Amino acid dipepetide frequency for Circovirus-like genome RW-D

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.529AlaAla: 1.529 ± 1.071
0.0AlaCys: 0.0 ± 0.0
1.529AlaAsp: 1.529 ± 1.071
0.0AlaGlu: 0.0 ± 0.0
1.529AlaPhe: 1.529 ± 0.939
3.058AlaGly: 3.058 ± 0.132
3.058AlaHis: 3.058 ± 0.132
1.529AlaIle: 1.529 ± 0.939
4.587AlaLys: 4.587 ± 0.806
6.116AlaLeu: 6.116 ± 2.273
0.0AlaMet: 0.0 ± 0.0
6.116AlaAsn: 6.116 ± 3.754
4.587AlaPro: 4.587 ± 1.203
4.587AlaGln: 4.587 ± 1.203
3.058AlaArg: 3.058 ± 0.132
6.116AlaSer: 6.116 ± 0.264
6.116AlaThr: 6.116 ± 1.745
1.529AlaVal: 1.529 ± 0.939
0.0AlaTrp: 0.0 ± 0.0
6.116AlaTyr: 6.116 ± 2.273
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
1.529CysAsn: 1.529 ± 1.071
0.0CysPro: 0.0 ± 0.0
1.529CysGln: 1.529 ± 1.071
1.529CysArg: 1.529 ± 0.939
0.0CysSer: 0.0 ± 0.0
1.529CysThr: 1.529 ± 1.071
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
0.0AspCys: 0.0 ± 0.0
3.058AspAsp: 3.058 ± 2.141
1.529AspGlu: 1.529 ± 0.939
1.529AspPhe: 1.529 ± 0.939
6.116AspGly: 6.116 ± 1.745
0.0AspHis: 0.0 ± 0.0
4.587AspIle: 4.587 ± 2.816
7.645AspLys: 7.645 ± 3.344
6.116AspLeu: 6.116 ± 4.282
0.0AspMet: 0.0 ± 0.0
1.529AspAsn: 1.529 ± 1.071
1.529AspPro: 1.529 ± 0.939
0.0AspGln: 0.0 ± 0.0
3.058AspArg: 3.058 ± 2.141
4.587AspSer: 4.587 ± 0.806
4.587AspThr: 4.587 ± 3.212
4.587AspVal: 4.587 ± 1.203
0.0AspTrp: 0.0 ± 0.0
1.529AspTyr: 1.529 ± 1.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.587GluAla: 4.587 ± 0.806
1.529GluCys: 1.529 ± 1.071
0.0GluAsp: 0.0 ± 0.0
1.529GluGlu: 1.529 ± 1.071
1.529GluPhe: 1.529 ± 0.939
1.529GluGly: 1.529 ± 1.071
1.529GluHis: 1.529 ± 1.071
6.116GluIle: 6.116 ± 2.273
1.529GluLys: 1.529 ± 1.071
3.058GluLeu: 3.058 ± 0.132
3.058GluMet: 3.058 ± 2.141
3.058GluAsn: 3.058 ± 0.132
0.0GluPro: 0.0 ± 0.0
1.529GluGln: 1.529 ± 0.939
3.058GluArg: 3.058 ± 2.141
1.529GluSer: 1.529 ± 1.071
3.058GluThr: 3.058 ± 1.877
6.116GluVal: 6.116 ± 0.264
0.0GluTrp: 0.0 ± 0.0
1.529GluTyr: 1.529 ± 1.071
0.0GluXaa: 0.0 ± 0.0
Phe
1.529PheAla: 1.529 ± 0.939
0.0PheCys: 0.0 ± 0.0
3.058PheAsp: 3.058 ± 2.141
3.058PheGlu: 3.058 ± 0.132
1.529PhePhe: 1.529 ± 1.071
3.058PheGly: 3.058 ± 0.132
