Amino acid dipepetide frequency for Streptococcus phage Javan264

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.803AlaAla: 6.803 ± 2.868
0.335AlaCys: 0.335 ± 0.179
4.684AlaAsp: 4.684 ± 0.619
4.907AlaGlu: 4.907 ± 0.973
3.346AlaPhe: 3.346 ± 0.636
5.911AlaGly: 5.911 ± 2.625
0.781AlaHis: 0.781 ± 0.296
7.361AlaIle: 7.361 ± 1.651
6.692AlaLys: 6.692 ± 0.791
6.246AlaLeu: 6.246 ± 1.325
2.231AlaMet: 2.231 ± 0.999
3.458AlaAsn: 3.458 ± 0.565
2.565AlaPro: 2.565 ± 0.597
4.015AlaGln: 4.015 ± 0.896
1.896AlaArg: 1.896 ± 0.493
6.134AlaSer: 6.134 ± 1.887
4.796AlaThr: 4.796 ± 0.747
5.688AlaVal: 5.688 ± 1.11
0.446AlaTrp: 0.446 ± 0.186
3.011AlaTyr: 3.011 ± 0.638
0.0AlaXaa: 0.0 ± 0.0
Cys
0.112CysAla: 0.112 ± 0.105
0.112CysCys: 0.112 ± 0.105
0.558CysAsp: 0.558 ± 0.236
0.335CysGlu: 0.335 ± 0.162
0.223CysPhe: 0.223 ± 0.162
0.112CysGly: 0.112 ± 0.114
0.223CysHis: 0.223 ± 0.255
0.669CysIle: 0.669 ± 0.363
0.558CysLys: 0.558 ± 0.229
0.112CysLeu: 0.112 ± 0.114
0.112CysMet: 0.112 ± 0.114
0.223CysAsn: 0.223 ± 0.17
0.223CysPro: 0.223 ± 0.127
0.223CysGln: 0.223 ± 0.151
0.223CysArg: 0.223 ± 0.137
0.223CysSer: 0.223 ± 0.137
0.335CysThr: 0.335 ± 0.239
0.112CysVal: 0.112 ± 0.114
0.112CysTrp: 0.112 ± 0.122
0.669CysTyr: 0.669 ± 0.243
0.0CysXaa: 0.0 ± 0.0
Asp
4.238AspAla: 4.238 ± 0.737
0.669AspCys: 0.669 ± 0.376
3.792AspAsp: 3.792 ± 0.849
5.577AspGlu: 5.577 ± 1.042
3.346AspPhe: 3.346 ± 0.8
4.796AspGly: 4.796 ± 0.919
0.781AspHis: 0.781 ± 0.242
2.565AspIle: 2.565 ± 0.632
4.238AspLys: 4.238 ± 0.84
4.573AspLeu: 4.573 ± 0.712
2.342AspMet: 2.342 ± 0.497
4.35AspAsn: 4.35 ± 0.605
1.45AspPro: 1.45 ± 0.488
1.561AspGln: 1.561 ± 0.542
1.561AspArg: 1.561 ± 0.436
4.127AspSer: 4.127 ± 0.635
3.011AspThr: 3.011 ± 0.573
4.684AspVal: 4.684 ± 0.813
1.338AspTrp: 1.338 ± 0.446
3.011AspTyr: 3.011 ± 0.63
0.0AspXaa: 0.0 ± 0.0
Glu
5.242GluAla: 5.242 ± 0.724
0.112GluCys: 0.112 ± 0.113
3.569GluAsp: 3.569 ± 0.745
5.242GluGlu: 5.242 ± 1.113
3.123GluPhe: 3.123 ± 0.661
2.342GluGly: 2.342 ± 0.657
0.446GluHis: 0.446 ± 0.249
4.684GluIle: 4.684 ± 0.973
6.357GluLys: 6.357 ± 0.841
7.027GluLeu: 7.027 ± 1.054
2.565GluMet: 2.565 ± 0.509
3.681GluAsn: 3.681 ± 0.856
2.342GluPro: 2.342 ± 0.565
3.234GluGln: 3.234 ± 0.618
2.454GluArg: 2.454 ± 0.591
3.569GluSer: 3.569 ± 0.635
4.015GluThr: 4.015 ± 0.914
4.35GluVal: 4.35 ± 0.793
1.227GluTrp: 1.227 ± 0.446
2.342GluTyr: 2.342 ± 0.642
0.0GluXaa: 0.0 ± 0.0
Phe
2.677PheAla: 2.677 ± 0.72
0.223PheCys: 0.223 ± 0.155
3.011PheAsp: 3.011 ± 0.728
4.238PheGlu: 4.238 ± 0.778
1.561PhePhe: 1.561 ± 0.428
2.9PheGly: 2.9 ± 0.393
0.669PheHis: 0.669 ± 0.285
1.896PheIle: 1.896 ± 0.422
3.011PheLys: 3.011 ± 0.507
2.454PheLeu: 2.454 ± 0.445
1.45PheMet: 1.45 ± 0.491
2.677PheAsn: 2.677 ± 0.548
0.892PhePro: 0.892 ± 0.265
1.227PheGln: 1.227 ± 0.315
1.115PheArg: 1.115 ± 0.307
2.565PheSer: 2.565 ± 0.462
3.234PheThr: 3.234 ± 0.688
2.9PheVal: 2.9 ± 0.427
0.223PheTrp: 0.223 ± 0.158
1.45PheTyr: 1.45 ± 0.516
0.0PheXaa: 0.0 ± 0.0
Gly
6.023GlyAla: 6.023 ± 1.152
0.0GlyCys: 0.0 ± 0.0
3.569GlyAsp: 3.569 ± 0.673
3.123GlyGlu: 3.123 ± 0.811
2.119GlyPhe: 2.119 ± 0.387
4.015GlyGly: 4.015 ± 1.006
1.338GlyHis: 1.338 ± 0.409
5.13GlyIle: 5.13 ± 1.01
5.688GlyLys: 5.688 ± 0.83
5.8GlyLeu: 5.8 ± 1.221
2.342GlyMet: 2.342 ± 0.772
4.015GlyAsn: 4.015 ± 0.839
0.223GlyPro: 0.223 ± 0.187
4.015GlyGln: 4.015 ± 0.824
1.338GlyArg: 1.338 ± 0.392
3.904GlySer: 3.904 ± 1.053
3.681GlyThr: 3.681 ± 0.677
4.127GlyVal: 4.127 ± 1.076
0.669GlyTrp: 0.669 ± 0.274
3.011GlyTyr: 3.011 ± 0.718
0.0GlyXaa: 0.0 ± 0.0
His
1.004HisAla: 1.004 ± 0.308
0.446HisCys: 0.446 ± 0.22
0.781HisAsp: 0.781 ± 0.285
0.892HisGlu: 0.892 ± 0.349
0.112HisPhe: 0.112 ± 0.106
1.45HisGly: 1.45 ± 0.483
0.112HisHis: 0.112 ± 0.106
0.892HisIle: 0.892 ± 0.29
1.115HisLys: 1.115 ± 0.35
1.561HisLeu: 1.561 ± 0.419
0.335HisMet: 0.335 ± 0.253
0.669HisAsn: 0.669 ± 0.185
0.558HisPro: 0.558 ± 0.285
0.446HisGln: 0.446 ± 0.228
0.446HisArg: 0.446 ± 0.234
0.892HisSer: 0.892 ± 0.239
0.446HisThr: 0.446 ± 0.245
0.781HisVal: 0.781 ± 0.322
0.0HisTrp: 0.0 ± 0.0
0.335HisTyr: 0.335 ± 0.179
0.0HisXaa: 0.0 ± 0.0
Ile
5.242IleAla: 5.242 ± 1.169
0.446IleCys: 0.446 ± 0.225
4.796IleAsp: 4.796 ± 0.72
4.238IleGlu: 4.238 ± 0.736
2.677IlePhe: 2.677 ± 0.683
3.681IleGly: 3.681 ± 1.156
0.446IleHis: 0.446 ± 0.224
3.681IleIle: 3.681 ± 0.808
6.023IleLys: 6.023 ± 0.623
4.684IleLeu: 4.684 ± 0.731
1.45IleMet: 1.45 ± 0.301
3.792IleAsn: 3.792 ± 0.558
3.011IlePro: 3.011 ± 0.546
3.011IleGln: 3.011 ± 0.585
2.342IleArg: 2.342 ± 0.459
4.684IleSer: 4.684 ± 1.076
4.238IleThr: 4.238 ± 0.601
3.234IleVal: 3.234 ± 0.902
0.223IleTrp: 0.223 ± 0.156
3.234IleTyr: 3.234 ± 0.728
0.0IleXaa: 0.0 ± 0.0
Lys
5.911LysAla: 5.911 ± 0.922
1.004LysCys: 1.004 ± 0.346
5.354LysAsp: 5.354 ± 1.062
5.911LysGlu: 5.911 ± 1.21
2.9LysPhe: 2.9 ± 0.585
5.354LysGly: 5.354 ± 0.694
0.892LysHis: 0.892 ± 0.385
6.134LysIle: 6.134 ± 0.854
5.019LysLys: 5.019 ± 1.071
6.134LysLeu: 6.134 ± 1.028
2.119LysMet: 2.119 ± 0.512
4.015LysAsn: 4.015 ± 0.635
2.342LysPro: 2.342 ± 0.487
4.684LysGln: 4.684 ± 0.859
4.127LysArg: 4.127 ± 1.057
5.242LysSer: 5.242 ± 0.927
5.577LysThr: 5.577 ± 0.927
5.465LysVal: 5.465 ± 0.943
0.558LysTrp: 0.558 ± 0.245
2.008LysTyr: 2.008 ± 0.589
0.0LysXaa: 0.0 ± 0.0
Leu
4.796LeuAla: 4.796 ± 0.801
0.0LeuCys: 0.0 ± 0.0
6.023LeuAsp: 6.023 ± 0.942
6.692LeuGlu: 6.692 ± 1.353
3.681LeuPhe: 3.681 ± 0.622
5.465LeuGly: 5.465 ± 0.938
1.115LeuHis: 1.115 ± 0.381
4.35LeuIle: 4.35 ± 0.591
7.25LeuLys: 7.25 ± 0.841
5.577LeuLeu: 5.577 ± 0.6
2.119LeuMet: 2.119 ± 0.417
4.796LeuAsn: 4.796 ± 0.67
2.788LeuPro: 2.788 ± 0.603
3.458LeuGln: 3.458 ± 0.813
2.788LeuArg: 2.788 ± 0.635
5.911LeuSer: 5.911 ± 0.861
5.465LeuThr: 5.465 ± 0.778
4.573LeuVal: 4.573 ± 0.687
0.0LeuTrp: 0.0 ± 0.0
2.119LeuTyr: 2.119 ± 0.45
0.0LeuXaa: 0.0 ± 0.0
Met
3.458MetAla: 3.458 ± 1.213
0.0MetCys: 0.0 ± 0.0
1.004MetAsp: 1.004 ± 0.283
2.454MetGlu: 2.454 ± 0.657
1.004MetPhe: 1.004 ± 0.352
1.45MetGly: 1.45 ± 0.375
1.004MetHis: 1.004 ± 0.408
1.673MetIle: 1.673 ± 0.472
2.565MetLys: 2.565 ± 0.596
1.785MetLeu: 1.785 ± 0.456
0.335MetMet: 0.335 ± 0.191
1.561MetAsn: 1.561 ± 0.453
0.223MetPro: 0.223 ± 0.165
1.896MetGln: 1.896 ± 0.504
1.115MetArg: 1.115 ± 0.392
2.119MetSer: 2.119 ± 0.654
2.9MetThr: 2.9 ± 0.611
1.896MetVal: 1.896 ± 0.609
0.223MetTrp: 0.223 ± 0.163
0.558MetTyr: 0.558 ± 0.31
0.0MetXaa: 0.0 ± 0.0
Asn
5.019AsnAla: 5.019 ± 0.747
0.446AsnCys: 0.446 ± 0.335
2.342AsnAsp: 2.342 ± 0.529
3.792AsnGlu: 3.792 ± 0.448
1.673AsnPhe: 1.673 ± 0.412
5.8AsnGly: 5.8 ± 0.936
0.669AsnHis: 0.669 ± 0.273
3.011AsnIle: 3.011 ± 0.529
4.238AsnLys: 4.238 ± 0.79
3.792AsnLeu: 3.792 ± 0.572
1.785AsnMet: 1.785 ± 0.549
2.231AsnAsn: 2.231 ± 0.367
3.011AsnPro: 3.011 ± 0.586
2.342AsnGln: 2.342 ± 0.515
2.788AsnArg: 2.788 ± 0.598
2.788AsnSer: 2.788 ± 0.461
4.127AsnThr: 4.127 ± 0.777
2.9AsnVal: 2.9 ± 0.485
1.227AsnTrp: 1.227 ± 0.318
2.9AsnTyr: 2.9 ± 0.622
0.0AsnXaa: 0.0 ± 0.0
Pro
2.454ProAla: 2.454 ± 0.619
0.335ProCys: 0.335 ± 0.197
1.896ProAsp: 1.896 ± 0.42
1.896ProGlu: 1.896 ± 0.662
1.561ProPhe: 1.561 ± 0.576
0.781ProGly: 0.781 ± 0.299
0.335ProHis: 0.335 ± 0.204
2.008ProIle: 2.008 ± 0.409
2.677ProLys: 2.677 ± 0.646
2.342ProLeu: 2.342 ± 0.453
0.781ProMet: 0.781 ± 0.283
2.9ProAsn: 2.9 ± 0.609
0.335ProPro: 0.335 ± 0.195
0.892ProGln: 0.892 ± 0.489
0.892ProArg: 0.892 ± 0.363
1.896ProSer: 1.896 ± 0.5
2.008ProThr: 2.008 ± 0.495
2.565ProVal: 2.565 ± 0.39
0.0ProTrp: 0.0 ± 0.0
1.115ProTyr: 1.115 ± 0.333
0.0ProXaa: 0.0 ± 0.0
Gln
5.577GlnAla: 5.577 ± 1.275
0.223GlnCys: 0.223 ± 0.15
2.231GlnAsp: 2.231 ± 0.46
2.565GlnGlu: 2.565 ± 0.691
1.896GlnPhe: 1.896 ± 0.454
2.565GlnGly: 2.565 ± 0.546
0.781GlnHis: 0.781 ± 0.273
2.9GlnIle: 2.9 ± 0.804
4.127GlnLys: 4.127 ± 1.0
3.904GlnLeu: 3.904 ± 0.697
1.561GlnMet: 1.561 ± 0.914
2.788GlnAsn: 2.788 ± 0.533
1.561GlnPro: 1.561 ± 0.432
2.119GlnGln: 2.119 ± 0.508
2.231GlnArg: 2.231 ± 0.574
2.454GlnSer: 2.454 ± 0.524
2.119GlnThr: 2.119 ± 0.483
2.231GlnVal: 2.231 ± 0.53
0.335GlnTrp: 0.335 ± 0.198
1.561GlnTyr: 1.561 ± 0.59
0.0GlnXaa: 0.0 ± 0.0
Arg
1.561ArgAla: 1.561 ± 0.414
0.223ArgCys: 0.223 ± 0.145
2.008ArgAsp: 2.008 ± 0.614
2.231ArgGlu: 2.231 ± 0.523
1.673ArgPhe: 1.673 ± 0.481
1.561ArgGly: 1.561 ± 0.427
0.112ArgHis: 0.112 ± 0.106
2.342ArgIle: 2.342 ± 0.521
4.573ArgLys: 4.573 ± 0.878
4.238ArgLeu: 4.238 ± 0.679
1.004ArgMet: 1.004 ± 0.311
2.342ArgAsn: 2.342 ± 0.514
1.115ArgPro: 1.115 ± 0.345
1.004ArgGln: 1.004 ± 0.34
2.008ArgArg: 2.008 ± 0.524
1.45ArgSer: 1.45 ± 0.35
2.677ArgThr: 2.677 ± 0.69
1.785ArgVal: 1.785 ± 0.519
0.669ArgTrp: 0.669 ± 0.29
1.785ArgTyr: 1.785 ± 0.48
0.0ArgXaa: 0.0 ± 0.0
Ser
7.027SerAla: 7.027 ± 2.221
0.112SerCys: 0.112 ± 0.092
4.015SerAsp: 4.015 ± 0.637
4.127SerGlu: 4.127 ± 0.796
1.896SerPhe: 1.896 ± 0.488
4.573SerGly: 4.573 ± 0.689
0.892SerHis: 0.892 ± 0.32
4.573SerIle: 4.573 ± 0.783
4.461SerLys: 4.461 ± 0.599
5.019SerLeu: 5.019 ± 0.949
2.119SerMet: 2.119 ± 0.655
2.9SerAsn: 2.9 ± 0.564
1.338SerPro: 1.338 ± 0.364
3.011SerGln: 3.011 ± 0.798
3.346SerArg: 3.346 ± 0.662
4.796SerSer: 4.796 ± 1.174
2.788SerThr: 2.788 ± 0.672
4.684SerVal: 4.684 ± 0.731
1.115SerTrp: 1.115 ± 0.323
2.788SerTyr: 2.788 ± 0.735
0.0SerXaa: 0.0 ± 0.0
Thr
4.796ThrAla: 4.796 ± 1.511
0.335ThrCys: 0.335 ± 0.212
3.792ThrAsp: 3.792 ± 0.707
3.681ThrGlu: 3.681 ± 0.875
2.9ThrPhe: 2.9 ± 0.619
3.458ThrGly: 3.458 ± 0.607
0.781ThrHis: 0.781 ± 0.28
4.796ThrIle: 4.796 ± 0.9
4.015ThrLys: 4.015 ± 0.752
5.13ThrLeu: 5.13 ± 0.888
1.561ThrMet: 1.561 ± 0.393
3.234ThrAsn: 3.234 ± 0.503
1.785ThrPro: 1.785 ± 0.41
3.346ThrGln: 3.346 ± 0.689
1.896ThrArg: 1.896 ± 0.327
4.684ThrSer: 4.684 ± 0.645
4.796ThrThr: 4.796 ± 0.972
5.465ThrVal: 5.465 ± 0.615
0.558ThrTrp: 0.558 ± 0.228
2.454ThrTyr: 2.454 ± 0.574
0.0ThrXaa: 0.0 ± 0.0
Val
5.019ValAla: 5.019 ± 1.495
0.112ValCys: 0.112 ± 0.104
4.796ValAsp: 4.796 ± 0.902
3.792ValGlu: 3.792 ± 0.738
1.896ValPhe: 1.896 ± 0.551
4.684ValGly: 4.684 ± 0.659
1.227ValHis: 1.227 ± 0.416
3.681ValIle: 3.681 ± 0.584
4.127ValLys: 4.127 ± 0.769
4.573ValLeu: 4.573 ± 0.644
1.785ValMet: 1.785 ± 0.318
4.238ValAsn: 4.238 ± 0.695
2.342ValPro: 2.342 ± 0.525
3.123ValGln: 3.123 ± 0.959
1.785ValArg: 1.785 ± 0.378
5.354ValSer: 5.354 ± 0.876
4.461ValThr: 4.461 ± 0.637
4.238ValVal: 4.238 ± 0.78
0.781ValTrp: 0.781 ± 0.241
2.008ValTyr: 2.008 ± 0.586
0.0ValXaa: 0.0 ± 0.0
Trp
0.669TrpAla: 0.669 ± 0.279
0.0TrpCys: 0.0 ± 0.0
1.115TrpAsp: 1.115 ± 0.33
0.892TrpGlu: 0.892 ± 0.248
0.335TrpPhe: 0.335 ± 0.189
1.004TrpGly: 1.004 ± 0.303
0.223TrpHis: 0.223 ± 0.169
0.669TrpIle: 0.669 ± 0.221
0.669TrpLys: 0.669 ± 0.282
1.115TrpLeu: 1.115 ± 0.325
0.223TrpMet: 0.223 ± 0.142
0.558TrpAsn: 0.558 ± 0.256
0.0TrpPro: 0.0 ± 0.0
0.446TrpGln: 0.446 ± 0.185
0.558TrpArg: 0.558 ± 0.254
0.112TrpSer: 0.112 ± 0.104
0.781TrpThr: 0.781 ± 0.315
0.446TrpVal: 0.446 ± 0.223
0.112TrpTrp: 0.112 ± 0.118
0.558TrpTyr: 0.558 ± 0.209
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.681TyrAla: 3.681 ± 0.781
0.335TyrCys: 0.335 ± 0.189
2.677TyrAsp: 2.677 ± 0.638
1.338TyrGlu: 1.338 ± 0.471
2.454TyrPhe: 2.454 ± 0.564
2.231TyrGly: 2.231 ± 0.576
0.446TyrHis: 0.446 ± 0.231
2.119TyrIle: 2.119 ± 0.465
3.458TyrLys: 3.458 ± 0.905
2.9TyrLeu: 2.9 ± 0.713
0.892TyrMet: 0.892 ± 0.289
2.454TyrAsn: 2.454 ± 0.524
1.561TyrPro: 1.561 ± 0.641
1.673TyrGln: 1.673 ± 0.37
1.45TyrArg: 1.45 ± 0.363
2.677TyrSer: 2.677 ± 0.531
2.008TyrThr: 2.008 ± 0.729
1.896TyrVal: 1.896 ± 0.482
0.669TyrTrp: 0.669 ± 0.293
2.342TyrTyr: 2.342 ± 0.62
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 44 proteins (8967 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski