Amino acid dipepetide frequency for Vagococcus entomophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.832AlaAla: 4.832 ± 0.115	0.612AlaCys: 0.612 ± 0.031	3.278AlaAsp: 3.278 ± 0.071	4.195AlaGlu: 4.195 ± 0.074	3.041AlaPhe: 3.041 ± 0.073	4.522AlaGly: 4.522 ± 0.104	1.3AlaHis: 1.3 ± 0.044	5.43AlaIle: 5.43 ± 0.088	5.329AlaLys: 5.329 ± 0.092	7.073AlaLeu: 7.073 ± 0.107	1.747AlaMet: 1.747 ± 0.061	2.855AlaAsn: 2.855 ± 0.07	1.966AlaPro: 1.966 ± 0.068	3.137AlaGln: 3.137 ± 0.079	2.324AlaArg: 2.324 ± 0.057	4.279AlaSer: 4.279 ± 0.078	4.46AlaThr: 4.46 ± 0.104	4.571AlaVal: 4.571 ± 0.099	0.521AlaTrp: 0.521 ± 0.027	2.431AlaTyr: 2.431 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.509CysAla: 0.509 ± 0.025	0.119CysCys: 0.119 ± 0.015	0.373CysAsp: 0.373 ± 0.024	0.492CysGlu: 0.492 ± 0.026	0.434CysPhe: 0.434 ± 0.023	0.674CysGly: 0.674 ± 0.036	0.196CysHis: 0.196 ± 0.018	0.563CysIle: 0.563 ± 0.028	0.354CysLys: 0.354 ± 0.026	0.885CysLeu: 0.885 ± 0.036	0.193CysMet: 0.193 ± 0.017	0.235CysAsn: 0.235 ± 0.017	0.314CysPro: 0.314 ± 0.022	0.368CysGln: 0.368 ± 0.022	0.225CysArg: 0.225 ± 0.02	0.521CysSer: 0.521 ± 0.027	0.41CysThr: 0.41 ± 0.023	0.566CysVal: 0.566 ± 0.028	0.055CysTrp: 0.055 ± 0.01	0.324CysTyr: 0.324 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.132AspAla: 3.132 ± 0.073	0.418AspCys: 0.418 ± 0.024	2.021AspAsp: 2.021 ± 0.071	3.821AspGlu: 3.821 ± 0.087	2.559AspPhe: 2.559 ± 0.063	3.078AspGly: 3.078 ± 0.082	0.846AspHis: 0.846 ± 0.033	3.519AspIle: 3.519 ± 0.082	3.376AspLys: 3.376 ± 0.083	4.468AspLeu: 4.468 ± 0.084	1.139AspMet: 1.139 ± 0.037	1.928AspAsn: 1.928 ± 0.063	1.595AspPro: 1.595 ± 0.05	2.134AspGln: 2.134 ± 0.064	1.522AspArg: 1.522 ± 0.052	3.061AspSer: 3.061 ± 0.082	2.876AspThr: 2.876 ± 0.081	3.28AspVal: 3.28 ± 0.078	0.562AspTrp: 0.562 ± 0.032	2.248AspTyr: 2.248 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	4.913GluAla: 4.913 ± 0.094	0.415GluCys: 0.415 ± 0.026	3.195GluAsp: 3.195 ± 0.078	6.033GluGlu: 6.033 ± 0.12	2.514GluPhe: 2.514 ± 0.058	3.47GluGly: 3.47 ± 0.087	1.317GluHis: 1.317 ± 0.044	5.495GluIle: 5.495 ± 0.097	7.561GluLys: 7.561 ± 0.126	7.046GluLeu: 7.046 ± 0.11	2.172GluMet: 2.172 ± 0.066	3.854GluAsn: 3.854 ± 0.082	1.767GluPro: 1.767 ± 0.053	3.649GluGln: 3.649 ± 0.082	2.827GluArg: 2.827 ± 0.07	3.538GluSer: 3.538 ± 0.076	3.987GluThr: 3.987 ± 0.074	4.869GluVal: 4.869 ± 0.094	0.646GluTrp: 0.646 ± 0.038	2.229GluTyr: 2.229 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	2.832PheAla: 2.832 ± 0.073	0.523PheCys: 0.523 ± 0.031	2.425PheAsp: 2.425 ± 0.066	2.891PheGlu: 2.891 ± 0.065	2.718PhePhe: 2.718 ± 0.078	3.125PheGly: 3.125 ± 0.076	0.913PheHis: 0.913 ± 0.041	3.531PheIle: 3.531 ± 0.088	2.606PheLys: 2.606 ± 0.076	4.982PheLeu: 4.982 ± 0.109	1.028PheMet: 1.028 ± 0.039	1.913PheAsn: 1.913 ± 0.056	1.593PhePro: 1.593 ± 0.045	1.765PheGln: 1.765 ± 0.057	1.386PheArg: 1.386 ± 0.041	3.874PheSer: 3.874 ± 0.094	2.418PheThr: 2.418 ± 0.061	3.315PheVal: 3.315 ± 0.086	0.481PheTrp: 0.481 ± 0.027	1.93PheTyr: 1.93 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.367GlyAla: 4.367 ± 0.104	0.6GlyCys: 0.6 ± 0.031	2.814GlyAsp: 2.814 ± 0.075	4.073GlyGlu: 4.073 ± 0.082	3.076GlyPhe: 3.076 ± 0.068	4.312GlyGly: 4.312 ± 0.103	1.131GlyHis: 1.131 ± 0.041	5.498GlyIle: 5.498 ± 0.088	5.269GlyLys: 5.269 ± 0.107	6.039GlyLeu: 6.039 ± 0.104	1.876GlyMet: 1.876 ± 0.067	2.866GlyAsn: 2.866 ± 0.066	1.309GlyPro: 1.309 ± 0.046	2.316GlyGln: 2.316 ± 0.059	2.171GlyArg: 2.171 ± 0.061	3.899GlySer: 3.899 ± 0.085	4.108GlyThr: 4.108 ± 0.123	4.694GlyVal: 4.694 ± 0.095	0.596GlyTrp: 0.596 ± 0.034	2.71GlyTyr: 2.71 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	1.226HisAla: 1.226 ± 0.044	0.205HisCys: 0.205 ± 0.02	0.869HisAsp: 0.869 ± 0.034	1.161HisGlu: 1.161 ± 0.041	1.04HisPhe: 1.04 ± 0.041	1.157HisGly: 1.157 ± 0.047	0.582HisHis: 0.582 ± 0.029	1.171HisIle: 1.171 ± 0.04	0.964HisLys: 0.964 ± 0.038	2.085HisLeu: 2.085 ± 0.054	0.45HisMet: 0.45 ± 0.026	0.68HisAsn: 0.68 ± 0.031	0.935HisPro: 0.935 ± 0.043	0.959HisGln: 0.959 ± 0.041	0.711HisArg: 0.711 ± 0.033	1.108HisSer: 1.108 ± 0.036	1.017HisThr: 1.017 ± 0.038	1.166HisVal: 1.166 ± 0.041	0.172HisTrp: 0.172 ± 0.016	1.02HisTyr: 1.02 ± 0.039	0.0HisXaa: 0.0 ± 0.0
Ile	5.535IleAla: 5.535 ± 0.088	0.788IleCys: 0.788 ± 0.03	3.938IleAsp: 3.938 ± 0.083	5.49IleGlu: 5.49 ± 0.095	3.471IlePhe: 3.471 ± 0.081	5.437IleGly: 5.437 ± 0.107	1.494IleHis: 1.494 ± 0.051	5.28IleIle: 5.28 ± 0.092	4.898IleLys: 4.898 ± 0.082	7.315IleLeu: 7.315 ± 0.137	1.679IleMet: 1.679 ± 0.047	3.174IleAsn: 3.174 ± 0.071	3.09IlePro: 3.09 ± 0.069	3.457IleGln: 3.457 ± 0.084	2.94IleArg: 2.94 ± 0.065	5.103IleSer: 5.103 ± 0.096	4.003IleThr: 4.003 ± 0.082	5.296IleVal: 5.296 ± 0.099	0.569IleTrp: 0.569 ± 0.03	2.585IleTyr: 2.585 ± 0.068	0.0IleXaa: 0.0 ± 0.0
Lys	4.867LysAla: 4.867 ± 0.108	0.329LysCys: 0.329 ± 0.024	3.599LysAsp: 3.599 ± 0.084	7.902LysGlu: 7.902 ± 0.113	2.179LysPhe: 2.179 ± 0.061	4.179LysGly: 4.179 ± 0.084	1.225LysHis: 1.225 ± 0.04	6.289LysIle: 6.289 ± 0.087	8.542LysLys: 8.542 ± 0.131	6.16LysLeu: 6.16 ± 0.088	2.595LysMet: 2.595 ± 0.061	4.912LysAsn: 4.912 ± 0.098	1.825LysPro: 1.825 ± 0.057	3.682LysGln: 3.682 ± 0.083	3.185LysArg: 3.185 ± 0.076	4.211LysSer: 4.211 ± 0.084	4.123LysThr: 4.123 ± 0.078	5.276LysVal: 5.276 ± 0.093	0.704LysTrp: 0.704 ± 0.036	2.499LysTyr: 2.499 ± 0.075	0.0LysXaa: 0.0 ± 0.0
Leu	7.557LeuAla: 7.557 ± 0.109	0.791LeuCys: 0.791 ± 0.035	4.962LeuAsp: 4.962 ± 0.097	6.768LeuGlu: 6.768 ± 0.128	5.275LeuPhe: 5.275 ± 0.144	6.377LeuGly: 6.377 ± 0.102	1.694LeuHis: 1.694 ± 0.057	6.948LeuIle: 6.948 ± 0.114	7.302LeuLys: 7.302 ± 0.116	10.2LeuLeu: 10.2 ± 0.174	2.215LeuMet: 2.215 ± 0.053	4.689LeuAsn: 4.689 ± 0.097	3.832LeuPro: 3.832 ± 0.082	3.491LeuGln: 3.491 ± 0.084	3.202LeuArg: 3.202 ± 0.073	7.451LeuSer: 7.451 ± 0.112	6.073LeuThr: 6.073 ± 0.086	6.669LeuVal: 6.669 ± 0.112	0.647LeuTrp: 0.647 ± 0.031	3.189LeuTyr: 3.189 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	1.686MetAla: 1.686 ± 0.053	0.176MetCys: 0.176 ± 0.015	1.326MetAsp: 1.326 ± 0.044	1.617MetGlu: 1.617 ± 0.048	0.942MetPhe: 0.942 ± 0.042	1.613MetGly: 1.613 ± 0.052	0.408MetHis: 0.408 ± 0.025	2.107MetIle: 2.107 ± 0.059	2.43MetLys: 2.43 ± 0.057	2.324MetLeu: 2.324 ± 0.062	0.815MetMet: 0.815 ± 0.037	1.457MetAsn: 1.457 ± 0.046	0.791MetPro: 0.791 ± 0.032	1.019MetGln: 1.019 ± 0.033	0.972MetArg: 0.972 ± 0.036	1.647MetSer: 1.647 ± 0.046	1.65MetThr: 1.65 ± 0.05	1.62MetVal: 1.62 ± 0.058	0.179MetTrp: 0.179 ± 0.017	0.711MetTyr: 0.711 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.728AsnAla: 2.728 ± 0.067	0.358AsnCys: 0.358 ± 0.025	2.036AsnAsp: 2.036 ± 0.058	3.272AsnGlu: 3.272 ± 0.061	2.093AsnPhe: 2.093 ± 0.054	3.199AsnGly: 3.199 ± 0.072	1.063AsnHis: 1.063 ± 0.043	3.427AsnIle: 3.427 ± 0.081	3.424AsnLys: 3.424 ± 0.078	4.333AsnLeu: 4.333 ± 0.09	1.144AsnMet: 1.144 ± 0.037	2.144AsnAsn: 2.144 ± 0.078	2.029AsnPro: 2.029 ± 0.053	2.943AsnGln: 2.943 ± 0.077	1.903AsnArg: 1.903 ± 0.061	2.768AsnSer: 2.768 ± 0.068	2.458AsnThr: 2.458 ± 0.07	3.071AsnVal: 3.071 ± 0.065	0.542AsnTrp: 0.542 ± 0.031	2.044AsnTyr: 2.044 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.033ProAla: 2.033 ± 0.053	0.203ProCys: 0.203 ± 0.018	1.676ProAsp: 1.676 ± 0.052	2.583ProGlu: 2.583 ± 0.067	1.718ProPhe: 1.718 ± 0.047	1.71ProGly: 1.71 ± 0.065	0.633ProHis: 0.633 ± 0.033	2.73ProIle: 2.73 ± 0.07	2.639ProLys: 2.639 ± 0.072	3.194ProLeu: 3.194 ± 0.069	0.696ProMet: 0.696 ± 0.032	1.704ProAsn: 1.704 ± 0.053	0.613ProPro: 0.613 ± 0.037	1.293ProGln: 1.293 ± 0.044	0.898ProArg: 0.898 ± 0.032	2.006ProSer: 2.006 ± 0.055	2.223ProThr: 2.223 ± 0.061	2.507ProVal: 2.507 ± 0.067	0.249ProTrp: 0.249 ± 0.02	1.289ProTyr: 1.289 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	3.599GlnAla: 3.599 ± 0.079	0.191GlnCys: 0.191 ± 0.017	1.788GlnAsp: 1.788 ± 0.057	3.546GlnGlu: 3.546 ± 0.086	1.711GlnPhe: 1.711 ± 0.054	2.319GlnGly: 2.319 ± 0.056	0.735GlnHis: 0.735 ± 0.031	3.088GlnIle: 3.088 ± 0.077	4.134GlnLys: 4.134 ± 0.088	4.798GlnLeu: 4.798 ± 0.095	1.09GlnMet: 1.09 ± 0.045	2.263GlnAsn: 2.263 ± 0.061	1.319GlnPro: 1.319 ± 0.045	2.277GlnGln: 2.277 ± 0.076	1.515GlnArg: 1.515 ± 0.049	2.394GlnSer: 2.394 ± 0.067	3.071GlnThr: 3.071 ± 0.076	2.97GlnVal: 2.97 ± 0.065	0.317GlnTrp: 0.317 ± 0.022	1.43GlnTyr: 1.43 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	2.161ArgAla: 2.161 ± 0.059	0.242ArgCys: 0.242 ± 0.019	1.505ArgAsp: 1.505 ± 0.055	2.585ArgGlu: 2.585 ± 0.061	1.59ArgPhe: 1.59 ± 0.049	1.962ArgGly: 1.962 ± 0.057	0.663ArgHis: 0.663 ± 0.03	2.683ArgIle: 2.683 ± 0.07	3.238ArgLys: 3.238 ± 0.079	3.581ArgLeu: 3.581 ± 0.081	1.04ArgMet: 1.04 ± 0.041	1.659ArgAsn: 1.659 ± 0.047	1.105ArgPro: 1.105 ± 0.039	1.585ArgGln: 1.585 ± 0.044	1.467ArgArg: 1.467 ± 0.051	1.873ArgSer: 1.873 ± 0.059	1.829ArgThr: 1.829 ± 0.058	2.457ArgVal: 2.457 ± 0.062	0.294ArgTrp: 0.294 ± 0.019	1.598ArgTyr: 1.598 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	3.891SerAla: 3.891 ± 0.09	0.437SerCys: 0.437 ± 0.027	3.095SerAsp: 3.095 ± 0.072	4.202SerGlu: 4.202 ± 0.089	3.502SerPhe: 3.502 ± 0.077	4.952SerGly: 4.952 ± 0.096	1.087SerHis: 1.087 ± 0.04	5.0SerIle: 5.0 ± 0.093	4.649SerLys: 4.649 ± 0.083	6.588SerLeu: 6.588 ± 0.122	1.541SerMet: 1.541 ± 0.05	2.976SerAsn: 2.976 ± 0.083	1.869SerPro: 1.869 ± 0.052	2.593SerGln: 2.593 ± 0.063	2.003SerArg: 2.003 ± 0.066	4.72SerSer: 4.72 ± 0.127	3.68SerThr: 3.68 ± 0.104	4.354SerVal: 4.354 ± 0.092	0.659SerTrp: 0.659 ± 0.033	2.58SerTyr: 2.58 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	3.912ThrAla: 3.912 ± 0.078	0.367ThrCys: 0.367 ± 0.028	2.953ThrAsp: 2.953 ± 0.075	3.437ThrGlu: 3.437 ± 0.07	2.77ThrPhe: 2.77 ± 0.068	4.104ThrGly: 4.104 ± 0.083	1.161ThrHis: 1.161 ± 0.04	4.936ThrIle: 4.936 ± 0.093	4.179ThrLys: 4.179 ± 0.086	5.979ThrLeu: 5.979 ± 0.116	1.337ThrMet: 1.337 ± 0.043	2.891ThrAsn: 2.891 ± 0.072	2.427ThrPro: 2.427 ± 0.069	2.302ThrGln: 2.302 ± 0.062	1.728ThrArg: 1.728 ± 0.059	4.101ThrSer: 4.101 ± 0.118	4.003ThrThr: 4.003 ± 0.12	4.288ThrVal: 4.288 ± 0.102	0.477ThrTrp: 0.477 ± 0.031	2.041ThrTyr: 2.041 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	5.265ValAla: 5.265 ± 0.105	0.6ValCys: 0.6 ± 0.028	3.39ValAsp: 3.39 ± 0.083	4.534ValGlu: 4.534 ± 0.081	3.085ValPhe: 3.085 ± 0.07	4.515ValGly: 4.515 ± 0.086	1.179ValHis: 1.179 ± 0.042	4.987ValIle: 4.987 ± 0.085	4.669ValLys: 4.669 ± 0.081	7.053ValLeu: 7.053 ± 0.117	1.697ValMet: 1.697 ± 0.052	2.855ValAsn: 2.855 ± 0.064	2.569ValPro: 2.569 ± 0.061	2.709ValGln: 2.709 ± 0.058	2.305ValArg: 2.305 ± 0.059	4.975ValSer: 4.975 ± 0.08	4.437ValThr: 4.437 ± 0.093	5.241ValVal: 5.241 ± 0.105	0.522ValTrp: 0.522 ± 0.028	2.434ValTyr: 2.434 ± 0.065	0.0ValXaa: 0.0 ± 0.0
Trp	0.468TrpAla: 0.468 ± 0.026	0.078TrpCys: 0.078 ± 0.011	0.403TrpAsp: 0.403 ± 0.027	0.499TrpGlu: 0.499 ± 0.028	0.478TrpPhe: 0.478 ± 0.027	0.579TrpGly: 0.579 ± 0.029	0.179TrpHis: 0.179 ± 0.016	0.656TrpIle: 0.656 ± 0.031	0.603TrpLys: 0.603 ± 0.031	1.038TrpLeu: 1.038 ± 0.047	0.235TrpMet: 0.235 ± 0.019	0.442TrpAsn: 0.442 ± 0.024	0.211TrpPro: 0.211 ± 0.018	0.539TrpGln: 0.539 ± 0.028	0.312TrpArg: 0.312 ± 0.022	0.58TrpSer: 0.58 ± 0.041	0.431TrpThr: 0.431 ± 0.024	0.479TrpVal: 0.479 ± 0.032	0.117TrpTrp: 0.117 ± 0.016	0.303TrpTyr: 0.303 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.388TyrAla: 2.388 ± 0.056	0.358TyrCys: 0.358 ± 0.023	1.94TyrAsp: 1.94 ± 0.059	2.396TyrGlu: 2.396 ± 0.063	2.054TyrPhe: 2.054 ± 0.056	2.44TyrGly: 2.44 ± 0.058	0.871TyrHis: 0.871 ± 0.04	2.201TyrIle: 2.201 ± 0.054	2.118TyrLys: 2.118 ± 0.053	4.192TyrLeu: 4.192 ± 0.091	0.801TyrMet: 0.801 ± 0.031	1.484TyrAsn: 1.484 ± 0.048	1.438TyrPro: 1.438 ± 0.046	2.34TyrGln: 2.34 ± 0.059	1.521TyrArg: 1.521 ± 0.05	2.269TyrSer: 2.269 ± 0.056	2.134TyrThr: 2.134 ± 0.055	2.33TyrVal: 2.33 ± 0.051	0.321TyrTrp: 0.321 ± 0.024	1.639TyrTyr: 1.639 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2255 proteins (702968 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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