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
1.529PheLys: 1.529 ± 1.071
0.0PheLeu: 0.0 ± 0.0
1.529PheMet: 1.529 ± 0.939
1.529PheAsn: 1.529 ± 0.939
3.058PhePro: 3.058 ± 0.132
3.058PheGln: 3.058 ± 1.877
1.529PheArg: 1.529 ± 0.939
1.529PheSer: 1.529 ± 0.939
4.587PheThr: 4.587 ± 2.816
1.529PheVal: 1.529 ± 0.939
1.529PheTrp: 1.529 ± 0.939
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
6.116GlyAla: 6.116 ± 1.745
0.0GlyCys: 0.0 ± 0.0
1.529GlyAsp: 1.529 ± 0.939
4.587GlyGlu: 4.587 ± 1.203
1.529GlyPhe: 1.529 ± 0.939
4.587GlyGly: 4.587 ± 2.816
0.0GlyHis: 0.0 ± 0.0
1.529GlyIle: 1.529 ± 1.071
3.058GlyLys: 3.058 ± 2.141
4.587GlyLeu: 4.587 ± 0.806
0.0GlyMet: 0.0 ± 0.0
0.0GlyAsn: 0.0 ± 0.0
7.645GlyPro: 7.645 ± 0.674
0.0GlyGln: 0.0 ± 0.0
9.174GlyArg: 9.174 ± 1.613
18.349GlySer: 18.349 ± 7.244
3.058GlyThr: 3.058 ± 1.877
1.529GlyVal: 1.529 ± 0.939
3.058GlyTrp: 3.058 ± 0.132
4.587GlyTyr: 4.587 ± 0.806
0.0GlyXaa: 0.0 ± 0.0
His
1.529HisAla: 1.529 ± 1.071
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
1.529HisGly: 1.529 ± 0.939
0.0HisHis: 0.0 ± 0.0
3.058HisIle: 3.058 ± 0.132
0.0HisLys: 0.0 ± 0.0
6.116HisLeu: 6.116 ± 2.273
1.529HisMet: 1.529 ± 1.071
0.0HisAsn: 0.0 ± 0.0
1.529HisPro: 1.529 ± 1.071
0.0HisGln: 0.0 ± 0.0
3.058HisArg: 3.058 ± 2.141
1.529HisSer: 1.529 ± 1.071
3.058HisThr: 3.058 ± 1.877
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.529HisTyr: 1.529 ± 1.071
0.0HisXaa: 0.0 ± 0.0
Ile
1.529IleAla: 1.529 ± 0.939
0.0IleCys: 0.0 ± 0.0
6.116IleAsp: 6.116 ± 0.264
1.529IleGlu: 1.529 ± 1.071
1.529IlePhe: 1.529 ± 0.939
6.116IleGly: 6.116 ± 1.745
3.058IleHis: 3.058 ± 0.132
10.703IleIle: 10.703 ± 3.476
1.529IleLys: 1.529 ± 1.071
3.058IleLeu: 3.058 ± 0.132
1.529IleMet: 1.529 ± 1.071
0.0IleAsn: 0.0 ± 0.0
3.058IlePro: 3.058 ± 1.877
1.529IleGln: 1.529 ± 0.939
3.058IleArg: 3.058 ± 0.132
4.587IleSer: 4.587 ± 1.203
6.116IleThr: 6.116 ± 4.282
4.587IleVal: 4.587 ± 0.806
1.529IleTrp: 1.529 ± 1.071
4.587IleTyr: 4.587 ± 1.203
0.0IleXaa: 0.0 ± 0.0
Lys
1.529LysAla: 1.529 ± 1.071
0.0LysCys: 0.0 ± 0.0
0.0LysAsp: 0.0 ± 0.0
3.058LysGlu: 3.058 ± 2.141
0.0LysPhe: 0.0 ± 0.0
3.058LysGly: 3.058 ± 0.132
1.529LysHis: 1.529 ± 1.071
1.529LysIle: 1.529 ± 0.939
3.058LysLys: 3.058 ± 0.132
6.116LysLeu: 6.116 ± 0.264
1.529LysMet: 1.529 ± 0.939
3.058LysAsn: 3.058 ± 0.132
3.058LysPro: 3.058 ± 0.132
1.529LysGln: 1.529 ± 1.071
3.058LysArg: 3.058 ± 0.132
4.587LysSer: 4.587 ± 1.203
6.116LysThr: 6.116 ± 0.264
3.058LysVal: 3.058 ± 2.141
0.0LysTrp: 0.0 ± 0.0
4.587LysTyr: 4.587 ± 1.203
0.0LysXaa: 0.0 ± 0.0
Leu
12.232LeuAla: 12.232 ± 0.528
0.0LeuCys: 0.0 ± 0.0
3.058LeuAsp: 3.058 ± 2.141
6.116LeuGlu: 6.116 ± 2.273
3.058LeuPhe: 3.058 ± 1.877
3.058LeuGly: 3.058 ± 1.877
0.0LeuHis: 0.0 ± 0.0
1.529LeuIle: 1.529 ± 1.071
1.529LeuLys: 1.529 ± 0.939
9.174LeuLeu: 9.174 ± 4.415
0.0LeuMet: 0.0 ± 0.0
1.529LeuAsn: 1.529 ± 0.939
1.529LeuPro: 1.529 ± 1.071
9.174LeuGln: 9.174 ± 2.405
3.058LeuArg: 3.058 ± 0.132
4.587LeuSer: 4.587 ± 1.203
3.058LeuThr: 3.058 ± 0.132
0.0LeuVal: 0.0 ± 0.0
1.529LeuTrp: 1.529 ± 0.939
6.116LeuTyr: 6.116 ± 1.745
0.0LeuXaa: 0.0 ± 0.0
Met
1.529MetAla: 1.529 ± 1.071
0.0MetCys: 0.0 ± 0.0
1.529MetAsp: 1.529 ± 0.939
1.529MetGlu: 1.529 ± 0.939
1.529MetPhe: 1.529 ± 0.939
1.529MetGly: 1.529 ± 1.071
0.0MetHis: 0.0 ± 0.0
1.529MetIle: 1.529 ± 1.071
0.0MetLys: 0.0 ± 0.0
1.529MetLeu: 1.529 ± 1.071
0.0MetMet: 0.0 ± 0.0
3.058MetAsn: 3.058 ± 1.877
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
3.058MetArg: 3.058 ± 0.132
3.058MetSer: 3.058 ± 2.141
4.587MetThr: 4.587 ± 2.816
1.529MetVal: 1.529 ± 0.939
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.529AsnAla: 1.529 ± 0.939
0.0AsnCys: 0.0 ± 0.0
1.529AsnAsp: 1.529 ± 1.071
1.529AsnGlu: 1.529 ± 0.939
3.058AsnPhe: 3.058 ± 0.132
0.0AsnGly: 0.0 ± 0.0
0.0AsnHis: 0.0 ± 0.0
1.529AsnIle: 1.529 ± 0.939
3.058AsnLys: 3.058 ± 1.877
4.587AsnLeu: 4.587 ± 2.816
1.529AsnMet: 1.529 ± 1.071
3.058AsnAsn: 3.058 ± 0.132
1.529AsnPro: 1.529 ± 1.071
3.058AsnGln: 3.058 ± 1.877
0.0AsnArg: 0.0 ± 0.0
4.587AsnSer: 4.587 ± 2.816
3.058AsnThr: 3.058 ± 0.132
4.587AsnVal: 4.587 ± 0.806
3.058AsnTrp: 3.058 ± 2.141
3.058AsnTyr: 3.058 ± 1.877
0.0AsnXaa: 0.0 ± 0.0
Pro
3.058ProAla: 3.058 ± 0.132
0.0ProCys: 0.0 ± 0.0
3.058ProAsp: 3.058 ± 0.132
3.058ProGlu: 3.058 ± 0.132
3.058ProPhe: 3.058 ± 0.132
3.058ProGly: 3.058 ± 0.132
1.529ProHis: 1.529 ± 1.071
0.0ProIle: 0.0 ± 0.0
0.0ProLys: 0.0 ± 0.0
3.058ProLeu: 3.058 ± 1.877
1.529ProMet: 1.529 ± 0.939
0.0ProAsn: 0.0 ± 0.0
0.0ProPro: 0.0 ± 0.0
1.529ProGln: 1.529 ± 1.071
7.645ProArg: 7.645 ± 3.344
4.587ProSer: 4.587 ± 0.806
1.529ProThr: 1.529 ± 0.939
3.058ProVal: 3.058 ± 1.877
1.529ProTrp: 1.529 ± 1.071
3.058ProTyr: 3.058 ± 0.132
0.0ProXaa: 0.0 ± 0.0
Gln
9.174GlnAla: 9.174 ± 2.405
0.0GlnCys: 0.0 ± 0.0
1.529GlnAsp: 1.529 ± 0.939
1.529GlnGlu: 1.529 ± 1.071
0.0GlnPhe: 0.0 ± 0.0
6.116GlnGly: 6.116 ± 1.745
0.0GlnHis: 0.0 ± 0.0
3.058GlnIle: 3.058 ± 2.141
3.058GlnLys: 3.058 ± 2.141
1.529GlnLeu: 1.529 ± 1.071
1.529GlnMet: 1.529 ± 0.939
4.587GlnAsn: 4.587 ± 0.806
0.0GlnPro: 0.0 ± 0.0
3.058GlnGln: 3.058 ± 0.132
0.0GlnArg: 0.0 ± 0.0
4.587GlnSer: 4.587 ± 2.816
0.0GlnThr: 0.0 ± 0.0
1.529GlnVal: 1.529 ± 1.071
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
4.587ArgAla: 4.587 ± 1.203
1.529ArgCys: 1.529 ± 0.939
4.587ArgAsp: 4.587 ± 1.203
3.058ArgGlu: 3.058 ± 2.141
3.058ArgPhe: 3.058 ± 1.877
6.116ArgGly: 6.116 ± 1.745
1.529ArgHis: 1.529 ± 1.071
9.174ArgIle: 9.174 ± 3.622
1.529ArgLys: 1.529 ± 0.939
0.0ArgLeu: 0.0 ± 0.0
3.058ArgMet: 3.058 ± 1.877
3.058ArgAsn: 3.058 ± 0.132
6.116ArgPro: 6.116 ± 0.264
4.587ArgGln: 4.587 ± 3.212
12.232ArgArg: 12.232 ± 5.499
4.587ArgSer: 4.587 ± 0.806
1.529ArgThr: 1.529 ± 1.071
1.529ArgVal: 1.529 ± 1.071
1.529ArgTrp: 1.529 ± 0.939
4.587ArgTyr: 4.587 ± 1.203
0.0ArgXaa: 0.0 ± 0.0
Ser
3.058SerAla: 3.058 ± 0.132
0.0SerCys: 0.0 ± 0.0
9.174SerAsp: 9.174 ± 1.613
3.058SerGlu: 3.058 ± 0.132
3.058SerPhe: 3.058 ± 0.132
10.703SerGly: 10.703 ± 0.542
3.058SerHis: 3.058 ± 0.132
9.174SerIle: 9.174 ± 2.405
3.058SerLys: 3.058 ± 0.132
9.174SerLeu: 9.174 ± 1.613
3.058SerMet: 3.058 ± 0.132
3.058SerAsn: 3.058 ± 1.877
1.529SerPro: 1.529 ± 1.071
0.0SerGln: 0.0 ± 0.0
7.645SerArg: 7.645 ± 4.693
4.587SerSer: 4.587 ± 0.806
3.058SerThr: 3.058 ± 0.132
6.116SerVal: 6.116 ± 3.754
1.529SerTrp: 1.529 ± 0.939
3.058SerTyr: 3.058 ± 1.877
0.0SerXaa: 0.0 ± 0.0
Thr
1.529ThrAla: 1.529 ± 0.939
1.529ThrCys: 1.529 ± 1.071
7.645ThrAsp: 7.645 ± 3.344
6.116ThrGlu: 6.116 ± 2.273
3.058ThrPhe: 3.058 ± 0.132
3.058ThrGly: 3.058 ± 1.877
1.529ThrHis: 1.529 ± 0.939
3.058ThrIle: 3.058 ± 0.132
3.058ThrLys: 3.058 ± 0.132
1.529ThrLeu: 1.529 ± 0.939
0.0ThrMet: 0.0 ± 0.0
3.058ThrAsn: 3.058 ± 1.877
7.645ThrPro: 7.645 ± 2.683
3.058ThrGln: 3.058 ± 0.132
7.645ThrArg: 7.645 ± 2.683
4.587ThrSer: 4.587 ± 0.806
6.116ThrThr: 6.116 ± 3.754
4.587ThrVal: 4.587 ± 3.212
0.0ThrTrp: 0.0 ± 0.0
3.058ThrTyr: 3.058 ± 1.877
0.0ThrXaa: 0.0 ± 0.0
Val
4.587ValAla: 4.587 ± 0.806
0.0ValCys: 0.0 ± 0.0
3.058ValAsp: 3.058 ± 0.132
1.529ValGlu: 1.529 ± 0.939
1.529ValPhe: 1.529 ± 0.939
7.645ValGly: 7.645 ± 4.693
1.529ValHis: 1.529 ± 1.071
4.587ValIle: 4.587 ± 1.203
7.645ValLys: 7.645 ± 1.335
1.529ValLeu: 1.529 ± 0.939
3.058ValMet: 3.058 ± 0.872
3.058ValAsn: 3.058 ± 2.141
0.0ValPro: 0.0 ± 0.0
1.529ValGln: 1.529 ± 0.939
0.0ValArg: 0.0 ± 0.0
3.058ValSer: 3.058 ± 1.877
1.529ValThr: 1.529 ± 1.071
3.058ValVal: 3.058 ± 0.132
1.529ValTrp: 1.529 ± 1.071
1.529ValTyr: 1.529 ± 1.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
1.529TrpPhe: 1.529 ± 1.071
1.529TrpGly: 1.529 ± 0.939
1.529TrpHis: 1.529 ± 1.071
1.529TrpIle: 1.529 ± 1.071
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
1.529TrpMet: 1.529 ± 0.939
1.529TrpAsn: 1.529 ± 0.939
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
3.058TrpThr: 3.058 ± 0.132
3.058TrpVal: 3.058 ± 0.132
0.0TrpTrp: 0.0 ± 0.0
1.529TrpTyr: 1.529 ± 1.071
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.529TyrAla: 1.529 ± 0.939
1.529TyrCys: 1.529 ± 1.071
1.529TyrAsp: 1.529 ± 1.071
3.058TyrGlu: 3.058 ± 0.132
1.529TyrPhe: 1.529 ± 1.071
3.058TyrGly: 3.058 ± 2.141
4.587TyrHis: 4.587 ± 1.203
1.529TyrIle: 1.529 ± 1.071
4.587TyrLys: 4.587 ± 1.203
3.058TyrLeu: 3.058 ± 0.132
0.0TyrMet: 0.0 ± 0.0
1.529TyrAsn: 1.529 ± 0.939
1.529TyrPro: 1.529 ± 1.071
1.529TyrGln: 1.529 ± 0.939
6.116TyrArg: 6.116 ± 0.264
6.116TyrSer: 6.116 ± 1.745
6.116TyrThr: 6.116 ± 1.745
1.529TyrVal: 1.529 ± 0.939
0.0TyrTrp: 0.0 ± 0.0
3.058TyrTyr: 3.058 ± 0.132
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (655 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski