Amino acid dipepetide frequency for Wuhan Fly Virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.086AlaAla: 2.086 ± 1.355
1.043AlaCys: 1.043 ± 0.32
2.086AlaAsp: 2.086 ± 0.672
2.868AlaGlu: 2.868 ± 1.291
2.347AlaPhe: 2.347 ± 1.287
1.043AlaGly: 1.043 ± 0.32
0.522AlaHis: 0.522 ± 0.326
2.608AlaIle: 2.608 ± 1.0
3.129AlaLys: 3.129 ± 2.031
4.433AlaLeu: 4.433 ± 2.63
1.825AlaMet: 1.825 ± 1.356
1.565AlaAsn: 1.565 ± 0.769
1.304AlaPro: 1.304 ± 0.534
1.565AlaGln: 1.565 ± 1.497
3.129AlaArg: 3.129 ± 1.169
4.954AlaSer: 4.954 ± 1.628
2.608AlaThr: 2.608 ± 0.346
3.129AlaVal: 3.129 ± 0.329
0.261AlaTrp: 0.261 ± 0.163
1.043AlaTyr: 1.043 ± 0.98
0.0AlaXaa: 0.0 ± 0.0
Cys
0.522CysAla: 0.522 ± 0.326
0.0CysCys: 0.0 ± 0.0
0.522CysAsp: 0.522 ± 0.496
1.565CysGlu: 1.565 ± 1.12
1.043CysPhe: 1.043 ± 0.627
1.043CysGly: 1.043 ± 0.627
0.261CysHis: 0.261 ± 0.248
0.782CysIle: 0.782 ± 0.745
3.129CysLys: 3.129 ± 1.221
2.086CysLeu: 2.086 ± 0.649
0.261CysMet: 0.261 ± 0.248
1.565CysAsn: 1.565 ± 1.12
1.043CysPro: 1.043 ± 0.627
0.261CysGln: 0.261 ± 0.163
0.261CysArg: 0.261 ± 0.163
1.565CysSer: 1.565 ± 1.12
1.565CysThr: 1.565 ± 1.12
0.782CysVal: 0.782 ± 0.206
0.0CysTrp: 0.0 ± 0.0
0.782CysTyr: 0.782 ± 0.384
0.0CysXaa: 0.0 ± 0.0
Asp
2.086AspAla: 2.086 ± 0.493
1.043AspCys: 1.043 ± 0.32
3.911AspAsp: 3.911 ± 0.931
4.172AspGlu: 4.172 ± 1.344
2.868AspPhe: 2.868 ± 0.731
2.347AspGly: 2.347 ± 0.346
0.782AspHis: 0.782 ± 0.745
3.651AspIle: 3.651 ± 0.985
2.608AspLys: 2.608 ± 0.972
5.997AspLeu: 5.997 ± 0.361
1.825AspMet: 1.825 ± 0.758
3.39AspAsn: 3.39 ± 1.444
1.825AspPro: 1.825 ± 0.7
1.304AspGln: 1.304 ± 0.632
2.347AspArg: 2.347 ± 0.882
5.476AspSer: 5.476 ± 0.462
2.868AspThr: 2.868 ± 0.492
2.868AspVal: 2.868 ± 0.395
0.522AspTrp: 0.522 ± 0.821
1.825AspTyr: 1.825 ± 0.802
0.0AspXaa: 0.0 ± 0.0
Glu
3.39GluAla: 3.39 ± 3.056
1.043GluCys: 1.043 ± 0.993
5.476GluAsp: 5.476 ± 2.4
5.997GluGlu: 5.997 ± 1.119
4.172GluPhe: 4.172 ± 1.344
2.608GluGly: 2.608 ± 0.736
2.347GluHis: 2.347 ± 0.844
5.737GluIle: 5.737 ± 0.625
3.651GluLys: 3.651 ± 0.963
4.954GluLeu: 4.954 ± 1.538
1.565GluMet: 1.565 ± 0.543
3.129GluAsn: 3.129 ± 1.008
2.347GluPro: 2.347 ± 0.494
2.086GluGln: 2.086 ± 1.355
2.347GluArg: 2.347 ± 0.619
6.78GluSer: 6.78 ± 0.188
4.172GluThr: 4.172 ± 1.057
5.997GluVal: 5.997 ± 0.557
1.043GluTrp: 1.043 ± 0.32
2.347GluTyr: 2.347 ± 1.124
0.0GluXaa: 0.0 ± 0.0
Phe
2.608PheAla: 2.608 ± 2.258
1.304PheCys: 1.304 ± 0.534
3.39PheAsp: 3.39 ± 0.256
1.825PheGlu: 1.825 ± 0.7
1.565PhePhe: 1.565 ± 0.928
2.086PheGly: 2.086 ± 1.445
0.261PheHis: 0.261 ± 0.163
3.651PheIle: 3.651 ± 0.963
5.997PheLys: 5.997 ± 1.142
3.39PheLeu: 3.39 ± 0.943
1.565PheMet: 1.565 ± 0.643
3.651PheAsn: 3.651 ± 0.015
1.825PhePro: 1.825 ± 1.02
1.565PheGln: 1.565 ± 0.643
1.304PheArg: 1.304 ± 0.331
3.129PheSer: 3.129 ± 0.806
3.39PheThr: 3.39 ± 0.256
2.347PheVal: 2.347 ± 1.499
0.782PheTrp: 0.782 ± 0.384
1.825PheTyr: 1.825 ± 0.533
0.0PheXaa: 0.0 ± 0.0
Gly
1.565GlyAla: 1.565 ± 0.968
1.043GlyCys: 1.043 ± 0.993
2.086GlyAsp: 2.086 ± 0.916
2.347GlyGlu: 2.347 ± 0.63
3.129GlyPhe: 3.129 ± 0.174
1.825GlyGly: 1.825 ± 0.802
0.522GlyHis: 0.522 ± 0.496
2.608GlyIle: 2.608 ± 0.334
2.086GlyLys: 2.086 ± 0.528
6.258GlyLeu: 6.258 ± 1.802
0.782GlyMet: 0.782 ± 0.384
2.608GlyAsn: 2.608 ± 0.655
0.782GlyPro: 0.782 ± 0.206
1.043GlyGln: 1.043 ± 0.32
2.086GlyArg: 2.086 ± 0.779
4.954GlySer: 4.954 ± 0.87
2.086GlyThr: 2.086 ± 0.639
4.433GlyVal: 4.433 ± 1.49
0.0GlyTrp: 0.0 ± 0.0
1.825GlyTyr: 1.825 ± 0.808
0.0GlyXaa: 0.0 ± 0.0
His
0.782HisAla: 0.782 ± 0.8
1.043HisCys: 1.043 ± 0.627
1.043HisAsp: 1.043 ± 0.32
2.086HisGlu: 2.086 ± 0.639
0.782HisPhe: 0.782 ± 0.384
2.086HisGly: 2.086 ± 0.672
0.782HisHis: 0.782 ± 0.206
1.565HisIle: 1.565 ± 0.413
1.825HisLys: 1.825 ± 0.533
1.565HisLeu: 1.565 ± 0.413
0.261HisMet: 0.261 ± 0.163
0.522HisAsn: 0.522 ± 0.16
1.043HisPro: 1.043 ± 0.627
1.043HisGln: 1.043 ± 0.32
1.043HisArg: 1.043 ± 0.652
0.782HisSer: 0.782 ± 0.489
1.043HisThr: 1.043 ± 0.336
1.565HisVal: 1.565 ± 0.479
0.261HisTrp: 0.261 ± 0.163
1.304HisTyr: 1.304 ± 0.486
0.0HisXaa: 0.0 ± 0.0
Ile
2.868IleAla: 2.868 ± 0.492
0.782IleCys: 0.782 ± 0.206
4.433IleAsp: 4.433 ± 1.14
6.258IleGlu: 6.258 ± 1.802
2.608IlePhe: 2.608 ± 0.346
3.911IleGly: 3.911 ± 1.318
1.825IleHis: 1.825 ± 0.802
5.997IleIle: 5.997 ± 0.557
5.476IleLys: 5.476 ± 0.507
6.258IleLeu: 6.258 ± 1.737
1.565IleMet: 1.565 ± 0.543
3.651IleAsn: 3.651 ± 0.774
3.651IlePro: 3.651 ± 0.955
3.651IleGln: 3.651 ± 0.781
4.172IleArg: 4.172 ± 0.324
10.43IleSer: 10.43 ± 1.743
4.694IleThr: 4.694 ± 2.635
3.911IleVal: 3.911 ± 1.78
0.782IleTrp: 0.782 ± 0.206
2.347IleTyr: 2.347 ± 1.287
0.0IleXaa: 0.0 ± 0.0
Lys
2.868LysAla: 2.868 ± 1.001
1.565LysCys: 1.565 ± 0.681
3.911LysAsp: 3.911 ± 0.544
5.476LysGlu: 5.476 ± 0.462
1.825LysPhe: 1.825 ± 0.7
3.129LysGly: 3.129 ± 1.855
1.043LysHis: 1.043 ± 0.32
3.911LysIle: 3.911 ± 0.626
5.737LysLys: 5.737 ± 2.582
7.562LysLeu: 7.562 ± 0.16
2.868LysMet: 2.868 ± 0.786
2.608LysAsn: 2.608 ± 1.29
4.954LysPro: 4.954 ± 1.133
2.868LysGln: 2.868 ± 0.786
2.347LysArg: 2.347 ± 1.313
7.301LysSer: 7.301 ± 0.976
4.694LysThr: 4.694 ± 0.827
2.868LysVal: 2.868 ± 0.492
1.043LysTrp: 1.043 ± 0.336
3.39LysTyr: 3.39 ± 1.023
0.0LysXaa: 0.0 ± 0.0
Leu
4.433LeuAla: 4.433 ± 0.194
2.347LeuCys: 2.347 ± 0.844
4.172LeuAsp: 4.172 ± 1.145
4.694LeuGlu: 4.694 ± 0.827
5.215LeuPhe: 5.215 ± 0.976
4.433LeuGly: 4.433 ± 1.49
2.608LeuHis: 2.608 ± 0.736
7.301LeuIle: 7.301 ± 0.784
5.997LeuLys: 5.997 ± 1.387
7.823LeuLeu: 7.823 ± 3.187
3.129LeuMet: 3.129 ± 0.826
4.954LeuAsn: 4.954 ± 0.479
2.347LeuPro: 2.347 ± 0.619
1.825LeuGln: 1.825 ± 1.471
6.258LeuArg: 6.258 ± 1.281
8.605LeuSer: 8.605 ± 1.403
5.215LeuThr: 5.215 ± 0.758
5.476LeuVal: 5.476 ± 0.675
1.565LeuTrp: 1.565 ± 0.979
3.129LeuTyr: 3.129 ± 0.174
0.0LeuXaa: 0.0 ± 0.0
Met
1.043MetAla: 1.043 ± 0.32
0.0MetCys: 0.0 ± 0.0
1.043MetAsp: 1.043 ± 0.677
2.086MetGlu: 2.086 ± 0.493
0.782MetPhe: 0.782 ± 0.206
1.565MetGly: 1.565 ± 0.413
1.043MetHis: 1.043 ± 0.32
3.651MetIle: 3.651 ± 1.4
2.347MetLys: 2.347 ± 0.63
3.911MetLeu: 3.911 ± 1.202
1.304MetMet: 1.304 ± 0.331
1.043MetAsn: 1.043 ± 0.627
0.522MetPro: 0.522 ± 0.496
0.522MetGln: 0.522 ± 0.326
1.043MetArg: 1.043 ± 0.813
1.825MetSer: 1.825 ± 0.7
1.825MetThr: 1.825 ± 0.808
2.086MetVal: 2.086 ± 0.426
0.0MetTrp: 0.0 ± 0.0
0.522MetTyr: 0.522 ± 0.326
0.0MetXaa: 0.0 ± 0.0
Asn
2.608AsnAla: 2.608 ± 2.173
0.522AsnCys: 0.522 ± 0.16
1.825AsnAsp: 1.825 ± 0.544
3.129AsnGlu: 3.129 ± 1.085
2.868AsnPhe: 2.868 ± 0.786
2.608AsnGly: 2.608 ± 1.067
1.565AsnHis: 1.565 ± 0.643
4.954AsnIle: 4.954 ± 2.216
4.694AsnLys: 4.694 ± 0.987
5.997AsnLeu: 5.997 ± 1.874
0.782AsnMet: 0.782 ± 0.8
1.825AsnAsn: 1.825 ± 0.7
2.868AsnPro: 2.868 ± 0.731
2.086AsnGln: 2.086 ± 0.779
1.565AsnArg: 1.565 ± 0.643
3.39AsnSer: 3.39 ± 0.166
2.347AsnThr: 2.347 ± 0.619
3.651AsnVal: 3.651 ± 2.372
1.043AsnTrp: 1.043 ± 0.652
2.608AsnTyr: 2.608 ± 1.394
0.0AsnXaa: 0.0 ± 0.0
Pro
1.043ProAla: 1.043 ± 0.677
0.261ProCys: 0.261 ± 0.248
1.565ProAsp: 1.565 ± 0.413
3.39ProGlu: 3.39 ± 1.444
1.565ProPhe: 1.565 ± 0.413
2.086ProGly: 2.086 ± 0.493
0.782ProHis: 0.782 ± 0.206
4.433ProIle: 4.433 ± 2.403
3.129ProLys: 3.129 ± 0.959
2.086ProLeu: 2.086 ± 0.639
0.782ProMet: 0.782 ± 0.878
2.868ProAsn: 2.868 ± 0.731
0.522ProPro: 0.522 ± 0.326
1.304ProGln: 1.304 ± 0.331
1.043ProArg: 1.043 ± 0.336
3.651ProSer: 3.651 ± 1.939
1.565ProThr: 1.565 ± 2.419
2.347ProVal: 2.347 ± 0.546
0.261ProTrp: 0.261 ± 0.163
1.304ProTyr: 1.304 ± 0.534
0.0ProXaa: 0.0 ± 0.0
Gln
1.304GlnAla: 1.304 ± 0.486
0.522GlnCys: 0.522 ± 0.16
2.347GlnAsp: 2.347 ± 0.546
3.651GlnGlu: 3.651 ± 0.781
2.086GlnPhe: 2.086 ± 0.493
1.565GlnGly: 1.565 ± 0.543
1.043GlnHis: 1.043 ± 0.677
2.608GlnIle: 2.608 ± 1.421
2.086GlnLys: 2.086 ± 0.672
1.825GlnLeu: 1.825 ± 0.808
0.0GlnMet: 0.0 ± 0.0
2.608GlnAsn: 2.608 ± 0.334
1.304GlnPro: 1.304 ± 0.534
0.261GlnGln: 0.261 ± 0.163
1.565GlnArg: 1.565 ± 0.653
3.129GlnSer: 3.129 ± 0.883
1.043GlnThr: 1.043 ± 0.32
1.043GlnVal: 1.043 ± 0.336
0.261GlnTrp: 0.261 ± 0.872
1.304GlnTyr: 1.304 ± 0.331
0.0GlnXaa: 0.0 ± 0.0
Arg
2.086ArgAla: 2.086 ± 1.355
0.782ArgCys: 0.782 ± 0.745
2.347ArgAsp: 2.347 ± 0.882
2.608ArgGlu: 2.608 ± 1.631
2.608ArgPhe: 2.608 ± 0.972
1.304ArgGly: 1.304 ± 0.645
1.043ArgHis: 1.043 ± 0.32
5.215ArgIle: 5.215 ± 1.945
4.172ArgLys: 4.172 ± 0.852
3.39ArgLeu: 3.39 ± 0.943
2.086ArgMet: 2.086 ± 0.962
1.304ArgAsn: 1.304 ± 0.632
1.304ArgPro: 1.304 ± 1.548
1.304ArgGln: 1.304 ± 0.331
3.129ArgArg: 3.129 ± 1.285
3.911ArgSer: 3.911 ± 0.972
3.129ArgThr: 3.129 ± 1.654
3.129ArgVal: 3.129 ± 0.504
0.0ArgTrp: 0.0 ± 0.0
2.608ArgTyr: 2.608 ± 0.972
0.0ArgXaa: 0.0 ± 0.0
Ser
4.694SerAla: 4.694 ± 1.749
3.129SerCys: 3.129 ± 1.881
5.215SerAsp: 5.215 ± 0.667
7.301SerGlu: 7.301 ± 1.16
3.129SerPhe: 3.129 ± 1.169
3.651SerGly: 3.651 ± 0.015
1.565SerHis: 1.565 ± 0.643
7.562SerIle: 7.562 ± 1.759
6.519SerLys: 6.519 ± 1.121
8.344SerLeu: 8.344 ± 1.4
3.39SerMet: 3.39 ± 0.943
5.997SerAsn: 5.997 ± 0.502
2.608SerPro: 2.608 ± 0.662
3.911SerGln: 3.911 ± 0.161
4.433SerArg: 4.433 ± 0.859
8.866SerSer: 8.866 ± 1.46
7.04SerThr: 7.04 ± 1.038
6.258SerVal: 6.258 ± 1.737
0.261SerTrp: 0.261 ± 0.248
2.608SerTyr: 2.608 ± 0.655
0.0SerXaa: 0.0 ± 0.0
Thr
2.868ThrAla: 2.868 ± 1.508
1.043ThrCys: 1.043 ± 0.993
2.608ThrAsp: 2.608 ± 1.0
2.086ThrGlu: 2.086 ± 0.649
3.911ThrPhe: 3.911 ± 2.902
3.129ThrGly: 3.129 ± 0.806
2.347ThrHis: 2.347 ± 0.82
4.954ThrIle: 4.954 ± 1.613
2.608ThrLys: 2.608 ± 2.173
6.519ThrLeu: 6.519 ± 0.76
2.086ThrMet: 2.086 ± 1.495
4.172ThrAsn: 4.172 ± 0.872
1.825ThrPro: 1.825 ± 0.7
1.304ThrGln: 1.304 ± 0.815
2.608ThrArg: 2.608 ± 1.0
5.997ThrSer: 5.997 ± 0.831
3.651ThrThr: 3.651 ± 0.015
1.565ThrVal: 1.565 ± 0.413
0.782ThrTrp: 0.782 ± 0.206
2.608ThrTyr: 2.608 ± 0.799
0.0ThrXaa: 0.0 ± 0.0
Val
2.608ValAla: 2.608 ± 1.0
0.782ValCys: 0.782 ± 0.384
2.868ValAsp: 2.868 ± 0.859
6.258ValGlu: 6.258 ± 0.348
3.911ValPhe: 3.911 ± 1.921
1.825ValGly: 1.825 ± 0.688
1.043ValHis: 1.043 ± 0.32
4.172ValIle: 4.172 ± 1.027
5.737ValLys: 5.737 ± 0.984
4.433ValLeu: 4.433 ± 0.859
1.043ValMet: 1.043 ± 0.559
3.39ValAsn: 3.39 ± 1.778
2.086ValPro: 2.086 ± 0.916
1.043ValGln: 1.043 ± 0.627
3.129ValArg: 3.129 ± 0.806
7.823ValSer: 7.823 ± 0.132
3.129ValThr: 3.129 ± 0.504
3.129ValVal: 3.129 ± 1.136
0.522ValTrp: 0.522 ± 0.16
0.522ValTyr: 0.522 ± 0.326
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.522TrpCys: 0.522 ± 0.16
0.261TrpAsp: 0.261 ± 0.163
1.043TrpGlu: 1.043 ± 0.677
0.522TrpPhe: 0.522 ± 0.16
0.522TrpGly: 0.522 ± 0.16
0.0TrpHis: 0.0 ± 0.0
0.782TrpIle: 0.782 ± 0.206
0.522TrpLys: 0.522 ± 0.326
1.043TrpLeu: 1.043 ± 0.813
0.0TrpMet: 0.0 ± 0.0
0.261TrpAsn: 0.261 ± 0.163
0.522TrpPro: 0.522 ± 0.16
1.043TrpGln: 1.043 ± 0.336
0.0TrpArg: 0.0 ± 0.0
1.043TrpSer: 1.043 ± 0.336
0.261TrpThr: 0.261 ± 0.163
0.522TrpVal: 0.522 ± 0.326
0.0TrpTrp: 0.0 ± 0.0
0.522TrpTyr: 0.522 ± 0.16
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.086TyrAla: 2.086 ± 1.372
0.261TyrCys: 0.261 ± 0.248
2.608TyrAsp: 2.608 ± 0.972
2.347TyrGlu: 2.347 ± 0.546
0.522TyrPhe: 0.522 ± 0.16
1.304TyrGly: 1.304 ± 0.486
1.043TyrHis: 1.043 ± 0.336
3.129TyrIle: 3.129 ± 0.959
0.522TyrLys: 0.522 ± 0.16
3.651TyrLeu: 3.651 ± 0.935
0.782TyrMet: 0.782 ± 0.206
1.825TyrAsn: 1.825 ± 0.533
1.304TyrPro: 1.304 ± 0.873
1.565TyrGln: 1.565 ± 1.489
3.651TyrArg: 3.651 ± 0.392
2.868TyrSer: 2.868 ± 0.731
2.347TyrThr: 2.347 ± 0.494
2.608TyrVal: 2.608 ± 0.662
0.0TyrTrp: 0.0 ± 0.0
1.304TyrTyr: 1.304 ± 0.534
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3836 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski