Amino acid dipepetide frequency for Parapedobacter indicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.493AlaAla: 7.493 ± 0.087
0.732AlaCys: 0.732 ± 0.022
5.064AlaAsp: 5.064 ± 0.057
4.921AlaGlu: 4.921 ± 0.059
3.706AlaPhe: 3.706 ± 0.052
6.255AlaGly: 6.255 ± 0.088
1.486AlaHis: 1.486 ± 0.031
5.392AlaIle: 5.392 ± 0.058
3.966AlaLys: 3.966 ± 0.05
7.783AlaLeu: 7.783 ± 0.075
1.803AlaMet: 1.803 ± 0.03
3.663AlaAsn: 3.663 ± 0.044
2.756AlaPro: 2.756 ± 0.037
2.954AlaGln: 2.954 ± 0.04
3.292AlaArg: 3.292 ± 0.048
4.987AlaSer: 4.987 ± 0.057
4.604AlaThr: 4.604 ± 0.081
5.618AlaVal: 5.618 ± 0.061
1.017AlaTrp: 1.017 ± 0.024
3.286AlaTyr: 3.286 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.536CysAla: 0.536 ± 0.021
0.127CysCys: 0.127 ± 0.009
0.373CysAsp: 0.373 ± 0.016
0.403CysGlu: 0.403 ± 0.016
0.375CysPhe: 0.375 ± 0.015
0.62CysGly: 0.62 ± 0.02
0.217CysHis: 0.217 ± 0.011
0.573CysIle: 0.573 ± 0.019
0.326CysLys: 0.326 ± 0.013
0.748CysLeu: 0.748 ± 0.02
0.185CysMet: 0.185 ± 0.011
0.327CysAsn: 0.327 ± 0.014
0.323CysPro: 0.323 ± 0.012
0.243CysGln: 0.243 ± 0.012
0.4CysArg: 0.4 ± 0.018
0.484CysSer: 0.484 ± 0.014
0.435CysThr: 0.435 ± 0.016
0.445CysVal: 0.445 ± 0.016
0.112CysTrp: 0.112 ± 0.009
0.319CysTyr: 0.319 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.631AspAla: 4.631 ± 0.055
0.367AspCys: 0.367 ± 0.014
3.054AspAsp: 3.054 ± 0.047
3.847AspGlu: 3.847 ± 0.05
3.033AspPhe: 3.033 ± 0.045
4.795AspGly: 4.795 ± 0.059
1.201AspHis: 1.201 ± 0.026
3.838AspIle: 3.838 ± 0.045
2.843AspLys: 2.843 ± 0.043
5.099AspLeu: 5.099 ± 0.048
1.177AspMet: 1.177 ± 0.025
2.555AspAsn: 2.555 ± 0.047
2.562AspPro: 2.562 ± 0.046
1.867AspGln: 1.867 ± 0.037
3.204AspArg: 3.204 ± 0.038
2.865AspSer: 2.865 ± 0.046
2.803AspThr: 2.803 ± 0.043
3.884AspVal: 3.884 ± 0.047
0.962AspTrp: 0.962 ± 0.023
2.575AspTyr: 2.575 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.037GluAla: 5.037 ± 0.056
0.344GluCys: 0.344 ± 0.015
2.826GluAsp: 2.826 ± 0.043
3.788GluGlu: 3.788 ± 0.059
2.123GluPhe: 2.123 ± 0.03
3.948GluGly: 3.948 ± 0.044
1.231GluHis: 1.231 ± 0.028
4.048GluIle: 4.048 ± 0.048
3.748GluLys: 3.748 ± 0.05
5.786GluLeu: 5.786 ± 0.064
1.414GluMet: 1.414 ± 0.029
3.077GluAsn: 3.077 ± 0.048
1.904GluPro: 1.904 ± 0.039
2.68GluGln: 2.68 ± 0.043
3.513GluArg: 3.513 ± 0.044
3.135GluSer: 3.135 ± 0.039
3.307GluThr: 3.307 ± 0.043
4.096GluVal: 4.096 ± 0.049
0.805GluTrp: 0.805 ± 0.021
2.0GluTyr: 2.0 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.438PheAla: 3.438 ± 0.036
0.408PheCys: 0.408 ± 0.014
2.981PheAsp: 2.981 ± 0.039
2.68PheGlu: 2.68 ± 0.042
2.277PhePhe: 2.277 ± 0.042
3.494PheGly: 3.494 ± 0.045
0.912PheHis: 0.912 ± 0.025
2.791PheIle: 2.791 ± 0.045
2.088PheLys: 2.088 ± 0.036
4.094PheLeu: 4.094 ± 0.056
1.087PheMet: 1.087 ± 0.027
2.439PheAsn: 2.439 ± 0.041
1.877PhePro: 1.877 ± 0.03
1.479PheGln: 1.479 ± 0.031
2.314PheArg: 2.314 ± 0.035
3.416PheSer: 3.416 ± 0.046
2.754PheThr: 2.754 ± 0.042
2.888PheVal: 2.888 ± 0.039
0.626PheTrp: 0.626 ± 0.021
1.833PheTyr: 1.833 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
5.298GlyAla: 5.298 ± 0.068
0.638GlyCys: 0.638 ± 0.018
4.027GlyAsp: 4.027 ± 0.058
3.941GlyGlu: 3.941 ± 0.05
3.597GlyPhe: 3.597 ± 0.046
5.744GlyGly: 5.744 ± 0.09
1.429GlyHis: 1.429 ± 0.03
5.452GlyIle: 5.452 ± 0.055
4.49GlyLys: 4.49 ± 0.054
6.713GlyLeu: 6.713 ± 0.065
1.92GlyMet: 1.92 ± 0.035
4.014GlyAsn: 4.014 ± 0.068
1.93GlyPro: 1.93 ± 0.036
2.7GlyGln: 2.7 ± 0.038
3.56GlyArg: 3.56 ± 0.047
4.667GlySer: 4.667 ± 0.067
4.824GlyThr: 4.824 ± 0.093
5.029GlyVal: 5.029 ± 0.058
1.18GlyTrp: 1.18 ± 0.026
3.525GlyTyr: 3.525 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.644HisAla: 1.644 ± 0.029
0.192HisCys: 0.192 ± 0.011
1.006HisAsp: 1.006 ± 0.024
1.137HisGlu: 1.137 ± 0.027
1.134HisPhe: 1.134 ± 0.023
1.414HisGly: 1.414 ± 0.033
0.592HisHis: 0.592 ± 0.02
1.492HisIle: 1.492 ± 0.032
0.848HisLys: 0.848 ± 0.019
1.942HisLeu: 1.942 ± 0.035
0.405HisMet: 0.405 ± 0.013
0.889HisAsn: 0.889 ± 0.022
1.24HisPro: 1.24 ± 0.027
0.83HisGln: 0.83 ± 0.02
1.249HisArg: 1.249 ± 0.031
1.118HisSer: 1.118 ± 0.024
1.247HisThr: 1.247 ± 0.025
1.334HisVal: 1.334 ± 0.024
0.343HisTrp: 0.343 ± 0.014
0.925HisTyr: 0.925 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.624IleAla: 5.624 ± 0.058
0.599IleCys: 0.599 ± 0.018
4.151IleAsp: 4.151 ± 0.051
3.717IleGlu: 3.717 ± 0.05
2.51IlePhe: 2.51 ± 0.041
5.064IleGly: 5.064 ± 0.058
1.398IleHis: 1.398 ± 0.026
3.607IleIle: 3.607 ± 0.053
3.154IleLys: 3.154 ± 0.046
5.298IleLeu: 5.298 ± 0.067
1.077IleMet: 1.077 ± 0.022
3.242IleAsn: 3.242 ± 0.047
3.094IlePro: 3.094 ± 0.037
2.402IleGln: 2.402 ± 0.036
3.693IleArg: 3.693 ± 0.043
4.297IleSer: 4.297 ± 0.053
4.093IleThr: 4.093 ± 0.065
4.089IleVal: 4.089 ± 0.05
0.728IleTrp: 0.728 ± 0.02
2.228IleTyr: 2.228 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.151LysAla: 4.151 ± 0.053
0.245LysCys: 0.245 ± 0.012
2.896LysAsp: 2.896 ± 0.041
3.467LysGlu: 3.467 ± 0.052
1.739LysPhe: 1.739 ± 0.029
3.654LysGly: 3.654 ± 0.046
1.138LysHis: 1.138 ± 0.026
3.225LysIle: 3.225 ± 0.046
3.299LysLys: 3.299 ± 0.048
4.72LysLeu: 4.72 ± 0.058
1.192LysMet: 1.192 ± 0.024
2.566LysAsn: 2.566 ± 0.04
2.355LysPro: 2.355 ± 0.04
2.246LysGln: 2.246 ± 0.038
2.937LysArg: 2.937 ± 0.051
2.958LysSer: 2.958 ± 0.041
3.121LysThr: 3.121 ± 0.046
3.195LysVal: 3.195 ± 0.047
0.713LysTrp: 0.713 ± 0.02
1.966LysTyr: 1.966 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
7.959LeuAla: 7.959 ± 0.082
0.802LeuCys: 0.802 ± 0.025
5.32LeuAsp: 5.32 ± 0.059
5.198LeuGlu: 5.198 ± 0.06
4.519LeuPhe: 4.519 ± 0.061
6.322LeuGly: 6.322 ± 0.055
1.996LeuHis: 1.996 ± 0.041
5.759LeuIle: 5.759 ± 0.071
5.178LeuLys: 5.178 ± 0.058
9.739LeuLeu: 9.739 ± 0.108
2.118LeuMet: 2.118 ± 0.038
4.608LeuAsn: 4.608 ± 0.055
4.433LeuPro: 4.433 ± 0.052
3.554LeuGln: 3.554 ± 0.055
4.834LeuArg: 4.834 ± 0.055
6.656LeuSer: 6.656 ± 0.069
5.872LeuThr: 5.872 ± 0.063
6.0LeuVal: 6.0 ± 0.066
1.129LeuTrp: 1.129 ± 0.026
3.367LeuTyr: 3.367 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.001MetAla: 2.001 ± 0.037
0.138MetCys: 0.138 ± 0.008
1.34MetAsp: 1.34 ± 0.028
1.471MetGlu: 1.471 ± 0.028
0.669MetPhe: 0.669 ± 0.019
1.678MetGly: 1.678 ± 0.03
0.435MetHis: 0.435 ± 0.015
1.185MetIle: 1.185 ± 0.026
1.486MetLys: 1.486 ± 0.027
2.051MetLeu: 2.051 ± 0.036
0.539MetMet: 0.539 ± 0.018
1.147MetAsn: 1.147 ± 0.025
1.066MetPro: 1.066 ± 0.024
0.892MetGln: 0.892 ± 0.019
1.166MetArg: 1.166 ± 0.023
1.146MetSer: 1.146 ± 0.025
1.146MetThr: 1.146 ± 0.027
1.473MetVal: 1.473 ± 0.03
0.222MetTrp: 0.222 ± 0.012
0.661MetTyr: 0.661 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.685AsnAla: 3.685 ± 0.048
0.288AsnCys: 0.288 ± 0.013
2.527AsnAsp: 2.527 ± 0.033
2.748AsnGlu: 2.748 ± 0.042
2.159AsnPhe: 2.159 ± 0.035
3.941AsnGly: 3.941 ± 0.063
1.024AsnHis: 1.024 ± 0.027
3.119AsnIle: 3.119 ± 0.046
2.239AsnLys: 2.239 ± 0.04
4.35AsnLeu: 4.35 ± 0.057
1.007AsnMet: 1.007 ± 0.026
2.36AsnAsn: 2.36 ± 0.045
2.716AsnPro: 2.716 ± 0.038
1.856AsnGln: 1.856 ± 0.032
2.92AsnArg: 2.92 ± 0.041
2.668AsnSer: 2.668 ± 0.049
2.975AsnThr: 2.975 ± 0.043
3.133AsnVal: 3.133 ± 0.046
0.735AsnTrp: 0.735 ± 0.022
2.212AsnTyr: 2.212 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
3.357ProAla: 3.357 ± 0.048
0.214ProCys: 0.214 ± 0.011
3.076ProAsp: 3.076 ± 0.046
3.16ProGlu: 3.16 ± 0.044
1.958ProPhe: 1.958 ± 0.03
3.133ProGly: 3.133 ± 0.05
0.912ProHis: 0.912 ± 0.024
2.532ProIle: 2.532 ± 0.04
1.867ProLys: 1.867 ± 0.033
3.833ProLeu: 3.833 ± 0.045
0.908ProMet: 0.908 ± 0.021
2.021ProAsn: 2.021 ± 0.032
1.337ProPro: 1.337 ± 0.03
1.512ProGln: 1.512 ± 0.028
1.539ProArg: 1.539 ± 0.029
2.481ProSer: 2.481 ± 0.043
2.36ProThr: 2.36 ± 0.039
3.17ProVal: 3.17 ± 0.043
0.543ProTrp: 0.543 ± 0.018
1.663ProTyr: 1.663 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.102GlnAla: 3.102 ± 0.043
0.194GlnCys: 0.194 ± 0.009
1.666GlnAsp: 1.666 ± 0.032
2.14GlnGlu: 2.14 ± 0.04
1.57GlnPhe: 1.57 ± 0.033
2.467GlnGly: 2.467 ± 0.038
0.995GlnHis: 0.995 ± 0.022
2.124GlnIle: 2.124 ± 0.032
1.827GlnLys: 1.827 ± 0.039
4.489GlnLeu: 4.489 ± 0.057
0.776GlnMet: 0.776 ± 0.019
1.604GlnAsn: 1.604 ± 0.029
1.729GlnPro: 1.729 ± 0.03
2.311GlnGln: 2.311 ± 0.04
2.269GlnArg: 2.269 ± 0.037
2.147GlnSer: 2.147 ± 0.032
2.238GlnThr: 2.238 ± 0.033
2.534GlnVal: 2.534 ± 0.034
0.563GlnTrp: 0.563 ± 0.019
1.552GlnTyr: 1.552 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
3.479ArgAla: 3.479 ± 0.053
0.336ArgCys: 0.336 ± 0.016
2.607ArgAsp: 2.607 ± 0.037
3.123ArgGlu: 3.123 ± 0.048
2.667ArgPhe: 2.667 ± 0.038
3.023ArgGly: 3.023 ± 0.042
1.025ArgHis: 1.025 ± 0.024
3.922ArgIle: 3.922 ± 0.048
3.052ArgLys: 3.052 ± 0.042
5.133ArgLeu: 5.133 ± 0.062
1.411ArgMet: 1.411 ± 0.029
2.71ArgAsn: 2.71 ± 0.041
1.883ArgPro: 1.883 ± 0.032
2.096ArgGln: 2.096 ± 0.037
2.596ArgArg: 2.596 ± 0.051
2.806ArgSer: 2.806 ± 0.047
2.726ArgThr: 2.726 ± 0.034
3.276ArgVal: 3.276 ± 0.047
0.863ArgTrp: 0.863 ± 0.021
2.565ArgTyr: 2.565 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
4.796SerAla: 4.796 ± 0.057
0.519SerCys: 0.519 ± 0.018
3.481SerAsp: 3.481 ± 0.042
3.265SerGlu: 3.265 ± 0.04
3.149SerPhe: 3.149 ± 0.039
5.315SerGly: 5.315 ± 0.074
1.199SerHis: 1.199 ± 0.027
4.009SerIle: 4.009 ± 0.05
2.801SerLys: 2.801 ± 0.045
5.923SerLeu: 5.923 ± 0.068
1.252SerMet: 1.252 ± 0.024
2.734SerAsn: 2.734 ± 0.044
2.424SerPro: 2.424 ± 0.036
2.004SerGln: 2.004 ± 0.036
3.03SerArg: 3.03 ± 0.045
3.696SerSer: 3.696 ± 0.055
3.376SerThr: 3.376 ± 0.045
4.334SerVal: 4.334 ± 0.062
0.813SerTrp: 0.813 ± 0.024
2.629SerTyr: 2.629 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
4.986ThrAla: 4.986 ± 0.074
0.373ThrCys: 0.373 ± 0.013
3.699ThrAsp: 3.699 ± 0.056
3.116ThrGlu: 3.116 ± 0.042
2.719ThrPhe: 2.719 ± 0.041
4.968ThrGly: 4.968 ± 0.079
1.253ThrHis: 1.253 ± 0.027
3.747ThrIle: 3.747 ± 0.052
2.52ThrLys: 2.52 ± 0.034
5.903ThrLeu: 5.903 ± 0.065
1.031ThrMet: 1.031 ± 0.027
2.536ThrAsn: 2.536 ± 0.044
2.816ThrPro: 2.816 ± 0.042
1.989ThrGln: 1.989 ± 0.031
2.32ThrArg: 2.32 ± 0.035
3.311ThrSer: 3.311 ± 0.047
3.444ThrThr: 3.444 ± 0.048
4.531ThrVal: 4.531 ± 0.094
0.82ThrTrp: 0.82 ± 0.022
2.512ThrTyr: 2.512 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
5.525ValAla: 5.525 ± 0.058
0.594ValCys: 0.594 ± 0.018
3.951ValAsp: 3.951 ± 0.052
3.6ValGlu: 3.6 ± 0.042
3.248ValPhe: 3.248 ± 0.041
4.658ValGly: 4.658 ± 0.05
1.211ValHis: 1.211 ± 0.028
4.305ValIle: 4.305 ± 0.054
3.452ValLys: 3.452 ± 0.047
6.416ValLeu: 6.416 ± 0.064
1.454ValMet: 1.454 ± 0.032
3.372ValAsn: 3.372 ± 0.046
2.779ValPro: 2.779 ± 0.038
2.22ValGln: 2.22 ± 0.037
3.19ValArg: 3.19 ± 0.044
4.793ValSer: 4.793 ± 0.057
4.143ValThr: 4.143 ± 0.07
4.964ValVal: 4.964 ± 0.058
0.836ValTrp: 0.836 ± 0.022
2.566ValTyr: 2.566 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
0.918TrpAla: 0.918 ± 0.024
0.129TrpCys: 0.129 ± 0.008
0.767TrpAsp: 0.767 ± 0.021
0.874TrpGlu: 0.874 ± 0.022
0.608TrpPhe: 0.608 ± 0.018
1.05TrpGly: 1.05 ± 0.028
0.345TrpHis: 0.345 ± 0.013
0.81TrpIle: 0.81 ± 0.023
0.832TrpLys: 0.832 ± 0.021
1.402TrpLeu: 1.402 ± 0.031
0.413TrpMet: 0.413 ± 0.015
0.725TrpAsn: 0.725 ± 0.02
0.491TrpPro: 0.491 ± 0.018
0.651TrpGln: 0.651 ± 0.022
0.717TrpArg: 0.717 ± 0.022
0.737TrpSer: 0.737 ± 0.025
0.679TrpThr: 0.679 ± 0.019
0.88TrpVal: 0.88 ± 0.02
0.237TrpTrp: 0.237 ± 0.011
0.568TrpTyr: 0.568 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.116TyrAla: 3.116 ± 0.043
0.332TyrCys: 0.332 ± 0.015
2.35TyrAsp: 2.35 ± 0.04
2.212TyrGlu: 2.212 ± 0.036
2.116TyrPhe: 2.116 ± 0.036
3.135TyrGly: 3.135 ± 0.04
0.979TyrHis: 0.979 ± 0.026
2.135TyrIle: 2.135 ± 0.039
1.77TyrLys: 1.77 ± 0.037
3.943TyrLeu: 3.943 ± 0.049
0.743TyrMet: 0.743 ± 0.022
2.072TyrAsn: 2.072 ± 0.038
1.862TyrPro: 1.862 ± 0.032
1.814TyrGln: 1.814 ± 0.034
2.559TyrArg: 2.559 ± 0.036
2.381TyrSer: 2.381 ± 0.038
2.446TyrThr: 2.446 ± 0.04
2.403TyrVal: 2.403 ± 0.035
0.586TyrTrp: 0.586 ± 0.016
1.781TyrTyr: 1.781 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5134 proteins (1905442 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski