GluCys: 2.096 ± 1.07
4.191GluAsp: 4.191 ± 1.414
2.515GluGlu: 2.515 ± 0.558
1.257GluPhe: 1.257 ± 0.084
1.257GluGly: 1.257 ± 0.81
0.419GluHis: 0.419 ± 0.214
3.772GluIle: 3.772 ± 0.474
6.287GluLys: 6.287 ± 1.758
6.706GluLeu: 6.706 ± 1.972
1.257GluMet: 1.257 ± 0.084
2.515GluAsn: 2.515 ± 1.619
0.419GluPro: 0.419 ± 0.214
0.838GluGln: 0.838 ± 0.428
2.515GluArg: 2.515 ± 1.284
2.934GluSer: 2.934 ± 0.772
2.515GluThr: 2.515 ± 0.168
4.191GluVal: 4.191 ± 0.688
0.0GluTrp: 0.0 ± 0.0
3.772GluTyr: 3.772 ± 1.2
0.0GluXaa: 0.0 ± 0.0
Phe
3.353PheAla: 3.353 ± 1.917
0.838PheCys: 0.838 ± 0.428
2.096PheAsp: 2.096 ± 1.07
0.419PheGlu: 0.419 ± 0.214
1.676PhePhe: 1.676 ± 0.596
1.676PheGly: 1.676 ± 0.596
0.838PheHis: 0.838 ± 0.298
1.257PheIle: 1.257 ± 0.084
2.096PheLys: 2.096 ± 0.344
7.125PheLeu: 7.125 ± 1.461
1.257PheMet: 1.257 ± 0.084
2.515PheAsn: 2.515 ± 0.893
3.353PhePro: 3.353 ± 0.26
1.676PheGln: 1.676 ± 0.596
2.934PheArg: 2.934 ± 0.046
4.191PheSer: 4.191 ± 0.688
4.191PheThr: 4.191 ± 1.489
2.515PheVal: 2.515 ± 0.168
1.676PheTrp: 1.676 ± 0.856
3.772PheTyr: 3.772 ± 0.251
0.0PheXaa: 0.0 ± 0.0
Gly
5.868GlyAla: 5.868 ± 2.811
2.515GlyCys: 2.515 ± 1.284
5.448GlyAsp: 5.448 ± 0.605
2.934GlyGlu: 2.934 ± 0.046
2.096GlyPhe: 2.096 ± 0.382
2.515GlyGly: 2.515 ± 0.558
0.838GlyHis: 0.838 ± 1.024
1.676GlyIle: 1.676 ± 0.13
6.706GlyLys: 6.706 ± 2.698
2.934GlyLeu: 2.934 ± 0.046
0.838GlyMet: 0.838 ± 0.435
1.257GlyAsn: 1.257 ± 0.084
2.515GlyPro: 2.515 ± 0.168
2.096GlyGln: 2.096 ± 1.833
2.096GlyArg: 2.096 ± 0.382
3.772GlySer: 3.772 ± 2.429
4.191GlyThr: 4.191 ± 2.215
4.61GlyVal: 4.61 ± 1.275
0.0GlyTrp: 0.0 ± 0.0
2.096GlyTyr: 2.096 ± 1.107
0.0GlyXaa: 0.0 ± 0.0
His
1.257HisAla: 1.257 ± 0.084
0.419HisCys: 0.419 ± 0.214
0.838HisAsp: 0.838 ± 0.428
2.096HisGlu: 2.096 ± 0.344
1.676HisPhe: 1.676 ± 0.856
1.257HisGly: 1.257 ± 0.642
0.0HisHis: 0.0 ± 0.0
2.096HisIle: 2.096 ± 1.07
0.419HisLys: 0.419 ± 0.512
1.257HisLeu: 1.257 ± 0.084
0.419HisMet: 0.419 ± 0.214
0.419HisAsn: 0.419 ± 0.214
0.838HisPro: 0.838 ± 0.428
0.419HisGln: 0.419 ± 0.214
1.257HisArg: 1.257 ± 0.81
1.676HisSer: 1.676 ± 0.13
1.257HisThr: 1.257 ± 0.642
1.676HisVal: 1.676 ± 0.596
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.029IleAla: 5.029 ± 1.061
0.838IleCys: 0.838 ± 0.428
0.838IleAsp: 0.838 ± 0.298
0.838IleGlu: 0.838 ± 0.298
3.353IlePhe: 3.353 ± 0.465
3.353IleGly: 3.353 ± 0.465
2.934IleHis: 2.934 ± 1.498
2.515IleIle: 2.515 ± 1.284
2.096IleLys: 2.096 ± 1.07
5.029IleLeu: 5.029 ± 0.391
2.096IleMet: 2.096 ± 1.07
1.676IleAsn: 1.676 ± 0.596
4.191IlePro: 4.191 ± 0.688
0.0IleGln: 0.0 ± 0.0
1.676IleArg: 1.676 ± 0.856
4.61IleSer: 4.61 ± 2.727
3.353IleThr: 3.353 ± 0.986
5.029IleVal: 5.029 ± 0.335
0.419IleTrp: 0.419 ± 0.214
3.353IleTyr: 3.353 ± 0.26
0.0IleXaa: 0.0 ± 0.0
Lys
2.515LysAla: 2.515 ± 1.284
1.676LysCys: 1.676 ± 0.13
2.934LysAsp: 2.934 ± 1.498
3.353LysGlu: 3.353 ± 0.986
3.353LysPhe: 3.353 ± 0.26
3.353LysGly: 3.353 ± 0.465
1.257LysHis: 1.257 ± 0.642
2.934LysIle: 2.934 ± 1.498
2.096LysLys: 2.096 ± 1.07
3.353LysLeu: 3.353 ± 0.465
1.257LysMet: 1.257 ± 0.642
2.096LysAsn: 2.096 ± 0.344
2.515LysPro: 2.515 ± 0.558
1.257LysGln: 1.257 ± 0.642
3.772LysArg: 3.772 ± 1.926
4.61LysSer: 4.61 ± 2.354
1.676LysThr: 1.676 ± 0.856
2.096LysVal: 2.096 ± 1.07
0.838LysTrp: 0.838 ± 0.428
1.257LysTyr: 1.257 ± 0.81
0.0LysXaa: 0.0 ± 0.0
Leu
9.64LeuAla: 9.64 ± 0.567
2.934LeuCys: 2.934 ± 1.498
4.191LeuAsp: 4.191 ± 0.688
7.125LeuGlu: 7.125 ± 2.187
3.772LeuPhe: 3.772 ± 1.2
4.61LeuGly: 4.61 ± 1.628
2.096LeuHis: 2.096 ± 0.382
4.191LeuIle: 4.191 ± 0.763
5.448LeuLys: 5.448 ± 2.782
5.029LeuLeu: 5.029 ± 1.842
1.676LeuMet: 1.676 ± 0.13
4.61LeuAsn: 4.61 ± 0.177
3.353LeuPro: 3.353 ± 0.26
2.934LeuGln: 2.934 ± 2.131
2.515LeuArg: 2.515 ± 0.558
7.125LeuSer: 7.125 ± 0.009
3.772LeuThr: 3.772 ± 1.703
2.515LeuVal: 2.515 ± 0.168
1.676LeuTrp: 1.676 ± 0.596
4.191LeuTyr: 4.191 ± 0.763
0.0LeuXaa: 0.0 ± 0.0
Met
2.515MetAla: 2.515 ± 0.558
0.0MetCys: 0.0 ± 0.0
0.419MetAsp: 0.419 ± 0.214
1.676MetGlu: 1.676 ± 0.856
2.515MetPhe: 2.515 ± 0.168
2.934MetGly: 2.934 ± 1.405
0.419MetHis: 0.419 ± 0.214
2.515MetIle: 2.515 ± 1.284
1.257MetLys: 1.257 ± 0.642
0.838MetLeu: 0.838 ± 1.024
0.0MetMet: 0.0 ± 0.0
0.838MetAsn: 0.838 ± 0.428
0.838MetPro: 0.838 ± 1.024
0.838MetGln: 0.838 ± 0.428
3.353MetArg: 3.353 ± 0.465
0.838MetSer: 0.838 ± 0.428
1.676MetThr: 1.676 ± 1.321
0.838MetVal: 0.838 ± 0.428
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.096AsnAla: 2.096 ± 0.382
0.0AsnCys: 0.0 ± 0.0
2.096AsnAsp: 2.096 ± 1.107
1.676AsnGlu: 1.676 ± 1.321
2.096AsnPhe: 2.096 ± 0.344
3.772AsnGly: 3.772 ± 1.703
0.838AsnHis: 0.838 ± 0.298
2.934AsnIle: 2.934 ± 0.679
0.838AsnLys: 0.838 ± 0.428
4.191AsnLeu: 4.191 ± 1.414
0.419AsnMet: 0.419 ± 0.214
2.515AsnAsn: 2.515 ± 0.168
0.419AsnPro: 0.419 ± 0.214
2.515AsnGln: 2.515 ± 0.893
3.772AsnArg: 3.772 ± 0.251
3.353AsnSer: 3.353 ± 0.26
0.838AsnThr: 0.838 ± 0.298
4.191AsnVal: 4.191 ± 0.688
1.257AsnTrp: 1.257 ± 0.81
1.676AsnTyr: 1.676 ± 2.047
0.0AsnXaa: 0.0 ± 0.0
Pro
3.353ProAla: 3.353 ± 0.465
0.419ProCys: 0.419 ± 0.214
2.515ProAsp: 2.515 ± 0.558
2.515ProGlu: 2.515 ± 1.284
2.515ProPhe: 2.515 ± 0.893
2.096ProGly: 2.096 ± 1.07
0.838ProHis: 0.838 ± 0.428
1.676ProIle: 1.676 ± 0.856
1.676ProLys: 1.676 ± 0.13
4.191ProLeu: 4.191 ± 0.037
2.515ProMet: 2.515 ± 0.34
1.257ProAsn: 1.257 ± 0.084
2.096ProPro: 2.096 ± 1.07
2.096ProGln: 2.096 ± 1.107
2.096ProArg: 2.096 ± 0.382
4.191ProSer: 4.191 ± 0.763
5.448ProThr: 5.448 ± 1.573
4.191ProVal: 4.191 ± 1.489
0.419ProTrp: 0.419 ± 0.214
2.934ProTyr: 2.934 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
5.868GlnAla: 5.868 ± 0.819
1.257GlnCys: 1.257 ± 0.084
2.515GlnAsp: 2.515 ± 1.619
0.838GlnGlu: 0.838 ± 0.428
2.096GlnPhe: 2.096 ± 1.107
1.257GlnGly: 1.257 ± 0.084
0.0GlnHis: 0.0 ± 0.0
1.676GlnIle: 1.676 ± 0.13
1.257GlnLys: 1.257 ± 0.642
1.257GlnLeu: 1.257 ± 0.084
0.419GlnMet: 0.419 ± 0.512
2.515GlnAsn: 2.515 ± 0.893
2.096GlnPro: 2.096 ± 0.382
1.257GlnGln: 1.257 ± 0.642
2.515GlnArg: 2.515 ± 0.168
3.353GlnSer: 3.353 ± 1.191
1.257GlnThr: 1.257 ± 0.084
1.257GlnVal: 1.257 ± 0.084
0.0GlnTrp: 0.0 ± 0.0
3.353GlnTyr: 3.353 ± 1.917
0.0GlnXaa: 0.0 ± 0.0
Arg
4.191ArgAla: 4.191 ± 0.688
0.838ArgCys: 0.838 ± 0.428
2.515ArgAsp: 2.515 ± 1.284
5.029ArgGlu: 5.029 ± 2.568
2.934ArgPhe: 2.934 ± 0.679
3.353ArgGly: 3.353 ± 2.643
1.257ArgHis: 1.257 ± 0.642
1.257ArgIle: 1.257 ± 0.81
1.676ArgLys: 1.676 ± 1.321
5.448ArgLeu: 5.448 ± 0.605
1.257ArgMet: 1.257 ± 0.81
2.096ArgAsn: 2.096 ± 0.344
1.257ArgPro: 1.257 ± 0.084
2.096ArgGln: 2.096 ± 1.07
2.934ArgArg: 2.934 ± 0.046
5.029ArgSer: 5.029 ± 1.116
3.353ArgThr: 3.353 ± 0.986
4.61ArgVal: 4.61 ± 0.177
0.838ArgTrp: 0.838 ± 0.428
1.257ArgTyr: 1.257 ± 0.642
0.0ArgXaa: 0.0 ± 0.0
Ser
4.191SerAla: 4.191 ± 0.763
1.676SerCys: 1.676 ± 0.856
6.287SerAsp: 6.287 ± 0.307
2.515SerGlu: 2.515 ± 1.284
4.61SerPhe: 4.61 ± 0.177
4.61SerGly: 4.61 ± 0.177
0.419SerHis: 0.419 ± 0.214
5.448SerIle: 5.448 ± 2.299
2.934SerLys: 2.934 ± 0.772
5.868SerLeu: 5.868 ± 0.093
1.257SerMet: 1.257 ± 0.084
3.353SerAsn: 3.353 ± 0.465
4.191SerPro: 4.191 ± 0.037
5.868SerGln: 5.868 ± 1.359
2.934SerArg: 2.934 ± 0.772
7.544SerSer: 7.544 ± 1.229
5.448SerThr: 5.448 ± 5.202
5.868SerVal: 5.868 ± 0.093
0.419SerTrp: 0.419 ± 0.214
4.191SerTyr: 4.191 ± 1.489
0.0SerXaa: 0.0 ± 0.0
Thr
2.515ThrAla: 2.515 ± 1.619
0.419ThrCys: 0.419 ± 0.214
5.448ThrAsp: 5.448 ± 3.75
1.676ThrGlu: 1.676 ± 0.13
2.934ThrPhe: 2.934 ± 0.679
4.61ThrGly: 4.61 ± 1.275
0.419ThrHis: 0.419 ± 0.214
3.353ThrIle: 3.353 ± 0.465
2.096ThrLys: 2.096 ± 0.344
4.61ThrLeu: 4.61 ± 1.275
2.515ThrMet: 2.515 ± 0.558
4.191ThrAsn: 4.191 ± 2.215
2.934ThrPro: 2.934 ± 0.046
1.676ThrGln: 1.676 ± 0.596
1.257ThrArg: 1.257 ± 0.084
6.706ThrSer: 6.706 ± 1.657
3.772ThrThr: 3.772 ± 0.977
4.61ThrVal: 4.61 ± 0.177
0.0ThrTrp: 0.0 ± 0.0
1.676ThrTyr: 1.676 ± 0.13
0.0ThrXaa: 0.0 ± 0.0
Val
5.448ValAla: 5.448 ± 1.33
1.676ValCys: 1.676 ± 0.13
4.191ValAsp: 4.191 ± 0.688
4.61ValGlu: 4.61 ± 0.549
1.257ValPhe: 1.257 ± 0.81
6.706ValGly: 6.706 ± 0.931
1.257ValHis: 1.257 ± 0.642
6.287ValIle: 6.287 ± 0.307
1.676ValLys: 1.676 ± 0.856
4.191ValLeu: 4.191 ± 0.037
0.419ValMet: 0.419 ± 0.214
2.934ValAsn: 2.934 ± 0.772
5.448ValPro: 5.448 ± 1.573
4.191ValGln: 4.191 ± 0.037
7.125ValArg: 7.125 ± 0.735
4.61ValSer: 4.61 ± 1.275
5.448ValThr: 5.448 ± 0.605
7.544ValVal: 7.544 ± 4.132
0.419ValTrp: 0.419 ± 0.214
2.934ValTyr: 2.934 ± 0.679
0.0ValXaa: 0.0 ± 0.0
Trp
0.838TrpAla: 0.838 ± 0.298
0.419TrpCys: 0.419 ± 0.512
1.257TrpAsp: 1.257 ± 0.084
0.419TrpGlu: 0.419 ± 0.214
1.257TrpPhe: 1.257 ± 0.084
0.0TrpGly: 0.0 ± 0.0
0.838TrpHis: 0.838 ± 0.428
0.838TrpIle: 0.838 ± 0.428
0.838TrpLys: 0.838 ± 0.428
0.419TrpLeu: 0.419 ± 0.214
0.0TrpMet: 0.0 ± 0.0
1.257TrpAsn: 1.257 ± 0.084
0.838TrpPro: 0.838 ± 0.298
0.419TrpGln: 0.419 ± 0.214
0.419TrpArg: 0.419 ± 0.512
1.257TrpSer: 1.257 ± 0.084
0.419TrpThr: 0.419 ± 0.214
2.096TrpVal: 2.096 ± 0.344
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.353TyrAla: 3.353 ± 0.465
1.257TyrCys: 1.257 ± 0.084
2.515TyrAsp: 2.515 ± 0.893
3.353TyrGlu: 3.353 ± 1.712
1.676TyrPhe: 1.676 ± 0.856
0.838TyrGly: 0.838 ± 0.298
0.838TyrHis: 0.838 ± 0.298
2.096TyrIle: 2.096 ± 0.344
2.096TyrLys: 2.096 ± 1.07
3.353TyrLeu: 3.353 ± 2.643
2.096TyrMet: 2.096 ± 2.559
1.676TyrAsn: 1.676 ± 0.596
0.838TyrPro: 0.838 ± 0.298
2.096TyrGln: 2.096 ± 0.382
2.096TyrArg: 2.096 ± 1.107
2.515TyrSer: 2.515 ± 0.168
1.676TyrThr: 1.676 ± 0.13
5.029TyrVal: 5.029 ± 0.391
1.676TyrTrp: 1.676 ± 0.596
0.838TyrTyr: 0.838 ± 0.298
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2387 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski